JP2013528368A - 個の医療のための幹細胞バンク - Google Patents
個の医療のための幹細胞バンク Download PDFInfo
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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| US61/429,773 | 2011-01-05 | ||
| PCT/IL2011/000362 WO2011138786A2 (en) | 2010-05-06 | 2011-05-05 | Stem cell bank for personalized medicine |
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| JP2016109872A Pending JP2016189783A (ja) | 2010-05-06 | 2016-06-01 | 個の医療のための幹細胞バンク |
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| JP2018072255A Pending JP2018121650A (ja) | 2010-05-06 | 2018-04-04 | 個の医療のための幹細胞バンク |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015030149A1 (ja) * | 2013-08-29 | 2015-03-05 | 国立大学法人鳥取大学 | 細胞のアンチエイジングに関連する生体分子群 |
| WO2017090509A1 (ja) * | 2015-11-24 | 2017-06-01 | ロート製薬株式会社 | 脂肪組織由来間質細胞を含む肝疾患治療剤およびその製造方法 |
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| US9480549B2 (en) | 2008-04-25 | 2016-11-01 | Allosource | Multi-layer tissue patches |
| US9358320B2 (en) | 2008-04-25 | 2016-06-07 | Allosource | Multi-layer tissue patches |
| US9162011B2 (en) | 2011-12-19 | 2015-10-20 | Allosource | Flowable matrix compositions and methods |
| JP2015521630A (ja) * | 2012-06-26 | 2015-07-30 | ラスティー プロパティー ホールディングス プロプライエタリー リミテッド | 頭痛の頻度および／または重症度を下げるための組成物および方法 |
| EP2968646B1 (en) | 2013-03-13 | 2019-05-29 | AlloSource | Fascia fibrous compositions and methods for their use and manufacture |
| WO2014150784A1 (en) | 2013-03-15 | 2014-09-25 | Allosource | Cell repopulated collagen matrix for soft tissue repair and regeneration |
| US10738323B2 (en) | 2013-07-12 | 2020-08-11 | Cedars-Sinai Medical Center | Generation of induced pluripotent stem cells from normal human mammary epithelial cells |
| US9795707B2 (en) | 2013-12-06 | 2017-10-24 | Allosource | Methods of drying sheets of donor-provided human birth tissue |
| EP3102124A1 (en) * | 2014-02-06 | 2016-12-14 | Stryker European Holdings I, LLC | Bone marrow harvesting and storage |
| US9867853B2 (en) | 2014-05-30 | 2018-01-16 | International Cell Technologies Inc. | Method of providing cellular based immune enhancement for restoring immunity and preventing age related diseases |
| US10264976B2 (en) | 2014-12-26 | 2019-04-23 | The University Of Akron | Biocompatible flavonoid compounds for organelle and cell imaging |
| EP3273881B1 (en) | 2015-03-24 | 2019-10-09 | Stryker European Holdings I, LLC | Bone marrow harvesting device |
| GB201600597D0 (en) * | 2016-01-12 | 2016-02-24 | Occhipinti Luigi G And Pluchino Stefano And Cambridge Innovation Technologies Consulting Ltd | Banking of stem cells and business methods related to the same |
| US11572545B2 (en) | 2016-06-16 | 2023-02-07 | Cedars-Sinai Medical Center | Efficient method for reprogramming blood to induced pluripotent stem cells |
| US10221395B2 (en) | 2016-06-16 | 2019-03-05 | Cedars-Sinai Medical Center | Efficient method for reprogramming blood to induced pluripotent stem cells |
| US10354218B2 (en) | 2016-08-04 | 2019-07-16 | Fanuc Corporation | System and method for iPS cell bank using internet technology |
| WO2018026576A1 (en) * | 2016-08-04 | 2018-02-08 | Good Start Genetics, Inc. | Genomic analysis of cord blood |
| WO2018027116A1 (en) * | 2016-08-05 | 2018-02-08 | Jay Yadav | Plasma banking to mitigate aging |
| US10772986B2 (en) | 2017-01-26 | 2020-09-15 | Allosource | Fascia fibrous compositions and methods for their use and manufacture |
| WO2018170046A1 (en) * | 2017-03-14 | 2018-09-20 | Orig3N, Inc. | Hla-indexed repository of ipscs and ipsc-derived stem cells, and related systems and methods |
| CA3090592A1 (en) * | 2017-09-01 | 2019-03-07 | Orig3N, Inc. | Allogeneic car-t platform using hla-matched bank of ipscs, and related compositions, systems, and methods |
| US20210187040A1 (en) * | 2017-09-01 | 2021-06-24 | Orig3N, Inc. | Ipsc-derived secretome compositions, and related systems and methods |
| CA3074734A1 (en) | 2017-09-06 | 2019-03-14 | Nant Holdings Ip, Llc | Hla tissue matching and methods therefor |
| US20190338244A1 (en) * | 2017-11-30 | 2019-11-07 | New York Medical College | Multipotent adult stem cells: characterization and use |
| WO2020129366A1 (ja) * | 2018-12-21 | 2020-06-25 | アイ ピース， インコーポレイテッド | 健康リスク情報管理装置、健康リスク情報管理方法、およびプログラム |
| CN114242191A (zh) * | 2021-10-29 | 2022-03-25 | 南京国青血液净化科技有限公司 | 干细胞自助配型方法及配型装置 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040258673A1 (en) * | 2003-04-03 | 2004-12-23 | Hirose Thomas Gordon | Elective collection and banking of autologous peripheral blood stem cells |
