JP2014088432A5 - - Google Patents
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- Publication number
- JP2014088432A5 JP2014088432A5 JP2014007144A JP2014007144A JP2014088432A5 JP 2014088432 A5 JP2014088432 A5 JP 2014088432A5 JP 2014007144 A JP2014007144 A JP 2014007144A JP 2014007144 A JP2014007144 A JP 2014007144A JP 2014088432 A5 JP2014088432 A5 JP 2014088432A5
- Authority
- JP
- Japan
- Prior art keywords
- subject
- genetically modified
- stem cells
- use according
- promoter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 39
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 39
- 210000000130 stem cell Anatomy 0.000 claims 39
- 239000003623 enhancer Substances 0.000 claims 15
- 102000004169 proteins and genes Human genes 0.000 claims 10
- 108090000623 proteins and genes Proteins 0.000 claims 10
- 230000004663 cell proliferation Effects 0.000 claims 9
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 8
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 8
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 8
- 210000002889 endothelial cell Anatomy 0.000 claims 8
- 208000014674 injury Diseases 0.000 claims 7
- 206010018429 Glucose tolerance impaired Diseases 0.000 claims 6
- 230000000735 allogeneic effect Effects 0.000 claims 6
- 230000008733 trauma Effects 0.000 claims 6
- 230000037396 body weight Effects 0.000 claims 5
- 210000001185 bone marrow Anatomy 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 210000003038 endothelium Anatomy 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 238000001356 surgical procedure Methods 0.000 claims 5
- 101100481408 Danio rerio tie2 gene Proteins 0.000 claims 4
- 101100481410 Mus musculus Tek gene Proteins 0.000 claims 4
- 206010012601 diabetes mellitus Diseases 0.000 claims 4
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 3
- 230000033115 angiogenesis Effects 0.000 claims 3
- 208000010643 digestive system disease Diseases 0.000 claims 3
- 208000018685 gastrointestinal system disease Diseases 0.000 claims 3
- 210000003205 muscle Anatomy 0.000 claims 3
- 210000000663 muscle cell Anatomy 0.000 claims 3
- 206010013801 Duchenne Muscular Dystrophy Diseases 0.000 claims 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 230000004089 microcirculation Effects 0.000 claims 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- 230000029663 wound healing Effects 0.000 claims 2
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 102000001039 Dystrophin Human genes 0.000 claims 1
- 108010069091 Dystrophin Proteins 0.000 claims 1
- 101001023030 Toxoplasma gondii Myosin-D Proteins 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 238000012084 abdominal surgery Methods 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 230000035606 childbirth Effects 0.000 claims 1
- 206010009887 colitis Diseases 0.000 claims 1
- 238000002316 cosmetic surgery Methods 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 238000002350 laparotomy Methods 0.000 claims 1
- 201000006938 muscular dystrophy Diseases 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93162207P | 2007-05-24 | 2007-05-24 | |
| US60/931,622 | 2007-05-24 | ||
| US305007P | 2007-11-14 | 2007-11-14 | |
| US61/003,050 | 2007-11-14 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010509362A Division JP2010528008A (ja) | 2007-05-24 | 2008-05-20 | Ｃｄ３４幹細胞に関連した方法および組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014088432A JP2014088432A (ja) | 2014-05-15 |
| JP2014088432A5 true JP2014088432A5 (https=) | 2014-10-16 |
Family
ID=40093981
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010509362A Pending JP2010528008A (ja) | 2007-05-24 | 2008-05-20 | Ｃｄ３４幹細胞に関連した方法および組成物 |
| JP2014007144A Pending JP2014088432A (ja) | 2007-05-24 | 2014-01-17 | Ｃｄ３４幹細胞に関連した方法および組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010509362A Pending JP2010528008A (ja) | 2007-05-24 | 2008-05-20 | Ｃｄ３４幹細胞に関連した方法および組成物 |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US7998472B2 (https=) |
| EP (4) | EP2223696B1 (https=) |
| JP (2) | JP2010528008A (https=) |
| CN (2) | CN103263439B (https=) |
| AU (1) | AU2008260651B2 (https=) |
| BR (1) | BRPI0811906A2 (https=) |
| CA (1) | CA2688032C (https=) |
| DK (1) | DK2223696T3 (https=) |
| ES (3) | ES2401608T3 (https=) |
