JP2013529679A - 関節の処置のための注射用医薬組成物 - Google Patents
関節の処置のための注射用医薬組成物 Download PDFInfo
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- JP2013529679A JP2013529679A JP2013517669A JP2013517669A JP2013529679A JP 2013529679 A JP2013529679 A JP 2013529679A JP 2013517669 A JP2013517669 A JP 2013517669A JP 2013517669 A JP2013517669 A JP 2013517669A JP 2013529679 A JP2013529679 A JP 2013529679A
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- Prior art keywords
- xylitol
- injectable pharmaceutical
- joint
- polyol
- irritation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A—HUMAN NECESSITIES
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/428—Vitamins, e.g. tocopherol, riboflavin
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
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- A—HUMAN NECESSITIES
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- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
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- A—HUMAN NECESSITIES
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- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/24—Materials or treatment for tissue regeneration for joint reconstruction
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
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- Molecular Biology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
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- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polymers & Plastics (AREA)
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| PCT/IL2011/000495 WO2012001679A1 (en) | 2010-06-30 | 2011-06-15 | Injectable pharmaceutical compositions for the treatment of joints |
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| IL206739A (en) | 2010-06-30 | 2016-06-30 | David Segal | An injectable drug containing silitol as an active substance |
| WO2017069822A2 (en) | 2015-07-20 | 2017-04-27 | The Brigham And Women's Hospital, Inc. | Shear-thinning compositions as an intravascular embolic agent |
| WO2019038763A1 (en) | 2017-08-22 | 2019-02-28 | Moebius Medical Ltd. | LIPOSOMAL FORMULATION FOR JOINT LUBRICATION |
| CN112218942A (zh) * | 2018-06-25 | 2021-01-12 | 赛斯特姆公司 | 从人诱导多能干细胞制备软骨细胞颗粒的方法及其用途 |
| WO2022168968A1 (ja) * | 2021-02-05 | 2022-08-11 | 学校法人近畿大学 | 末梢神経障害の予防又は改善剤 |
| CA3266614A1 (en) | 2023-01-19 | 2024-07-25 | Moebius Medical Ltd. | LONG-ACTING LIPOSOMAL COMPOSITION FOR THE TREATMENT OF PAIN IN JOINT DISORDERS |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03236330A (ja) * | 1989-12-21 | 1991-10-22 | Nissho Corp | 炎症治療剤 |
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| US4767785A (en) * | 1984-01-18 | 1988-08-30 | Michael Georgieff | Hypocaloric preparation and intravenous method for hypocaloric treatment of patients |
| IT1198449B (it) | 1986-10-13 | 1988-12-21 | F I D I Farmaceutici Italiani | Esteri di alcoli polivalenti di acido ialuronico |
| US5510418A (en) * | 1988-11-21 | 1996-04-23 | Collagen Corporation | Glycosaminoglycan-synthetic polymer conjugates |
| US5095037B1 (en) | 1989-12-21 | 1995-12-19 | Nissho Kk | Combined anti-inflammatory agent |
| AUPM922394A0 (en) * | 1994-11-03 | 1994-11-24 | Astra Pharmaceuticals Pty Ltd | Plastic syringe with overcap |
| PT790056E (pt) * | 1995-08-07 | 2005-02-28 | Suntory Ltd | Preventivo ou remedio para doencas provocadas por anormalidades nos tecidos cartilaginosos |
| US6294170B1 (en) * | 1997-08-08 | 2001-09-25 | Amgen Inc. | Composition and method for treating inflammatory diseases |
| DK1092447T3 (da) * | 1999-10-14 | 2004-05-10 | Becton Dickinson Co | Nasalafgivelsesindretning indbefattende en spröjtedyse |
| US6716819B2 (en) * | 2000-05-19 | 2004-04-06 | University Of Iowa Research Foundation | Use of xylitol to reduce ionic strength and activate endogenous antimicrobials for prevention and treatment of infections |
| FR2833173B1 (fr) * | 2001-12-10 | 2004-08-27 | Roquette Freres | Preparation antipyretique renfermant du xylitol |
| KR100931784B1 (ko) * | 2003-10-23 | 2009-12-14 | 오츠카 세이야쿠 가부시키가이샤 | 방출조절성 멸균 아리피프라졸 주사제, 그 제조방법 |
| US20070021357A1 (en) * | 2005-06-17 | 2007-01-25 | Dynamis Therapeutics, Inc. | Treatment of inflammatory conditions |
| US20070293587A1 (en) * | 2006-05-23 | 2007-12-20 | Haley Jeffrey T | Combating sinus, throat, and blood infections with xylitol delivered in the mouth |
| CN101209344B (zh) * | 2006-12-28 | 2012-07-04 | 赵超英 | 高渗液组合物在制备促进伤口愈合的药物中的应用 |
| CN101450037A (zh) * | 2007-11-28 | 2009-06-10 | 天津太平洋制药有限公司 | 一种木糖醇静脉注射液及其制备方法 |
| FR2938187B1 (fr) | 2008-11-07 | 2012-08-17 | Anteis Sa | Composition injectable a base d'acide hyaluronique ou l'un de ses sels, de polyols et de lidocaine, sterilisee a la chaleur |
| CN101664384B (zh) * | 2009-09-18 | 2011-09-14 | 杭州市第六人民医院 | N-乙酰半胱氨酸盐木糖醇注射液及其制备方法和应用 |
| CN101669962A (zh) * | 2009-09-18 | 2010-03-17 | 杭州市第六人民医院 | 复合甘草酸氨基酸注射液及其制备方法和应用 |
| IL206739A (en) | 2010-06-30 | 2016-06-30 | David Segal | An injectable drug containing silitol as an active substance |
| WO2012143876A1 (en) | 2011-04-19 | 2012-10-26 | Anteis S.A. | A sterile and injectable aqueous formulation for administration in the intra-articular space of an intra-articular joint |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03236330A (ja) * | 1989-12-21 | 1991-10-22 | Nissho Corp | 炎症治療剤 |
Non-Patent Citations (3)
| Title |
|---|
| JPN6015017971; Ｊ． Ｎｕｔｒ． Ｖｏｌ．１２８, 1998, ｐｐ．１８１１-１８１４ * |
| JPN6015017973; Ｍｅｔａｂｏｌｉｓｍ Ｖｏｌ．５７, 2008, ｐｐ．１０５２-１０５５ * |
| JPN6015017976; Ｃｌｉｎ． Ｄｉａｇｎ． Ｌａｂ． Ｉｍｍｕｎｏｌ． Ｖｏｌ．１２ Ｎｏ．１１, 2005, ｐｐ．１２８５-１２９１ * |
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| US20130289131A1 (en) | 2013-10-31 |
| JP6166811B2 (ja) | 2017-07-19 |
| EP2588080B1 (en) | 2018-05-16 |
| IL206739A0 (en) | 2010-12-30 |
| US9707190B2 (en) | 2017-07-18 |
| WO2012001679A1 (en) | 2012-01-05 |
| JP2016153416A (ja) | 2016-08-25 |
| KR20130135731A (ko) | 2013-12-11 |
| CA2803257A1 (en) | 2012-01-05 |
| EP2588080A1 (en) | 2013-05-08 |
| US9913808B2 (en) | 2018-03-13 |
| CA2803257C (en) | 2019-01-08 |
| ES2679279T3 (es) | 2018-08-23 |
| IL206739A (en) | 2016-06-30 |
| HUE039724T2 (hu) | 2019-02-28 |
| EP2588080A4 (en) | 2015-01-07 |
| KR101842295B1 (ko) | 2018-03-27 |
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