JP2013543004A5 - - Google Patents
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- Publication number
- JP2013543004A5 JP2013543004A5 JP2013540032A JP2013540032A JP2013543004A5 JP 2013543004 A5 JP2013543004 A5 JP 2013543004A5 JP 2013540032 A JP2013540032 A JP 2013540032A JP 2013540032 A JP2013540032 A JP 2013540032A JP 2013543004 A5 JP2013543004 A5 JP 2013543004A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- testosterone
- administration
- level
- free
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims 88
- 229960003604 testosterone Drugs 0.000 claims 44
- 210000002966 serum Anatomy 0.000 claims 18
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 208000035475 disorder Diseases 0.000 claims 5
- 206010049119 Emotional distress Diseases 0.000 claims 4
- 208000004454 Hyperalgesia Diseases 0.000 claims 4
- 108010093625 Opioid Peptides Proteins 0.000 claims 4
- 102000001490 Opioid Peptides Human genes 0.000 claims 4
- 208000002193 Pain Diseases 0.000 claims 4
- 208000000114 Pain Threshold Diseases 0.000 claims 4
- 229940121991 Serotonin and norepinephrine reuptake inhibitor Drugs 0.000 claims 4
- 230000001684 chronic effect Effects 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 4
- 210000002149 gonad Anatomy 0.000 claims 4
- 238000007918 intramuscular administration Methods 0.000 claims 4
- 239000003399 opiate peptide Substances 0.000 claims 4
- 230000037040 pain threshold Effects 0.000 claims 4
- 208000028173 post-traumatic stress disease Diseases 0.000 claims 4
- 229940124834 selective serotonin reuptake inhibitor Drugs 0.000 claims 4
- 239000012896 selective serotonin reuptake inhibitor Substances 0.000 claims 4
- 239000003775 serotonin noradrenalin reuptake inhibitor Substances 0.000 claims 4
- 230000001225 therapeutic effect Effects 0.000 claims 4
- 206010002261 Androgen deficiency Diseases 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 208000035154 Hyperesthesia Diseases 0.000 claims 2
- 206010065390 Inflammatory pain Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 229940123445 Tricyclic antidepressant Drugs 0.000 claims 2
- 208000036142 Viral infection Diseases 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 230000002411 adverse Effects 0.000 claims 2
- 206010053552 allodynia Diseases 0.000 claims 2
- 230000001430 anti-depressive effect Effects 0.000 claims 2
- 239000000935 antidepressant agent Substances 0.000 claims 2
- 229940005513 antidepressants Drugs 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 230000009429 distress Effects 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 206010016256 fatigue Diseases 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 208000014674 injury Diseases 0.000 claims 2
- 230000036651 mood Effects 0.000 claims 2
- 230000036407 pain Effects 0.000 claims 2
- 238000001356 surgical procedure Methods 0.000 claims 2
- 230000008733 trauma Effects 0.000 claims 2
- 239000003029 tricyclic antidepressant agent Substances 0.000 claims 2
- 230000009385 viral infection Effects 0.000 claims 2
- 108010074051 C-Reactive Protein Proteins 0.000 claims 1
- 102100032752 C-reactive protein Human genes 0.000 claims 1
- 208000000094 Chronic Pain Diseases 0.000 claims 1
- 108010065372 Dynorphins Proteins 0.000 claims 1
- 108010049140 Endorphins Proteins 0.000 claims 1
- 102000009025 Endorphins Human genes 0.000 claims 1
- 108010092674 Enkephalins Proteins 0.000 claims 1
- URLZCHNOLZSCCA-VABKMULXSA-N Leu-enkephalin Chemical class C([C@@H](C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 URLZCHNOLZSCCA-VABKMULXSA-N 0.000 claims 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
- 230000002950 deficient Effects 0.000 claims 1
- JMNJYGMAUMANNW-FIXZTSJVSA-N dynorphin a Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 JMNJYGMAUMANNW-FIXZTSJVSA-N 0.000 claims 1
- 210000003743 erythrocyte Anatomy 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 230000000630 rising effect Effects 0.000 claims 1
