JP2013538079A5 - - Google Patents
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- Publication number
- JP2013538079A5 JP2013538079A5 JP2013523347A JP2013523347A JP2013538079A5 JP 2013538079 A5 JP2013538079 A5 JP 2013538079A5 JP 2013523347 A JP2013523347 A JP 2013523347A JP 2013523347 A JP2013523347 A JP 2013523347A JP 2013538079 A5 JP2013538079 A5 JP 2013538079A5
- Authority
- JP
- Japan
- Prior art keywords
- nanofibers
- arrayed
- support
- sequences
- coating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002121 nanofiber Substances 0.000 claims 16
- 210000004881 tumor cell Anatomy 0.000 claims 5
- 239000011248 coating agent Substances 0.000 claims 4
- 238000000576 coating method Methods 0.000 claims 4
- 230000012292 cell migration Effects 0.000 claims 3
- 239000000835 fiber Substances 0.000 claims 3
- 230000001737 promoting effect Effects 0.000 claims 3
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims 2
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 231100000433 cytotoxic Toxicity 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 239000002254 cytotoxic agent Substances 0.000 claims 2
- 231100000599 cytotoxic agent Toxicity 0.000 claims 2
- 230000001472 cytotoxic effect Effects 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 230000005012 migration Effects 0.000 claims 2
- 238000013508 migration Methods 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 229920001059 synthetic polymer Polymers 0.000 claims 2
- QASFUMOKHFSJGL-LAFRSMQTSA-N Cyclopamine Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H](CC2=C3C)[C@@H]1[C@@H]2CC[C@@]13O[C@@H]2C[C@H](C)CN[C@H]2[C@H]1C QASFUMOKHFSJGL-LAFRSMQTSA-N 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- BYTORXDZJWWIKR-UHFFFAOYSA-N Hinokiol Natural products CC(C)c1cc2CCC3C(C)(CO)C(O)CCC3(C)c2cc1O BYTORXDZJWWIKR-UHFFFAOYSA-N 0.000 claims 1
- 108010052285 Membrane Proteins Proteins 0.000 claims 1
- 102000018697 Membrane Proteins Human genes 0.000 claims 1
- 102000006386 Myelin Proteins Human genes 0.000 claims 1
- 108010083674 Myelin Proteins Proteins 0.000 claims 1
- 210000002469 basement membrane Anatomy 0.000 claims 1
- 230000002457 bidirectional effect Effects 0.000 claims 1
- QASFUMOKHFSJGL-UHFFFAOYSA-N cyclopamine Natural products C1C=C2CC(O)CCC2(C)C(CC2=C3C)C1C2CCC13OC2CC(C)CNC2C1C QASFUMOKHFSJGL-UHFFFAOYSA-N 0.000 claims 1
- 229960004679 doxorubicin Drugs 0.000 claims 1
- -1 fredrelate Chemical compound 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- FVYXIJYOAGAUQK-UHFFFAOYSA-N honokiol Chemical compound C1=C(CC=C)C(O)=CC=C1C1=CC(CC=C)=CC=C1O FVYXIJYOAGAUQK-UHFFFAOYSA-N 0.000 claims 1
- VVOAZFWZEDHOOU-UHFFFAOYSA-N honokiol Natural products OC1=CC=C(CC=C)C=C1C1=CC(CC=C)=CC=C1O VVOAZFWZEDHOOU-UHFFFAOYSA-N 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 210000005012 myelin Anatomy 0.000 claims 1
- 210000004882 non-tumor cell Anatomy 0.000 claims 1
- 229920001610 polycaprolactone Polymers 0.000 claims 1
- 239000004632 polycaprolactone Substances 0.000 claims 1
- 229920002635 polyurethane Polymers 0.000 claims 1
- 239000004814 polyurethane Substances 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37063010P | 2010-08-04 | 2010-08-04 | |
| US61/370,630 | 2010-08-04 | ||
| PCT/US2011/046653 WO2012019049A1 (en) | 2010-08-04 | 2011-08-04 | Devices, systems, and methods for excavating cancer cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013538079A JP2013538079A (ja) | 2013-10-10 |
