JP2014088432A5 - - Google Patents
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- JP2014088432A5 JP2014088432A5 JP2014007144A JP2014007144A JP2014088432A5 JP 2014088432 A5 JP2014088432 A5 JP 2014088432A5 JP 2014007144 A JP2014007144 A JP 2014007144A JP 2014007144 A JP2014007144 A JP 2014007144A JP 2014088432 A5 JP2014088432 A5 JP 2014088432A5
- Authority
- JP
- Japan
- Prior art keywords
- subject
- genetically modified
- stem cells
- use according
- promoter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 39
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 39
- 210000000130 stem cell Anatomy 0.000 claims 39
- 239000003623 enhancer Substances 0.000 claims 15
- 102000004169 proteins and genes Human genes 0.000 claims 10
- 108090000623 proteins and genes Proteins 0.000 claims 10
- 230000004663 cell proliferation Effects 0.000 claims 9
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 8
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 8
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 8
- 210000002889 endothelial cell Anatomy 0.000 claims 8
- 208000014674 injury Diseases 0.000 claims 7
- 206010018429 Glucose tolerance impaired Diseases 0.000 claims 6
- 230000000735 allogeneic effect Effects 0.000 claims 6
- 230000008733 trauma Effects 0.000 claims 6
- 230000037396 body weight Effects 0.000 claims 5
- 210000001185 bone marrow Anatomy 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 210000003038 endothelium Anatomy 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 238000001356 surgical procedure Methods 0.000 claims 5
- 101100481408 Danio rerio tie2 gene Proteins 0.000 claims 4
- 101100481410 Mus musculus Tek gene Proteins 0.000 claims 4
- 206010012601 diabetes mellitus Diseases 0.000 claims 4
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 3
- 230000033115 angiogenesis Effects 0.000 claims 3
- 208000010643 digestive system disease Diseases 0.000 claims 3
- 208000018685 gastrointestinal system disease Diseases 0.000 claims 3
- 210000003205 muscle Anatomy 0.000 claims 3
- 210000000663 muscle cell Anatomy 0.000 claims 3
- 206010013801 Duchenne Muscular Dystrophy Diseases 0.000 claims 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 230000004089 microcirculation Effects 0.000 claims 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- 230000029663 wound healing Effects 0.000 claims 2
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 102000001039 Dystrophin Human genes 0.000 claims 1
- 108010069091 Dystrophin Proteins 0.000 claims 1
- 101001023030 Toxoplasma gondii Myosin-D Proteins 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 238000012084 abdominal surgery Methods 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 230000035606 childbirth Effects 0.000 claims 1
- 206010009887 colitis Diseases 0.000 claims 1
- 238000002316 cosmetic surgery Methods 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 238000002350 laparotomy Methods 0.000 claims 1
- 201000006938 muscular dystrophy Diseases 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93162207P | 2007-05-24 | 2007-05-24 | |
| US60/931,622 | 2007-05-24 | ||
| US305007P | 2007-11-14 | 2007-11-14 | |
| US61/003,050 | 2007-11-14 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010509362A Division JP2010528008A (ja) | 2007-05-24 | 2008-05-20 | Ｃｄ３４幹細胞に関連した方法および組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014088432A JP2014088432A (ja) | 2014-05-15 |
| JP2014088432A5 true JP2014088432A5 (enExample) | 2014-10-16 |
Family
ID=40093981
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010509362A Pending JP2010528008A (ja) | 2007-05-24 | 2008-05-20 | Ｃｄ３４幹細胞に関連した方法および組成物 |
| JP2014007144A Pending JP2014088432A (ja) | 2007-05-24 | 2014-01-17 | Ｃｄ３４幹細胞に関連した方法および組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010509362A Pending JP2010528008A (ja) | 2007-05-24 | 2008-05-20 | Ｃｄ３４幹細胞に関連した方法および組成物 |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US7998472B2 (enExample) |
| EP (4) | EP2851422A3 (enExample) |
| JP (2) | JP2010528008A (enExample) |
| CN (2) | CN101778934B (enExample) |
| AU (1) | AU2008260651B2 (enExample) |
| BR (1) | BRPI0811906A2 (enExample) |
| CA (1) | CA2688032C (enExample) |
| DK (1) | DK2223696T3 (enExample) |