- 238000004062 sedimentation Methods 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41525810P | 2010-11-18 | 2010-11-18 | |
| US61/415,258 | 2010-11-18 | ||
| US201161534174P | 2011-09-13 | 2011-09-13 | |
| US61/534,174 | 2011-09-13 | ||
| PCT/US2011/061254 WO2012068410A1 (en) | 2010-11-18 | 2011-11-17 | Methods for treating chronic or unresolvable pain and/or increasing the pain threshold in a subject and pharmaceutical compositions for use therein |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018000146A Division JP2018087193A (ja) | 2010-11-18 | 2018-01-04 | 対象における慢性または解決不能な疼痛を処置するための、および／または痛覚閾値を高めるための方法、およびこれに用いる医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013543004A JP2013543004A (ja) | 2013-11-28 |
| JP2013543004A5 true JP2013543004A5 (enExample) | 2015-04-09 |
| JP6912852B2 JP6912852B2 (ja) | 2021-08-04 |
Family
ID=46064977
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013540032A Expired - Fee Related JP6912852B2 (ja) | 2010-11-18 | 2011-11-17 | 対象における慢性または解決不能な疼痛を処置するための、および／または痛覚閾値を高めるための方法、およびこれに用いる医薬組成物 |
| JP2018000146A Pending JP2018087193A (ja) | 2010-11-18 | 2018-01-04 | 対象における慢性または解決不能な疼痛を処置するための、および／または痛覚閾値を高めるための方法、およびこれに用いる医薬組成物 |
| JP2019182786A Pending JP2020033354A (ja) | 2010-11-18 | 2019-10-03 | 対象における慢性または解決不能な疼痛を処置するための、および／または痛覚閾値を高めるための方法、およびこれに用いる医薬組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018000146A Pending JP2018087193A (ja) | 2010-11-18 | 2018-01-04 | 対象における慢性または解決不能な疼痛を処置するための、および／または痛覚閾値を高めるための方法、およびこれに用いる医薬組成物 |
| JP2019182786A Pending JP2020033354A (ja) | 2010-11-18 | 2019-10-03 | 対象における慢性または解決不能な疼痛を処置するための、および／または痛覚閾値を高めるための方法、およびこれに用いる医薬組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US9642863B2 (enExample) |
| EP (1) | EP2640398A4 (enExample) |
| JP (3) | JP6912852B2 (enExample) |
| AU (3) | AU2011329782A1 (enExample) |
| CA (1) | CA2818491A1 (enExample) |
| WO (1) | WO2012068410A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040259852A1 (en) * | 2003-06-18 | 2004-12-23 | White Hillary D. | Trandsdermal compositions and methods for treatment of fibromyalgia and chronic fatigue syndrome |
| CA2885060A1 (en) * | 2012-10-12 | 2014-04-17 | Analgesic Solutions | Training methods for improved assaying of pain in clinical trial subjects |
| US11311529B2 (en) * | 2018-11-08 | 2022-04-26 | Varsona Therapeutics, Inc. | Topical formulations of 5-α-reductase inhibitors and uses thereof |
| CN113924087A (zh) | 2019-04-09 | 2022-01-11 | 纽约市哥伦比亚大学理事会 | 血清素4受体激动剂对抗应激的预防功效 |
| EP4033237A4 (en) * | 2019-09-20 | 2023-08-30 | Aska Pharma Medical Co., Ltd | METHOD FOR ANALYSIS OF STEROID HORMONES CONTAINED IN A SAMPLE OF ANIMAL HAIR, METHOD FOR EVALUATION OF STRESS AND METHOD FOR ANALYSIS OF CAUSE OF HAIR LOSS |
| EP4143580A1 (en) * | 2020-04-30 | 2023-03-08 | Leibniz-Institut für Virologie | Method for predicting the course of a viral disease |
| WO2023220487A1 (en) * | 2022-05-13 | 2023-11-16 | Imx, Inc. | Systems and methods for generating financial indexes for medical conditions |
| CN117982655B (zh) * | 2023-11-21 | 2024-10-15 | 北京大学人民医院 | 芳香化酶抑制剂治疗相关的疼痛动物模型构建方法及应用 |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4542129A (en) | 1982-08-16 | 1985-09-17 | Norman Orentreich | DHEA Formulations and methods for treating dry skin |
| US5019395A (en) | 1988-03-08 | 1991-05-28 | Warner-Lambert Company | Compositions with enhanced penetration |
| US5461042A (en) | 1988-12-30 | 1995-10-24 | Loria; Roger M. | Regulation of the immune system |
| US5206008A (en) | 1991-04-15 | 1993-04-27 | Virginia Commonwealth University | Enhancement of immune response |
| US5676968A (en) | 1991-10-31 | 1997-10-14 | Schering Aktiengesellschaft | Transdermal therapeutic systems with crystallization inhibitors |
| US5656606A (en) | 1995-02-17 | 1997-08-12 | Merck & Co., Inc. | Camphor compounds promote release of growth hormone |
| US6197830B1 (en) * | 1995-09-22 | 2001-03-06 | Bruce M. Frome | Method for achieving relief from sympathetically mediated pain |
| AUPN814496A0 (en) | 1996-02-19 | 1996-03-14 | Monash University | Dermal penetration enhancer |
