JP2013540771A - 新規ｎ末端修飾インスリン誘導体 - Google Patents
新規ｎ末端修飾インスリン誘導体 Download PDFInfo
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- JP2013540771A JP2013540771A JP2013533235A JP2013533235A JP2013540771A JP 2013540771 A JP2013540771 A JP 2013540771A JP 2013533235 A JP2013533235 A JP 2013533235A JP 2013533235 A JP2013533235 A JP 2013533235A JP 2013540771 A JP2013540771 A JP 2013540771A
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- insulin
- human insulin
- gglu
- desb30 human
- des
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Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10187706 | 2010-10-15 | ||
| EP10187706.6 | 2010-10-15 | ||
| US39409010P | 2010-10-18 | 2010-10-18 | |
| US61/394,090 | 2010-10-18 | ||
| PCT/EP2011/068019 WO2012049307A2 (en) | 2010-10-15 | 2011-10-14 | Novel n-terminally modified insulin derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013540771A true JP2013540771A (ja) | 2013-11-07 |
| JP2013540771A5 JP2013540771A5 (enExample) | 2014-11-20 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013533235A Withdrawn JP2013540771A (ja) | 2010-10-15 | 2011-10-14 | 新規ｎ末端修飾インスリン誘導体 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20140315797A1 (enExample) |
| EP (1) | EP2627670A2 (enExample) |
| JP (1) | JP2013540771A (enExample) |
| CN (1) | CN103154024A (enExample) |
| WO (1) | WO2012049307A2 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018531900A (ja) * | 2015-08-25 | 2018-11-01 | ノヴォ ノルディスク アー／エス | 新規インスリン誘導体及びその医学的使用 |
| JP2019011357A (ja) * | 2014-11-21 | 2019-01-24 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | インスリン受容体部分アゴニスト |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2010009850A (es) | 2008-03-18 | 2010-09-30 | Novo Nordisk As | Analogos de insulina acilados y etabilizados contra proteasas. |
| KR20150002777A (ko) | 2012-04-11 | 2015-01-07 | 노보 노르디스크 에이/에스 | 인슐린 제제 |
| WO2017032795A1 (en) * | 2015-08-25 | 2017-03-02 | Novo Nordisk A/S | Novel insulin derivatives and the medical uses hereof |
| EP3341402A1 (en) * | 2015-08-25 | 2018-07-04 | Novo Nordisk A/S | Novel insulin derivatives and the medical uses hereof |
| EP3458032A4 (en) | 2016-05-16 | 2019-12-25 | The Board of Regents of The University of Texas System | CATIONIC SULFONAMIDE AMINOLIPIDS AND AMPHIPHILE ZWITTERIONIC AMINOLIPIDS |
| MA49116A (fr) | 2016-12-16 | 2020-03-25 | Novo Nordisk As | Compositions pharmaceutiques contenant de l'insuline |
| PE20211264A1 (es) | 2017-08-17 | 2021-07-15 | Novo Nordisk As | Analogos de insulina acilados novedosos y usos de estos |
| SG11202106168VA (en) | 2018-12-11 | 2021-07-29 | Sanofi Sa | Insulin analogs having reduced insulin receptor binding affinity |
| BR112021016782A2 (pt) * | 2019-03-29 | 2021-11-30 | Novo Nordisk As | Composto, composição, e, método para o tratamento ou prevenção de diabetes, diabetes do tipo 1, diabetes do tipo 2, tolerância à glicose comprometida, hiperglicemia e síndrome metabólica |
| FI4073097T3 (fi) | 2019-12-11 | 2024-08-13 | Novo Nordisk As | Uusia insuliinianalogeja ja niiden käyttötapoja |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008528659A (ja) * | 2005-02-02 | 2008-07-31 | ノボ ノルディスク アクティーゼルスカブ | インスリン誘導体 |
| WO2008145721A2 (en) * | 2007-06-01 | 2008-12-04 | Novo Nordisk A/S | N-terminal modification of polypeptides for protection against degradation by aminopeptidases |
| WO2009022013A1 (en) * | 2007-08-15 | 2009-02-19 | Novo Nordisk A/S | Insulin analogues with an acyl and aklylene glycol moiety |
