JP2014047156A5 - - Google Patents
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- Publication number
- JP2014047156A5 JP2014047156A5 JP2012190551A JP2012190551A JP2014047156A5 JP 2014047156 A5 JP2014047156 A5 JP 2014047156A5 JP 2012190551 A JP2012190551 A JP 2012190551A JP 2012190551 A JP2012190551 A JP 2012190551A JP 2014047156 A5 JP2014047156 A5 JP 2014047156A5
- Authority
- JP
- Japan
- Prior art keywords
- vegf
- amino acid
- peptide
- block
- binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 23
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 13
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 13
- 125000003275 alpha amino acid group Chemical group 0.000 claims 13
- 230000004927 fusion Effects 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 4
- 235000001014 amino acid Nutrition 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 1
- 102000002933 Thioredoxin Human genes 0.000 claims 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 1
- 239000004473 Threonine Substances 0.000 claims 1
- 238000007792 addition Methods 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000003712 anti-aging effect Effects 0.000 claims 1
- 230000001093 anti-cancer Effects 0.000 claims 1
- 230000003178 anti-diabetic effect Effects 0.000 claims 1
- 230000003356 anti-rheumatic effect Effects 0.000 claims 1
- 239000003472 antidiabetic agent Substances 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 229940094937 thioredoxin Drugs 0.000 claims 1
- 108060008226 thioredoxin Proteins 0.000 claims 1
- 210000003556 vascular endothelial cell Anatomy 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012190551A JP6032735B2 (ja) | 2012-08-30 | 2012-08-30 | Ｖｅｇｆ結合性融合ペプチド |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012190551A JP6032735B2 (ja) | 2012-08-30 | 2012-08-30 | Ｖｅｇｆ結合性融合ペプチド |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016188598A Division JP2017043625A (ja) | 2016-09-27 | 2016-09-27 | Ｖｅｇｆ結合性ペプチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014047156A JP2014047156A (ja) | 2014-03-17 |
| JP2014047156A5 true JP2014047156A5 (enrdf_load_stackoverflow) | 2015-10-08 |
| JP6032735B2 JP6032735B2 (ja) | 2016-11-30 |
Family
ID=50607182
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012190551A Active JP6032735B2 (ja) | 2012-08-30 | 2012-08-30 | Ｖｅｇｆ結合性融合ペプチド |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP6032735B2 (enrdf_load_stackoverflow) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6583411B2 (ja) * | 2015-06-25 | 2019-10-02 | 株式会社島津製作所 | 薬物複合体 |
| JP6761993B2 (ja) * | 2016-01-29 | 2020-09-30 | 公立大学法人大阪 | プロテインキナーゼ阻害剤 |
| JP7138909B2 (ja) * | 2018-03-29 | 2022-09-20 | 公立大学法人大阪 | Ｖｅｇｆ結合阻害ペプチド |
| CN108671229B (zh) * | 2018-05-08 | 2022-03-25 | 华博生物医药技术（上海）有限公司 | 一种重组人血管内皮生长因子受体-抗体融合蛋白的药物组合制剂 |
| JP2019196326A (ja) * | 2018-05-09 | 2019-11-14 | 公立大学法人大阪府立大学 | Ｖｅｇｆ結合阻害剤 |
| WO2021210537A1 (ja) * | 2020-04-13 | 2021-10-21 | 株式会社島津製作所 | 分化誘導用ペプチド |
| JP7722677B2 (ja) * | 2020-10-07 | 2025-08-13 | 公立大学法人大阪 | Ｈｓａ結合性タンパク |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4394932B2 (ja) * | 2003-11-28 | 2010-01-06 | 第一三共株式会社 | 顆粒球コロニー刺激因子（ｇ−ｃｓｆ）受容体結合ペプチド |
| JP4394931B2 (ja) * | 2003-11-28 | 2010-01-06 | 第一三共株式会社 | ヒトインターロイキン４およびヒトインターロイキン１３のアンタゴニストであるペプチド |
| JP2008214254A (ja) * | 2007-03-02 | 2008-09-18 | Osaka Prefecture Univ | ヒトインターロイキン−５受容体（ｈＩＬ−５Ｒ）結合ペプチド |
| JP5677453B2 (ja) * | 2009-12-11 | 2015-02-25 | グワンジュ・インスティテュート・オブ・サイエンス・アンド・テクノロジー | Ｂｐｂベースのカーゴ運搬システム |
| JP2011231085A (ja) * | 2010-04-30 | 2011-11-17 | Osaka Prefecture Univ | 環状ペプチド |
-
2012
- 2012-08-30 JP JP2012190551A patent/JP6032735B2/ja active Active
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