| US6923983B2 (en) | 1996-02-19 | 2005-08-02 | Acrux Dds Pty Ltd | Transdermal delivery of hormones |
| DE19619045C1 (de) | 1996-05-02 | 1997-11-13 | Jenapharm Gmbh | Verwendung von Kombinationspräparaten zur Behandlung hypogonadaler Männer sowie Männern mit Hypophysenerkrankungen |
| US5709878A (en) | 1996-08-02 | 1998-01-20 | Rosenbaum; Jerry | Transdermal delivery of dehydroepiandrosterone |
| US5855920A (en) | 1996-12-13 | 1999-01-05 | Chein; Edmund Y. M. | Total hormone replacement therapy |
| DE19701949A1 (de) | 1997-01-13 | 1998-07-16 | Jenapharm Gmbh | Transdermales therapeutisches System |
| HUP0001748A3 (en) | 1997-02-28 | 2001-03-28 | Minnesota Mining And Mfg Co Sa | Transdermal device for the delivery of testosterone |
| US5968919A (en) | 1997-10-16 | 1999-10-19 | Macrochem Corporation | Hormone replacement therapy drug formulations for topical application to the skin |
| US20020013304A1 (en) | 1997-10-28 | 2002-01-31 | Wilson Leland F. | As-needed administration of an androgenic agent to enhance female sexual desire and responsiveness |
| JP4139860B2 (ja) | 1997-11-10 | 2008-08-27 | ストラカン インターナショナル リミティッド | 浸透増強および刺激減少システム |
| US5869090A (en) | 1998-01-20 | 1999-02-09 | Rosenbaum; Jerry | Transdermal delivery of dehydroepiandrosterone |
| US5935949A (en) | 1998-03-20 | 1999-08-10 | Trustees Of Dartmouth College | Use of androgen therapy in fibromyalgia and chronic fatigue syndrome |
| US6165504A (en) * | 1998-09-23 | 2000-12-26 | Barr Laboratories, Inc. | Methods for treating hot flashes and improving the quality of life of castrated prostatic cancer patients |
| FR2801507B1 (fr) | 1999-11-30 | 2003-06-27 | Pf Medicament | Dispositif transdermique auto-adhesif comprenant un reservoir et une matrice contenant le meme principe actif, son procede de preparation et ses utilisations |
| US8980290B2 (en) | 2000-08-03 | 2015-03-17 | Antares Pharma Ipl Ag | Transdermal compositions for anticholinergic agents |
| US20040198706A1 (en) | 2003-03-11 | 2004-10-07 | Carrara Dario Norberto R. | Methods and formulations for transdermal or transmucosal application of active agents |
| US7198801B2 (en) | 2000-08-03 | 2007-04-03 | Antares Pharma Ipl Ag | Formulations for transdermal or transmucosal application |
| ATE485837T1 (de) | 2000-08-03 | 2010-11-15 | Antares Pharma Ipl Ag | Zusammensetzung zur transdermalen und/oder transmukosalen verabreichung von wirkstoffen, die ausreichende therapeutische spiegel garantiert |
| US20030139384A1 (en) | 2000-08-30 | 2003-07-24 | Dudley Robert E. | Method for treating erectile dysfunction and increasing libido in men |
| US20040092494A9 (en) | 2000-08-30 | 2004-05-13 | Dudley Robert E. | Method of increasing testosterone and related steroid concentrations in women |
| ES2341090T3 (es) | 2000-08-30 | 2010-06-15 | Unimed Pharmaceuticals, Llc | Procedimiento para tratar la disfuncion erectil y aumentar la libido en hombres. |
| US6503894B1 (en) | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
| AU2001285367B2 (en) | 2000-08-30 | 2006-05-18 | Besins Healthcare Luxembourg Sarl | Method of increasing testosterone and related steroid concentrations in women |
| US20040002482A1 (en) | 2000-08-30 | 2004-01-01 | Dudley Robert E. | Androgen pharmaceutical composition and method for treating depression |
| US20040115175A1 (en) * | 2000-11-10 | 2004-06-17 | The Board Of Trustees Of The Leland | Methods for treating disorders of neuronal deficiency with bone marrow-derived cells |
| WO2002055020A2 (en) | 2000-12-11 | 2002-07-18 | Testocreme Llc | Topical testosterone formulations and associated methods |
| CA2446060A1 (en) | 2001-05-07 | 2002-11-14 | Corium International | Compositions and delivery systems for administration of a local anesthetic agent |
| US20030027804A1 (en) | 2001-06-27 | 2003-02-06 | Van Der Hoop Roland Gerritsen | Therapeutic combinations for the treatment of hormone deficiencies |