| PL (1) | PL2162534T3 (https=) |
| WO (1) | WO2008150368A1 (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8574567B2 (en) | 2007-05-03 | 2013-11-05 | The Brigham And Women's Hospital, Inc. | Multipotent stem cells and uses thereof |
| EP2607477B1 (en) | 2007-05-03 | 2020-09-23 | The Brigham and Women's Hospital, Inc. | Multipotent stem cells and uses thereof |
| PL2557520T3 (pl) | 2007-07-23 | 2021-10-11 | The Chinese University Of Hong Kong | Określanie zaburzenia równowagi sekwencji kwasu nukleinowego |
| US12180549B2 (en) | 2007-07-23 | 2024-12-31 | The Chinese University Of Hong Kong | Diagnosing fetal chromosomal aneuploidy using genomic sequencing |
| BRPI0909541A2 (pt) * | 2008-05-27 | 2016-10-11 | Pluristem Ltd | ''método para tratamento de doenças inflamatórias do cólon'' |
| RU2539099C2 (ru) * | 2009-04-13 | 2015-01-10 | Апцет Гмбх Унд Ко.Кг | Сконструированные мезенхимальные стволовые клетки и способ их применения для лечения опухолей |
| US20110027239A1 (en) * | 2009-07-29 | 2011-02-03 | Tissue Genesis, Inc. | Adipose-derived stromal cells (asc) as delivery tool for treatment of cancer |
| US9352003B1 (en) | 2010-05-14 | 2016-05-31 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US10130736B1 (en) | 2010-05-14 | 2018-11-20 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US8883210B1 (en) | 2010-05-14 | 2014-11-11 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| WO2012018127A1 (ja) * | 2010-08-06 | 2012-02-09 | 国立大学法人大阪大学 | 膵島と脂肪組織由来幹細胞を利用した膵島移植 |
| US8834928B1 (en) | 2011-05-16 | 2014-09-16 | Musculoskeletal Transplant Foundation | Tissue-derived tissugenic implants, and methods of fabricating and using same |
| US8961956B2 (en) | 2011-11-30 | 2015-02-24 | Ocata Therapeutics, Inc. | Mesenchymal stromal cells and uses related thereto |
| SI2785359T1 (sl) | 2011-11-30 | 2018-11-30 | Astellas Institute For Regenerative Medicine | Mezenhimske stromalne celice in uporabe povezane z njimi |
| US20130171115A1 (en) * | 2011-12-30 | 2013-07-04 | Gang Li | Cell-mediated gene therapy for cancer using mesenchymal stem cells expressing a suicide gene |
| JP2015506697A (ja) * | 2012-02-01 | 2015-03-05 | ポステック アカデミー‐インダストリー ファウンデーション | １２量体ｔｒａｉｌ及びｈｓｖ−ｔｋ自殺遺伝子を同時に発現するベクター並びにそれを用いた抗癌幹細胞治療剤 |
| US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
| HK1208054A1 (en) | 2012-07-12 | 2016-02-19 | 爱姆斯坦生物技术公司 | Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof |
| US20150037436A1 (en) | 2013-07-30 | 2015-02-05 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
| WO2016026854A2 (en) * | 2014-08-18 | 2016-02-25 | Apceth Gmbh & Co. Kg | Genetically modified mesenchymal stem cells expressing an immune response-stimulating cytokine to attract and/or activate immune cells |
| US10364467B2 (en) | 2015-01-13 | 2019-07-30 | The Chinese University Of Hong Kong | Using size and number aberrations in plasma DNA for detecting cancer |
| CN104622903B (zh) * | 2015-01-20 | 2018-10-09 | 奥思达干细胞有限公司 | 抗恶性黑色素瘤的干细胞制剂及其制备方法 |
| CA2986702C (en) | 2015-05-21 | 2023-04-04 | David Wang | Modified demineralized cortical bone fibers |
| US10912864B2 (en) | 2015-07-24 | 2021-02-09 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
| US11052175B2 (en) | 2015-08-19 | 2021-07-06 | Musculoskeletal Transplant Foundation | Cartilage-derived implants and methods of making and using same |
| KR20190003456A (ko) | 2016-04-01 | 2019-01-09 | 아프세스 게엠베하 & 씨오. 카게 | 면역치료의 항-종양 활성을 높이기 위한 중간엽 줄기세포 |
| JP7332474B2 (ja) * | 2017-02-24 | 2023-08-23 | ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム | ミオミキサーにより促進される筋細胞融合に関連する組成物および方法 |
| EP3366303B1 (en) * | 2017-02-28 | 2020-06-24 | Martin-Luther-Universität Halle-Wittenberg | Enhancing the targeted in vivo delivery of cellular therapies |
| WO2018191619A1 (en) | 2017-04-13 | 2018-10-18 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| EP3807304A1 (en) | 2018-06-15 | 2021-04-21 | Children's Hospital Medical Center | Polypeptides, nucleic acid molecules, compositions, and related methods |
| AU2019359890B2 (en) | 2018-10-17 | 2024-10-24 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| US11419898B2 (en) | 2018-10-17 | 2022-08-23 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| CN120678804A (zh) * | 2025-08-07 | 2025-09-23 | 黄永茂 | 调理人体经络生物电的氯化氢组分液及其应用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7514074B2 (en) * | 1997-07-14 | 2009-04-07 | Osiris Therapeutics, Inc. | Cardiac muscle regeneration using mesenchymal stem cells |
