AU2008260651B2 - CD34 stem cell-related methods and compositions - Google Patents
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| US20100291042A1 (en) | 2007-05-03 | 2010-11-18 | The Brigham And Women's Hospital, Inc. | Multipotent stem cells and uses thereof |
| US12180549B2 (en) | 2007-07-23 | 2024-12-31 | The Chinese University Of Hong Kong | Diagnosing fetal chromosomal aneuploidy using genomic sequencing |
| LT2557517T (lt) | 2007-07-23 | 2023-01-10 | The Chinese University Of Hong Kong | Nukleino rūgščių sekos disbalanso nustatymas |
| EP2641606A1 (en) * | 2008-05-27 | 2013-09-25 | Pluristem Ltd. | Methods of treating inflammatory colon diseases |
| JP5727458B2 (ja) | 2009-04-13 | 2015-06-03 | アプセト ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフトＡｐｃｅｔｈ Ｇｍｂｈ ＆ Ｃｏ． Ｋｇ | 改変間葉系幹細胞及びそれを使用した腫瘍の治療方法 |
| US20110027239A1 (en) * | 2009-07-29 | 2011-02-03 | Tissue Genesis, Inc. | Adipose-derived stromal cells (asc) as delivery tool for treatment of cancer |
| US8883210B1 (en) | 2010-05-14 | 2014-11-11 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US9352003B1 (en) | 2010-05-14 | 2016-05-31 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US10130736B1 (en) | 2010-05-14 | 2018-11-20 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| WO2012018127A1 (ja) * | 2010-08-06 | 2012-02-09 | 国立大学法人大阪大学 | 膵島と脂肪組織由来幹細胞を利用した膵島移植 |
| US8834928B1 (en) | 2011-05-16 | 2014-09-16 | Musculoskeletal Transplant Foundation | Tissue-derived tissugenic implants, and methods of fabricating and using same |
| US8961956B2 (en) | 2011-11-30 | 2015-02-24 | Ocata Therapeutics, Inc. | Mesenchymal stromal cells and uses related thereto |
| KR102246369B1 (ko) | 2011-11-30 | 2021-04-29 | 아스텔라스 인스티튜트 포 리제너러티브 메디슨 | 중간엽 간질 세포 및 이에 관련된 용도 |
| US20130171115A1 (en) * | 2011-12-30 | 2013-07-04 | Gang Li | Cell-mediated gene therapy for cancer using mesenchymal stem cells expressing a suicide gene |
| KR102053385B1 (ko) * | 2012-02-01 | 2019-12-06 | 포항공과대학교 산학협력단 | 12량체 ｔｒａｉｌ 및 ｈｓｖ-ｔｋ 자살유전자를 동시에 발현하는 벡터 및 이를 이용한 항암 줄기세포 치료제 |
| US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
| US9745551B2 (en) | 2012-07-12 | 2017-08-29 | Imstem Biotechnology, Inc. | Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof |
| MX2016001247A (es) | 2013-07-30 | 2016-08-17 | Musculoskeletal Transplant Foundation | Matrices derivadas de tejido suave acelular y metodos para preparar las mismas. |
| CN106659742B (zh) * | 2014-08-18 | 2021-09-03 | 埃普塞斯有限责任两合公司 | 表达免疫应答刺激细胞因子以吸引和/或激活免疫细胞的基因修饰间充质干细胞 |
| US10364467B2 (en) | 2015-01-13 | 2019-07-30 | The Chinese University Of Hong Kong | Using size and number aberrations in plasma DNA for detecting cancer |
| CN104622903B (zh) * | 2015-01-20 | 2018-10-09 | 奥思达干细胞有限公司 | 抗恶性黑色素瘤的干细胞制剂及其制备方法 |
| CA3177726A1 (en) | 2015-05-21 | 2016-11-24 | Musculoskeletal Transplant Foundation | Modified demineralized cortical bone fibers |
| US10912864B2 (en) | 2015-07-24 | 2021-02-09 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
| US11052175B2 (en) | 2015-08-19 | 2021-07-06 | Musculoskeletal Transplant Foundation | Cartilage-derived implants and methods of making and using same |
| PL3411473T3 (pl) * | 2016-04-01 | 2021-05-04 | JunctuCell Biomed Manufacturing GmbH | Mezenchymalne komórki macierzyste nasilające aktywność antynowotworową immunoterapii |
| US20190382732A1 (en) * | 2017-02-24 | 2019-12-19 | The Board Of Regents Of The University Of Texas System | Compositions and methods relating to myomixer-promoted muscle cell fusion |
| EP3366303B1 (en) * | 2017-02-28 | 2020-06-24 | Martin-Luther-Universität Halle-Wittenberg | Enhancing the targeted in vivo delivery of cellular therapies |
