JP2013536419A5 - - Google Patents
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- Publication number
- JP2013536419A5 JP2013536419A5 JP2013524450A JP2013524450A JP2013536419A5 JP 2013536419 A5 JP2013536419 A5 JP 2013536419A5 JP 2013524450 A JP2013524450 A JP 2013524450A JP 2013524450 A JP2013524450 A JP 2013524450A JP 2013536419 A5 JP2013536419 A5 JP 2013536419A5
- Authority
- JP
- Japan
- Prior art keywords
- tmab
- monoclonal antibody
- antibody
- alternative
- agg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 18
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 8
- 239000007790 solid phase Substances 0.000 claims 5
- 229960002685 biotin Drugs 0.000 claims 4
- 235000020958 biotin Nutrition 0.000 claims 4
- 239000011616 biotin Substances 0.000 claims 4
- 229960004641 rituximab Drugs 0.000 claims 4
- 206010061623 Adverse drug reaction Diseases 0.000 claims 3
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 claims 3
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 3
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 3
- 229960002964 adalimumab Drugs 0.000 claims 3
- 229960003115 certolizumab pegol Drugs 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 229960000598 infliximab Drugs 0.000 claims 3
- 238000010494 dissociation reaction Methods 0.000 claims 2
- 230000005593 dissociations Effects 0.000 claims 2
- 238000003018 immunoassay Methods 0.000 claims 2
- DDFYFBUWEBINLX-UHFFFAOYSA-M tetramethylammonium bromide Chemical compound [Br-].C[N+](C)(C)C DDFYFBUWEBINLX-UHFFFAOYSA-M 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 108090001008 Avidin Proteins 0.000 claims 1
- 108010090804 Streptavidin Proteins 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 238000011534 incubation Methods 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 229940126622 therapeutic monoclonal antibody Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10173408 | 2010-08-19 | ||
| EP10173408.5 | 2010-08-19 | ||
| PCT/EP2011/064178 WO2012022774A1 (en) | 2010-08-19 | 2011-08-17 | An assay for measurement of antibodies binding to a therapeutic monoclonal antibody |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013536419A JP2013536419A (ja) | 2013-09-19 |
| JP2013536419A5 true JP2013536419A5 (https=) | 2014-04-24 |
| JP5805190B2 JP5805190B2 (ja) | 2015-11-04 |
Family
ID=42727619
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013524450A Active JP5805190B2 (ja) | 2010-08-19 | 2011-08-17 | 療法用モノクローナル抗体に結合する抗体の測定のためのアッセイ |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9081016B2 (https=) |
| EP (1) | EP2606362B1 (https=) |
| JP (1) | JP5805190B2 (https=) |
| CN (1) | CN103109190B (https=) |
| CA (1) | CA2802278A1 (https=) |
| ES (1) | ES2555864T3 (https=) |
| WO (1) | WO2012022774A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104614535B (zh) * | 2015-02-10 | 2017-11-28 | 深圳市新产业生物医学工程股份有限公司 | 甲状腺微粒体抗体检测试剂盒及其制备方法和应用 |
| EP3482199A1 (en) * | 2016-07-08 | 2019-05-15 | Atonomics A/S | A universal assay for determining the quantity of therapeutic monoclonal antibodies and their corresponding anti-drug-antibodies in samples |
| CN106093413A (zh) * | 2016-07-18 | 2016-11-09 | 本·沙朗 | 一种抗英夫利西抗体elisa检测试剂盒和检测方法 |
| EP3682237A1 (en) * | 2017-09-15 | 2020-07-22 | Beckman Coulter, Inc. | Flow based assays for therapeutics |
| CN111971305A (zh) * | 2018-03-27 | 2020-11-20 | 美国控股实验室公司 | 用于鉴定可能受益于治疗剂治疗的受试者的夹心酶联免疫吸附测定 |
| JP7570421B2 (ja) * | 2020-01-02 | 2024-10-21 | エフ． ホフマン－ラ ロシュ アーゲー | Ａｄａ応答特定アッセイ |
| US12560598B2 (en) | 2020-03-11 | 2026-02-24 | Genesis Intelligence, Llc | Cartridge-based automated rapid test analyzer |
| WO2021224360A1 (en) * | 2020-05-08 | 2021-11-11 | F. Hoffmann-La Roche Ag | High ionic strength dissociation assay for high drug tolerant testing |
| CN117590002B (zh) * | 2023-11-23 | 2024-10-22 | 上海领检科技有限公司 | 一种TNFα抗药抗体的检测方法及检测试剂盒 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1508132A (en) | 1974-05-20 | 1978-04-19 | Technicon Instr | Analysis of biological fluids |
| US5219730A (en) | 1982-09-28 | 1993-06-15 | New York University | Idiotype-anti-idiotype immunoassay |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4554088A (en) | 1983-05-12 | 1985-11-19 | Advanced Magnetics Inc. | Magnetic particles for use in separations |
| US4628037A (en) | 1983-05-12 | 1986-12-09 | Advanced Magnetics, Inc. | Binding assays employing magnetic particles |
| US4695393A (en) | 1983-05-12 | 1987-09-22 | Advanced Magnetics Inc. | Magnetic particles for use in separations |
| US4698302A (en) | 1983-05-12 | 1987-10-06 | Advanced Magnetics, Inc. | Enzymatic reactions using magnetic particles |
