JP2013543004A5 - - Google Patents

Info

Publication number

JP2013543004A5

JP2013543004A5 JP2013540032A JP2013540032A JP2013543004A5 JP 2013543004 A5 JP2013543004 A5 JP 2013543004A5 JP 2013540032 A JP2013540032 A JP 2013540032A JP 2013540032 A JP2013540032 A JP 2013540032A JP 2013543004 A5 JP2013543004 A5 JP 2013543004A5

Authority

JP

Japan

Prior art keywords

composition

testosterone

administration

level

free

Prior art date

2011-11-17

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims 88
• 229960003604 testosterone Drugs 0.000 claims 44
• 210000002966 serum Anatomy 0.000 claims 18
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
• 208000035475 disorder Diseases 0.000 claims 5
• 206010049119 Emotional distress Diseases 0.000 claims 4
• 208000004454 Hyperalgesia Diseases 0.000 claims 4
• 108010093625 Opioid Peptides Proteins 0.000 claims 4
• 102000001490 Opioid Peptides Human genes 0.000 claims 4
• 208000002193 Pain Diseases 0.000 claims 4
• 208000000114 Pain Threshold Diseases 0.000 claims 4
• 229940121991 Serotonin and norepinephrine reuptake inhibitor Drugs 0.000 claims 4
• 230000001684 chronic effect Effects 0.000 claims 4
• 239000003937 drug carrier Substances 0.000 claims 4
• 210000002149 gonad Anatomy 0.000 claims 4
• 238000007918 intramuscular administration Methods 0.000 claims 4
• 239000003399 opiate peptide Substances 0.000 claims 4
• 230000037040 pain threshold Effects 0.000 claims 4
• 208000028173 post-traumatic stress disease Diseases 0.000 claims 4
• 229940124834 selective serotonin reuptake inhibitor Drugs 0.000 claims 4
• 239000012896 selective serotonin reuptake inhibitor Substances 0.000 claims 4
• 239000003775 serotonin noradrenalin reuptake inhibitor Substances 0.000 claims 4
• 230000001225 therapeutic effect Effects 0.000 claims 4
• 206010002261 Androgen deficiency Diseases 0.000 claims 2
• 208000023275 Autoimmune disease Diseases 0.000 claims 2
• 208000035154 Hyperesthesia Diseases 0.000 claims 2
• 206010065390 Inflammatory pain Diseases 0.000 claims 2
• 206010028980 Neoplasm Diseases 0.000 claims 2
• 229940123445 Tricyclic antidepressant Drugs 0.000 claims 2
• 208000036142 Viral infection Diseases 0.000 claims 2
• 230000001154 acute effect Effects 0.000 claims 2
• 230000002411 adverse Effects 0.000 claims 2
• 206010053552 allodynia Diseases 0.000 claims 2
• 230000001430 anti-depressive effect Effects 0.000 claims 2
• 239000000935 antidepressant agent Substances 0.000 claims 2
• 229940005513 antidepressants Drugs 0.000 claims 2
• 201000011510 cancer Diseases 0.000 claims 2
• 230000009429 distress Effects 0.000 claims 2
• 230000000694 effects Effects 0.000 claims 2
• 206010016256 fatigue Diseases 0.000 claims 2
• 208000015181 infectious disease Diseases 0.000 claims 2
• 208000014674 injury Diseases 0.000 claims 2
• 230000036651 mood Effects 0.000 claims 2
• 230000036407 pain Effects 0.000 claims 2
• 238000001356 surgical procedure Methods 0.000 claims 2
• 230000008733 trauma Effects 0.000 claims 2
• 239000003029 tricyclic antidepressant agent Substances 0.000 claims 2
• 230000009385 viral infection Effects 0.000 claims 2
• 108010074051 C-Reactive Protein Proteins 0.000 claims 1
• 102100032752 C-reactive protein Human genes 0.000 claims 1
• 208000000094 Chronic Pain Diseases 0.000 claims 1
• 108010065372 Dynorphins Proteins 0.000 claims 1
• 108010049140 Endorphins Proteins 0.000 claims 1
• 102000009025 Endorphins Human genes 0.000 claims 1
• 108010092674 Enkephalins Proteins 0.000 claims 1
• URLZCHNOLZSCCA-VABKMULXSA-N Leu-enkephalin Chemical class C([C@@H](C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 URLZCHNOLZSCCA-VABKMULXSA-N 0.000 claims 1
• 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
• 230000002950 deficient Effects 0.000 claims 1
• JMNJYGMAUMANNW-FIXZTSJVSA-N dynorphin a Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 JMNJYGMAUMANNW-FIXZTSJVSA-N 0.000 claims 1
• 210000003743 erythrocyte Anatomy 0.000 claims 1
• 210000005036 nerve Anatomy 0.000 claims 1
• 201000001119 neuropathy Diseases 0.000 claims 1
• 230000007823 neuropathy Effects 0.000 claims 1
• 208000033808 peripheral neuropathy Diseases 0.000 claims 1
• 230000000630 rising effect Effects 0.000 claims 1
• 238000004062 sedimentation Methods 0.000 claims 1
• 208000024891 symptom Diseases 0.000 claims 1