| JP2013538079A5 true JP2013538079A5 (enExample) | 2014-09-11 |
| JP5894989B2 JP5894989B2 (ja) | 2016-03-30 |
Family
ID=45559831
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013523347A Active JP5894989B2 (ja) | 2010-08-04 | 2011-08-04 | 癌細胞を摘出するための装置、システム、及び方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11273250B2 (enExample) |
| EP (2) | EP3298986A1 (enExample) |
| JP (1) | JP5894989B2 (enExample) |
| AU (1) | AU2011285639B2 (enExample) |
| CA (1) | CA2807483C (enExample) |
| WO (1) | WO2012019049A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2347775T3 (da) | 2005-12-13 | 2020-07-13 | Harvard College | Skabeloner til celletransplantation |
| WO2009002401A2 (en) | 2007-06-21 | 2008-12-31 | President And Fellows Of Harvard College | Scaffolds for cell collection or elimination |
| US9370558B2 (en) | 2008-02-13 | 2016-06-21 | President And Fellows Of Harvard College | Controlled delivery of TLR agonists in structural polymeric devices |
| US10328133B2 (en) | 2008-02-13 | 2019-06-25 | President And Fellows Of Harvard College | Continuous cell programming devices |
| WO2010120749A2 (en) | 2009-04-13 | 2010-10-21 | President And Fellow Of Harvard College | Harnessing cell dynamics to engineer materials |
| WO2011014871A1 (en) | 2009-07-31 | 2011-02-03 | President And Fellows Of Harvard College | Programming of cells for tolerogenic therapies |
| EP2542230A4 (en) | 2010-03-05 | 2013-08-28 | Harvard College | PROMOTING THE ADHESION OF SKELETAL MUSCLE STEM CELLS BY SIMULTANEOUS ADMINISTRATION OF VEGF AND IGF-1 |
| US9693954B2 (en) | 2010-06-25 | 2017-07-04 | President And Fellows Of Harvard College | Co-delivery of stimulatory and inhibitory factors to create temporally stable and spatially restricted zones |
| CN107648668B (zh) | 2010-10-06 | 2021-06-18 | 哈佛学院董事会 | 用于基于材料的细胞疗法的可注射的成孔水凝胶 |
| WO2012064697A2 (en) | 2010-11-08 | 2012-05-18 | President And Fellows Of Harvard College | Materials presenting notch signaling molecules to control cell behavior |
| WO2012148684A1 (en) | 2011-04-27 | 2012-11-01 | President And Fellows Of Harvard College | Cell-friendly inverse opal hydrogels for cell encapsulation, drug and protein delivery, and functional nanoparticle encapsulation |
| WO2012149358A1 (en) | 2011-04-28 | 2012-11-01 | President And Fellows Of Harvard College | Injectable preformed macroscopic 3-dimensional scaffolds for minimally invasive administration |
| US9675561B2 (en) | 2011-04-28 | 2017-06-13 | President And Fellows Of Harvard College | Injectable cryogel vaccine devices and methods of use thereof |
| AU2012261848B2 (en) * | 2011-06-03 | 2017-06-15 | President And Fellows Of Harvard College | In situ antigen-generating cancer vaccine |
| US20150024025A1 (en) * | 2012-03-06 | 2015-01-22 | The UABB Research Foundation | Aligned nanofibrous structures for axonal regeneration after spinal cord injury or surgery |
| CN104244929B (zh) | 2012-04-16 | 2017-04-05 | 哈佛学院董事会 | 用于调节免疫反应的介孔二氧化硅组合物 |
| GB201301571D0 (en) * | 2012-11-27 | 2013-03-13 | Fundanci N Pedro Barri De La Maza | Product and use |
| US10682400B2 (en) | 2014-04-30 | 2020-06-16 | President And Fellows Of Harvard College | Combination vaccine devices and methods of killing cancer cells |
| CN106573061A (zh) | 2014-04-30 | 2017-04-19 | 佩德罗巴里德拉玛泽康德德费诺萨基金会 | 药剂、制品和用途 |
| WO2016049627A1 (en) | 2014-09-26 | 2016-03-31 | Rensselaer Polytechnic Institute | Nanocomposite scaffold for the in vitro isolation of cells |