| WO2009115469A1 (en) * | 2008-03-18 | 2009-09-24 | Novo Nordisk A/S | Protease stabilized, acylated insulin analogues |
| WO2010029159A1 (en) * | 2008-09-12 | 2010-03-18 | Novo Nordisk A/S | Method of acylating a peptide or protein |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI0792290T1 (en) * | 1993-09-17 | 2001-12-31 | Novo Nordisk As | Acylated insulin |
| KR101159559B1 (ko) | 2003-08-05 | 2012-06-26 | 노보 노르디스크 에이/에스 | 신규의 인슐린 유도체 |
| EP1888118B1 (en) | 2005-05-25 | 2016-08-17 | Novo Nordisk A/S | Polypeptide formulations stabilized with ethylenediamine |
| EP2404934A1 (en) | 2006-09-22 | 2012-01-11 | Novo Nordisk A/S | Protease resistant insulin analogues |
| EP2164466A1 (en) * | 2007-06-01 | 2010-03-24 | Novo Nordisk A/S | Spontaneously dispersible preconcentrates including a peptide drug in a solid or semisolid carrier |
| EP2344200A2 (en) | 2008-09-19 | 2011-07-20 | Nektar Therapeutics | Modified therapeutics peptides, methods of their preparation and use |
| EP2370059A1 (en) * | 2008-11-28 | 2011-10-05 | Novo Nordisk A/S | Pharmaceutical compositions suitable for oral administration of derivatized insulin peptides |
| CN102753150A (zh) | 2010-01-12 | 2012-10-24 | 诺沃—诺迪斯克有限公司 | 用于口服给予胰岛素肽的药物组合物 |
-
2011
- 2011-10-14 EP EP11770428.8A patent/EP2627670A2/en not_active Withdrawn
- 2011-10-14 US US13/823,952 patent/US20140315797A1/en not_active Abandoned
- 2011-10-14 CN CN2011800496891A patent/CN103154024A/zh active Pending
- 2011-10-14 WO PCT/EP2011/068019 patent/WO2012049307A2/en not_active Ceased
- 2011-10-14 JP JP2013533235A patent/JP2013540771A/ja not_active Withdrawn
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008528659A (ja) * | 2005-02-02 | 2008-07-31 | ノボ ノルディスク アクティーゼルスカブ | インスリン誘導体 |
| WO2008145721A2 (en) * | 2007-06-01 | 2008-12-04 | Novo Nordisk A/S | N-terminal modification of polypeptides for protection against degradation by aminopeptidases |
| WO2009022013A1 (en) * | 2007-08-15 | 2009-02-19 | Novo Nordisk A/S | Insulin analogues with an acyl and aklylene glycol moiety |
| WO2009115469A1 (en) * | 2008-03-18 | 2009-09-24 | Novo Nordisk A/S | Protease stabilized, acylated insulin analogues |
| WO2010029159A1 (en) * | 2008-09-12 | 2010-03-18 | Novo Nordisk A/S | Method of acylating a peptide or protein |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019011357A (ja) * | 2014-11-21 | 2019-01-24 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | インスリン受容体部分アゴニスト |
| JP2019014734A (ja) * | 2014-11-21 | 2019-01-31 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | インスリン受容体部分アゴニスト |
| JP2019014735A (ja) * | 2014-11-21 | 2019-01-31 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | インスリン受容体部分アゴニスト |
| US10800827B2 (en) | 2014-11-21 | 2020-10-13 | Merck Sharp & Dohme Corp. | Insulin receptor partial agonists |
| CN112494656A (zh) * | 2014-11-21 | 2021-03-16 | 默沙东公司 | 胰岛素受体部分激动剂 |
| CN112494656B (zh) * | 2014-11-21 | 2024-01-30 | 默沙东有限责任公司 | 胰岛素受体部分激动剂 |
| JP2018531900A (ja) * | 2015-08-25 | 2018-11-01 | ノヴォ ノルディスク アー／エス | 新規インスリン誘導体及びその医学的使用 |
| JP2021177779A (ja) * | 2015-08-25 | 2021-11-18 | ノヴォ ノルディスク アー／エス | 新規インスリン誘導体及びその医学的使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2627670A2 (en) | 2013-08-21 |
| WO2012049307A2 (en) | 2012-04-19 |
| WO2012049307A3 (en) | 2012-06-14 |
| US20140315797A1 (en) | 2014-10-23 |
| CN103154024A (zh) | 2013-06-12 |
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