JP2013541589A - （ｓ）−２−アミノ−３−（４−（２−アミノ−６−（（ｒ）−１−（４−クロロ−２−（３−メチル−１ｈ−ピラゾール−１−イル）フェニル）−２，２，２−トリフルオロエトキシ）ピリミジン−４−イル）フェニル）プロパン酸の結晶形態 - Google Patents

（ｓ）−２−アミノ−３−（４−（２−アミノ−６−（（ｒ）−１−（４−クロロ−２−（３−メチル−１ｈ−ピラゾール−１−イル）フェニル）−２，２，２−トリフルオロエトキシ）ピリミジン−４−イル）フェニル）プロパン酸の結晶形態 Download PDF

Info

Publication number
JP2013541589A
JP2013541589A JP2013537814A JP2013537814A JP2013541589A JP 2013541589 A JP2013541589 A JP 2013541589A JP 2013537814 A JP2013537814 A JP 2013537814A JP 2013537814 A JP2013537814 A JP 2013537814A JP 2013541589 A JP2013541589 A JP 2013541589A
Authority
JP
Japan
Prior art keywords
degrees
phenyl
amino
methyl
crystalline compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2013537814A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013541589A5 (enExample
Inventor
チュン リー
ウェイフォン フー
シャオゲン ヤン
ジャンチョン チャオ
マシュー マンチュ チャオ
Original Assignee
レクシコン ファーマシューティカルズ インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by レクシコン ファーマシューティカルズ インコーポレイテッド filed Critical レクシコン ファーマシューティカルズ インコーポレイテッド
Publication of JP2013541589A publication Critical patent/JP2013541589A/ja
Publication of JP2013541589A5 publication Critical patent/JP2013541589A5/ja
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Nutrition Science (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2013537814A 2010-11-05 2011-11-03 （ｓ）−２−アミノ−３−（４−（２−アミノ−６−（（ｒ）−１−（４−クロロ−２−（３−メチル−１ｈ−ピラゾール−１−イル）フェニル）−２，２，２−トリフルオロエトキシ）ピリミジン−４−イル）フェニル）プロパン酸の結晶形態 Withdrawn JP2013541589A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41042110P 2010-11-05 2010-11-05
US61/410,421 2010-11-05
PCT/US2011/059107 WO2012061576A1 (en) 2010-11-05 2011-11-03 Crystalline forms of ( s ) - 2 - amino - 3 - (4 - ( 2 - amino - 6 - ( (r) - 1 - (4 - ch loro-2- (3 -methyl- 1h- pyrazol- 1 -yl) phenyl) - 2, 2, 2 - trifluoroethoxy) pyrimidin- 4 - yl) phenyl) propanoic acid

Publications (2)

Publication Number Publication Date
JP2013541589A true JP2013541589A (ja) 2013-11-14
JP2013541589A5 JP2013541589A5 (enExample) 2014-12-04

Family

ID=45023872

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013537814A Withdrawn JP2013541589A (ja) 2010-11-05 2011-11-03 （ｓ）−２−アミノ−３−（４−（２−アミノ−６−（（ｒ）−１−（４−クロロ−２−（３−メチル−１ｈ−ピラゾール−１−イル）フェニル）−２，２，２−トリフルオロエトキシ）ピリミジン−４−イル）フェニル）プロパン酸の結晶形態

Country Status (15)

Country Link
US (1) US8772483B2 (enExample)
EP (1) EP2635569A1 (enExample)
JP (1) JP2013541589A (enExample)
KR (1) KR20130141572A (enExample)
CN (1) CN103228648A (enExample)
AR (1) AR083755A1 (enExample)
AU (1) AU2011323302A1 (enExample)
BR (1) BR112013011015A2 (enExample)
CA (1) CA2816963A1 (enExample)
MX (1) MX2013004921A (enExample)
RU (1) RU2013125756A (enExample)
SG (1) SG189535A1 (enExample)
TW (1) TW201245183A (enExample)
WO (1) WO2012061576A1 (enExample)
ZA (1) ZA201303049B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120077831A1 (en) * 2009-11-23 2012-03-29 Philip Manton Brown Methods and assays for the treatment of irritable bowel syndrome
CN102711757A (zh) * 2009-11-23 2012-10-03 莱西肯医药有限公司 用于治疗肠易激综合征的方法和分析法
UA119247C2 (uk) 2013-09-06 2019-05-27 РОЙВЕНТ САЙЕНСИЗ ҐмбГ Спіроциклічні сполуки як інгібітори триптофангідроксилази
US9611201B2 (en) 2015-03-05 2017-04-04 Karos Pharmaceuticals, Inc. Processes for preparing (R)-1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone
CN109180650A (zh) * 2018-08-28 2019-01-11 湖南华腾制药有限公司 一种氘代色氨酸羟化酶抑制剂的晶型
AU2019382168A1 (en) * 2018-11-16 2021-06-03 Altavant Sciences Gmbh A method for treating pulmonary arterial hypertension and associated pulmonary arterial hypertension