| US4828981A (en) | 1983-08-24 | 1989-05-09 | Synbiotics Corporation | Immunoassays for determining Dirofilaria immitis infection using antiidiotype monoclonal antibody reagents |
| EP0170302A1 (fr) | 1984-06-27 | 1986-02-05 | l'Association internationale à but scientifique, dite: Institut international de pathologie cellulaire et moléculaire | Procédé de dosage immunologique d'une substance dans un échantillon liquide au moyen d'anticorps anti-idiotypiques |
| US5238808A (en) | 1984-10-31 | 1993-08-24 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
| JPH0823558B2 (ja) | 1984-11-27 | 1996-03-06 | オ−ジエニクス リミテツド | 検定装置 |
| DE3689645D1 (de) | 1985-10-16 | 1994-03-24 | Fresenius Ag | Selektives Adsorbens zur Bindung von Immunkomplexen. |
| EP0243471A4 (en) | 1985-10-22 | 1989-07-11 | Cooper Lipotech Inc | SOLID PHASE LIPOSOME IMMUNOANALYSIS SYSTEM. |
| US6316607B1 (en) | 1986-04-30 | 2001-11-13 | Igen International, Inc. | Electrochemiluminescent assays |
| US4965392A (en) | 1987-03-26 | 1990-10-23 | Neorx Corporation | Chelating compounds for metal-radionuclide labeled proteins |
| US5935779A (en) | 1988-11-03 | 1999-08-10 | Igen International Inc. | Methods for improved particle electrochemiluminescence assay |
| GB8803000D0 (en) | 1988-02-10 | 1988-03-09 | Ekins Roger Philip | Determination of ambient concentrations of several analytes |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5068088A (en) | 1988-11-03 | 1991-11-26 | Igen, Inc. | Method and apparatus for conducting electrochemiluminescent measurements |
| ZA898290B (en) | 1988-11-03 | 1991-06-26 | Igen Inc | Electrochemiluminescent assays |
| EP0448632A1 (en) | 1988-12-09 | 1991-10-02 | Centocor, Inc. | Anti-idiotopic immunometric assay |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| ATE300615T1 (de) | 1990-08-29 | 2005-08-15 | Genpharm Int | Transgene mäuse fähig zur produktion heterologer antikörper |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5364930A (en) | 1990-10-16 | 1994-11-15 | Northwestern University | Synthetic C1q peptide fragments |
| CA2405246A1 (en) | 1990-12-03 | 1992-06-11 | Genentech, Inc. | Enrichment method for variant proteins with alterred binding properties |
| IL100866A (en) | 1991-02-06 | 1995-10-31 | Igen Inc | Method and apparatus for magnetic microparticulate based luminescence assay including plurality of magnets |
| DE69223980T2 (de) | 1991-10-15 | 1998-05-28 | Multilyte Ltd | Bindungstest unter benutzung eines markierten reagens |
| DE69232137T2 (de) | 1991-11-25 | 2002-05-29 | Enzon Inc | Multivalente antigen-bindende proteine |
| US5466416A (en) | 1993-05-14 | 1995-11-14 | Ghaed; Ali | Apparatus and methods for carrying out electrochemiluminescence test measurements |
| US6241963B1 (en) | 1995-10-19 | 2001-06-05 | The Trustees Of The University Of Pennsylvania | Dopamine and serotonin transporter ligands and imaging agents |
| DE19806989A1 (de) | 1998-02-19 | 1999-08-26 | Roche Diagnostics Gmbh | Erzeugung räumlich scharf begrenzter Festphasen für Bindungsassays |
| IT1315254B1 (it) | 1999-11-05 | 2003-02-03 | Diesse Diagnostica Senese Spa | Metodo per la determinazione qualitativa e quantitativa di anticorpiumani di classe igc. |
| ATE315789T1 (de) | 1999-11-16 | 2006-02-15 | Genentech Inc | Elisa für vegf |
| CA2543830A1 (en) | 2003-10-27 | 2005-05-19 | Monogram Biosciences, Inc. | Detecting human anti-therapeutic antibodies |
| DE102004052729A1 (de) * | 2004-10-30 | 2006-05-04 | Roche Diagnostics Gmbh | Immunkomplex-spezifsicher Antikörper zur Reduktion des Nullwerts beim Nachweis von Antigen-spezifisch gebundenen Antikörpern einer bestimmten Immunglobulinklasse in Array-Testformaten |
| EP3796003A1 (en) | 2005-04-04 | 2021-03-24 | Biogen MA Inc. | Methods for evaluating an immune response to a therapeutic agent |
| EP2389947A1 (en) | 2006-03-23 | 2011-11-30 | Novartis AG | Anti-tumor cell antigen antibody therapeutics |
| CA2683137A1 (en) | 2006-10-10 | 2008-04-17 | Squicor | Compositions and methods for treating and diagnosing cancers |
| WO2009003082A2 (en) * | 2007-06-26 | 2008-12-31 | Vanderbilt University | Immunological compositions as cancer biomarkers and/or therapeutics |
-
2011
- 2011-08-17 CA CA2802278A patent/CA2802278A1/en not_active Abandoned
- 2011-08-17 JP JP2013524450A patent/JP5805190B2/ja active Active
- 2011-08-17 CN CN201180042537.9A patent/CN103109190B/zh active Active
- 2011-08-17 WO PCT/EP2011/064178 patent/WO2012022774A1/en not_active Ceased
- 2011-08-17 EP EP11746230.9A patent/EP2606362B1/en active Active
- 2011-08-17 ES ES11746230.9T patent/ES2555864T3/es active Active
-
2013
- 2013-02-13 US US13/766,130 patent/US9081016B2/en active Active
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