| US20070116691A1 (en) * | 2005-10-18 | 2007-05-24 | National Jewish Medical And Research Center | Conditionally immortalized long-term stem cells and methods of making and using such cells |
| WO2007059084A2 (en) * | 2005-11-14 | 2007-05-24 | The New England Medical Center Hospitals, Inc. | Methods for preparing cord matrix stem cells (cmsc) for long term storage and for preparing a segment of umbilical cord for cryopreservation |
| WO2008127670A1 (en) * | 2007-04-11 | 2008-10-23 | Alecia Hathaway | Autologous/allogeneic human dna grafting, anti-and reserve aging stem cell, and bone marrow compositions/methods |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040091936A1 (en) * | 2002-05-24 | 2004-05-13 | Michael West | Bank of stem cells for producing cells for transplantation having HLA antigens matching those of transplant recipients, and methods for making and using such a stem cell bank |
| JP2007531116A (ja) * | 2004-03-26 | 2007-11-01 | セルジーン・コーポレーション | 幹細胞バンクを提供するためのシステム及び方法 |
| US20090227032A1 (en) * | 2005-12-13 | 2009-09-10 | Kyoto University | Nuclear reprogramming factor and induced pluripotent stem cells |
| AU2006332679A1 (en) * | 2005-12-29 | 2007-07-12 | Anthrogenesis Corporation | Co-culture of placental stem cells and stem cells from a second source |
| EP2489728A1 (en) * | 2006-06-15 | 2012-08-22 | Neostem, Inc | Processing procedure for peripheral blood stem cells |
-
2011
- 2011-05-05 WO PCT/IL2011/000362 patent/WO2011138786A2/en not_active Ceased
- 2011-05-05 US US13/696,383 patent/US20130052169A1/en not_active Abandoned
- 2011-05-05 CA CA2798571A patent/CA2798571A1/en not_active Abandoned
- 2011-05-05 CN CN2011800335103A patent/CN103025865A/zh active Pending
- 2011-05-05 JP JP2013508612A patent/JP2013528368A/ja active Pending
- 2011-05-05 AU AU2011249406A patent/AU2011249406B2/en not_active Ceased
- 2011-05-05 EP EP11777360.6A patent/EP2566955A4/en not_active Withdrawn
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2016
- 2016-01-15 US US14/996,408 patent/US20160122709A1/en not_active Abandoned
- 2016-06-01 JP JP2016109872A patent/JP2016189783A/ja active Pending
-
2018
- 2018-04-04 JP JP2018072255A patent/JP2018121650A/ja active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040258673A1 (en) * | 2003-04-03 | 2004-12-23 | Hirose Thomas Gordon | Elective collection and banking of autologous peripheral blood stem cells |
| US20070116691A1 (en) * | 2005-10-18 | 2007-05-24 | National Jewish Medical And Research Center | Conditionally immortalized long-term stem cells and methods of making and using such cells |
| WO2007059084A2 (en) * | 2005-11-14 | 2007-05-24 | The New England Medical Center Hospitals, Inc. | Methods for preparing cord matrix stem cells (cmsc) for long term storage and for preparing a segment of umbilical cord for cryopreservation |
| WO2008127670A1 (en) * | 2007-04-11 | 2008-10-23 | Alecia Hathaway | Autologous/allogeneic human dna grafting, anti-and reserve aging stem cell, and bone marrow compositions/methods |
Non-Patent Citations (1)
| Title |
|---|
| JPN6015027730; Ｎａｔｕｒｅ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ Ｖｏｌ．２６, 2008, ｐ．７３９-７４０ * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015030149A1 (ja) * | 2013-08-29 | 2015-03-05 | 国立大学法人鳥取大学 | 細胞のアンチエイジングに関連する生体分子群 |
| JPWO2015030149A1 (ja) * | 2013-08-29 | 2017-03-02 | 国立大学法人鳥取大学 | 細胞のアンチエイジングに関連する生体分子群 |
| US10265347B2 (en) | 2013-08-29 | 2019-04-23 | Norimasa Miura | Biomolecular group related to cell anti-aging |
| WO2017090509A1 (ja) * | 2015-11-24 | 2017-06-01 | ロート製薬株式会社 | 脂肪組織由来間質細胞を含む肝疾患治療剤およびその製造方法 |
| JPWO2017090509A1 (ja) * | 2015-11-24 | 2018-09-06 | ロート製薬株式会社 | 脂肪組織由来間質細胞を含む肝疾患治療剤およびその製造方法 |
| JP7244991B2 (ja) | 2015-11-24 | 2023-03-23 | ロート製薬株式会社 | 脂肪組織由来間質細胞を含む肝疾患治療剤およびその製造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2011249406B2 (en) | 2015-05-14 |
| EP2566955A4 (en) | 2014-10-29 |
| US20130052169A1 (en) | 2013-02-28 |
| EP2566955A2 (en) | 2013-03-13 |
| US20160122709A1 (en) | 2016-05-05 |
| AU2011249406A1 (en) | 2012-11-29 |
| CN103025865A (zh) | 2013-04-03 |
| JP2018121650A (ja) | 2018-08-09 |
| WO2011138786A3 (en) | 2012-04-12 |
| CA2798571A1 (en) | 2011-11-10 |
| WO2011138786A2 (en) | 2011-11-10 |
| JP2016189783A (ja) | 2016-11-10 |
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