| ES (3) | ES2430071T3 (enExample) |
| PL (1) | PL2162534T3 (enExample) |
| WO (1) | WO2008150368A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8574567B2 (en) | 2007-05-03 | 2013-11-05 | The Brigham And Women's Hospital, Inc. | Multipotent stem cells and uses thereof |
| EP2607477B1 (en) | 2007-05-03 | 2020-09-23 | The Brigham and Women's Hospital, Inc. | Multipotent stem cells and uses thereof |
| US12180549B2 (en) | 2007-07-23 | 2024-12-31 | The Chinese University Of Hong Kong | Diagnosing fetal chromosomal aneuploidy using genomic sequencing |
| EP3892736A1 (en) | 2007-07-23 | 2021-10-13 | The Chinese University of Hong Kong | Determining a nucleic acid sequence imbalance |
| CN102123717A (zh) | 2008-05-27 | 2011-07-13 | 普拉里斯坦有限公司 | 治疗炎性结肠疾病的方法 |
| KR20120088542A (ko) | 2009-04-13 | 2012-08-08 | 아프세스 게엠베하 & 씨오. 카게 | 종양 치료를 위한 조작된 중간엽 줄기세포 및 이를 사용하는 방법 |
| US20110027239A1 (en) * | 2009-07-29 | 2011-02-03 | Tissue Genesis, Inc. | Adipose-derived stromal cells (asc) as delivery tool for treatment of cancer |
| US8883210B1 (en) | 2010-05-14 | 2014-11-11 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US10130736B1 (en) | 2010-05-14 | 2018-11-20 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US9352003B1 (en) | 2010-05-14 | 2016-05-31 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| EP2601956B1 (en) | 2010-08-06 | 2017-04-12 | Osaka University | Islets of langerhans transplant using islets of langerhans and adipose tissue derived stem cells |
| US8834928B1 (en) | 2011-05-16 | 2014-09-16 | Musculoskeletal Transplant Foundation | Tissue-derived tissugenic implants, and methods of fabricating and using same |
| US8961956B2 (en) | 2011-11-30 | 2015-02-24 | Ocata Therapeutics, Inc. | Mesenchymal stromal cells and uses related thereto |
| KR102108245B1 (ko) | 2011-11-30 | 2020-05-08 | 아스텔라스 인스티튜트 포 리제너러티브 메디슨 | 중간엽 간질 세포 및 이에 관련된 용도 |
| US20130171115A1 (en) * | 2011-12-30 | 2013-07-04 | Gang Li | Cell-mediated gene therapy for cancer using mesenchymal stem cells expressing a suicide gene |
| US20140369979A1 (en) * | 2012-02-01 | 2014-12-18 | Postech Academy-Industry Foundation | Vector simultaneously expressing dodecameric trail and hsv-tk suicide genes, and anticancer stem cell therapeutic agent using same |
| US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
| CN104471059B (zh) | 2012-07-12 | 2018-04-17 | 珠海横琴爱姆斯坦生物科技有限公司 | 人胚胎干细胞衍生的间充质样干细胞、方法及其应用 |
| US20150037436A1 (en) | 2013-07-30 | 2015-02-05 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
| CA2956987C (en) | 2014-08-18 | 2023-03-21 | Apceth Gmbh & Co. Kg | Genetically modified mesenchymal stem cells expressing an immune response-stimulating cytokine to attract and/or activate immune cells |
| US10364467B2 (en) | 2015-01-13 | 2019-07-30 | The Chinese University Of Hong Kong | Using size and number aberrations in plasma DNA for detecting cancer |
| CN104622903B (zh) * | 2015-01-20 | 2018-10-09 | 奥思达干细胞有限公司 | 抗恶性黑色素瘤的干细胞制剂及其制备方法 |
| EP3297694A1 (en) | 2015-05-21 | 2018-03-28 | Musculoskeletal Transplant Foundation | Modified demineralized cortical bone fibers |
| US10912864B2 (en) | 2015-07-24 | 2021-02-09 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
| US11052175B2 (en) | 2015-08-19 | 2021-07-06 | Musculoskeletal Transplant Foundation | Cartilage-derived implants and methods of making and using same |
| CN108884440A (zh) | 2016-04-01 | 2018-11-23 | 埃普塞斯有限责任两合公司 | 用于增强免疫疗法的抗肿瘤活性的间充质干细胞 |
| US20190382732A1 (en) * | 2017-02-24 | 2019-12-19 | The Board Of Regents Of The University Of Texas System | Compositions and methods relating to myomixer-promoted muscle cell fusion |
| EP3366303B1 (en) * | 2017-02-28 | 2020-06-24 | Martin-Luther-Universität Halle-Wittenberg | Enhancing the targeted in vivo delivery of cellular therapies |
| SG10202111394XA (en) | 2017-04-13 | 2021-12-30 | Senti Biosciences Inc | Combinatorial cancer immunotherapy |
| US12054526B2 (en) | 2018-06-15 | 2024-08-06 | Children's Hospital Medical Center | Polypeptides, nucleic acid molecules, compositions, and related methods |