| CN107206121B (zh) * | 2014-11-13 | 2020-09-08 | 新加坡国立大学 | 组织支架装置和用于制造其的方法 |
| EP3250250A4 (en) | 2015-01-30 | 2019-05-22 | President and Fellows of Harvard College | PERITUMORAL AND INTRATUMORAL MATERIALS FOR CANCER THERAPY |
| JP7094533B2 (ja) | 2015-04-10 | 2022-07-04 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 免疫細胞捕捉デバイスおよびその製造および使用方法 |
| EP3411475B1 (en) | 2016-02-06 | 2025-08-27 | President and Fellows of Harvard College | Recapitulating the hematopoietic niche to reconstitute immunity |
| CN115537372A (zh) | 2016-07-13 | 2022-12-30 | 哈佛学院院长等 | 抗原呈递细胞模拟支架及其制备和使用方法 |
| EP3493842A4 (en) | 2016-08-02 | 2020-07-29 | President and Fellows of Harvard College | BIOMATERIALS TO MODULATE IMMUNE RESPONSES |
| US10493233B1 (en) * | 2018-06-05 | 2019-12-03 | Duke University | Bi-directional access to tumors |
| WO2020061129A1 (en) | 2018-09-19 | 2020-03-26 | President And Fellows Of Harvard College | Compositions and methods for labeling and modulation of cells in vitro and in vivo |
| CN112076179A (zh) * | 2020-09-27 | 2020-12-15 | 成都金瑞基业生物科技有限公司 | 和厚朴酚的医药用途 |
| CN115282341B (zh) * | 2022-06-27 | 2023-05-23 | 华南理工大学 | 一种具有多肽双向梯度分布表面的多孔金属材料及其制备方法与应用 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2121286B (en) | 1982-06-02 | 1985-11-06 | Ethicon Inc | Improvements in synthetic vascular grafts, and methods of manufacturing such grafts |
| US5217492A (en) | 1982-09-29 | 1993-06-08 | Bio-Metric Systems, Inc. | Biomolecule attachment to hydrophobic surfaces |
| EP0432141A3 (en) | 1984-03-30 | 1991-08-21 | Osteonics Biomaterials, Inc. | A femoral stem for permanent implantation into the natural femur |
| US5053453A (en) | 1988-11-01 | 1991-10-01 | Baxter International Inc. | Thromboresistant materials and methods for making same |
| USRE36370E (en) | 1992-01-13 | 1999-11-02 | Li; Shu-Tung | Resorbable vascular wound dressings |
| US5916585A (en) | 1996-06-03 | 1999-06-29 | Gore Enterprise Holdings, Inc. | Materials and method for the immobilization of bioactive species onto biodegradable polymers |
| US6347930B1 (en) | 1997-09-11 | 2002-02-19 | Hospal R & D Int. | Device and method for manufacturing a segmented tubular capsule containing a biologically active medium |
| US6165217A (en) | 1997-10-02 | 2000-12-26 | Gore Enterprise Holdings, Inc. | Self-cohering, continuous filament non-woven webs |
| US6303136B1 (en) | 1998-04-13 | 2001-10-16 | Neurotech S.A. | Cells or tissue attached to a non-degradable filamentous matrix encapsulated by a semi-permeable membrane |
| DE69940466D1 (de) | 1998-06-05 | 2009-04-09 | Organogenesis Inc | Biologisch modellierte implantierbare prothesen |
| US7615373B2 (en) | 1999-02-25 | 2009-11-10 | Virginia Commonwealth University Intellectual Property Foundation | Electroprocessed collagen and tissue engineering |
| US20020081732A1 (en) | 2000-10-18 | 2002-06-27 | Bowlin Gary L. | Electroprocessing in drug delivery and cell encapsulation |
| CA2367173A1 (en) | 1999-04-08 | 2000-10-12 | The General Hospital Corporation | Purposeful movement of human migratory cells away from an agent source |
| US6716225B2 (en) | 2001-08-02 | 2004-04-06 | Collagen Matrix, Inc. | Implant devices for nerve repair |
| US6893431B2 (en) | 2001-10-15 | 2005-05-17 | Scimed Life Systems, Inc. | Medical device for delivering patches |
| WO2003072748A2 (en) | 2002-02-22 | 2003-09-04 | University Of Washington | Bioengineered tissue substitutes |