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007089335A2 (en) * 2005-12-29 2007-08-09 Lexicon Pharmaceutical Inc. Multicyclic amino acid derivatives and methods of their use
US7897763B2 (en) 2005-12-29 2011-03-01 Lexicon Pharmaceuticals, Inc. Process for the preparation of substituted phenylalanines
US7855291B2 (en) 2005-12-29 2010-12-21 Lexicon Pharmaceuticals, Inc. Process for the preparation of substituted phenylalanines
UA99270C2 (en) * 2006-12-12 2012-08-10 Лексикон Фармасьютикалз, Инк. 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use
RU2493156C2 (ru) 2007-08-24 2013-09-20 Лексикон Фармасьютикалз, Инк. Способы получения соединений на основе 4-фенил-6-(2,2,2-трифтор-1-фенилэтокси)пиримидина

Also Published As

Publication number Publication date
ZA201303049B (en) 2014-07-30
CN103228648A (zh) 2013-07-31
AU2011323302A1 (en) 2013-05-30
MX2013004921A (es) 2013-06-28
BR112013011015A2 (pt) 2016-08-23
US20120122904A1 (en) 2012-05-17
WO2012061576A1 (en) 2012-05-10
KR20130141572A (ko) 2013-12-26
SG189535A1 (en) 2013-06-28
RU2013125756A (ru) 2014-12-10
US8772483B2 (en) 2014-07-08
CA2816963A1 (en) 2012-05-10
AR083755A1 (es) 2013-03-20
TW201245183A (en) 2012-11-16
EP2635569A1 (en) 2013-09-11

Similar Documents

Publication Publication Date Title
JP7769650B2 (ja) 抗がん薬としてのキノキサリン誘導体
AU2020341681B2 (en) RIP1 inhibitory compounds and methods for making and using the same
JP5717445B2 (ja) （ｓ）−エチル２−アミノ−３−（４−（２−アミノ−６−（（ｒ）−１−（４−クロロ−２−（３−メチル−１ｈ−ピラゾール−１−イル）フェニル）−２，２，２−トリフルオロエトキシ）−ピリミジン−４−イル）フェニル）プロパノエートの固体形態
US8772483B2 (en) Solid forms of (S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid
JP5689875B2 (ja) トランス−４−［［（５ｓ）−５−［［［３，５−ビス（トリフルオロメチル）フェニル］メチル］（２−メチル−２ｈ−テトラゾール−５−イル）アミノ］−２，３，４，５−テトラヒドロ−７，９−ジメチル−１ｈ−１−ベンゾアゼピン−１−イル］メチル］−シクロヘキサンカルボン酸
WO2011069053A1 (en) Process for the preparation of pazopanip hcl and crystalline forms of pazopanib hcl
TW201121953A (en) Novel 5-fluorouracil derivative
JP2010540665A (ja) （ｓ）−２−アミノ−３−（４−（２−アミノ−６−（（ｒ）−２，２，２−トリフルオロ−１−（３’−メトキシビフェニル−４−イル）エトキシ）ピリミジン−４−イル）フェニル）プロパン酸の固体形態、及びそれらを使用する方法
AU2019357592A1 (en) Inhibiting fatty acid synthase (FASN)
TW202519231A (zh) 結晶形式
CN117642396A (zh) αVβ6和αVβ1整联蛋白抑制剂及其用途
TW200538116A (en) Process for the preparation of substituted triazole compounds
JP2025142238A (ja) 血漿カリクレインの阻害剤の形態及び組成物
JP2024529088A (ja) 小分子ｓｔｉｎｇアンタゴニスト
HK1182698A (en) Crystalline forms of ( s ) - 2 - amino - 3 - (4 - ( 2 - amino - 6 - ( (r) - 1 - (4 - ch loro-2- (3-methyl- 1h- pyrazol- 1 -yl) phenyl) - 2, 2, 2 - trifluoroethoxy) pyrimidin- 4 - yl) phenyl) propanoic acid
WO2020077071A1 (en) Inhibiting fatty acid synthase (fasn)
HK1145023B (en) Solids forms of (s) -ethyl 2-amin0-3- (4- (2-amino- 6-((r) -1- (4-chl0r0-2-o-methyl-ih-pyrazol- 1-yl)phenyl) -2, 2, 2-trifluorethoxy) -pyrimidin-4-yl)phenyl) propanoate

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20141020

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20141020

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20150709

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20150714