| US11419898B2 (en) | 2018-10-17 | 2022-08-23 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| AU2019359890B2 (en) | 2018-10-17 | 2024-10-24 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7514074B2 (en) * | 1997-07-14 | 2009-04-07 | Osiris Therapeutics, Inc. | Cardiac muscle regeneration using mesenchymal stem cells |
| US20010038834A1 (en) * | 1998-01-26 | 2001-11-08 | Gary Balian | Bone cancer therapy |
| US20030100107A1 (en) * | 1998-05-29 | 2003-05-29 | Thomas Jefferson University | Compositions and methods for generating differentiated human cells |
| DE19833476B4 (de) * | 1998-07-24 | 2005-08-25 | Huss, Ralf, Dr. | Genetisch modifizierte CD34-Negative, adhärent wachsende hämatopoetische Stammzellen und deren Verwendung in der Gentherapie |
| US20030082155A1 (en) * | 1999-12-06 | 2003-05-01 | Habener Joel F. | Stem cells of the islets of langerhans and their use in treating diabetes mellitus |
| EP1257282A4 (en) * | 1999-12-06 | 2003-05-02 | Gen Hospital Corp | PANCREATIC STEM CELLS AND THEIR USE IN TRANSPLANTATION |
| CA2430653A1 (en) * | 2000-11-27 | 2002-08-08 | Yissum Research Development Company Of The Hebrew University In Jerusalem | Transfection of human embryonic stem cells |
| DE60227519D1 (de) * | 2001-06-14 | 2008-08-21 | Takeda Pharmaceutical | Neuer ligand und dna davon |
| WO2003010305A1 (en) | 2001-07-27 | 2003-02-06 | Arhus Amt | Immortilized stem cells |
| US20050053587A1 (en) * | 2001-09-20 | 2005-03-10 | Jacques Galipeau | Cultured stromal cells and uses thereof |
| WO2003087333A2 (en) * | 2002-04-12 | 2003-10-23 | Celgene Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
| JP2005532810A (ja) * | 2002-07-16 | 2005-11-04 | イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム | 組織修復および組織形成のために間葉性幹細胞を移植する方法 |
| US20040258669A1 (en) * | 2002-11-05 | 2004-12-23 | Dzau Victor J. | Mesenchymal stem cells and methods of use thereof |
| WO2005026335A2 (en) * | 2003-09-15 | 2005-03-24 | Ramot At Tel Aviv University Ltd. | Insulin-producing bone marrow derived cells and methods of generating and using same |
| EP1708757A4 (en) * | 2003-12-19 | 2007-01-17 | Viacell Inc | USE OF PLURIPOTENTIAL CELLS TAKEN FROM HUMAN CORDIAL BLOOD BLOOD FOR THE TREATMENT OF DISEASE |
| EP2298861B1 (en) * | 2004-03-22 | 2017-09-13 | Mesoblast International Sàrl | Mesenchymal stem cells and uses therefor |
| US20050233443A1 (en) * | 2004-03-30 | 2005-10-20 | Toby Freyman | Restenosis therapy using mesenchymal stem cells |
| JP2006345726A (ja) | 2005-06-14 | 2006-12-28 | Hamamatsu Univ School Of Medicine | 脳腫瘍治療用発現ベクター |
| KR101022401B1 (ko) * | 2005-09-29 | 2011-03-15 | 아주대학교산학협력단 | 자살유전자를 발현하는 중간엽 줄기세포를 포함하는 암치료용 조성물 |
-
2008
- 2008-05-20 BR BRPI0811906-6A2A patent/BRPI0811906A2/pt not_active IP Right Cessation
- 2008-05-20 PL PL08754569T patent/PL2162534T3/pl unknown
- 2008-05-20 DK DK10163667.8T patent/DK2223696T3/da active
- 2008-05-20 ES ES10163667T patent/ES2430071T3/es active Active
- 2008-05-20 ES ES10163663T patent/ES2401608T3/es active Active
- 2008-05-20 CA CA2688032A patent/CA2688032C/en not_active Expired - Fee Related
- 2008-05-20 ES ES08754569.5T patent/ES2507507T3/es active Active
- 2008-05-20 EP EP14172302.3A patent/EP2851422A3/en not_active Withdrawn
- 2008-05-20 WO PCT/US2008/006434 patent/WO2008150368A1/en not_active Ceased
- 2008-05-20 JP JP2010509362A patent/JP2010528008A/ja active Pending
- 2008-05-20 EP EP10163667.8A patent/EP2223696B1/en not_active Not-in-force
- 2008-05-20 CN CN2008801001004A patent/CN101778934B/zh not_active Expired - Fee Related
- 2008-05-20 CN CN201310125890.4A patent/CN103263439B/zh not_active Expired - Fee Related
- 2008-05-20 EP EP10163663A patent/EP2229948B1/en not_active Not-in-force
- 2008-05-20 AU AU2008260651A patent/AU2008260651B2/en not_active Ceased
- 2008-05-20 EP EP08754569.5A patent/EP2162534B1/en not_active Not-in-force
- 2008-05-20 US US12/154,059 patent/US7998472B2/en not_active Expired - Fee Related
-
2011
- 2011-07-08 US US13/179,374 patent/US20110268714A1/en not_active Abandoned
-
2014
- 2014-01-17 JP JP2014007144A patent/JP2014088432A/ja active Pending
-
2015
- 2015-05-08 US US14/707,872 patent/US20150238541A1/en not_active Abandoned
- 2015-05-08 US US14/707,739 patent/US20160136207A1/en not_active Abandoned
- 2015-05-08 US US14/707,654 patent/US20150238526A1/en not_active Abandoned
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