| US20030175329A1 (en) | 2001-10-04 | 2003-09-18 | Cellegy Pharmaceuticals, Inc. | Semisolid topical hormonal compositions and methods for treatment |
| US6980852B2 (en) | 2002-01-25 | 2005-12-27 | Subqiview Inc. | Film barrier dressing for intravascular tissue monitoring system |
| HU230920B1 (hu) | 2002-03-15 | 2019-03-28 | Besins Healthcare Luxembourg Sarl | Depresszió kezelésére szolgáló androgén gyógyászati készítmények |
| IL163981A0 (en) | 2002-03-15 | 2005-12-18 | Unimed Pharmaceuticals Inc | Androgen pharmaceutical composition and method fortreating depression |
| MY139721A (en) | 2002-04-19 | 2009-10-30 | Cpex Pharmaceuticals Inc | Pharmaceutical composition |
| EP1558231A4 (en) * | 2002-10-03 | 2010-09-08 | Cypress Bioscience Inc | DOSAGE CLIMBING AND FRICTIONAL DAILY DOSE OF ANTIDEPRESSANTS TO TREAT NEUROLOGICAL DISORDERS |
| US20040259852A1 (en) * | 2003-06-18 | 2004-12-23 | White Hillary D. | Trandsdermal compositions and methods for treatment of fibromyalgia and chronic fatigue syndrome |
| US20040259784A1 (en) | 2003-06-18 | 2004-12-23 | White Hillary D. | Compositions and methods for treatment of muscle pain and muscle wasting |
| US8883769B2 (en) | 2003-06-18 | 2014-11-11 | White Mountain Pharma, Inc. | Methods for the treatment of fibromyalgia and chronic fatigue syndrome |
| US20050020552A1 (en) | 2003-07-16 | 2005-01-27 | Chaim Aschkenasy | Pharmaceutical composition and method for transdermal drug delivery |
| US20050042268A1 (en) | 2003-07-16 | 2005-02-24 | Chaim Aschkenasy | Pharmaceutical composition and method for transdermal drug delivery |
| US20050025833A1 (en) | 2003-07-16 | 2005-02-03 | Chaim Aschkenasy | Pharmaceutical composition and method for transdermal drug delivery |
| ATE534373T1 (de) | 2003-10-10 | 2011-12-15 | Antares Pharma Ipl Ag | Transdermale pharmazeutische formulierung zur minimierung von rückständen auf der haut |
| WO2006102476A2 (en) | 2005-03-21 | 2006-09-28 | Vicus Therapeutics Spe 1, Llc | Compositions and methods for ameliorating cachexia |
| EP1868437A4 (en) | 2005-04-12 | 2009-08-05 | Unimed Pharmaceuticals Inc | METHOD FOR TREATING OR PREVENTING BONE REMOVAL OR OSTEOPOROSIS |
| EP1868590A4 (en) | 2005-04-13 | 2012-08-29 | Unimed Pharmaceuticals Inc | PROCESS FOR INCREASING TESTOSTERONE AND CORRESPONDING STEROID CONCENTRATIONS IN WOMEN |
| CA2604943C (en) | 2005-04-15 | 2013-09-17 | Clarus Therapeutics, Inc. | Pharmaceutical delivery systems for hydrophobic drugs and compositions comprising same |
| US8492369B2 (en) | 2010-04-12 | 2013-07-23 | Clarus Therapeutics Inc | Oral testosterone ester formulations and methods of treating testosterone deficiency comprising same |
| KR20130114229A (ko) * | 2005-06-03 | 2013-10-16 | 애크럭스 디디에스 피티와이 리미티드 | 경피 약물 전달 방법 및 조성물 |
| US20080261937A1 (en) | 2007-03-23 | 2008-10-23 | Dudley Robert E | Pharmaceutical compositions and method for treating pediatric hypogonadism |
| US20080287406A1 (en) | 2007-03-26 | 2008-11-20 | Lessem Jan N | Compositions and methods for treating medical conditions |
-
2011
- 2011-11-17 EP EP11841292.3A patent/EP2640398A4/en not_active Withdrawn
- 2011-11-17 CA CA2818491A patent/CA2818491A1/en not_active Abandoned
- 2011-11-17 AU AU2011329782A patent/AU2011329782A1/en not_active Abandoned
- 2011-11-17 JP JP2013540032A patent/JP6912852B2/ja not_active Expired - Fee Related
- 2011-11-17 US US13/988,245 patent/US9642863B2/en not_active Expired - Fee Related
- 2011-11-17 WO PCT/US2011/061254 patent/WO2012068410A1/en not_active Ceased
- 2011-11-17 US US13/299,232 patent/US9642862B2/en not_active Expired - Fee Related
-
2017
- 2017-05-08 US US15/588,855 patent/US20170239270A1/en not_active Abandoned
- 2017-05-12 AU AU2017203161A patent/AU2017203161A1/en not_active Abandoned
-
2018
- 2018-01-04 JP JP2018000146A patent/JP2018087193A/ja active Pending
-
2019
- 2019-03-18 AU AU2019201863A patent/AU2019201863A1/en not_active Abandoned
- 2019-10-03 JP JP2019182786A patent/JP2020033354A/ja active Pending
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