| EP4317422A3 (en) | 2017-04-13 | 2024-05-01 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| EP3807304A1 (en) | 2018-06-15 | 2021-04-21 | Children's Hospital Medical Center | Polypeptides, nucleic acid molecules, compositions, and related methods |
| US11419898B2 (en) | 2018-10-17 | 2022-08-23 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| SG11202103317XA (en) | 2018-10-17 | 2021-05-28 | Senti Biosciences Inc | Combinatorial cancer immunotherapy |
| CN120678804A (zh) * | 2025-08-07 | 2025-09-23 | 黄永茂 | 调理人体经络生物电的氯化氢组分液及其应用 |
Family Cites Families (19)
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|---|---|---|---|---|
| US7514074B2 (en) * | 1997-07-14 | 2009-04-07 | Osiris Therapeutics, Inc. | Cardiac muscle regeneration using mesenchymal stem cells |
| US20010038834A1 (en) | 1998-01-26 | 2001-11-08 | Gary Balian | Bone cancer therapy |
| US20030100107A1 (en) * | 1998-05-29 | 2003-05-29 | Thomas Jefferson University | Compositions and methods for generating differentiated human cells |
| DE19833476B4 (de) * | 1998-07-24 | 2005-08-25 | Huss, Ralf, Dr. | Genetisch modifizierte CD34-Negative, adhärent wachsende hämatopoetische Stammzellen und deren Verwendung in der Gentherapie |
| US20010046489A1 (en) * | 1999-12-06 | 2001-11-29 | Habener Joel E. | Stem cells of the islets of langerhans and their use in treating diabetes mellitus |
| US20030082155A1 (en) | 1999-12-06 | 2003-05-01 | Habener Joel F. | Stem cells of the islets of langerhans and their use in treating diabetes mellitus |
| EP1379624A2 (en) * | 2000-11-27 | 2004-01-14 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Transfection of human embryonic stem cells |
| WO2002102847A1 (fr) * | 2001-06-14 | 2002-12-27 | Takeda Chemical Industries, Ltd. | Nouveau ligand et son adn |
| EP1430115A1 (en) | 2001-07-27 | 2004-06-23 | Arhus Amt | Immortilized stem cells |
| CA2484050A1 (en) * | 2001-09-20 | 2003-03-27 | Centre For Translational Research In Cancer | Cultured stromal cells and uses thereof |
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| CA2550326A1 (en) * | 2003-12-19 | 2005-07-14 | Viacell, Inc. | Use of human cord blood-derived pluripotent cells for the treatment of disease |
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| US20050233443A1 (en) * | 2004-03-30 | 2005-10-20 | Toby Freyman | Restenosis therapy using mesenchymal stem cells |
| JP2006345726A (ja) | 2005-06-14 | 2006-12-28 | Hamamatsu Univ School Of Medicine | 脳腫瘍治療用発現ベクター |
| KR101022401B1 (ko) * | 2005-09-29 | 2011-03-15 | 아주대학교산학협력단 | 자살유전자를 발현하는 중간엽 줄기세포를 포함하는 암치료용 조성물 |
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Non-Patent Citations (2)
| Title |
|---|
| KHALIL P.N. et al., Gastroenterology, March 2007, Vol. 132, pages 944-954 * |
| MARIAM, A. et al., Breast Cancer Res. Treat., 2007. Vol. 105, pages 157-167 * |
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| CN101778934B (zh) | 2013-05-22 |
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| ES2401608T3 (es) | 2013-04-23 |
| BRPI0811906A2 (pt) | 2014-11-18 |
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| AU2008260651A1 (en) | 2008-12-11 |
| US20160136207A1 (en) | 2016-05-19 |
| CN103263439B (zh) | 2015-04-22 |
| CN101778934A (zh) | 2010-07-14 |
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| JP2010528008A (ja) | 2010-08-19 |
| EP2851422A2 (en) | 2015-03-25 |
| HK1146488A1 (en) | 2011-06-10 |
| WO2008150368A1 (en) | 2008-12-11 |
| HK1188735A1 (en) | 2014-05-16 |
| EP2229948A1 (en) | 2010-09-22 |
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