JP2013536408A - ガレクチン−3測定によりモニタリングされるスタチン療法 - Google Patents

ガレクチン−3測定によりモニタリングされるスタチン療法 Download PDF

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JP2013536408A
JP2013536408A JP2013518767A JP2013518767A JP2013536408A JP 2013536408 A JP2013536408 A JP 2013536408A JP 2013518767 A JP2013518767 A JP 2013518767A JP 2013518767 A JP2013518767 A JP 2013518767A JP 2013536408 A JP2013536408 A JP 2013536408A
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galectin
maximum threshold
population
statin
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JP2013536408A5 (enExample
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ピーター ムンテンダム,
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ビージー メディシン, インコーポレイテッド
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701Details
    • G01N2333/4724Lectins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/32Cardiovascular disorders
    • G01N2800/324Coronary artery diseases, e.g. angina pectoris, myocardial infarction
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/32Cardiovascular disorders
    • G01N2800/325Heart failure or cardiac arrest, e.g. cardiomyopathy, congestive heart failure
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
JP2013518767A 2010-07-02 2011-07-01 ガレクチン−3測定によりモニタリングされるスタチン療法 Pending JP2013536408A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36121610P 2010-07-02 2010-07-02
US61/361,216 2010-07-02
PCT/US2011/042846 WO2012003475A1 (en) 2010-07-02 2011-07-01 Statin therapy monitored by galectin- 3 measurement

Publications (2)

Publication Number Publication Date
JP2013536408A true JP2013536408A (ja) 2013-09-19
JP2013536408A5 JP2013536408A5 (enExample) 2014-08-07

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JP2013518767A Pending JP2013536408A (ja) 2010-07-02 2011-07-01 ガレクチン−3測定によりモニタリングされるスタチン療法

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Country Link
US (1) US20120029003A1 (enExample)
EP (1) EP2588111A1 (enExample)
JP (1) JP2013536408A (enExample)
WO (1) WO2012003475A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2742265C (en) * 2008-10-29 2014-07-15 Bg Medicine, Inc. Galectin-3 immunoassay
KR20120104167A (ko) * 2009-08-25 2012-09-20 비쥐 메디신, 인코포레이티드 갈렉틴―3 및 심장 재동기화 요법
WO2013169890A1 (en) * 2012-05-08 2013-11-14 Bg Medicine, Inc. Systems and methods for assessing disease risk, status, and prognosis
EP2843414B1 (en) 2013-08-26 2018-09-19 Roche Diagniostics GmbH Marker for statin treatment stratification in heart failure
ES2712201T3 (es) 2014-01-28 2019-05-09 Hoffmann La Roche Biomarcadores para la evaluación de riesgos y la monitorización del tratamiento en pacientes de insuficiencia cardíaca que han recibido terapia guiada por el péptido natriurético de tipo B

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005040817A1 (en) * 2003-10-09 2005-05-06 Universiteit Maastricht Method for identifying a subject at risk of developing heart failure by determining the level of galectin-3 or thrombospondin-2
JP2007523644A (ja) * 2004-02-03 2007-08-23 ディアデクサス インコーポレーテッド Lp−PLA2活性を検出する方法

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US4632901A (en) 1984-05-11 1986-12-30 Hybritech Incorporated Method and apparatus for immunoassays
US4704692A (en) 1986-09-02 1987-11-03 Ladner Robert C Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5091513A (en) 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US5132405A (en) 1987-05-21 1992-07-21 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
AU2684488A (en) 1988-06-27 1990-01-04 Carter-Wallace, Inc. Test device and method for colored particle immunoassay
US20010051350A1 (en) 1995-05-02 2001-12-13 Albert Nazareth Diagnostic detection device and method
CA2293718A1 (en) 1997-06-10 1998-12-17 Medlyte Diagnostics, Inc. Methods for early detection of heart disease
WO2004111654A2 (en) * 2003-06-06 2004-12-23 Ciphergen Biosystems, Inc. Serum biomarkers in ischaemic heart disease
US9934294B2 (en) 2014-09-26 2018-04-03 Wal-Mart Stores, Inc. System and method for using past or external information for future search results

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
WO2005040817A1 (en) * 2003-10-09 2005-05-06 Universiteit Maastricht Method for identifying a subject at risk of developing heart failure by determining the level of galectin-3 or thrombospondin-2
JP2007508527A (ja) * 2003-10-09 2007-04-05 ユニフェルジテイト・マーストリヒト ガレクチン−3またはトロンボスポンジン−2のレベルを定量することによって心不全を発症する危険性がある対象を同定する方法
JP2007523644A (ja) * 2004-02-03 2007-08-23 ディアデクサス インコーポレーテッド Lp−PLA2活性を検出する方法

Non-Patent Citations (8)

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Title
JPN5013008218; RUDOLF A DE BOER: 'GALECTIN-3: A NOVEL MEDIATOR OF HEART FAILURE DEVELOPMENT AND PROGRESSION' EUROPEAN JOURNAL OF HEART FAILURE V11, 20090101, P811-817, ELSEVIER *
JPN5013008219; LOK: 'PROGNOSTIC VALUE OF GALECTIN-3, A NOVEL MARKER OF FIBROSIS, IN PATIENTS WITH CHRONIC HEART FAILURE:' CLIN RES CARDIOL V99, 20100204, P323-328 *
JPN5013008220; ERKILET G.: '181: PLASMA GALECTIN 3 IS INCREASED IN TERMINAL HEART FAILURE PATIENTS AND IS ELEVATED IN PATIENTS N' JOURNAL OF HEART AND LUNG TRANSPLANTATION V29 N2, 20100201, P S65, MOSBY-YEAR BOOK INC. *
JPN5013008221; DE BOER R. A.: 'CLINICAL AND PROGNOSTIC VALUE OF GALECTIN-3, A NOVEL FIBROSIS-ASSOCIATED BIOMARKER. RELATION WITH CL' JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY V55 N10A, 20100309, P A26.E243, ELSEVIER *
JPN5013008222; LOK D.: 'PLASMA GALECTIN-3 LEVELS PREDICT LEFT VENTRICULAR REMODELLING DETERMINED BY SEQUENTIAL ECHOCARDIOGRA' JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY V55 N10A, 20100309, P A17.E161, ELSEVIER *
JPN5013008223; SHAH R. V.: 'GALECTIN-3, CARDIAC STRUCTURE AND FUNCTION, AND LONG-TERM MORTALITY IN PATIENTS WITH ACUTE HEART FAI' JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY V55 N10A, 20100309, P A34.E329, ELSEVIER *
JPN5013008224; VAN VELDHUISEN D. J.: 'CLINICAL AND PROGNOSTIC VALUE OF GALECTIN-3, A NOVEL FIBROSIS-ASSOCIATED BIOMARKER, IN PATIENTS WITH' JOURNAL OF CARDIAC FAILURE V15 N9, 20091101, P814, CHURCHILL LIVINGSTONE *
JPN6015001970; 高野博之、小室一成: 'スタチンを用いた心不全治療の臨床試験' Annual Review 循環器 2009 III.診断と治療 最近の進歩 B:心不全 , 2009, P177-184 *

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EP2588111A1 (en) 2013-05-08
US20120029003A1 (en) 2012-02-02
WO2012003475A1 (en) 2012-01-05

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