| US20010038834A1 (en) | 1998-01-26 | 2001-11-08 | Gary Balian | Bone cancer therapy |
| US20030100107A1 (en) * | 1998-05-29 | 2003-05-29 | Thomas Jefferson University | Compositions and methods for generating differentiated human cells |
| DE19833476B4 (de) * | 1998-07-24 | 2005-08-25 | Huss, Ralf, Dr. | Genetisch modifizierte CD34-Negative, adhärent wachsende hämatopoetische Stammzellen und deren Verwendung in der Gentherapie |
| US20030082155A1 (en) * | 1999-12-06 | 2003-05-01 | Habener Joel F. | Stem cells of the islets of langerhans and their use in treating diabetes mellitus |
| CA2392615A1 (en) * | 1999-12-06 | 2001-06-07 | The General Hospital Corporation | Pancreatic stem cells and their use in transplantation |
| WO2002061033A2 (en) * | 2000-11-27 | 2002-08-08 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Transfection of human embryonic stem cells |
| EP1403281B1 (en) * | 2001-06-14 | 2008-07-09 | Takeda Pharmaceutical Company Limited | Novel ligand and dna thereof |
| WO2003010305A1 (en) * | 2001-07-27 | 2003-02-06 | Arhus Amt | Immortilized stem cells |
| AU2002325758A1 (en) | 2001-09-20 | 2003-04-01 | Centre For Translational Research In Cancer | Cultured stromal cells and uses thereof |
| JP2005522215A (ja) * | 2002-04-12 | 2005-07-28 | セルジーン・コーポレーション | 幹細胞及び前駆細胞の分化のモジュレーション、アッセイ、並びにそれらの使用 |
| JP2005532810A (ja) * | 2002-07-16 | 2005-11-04 | イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム | 組織修復および組織形成のために間葉性幹細胞を移植する方法 |
| CA2505251A1 (en) * | 2002-11-05 | 2004-05-27 | Brigham And Women's Hospital, Inc. | Mesenchymal stem cells and methods of use thereof |
| EP1668119A2 (en) | 2003-09-15 | 2006-06-14 | Ramot at Tel Aviv University Ltd. | Insulin-producing bone marrow derived cells and methods of generating and using same |
| JP2007520462A (ja) * | 2003-12-19 | 2007-07-26 | バイアセル インコーポレーティッド | ヒト臍帯血由来多能性細胞の疾患の処置のための使用方法 |
| EP3461884B1 (en) * | 2004-03-22 | 2025-05-28 | Mesoblast International Sàrl | Mesenchymal stem cells and uses therefor |
| WO2005097147A1 (en) * | 2004-03-30 | 2005-10-20 | Boston Scientific Limited (Incorporated In Ireland) | Restenosis therapy using mesenchymal stem cells |
| JP2006345726A (ja) | 2005-06-14 | 2006-12-28 | Hamamatsu Univ School Of Medicine | 脳腫瘍治療用発現ベクター |
| KR101022401B1 (ko) | 2005-09-29 | 2011-03-15 | 아주대학교산학협력단 | 자살유전자를 발현하는 중간엽 줄기세포를 포함하는 암치료용 조성물 |
-
2008
- 2008-05-20 WO PCT/US2008/006434 patent/WO2008150368A1/en not_active Ceased
- 2008-05-20 BR BRPI0811906-6A2A patent/BRPI0811906A2/pt not_active IP Right Cessation
- 2008-05-20 EP EP10163667.8A patent/EP2223696B1/en not_active Not-in-force
- 2008-05-20 ES ES10163663T patent/ES2401608T3/es active Active
- 2008-05-20 EP EP08754569.5A patent/EP2162534B1/en not_active Not-in-force
- 2008-05-20 ES ES08754569.5T patent/ES2507507T3/es active Active
- 2008-05-20 JP JP2010509362A patent/JP2010528008A/ja active Pending
- 2008-05-20 PL PL08754569T patent/PL2162534T3/pl unknown
- 2008-05-20 US US12/154,059 patent/US7998472B2/en not_active Expired - Fee Related
- 2008-05-20 CA CA2688032A patent/CA2688032C/en not_active Expired - Fee Related
- 2008-05-20 EP EP14172302.3A patent/EP2851422A3/en not_active Withdrawn
- 2008-05-20 CN CN201310125890.4A patent/CN103263439B/zh not_active Expired - Fee Related
- 2008-05-20 CN CN2008801001004A patent/CN101778934B/zh not_active Expired - Fee Related
- 2008-05-20 AU AU2008260651A patent/AU2008260651B2/en not_active Ceased
- 2008-05-20 DK DK10163667.8T patent/DK2223696T3/da active
- 2008-05-20 ES ES10163667T patent/ES2430071T3/es active Active
- 2008-05-20 EP EP10163663A patent/EP2229948B1/en not_active Not-in-force
-
2011
- 2011-07-08 US US13/179,374 patent/US20110268714A1/en not_active Abandoned
-
2014
- 2014-01-17 JP JP2014007144A patent/JP2014088432A/ja active Pending
-
2015
- 2015-05-08 US US14/707,872 patent/US20150238541A1/en not_active Abandoned
- 2015-05-08 US US14/707,654 patent/US20150238526A1/en not_active Abandoned
- 2015-05-08 US US14/707,739 patent/US20160136207A1/en not_active Abandoned
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