| WO2003079985A2 (en) | 2002-03-18 | 2003-10-02 | Carnegie Mellon University | Method and apparatus for preparing biomimetic scaffold |
| AU2003251899A1 (en) | 2002-07-10 | 2004-01-23 | University Of Florida | Sol-gel derived bioactive glass polymer composite |
| US20050038498A1 (en) | 2003-04-17 | 2005-02-17 | Nanosys, Inc. | Medical device applications of nanostructured surfaces |
| US7163920B2 (en) | 2003-09-30 | 2007-01-16 | Ethicon, Inc. | Peptide with osteogenic activity |
| US7704740B2 (en) | 2003-11-05 | 2010-04-27 | Michigan State University | Nanofibrillar structure and applications including cell and tissue culture |
| WO2006044904A2 (en) | 2004-10-15 | 2006-04-27 | Vanderbilt University | Nano- and micro-scale engineering of polymeric scaffolds for vascular tissue engineering |
| AU2006220565A1 (en) | 2005-03-07 | 2006-09-14 | Georgia Tech Research Corporation | Nanofilament scaffold for tissue regeneration |
| US7531503B2 (en) | 2005-03-11 | 2009-05-12 | Wake Forest University Health Sciences | Cell scaffold matrices with incorporated therapeutic agents |
| US20080220042A1 (en) | 2006-01-27 | 2008-09-11 | The Regents Of The University Of California | Biomolecule-linked biomimetic scaffolds |
| WO2007090102A2 (en) | 2006-01-27 | 2007-08-09 | The Regents Of The University Of California | Biomimetic scaffolds |
| US20100211172A1 (en) | 2007-04-02 | 2010-08-19 | Georgia Tech Research Corporation | Implantable Device For Communicating With Biological Tissue |
| WO2008137659A1 (en) * | 2007-05-04 | 2008-11-13 | University Of Virginia Patent Foundation | Compositions and methods for making and using laminin nanofibers |
| WO2009002401A2 (en) * | 2007-06-21 | 2008-12-31 | President And Fellows Of Harvard College | Scaffolds for cell collection or elimination |
| US20090043380A1 (en) * | 2007-08-09 | 2009-02-12 | Specialized Vascular Technologies, Inc. | Coatings for promoting endothelization of medical devices |
| ATE537857T1 (de) * | 2007-09-21 | 2012-01-15 | Boston Scient Scimed Inc | Medizinische vorrichtungen mit oberflächen mit nanofaser-struktur |
| US20100129418A1 (en) | 2008-11-18 | 2010-05-27 | Lowell Jeffry Lawrence | Method of inducing negative chemotaxis using an ellagitannin or gallotannin |
| US8940331B2 (en) * | 2008-11-22 | 2015-01-27 | The Board Of Trustees Of The Leland Stanford Junior University | Hydrogels, methods of making hydrogels, methods of using hydrogels, and methods of isolating, trapping, attracting, and/or killing cancer cells |
| JP2012527217A (ja) | 2009-04-24 | 2012-11-08 | ジ・オハイオ・ステート・ユニバーシティ | 双方向微小環境系 |
| US20110038936A1 (en) | 2009-08-17 | 2011-02-17 | Kimberly Ann Griswold | System and method for electrospun drug loaded biodegradable chemotherapy applications |
| US9572909B2 (en) | 2009-09-14 | 2017-02-21 | Virginia Commonwealth University | Electrospun nerve guides for nerve regeneration designed to modulate nerve architecture |
-
2011
- 2011-08-04 WO PCT/US2011/046653 patent/WO2012019049A1/en not_active Ceased
- 2011-08-04 EP EP17199344.7A patent/EP3298986A1/en not_active Withdrawn
- 2011-08-04 JP JP2013523347A patent/JP5894989B2/ja active Active
- 2011-08-04 CA CA2807483A patent/CA2807483C/en active Active
- 2011-08-04 AU AU2011285639A patent/AU2011285639B2/en active Active
- 2011-08-04 EP EP11815346.9A patent/EP2600792B1/en active Active
- 2011-08-04 US US13/814,009 patent/US11273250B2/en active Active
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