JP2013528368A - 個の医療のための幹細胞バンク - Google Patents
個の医療のための幹細胞バンク Download PDFInfo
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| PCT/IL2011/000362 WO2011138786A2 (en) | 2010-05-06 | 2011-05-05 | Stem cell bank for personalized medicine |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015030149A1 (ja) * | 2013-08-29 | 2015-03-05 | 国立大学法人鳥取大学 | 細胞のアンチエイジングに関連する生体分子群 |
| WO2017090509A1 (ja) * | 2015-11-24 | 2017-06-01 | ロート製薬株式会社 | 脂肪組織由来間質細胞を含む肝疾患治療剤およびその製造方法 |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US9358320B2 (en) | 2008-04-25 | 2016-06-07 | Allosource | Multi-layer tissue patches |
| US9480549B2 (en) | 2008-04-25 | 2016-11-01 | Allosource | Multi-layer tissue patches |
| US9162011B2 (en) | 2011-12-19 | 2015-10-20 | Allosource | Flowable matrix compositions and methods |
| EP2863927A4 (en) | 2012-06-26 | 2015-12-02 | Rusty Property Holdings Pty Ltd | COMPOSITIONS AND METHODS FOR REDUCING THE FREQUENCY AND / OR INTENSITY OF THE CEPHALA |
| AU2014248873B2 (en) | 2013-03-13 | 2017-03-23 | Allosource | Fascia fibrous compositions and methods for their use and manufacture |
| WO2014150784A1 (en) | 2013-03-15 | 2014-09-25 | Allosource | Cell repopulated collagen matrix for soft tissue repair and regeneration |
| US10738323B2 (en) | 2013-07-12 | 2020-08-11 | Cedars-Sinai Medical Center | Generation of induced pluripotent stem cells from normal human mammary epithelial cells |
| KR102161901B1 (ko) | 2013-12-06 | 2020-10-05 | 알로소스 | 조직의 시트를 건조하는 방법 |
| WO2015120268A1 (en) | 2014-02-06 | 2015-08-13 | Stryker European Holdings I, Llc | Bone marrow harvesting and storage |
| US9867853B2 (en) | 2014-05-30 | 2018-01-16 | International Cell Technologies Inc. | Method of providing cellular based immune enhancement for restoring immunity and preventing age related diseases |
| US10264976B2 (en) | 2014-12-26 | 2019-04-23 | The University Of Akron | Biocompatible flavonoid compounds for organelle and cell imaging |
| WO2016154310A1 (en) | 2015-03-24 | 2016-09-29 | Stryker European Holdings I, Llc | Bone marrow harvesting device and storage methods |
| GB201600597D0 (en) * | 2016-01-12 | 2016-02-24 | Occhipinti Luigi G And Pluchino Stefano And Cambridge Innovation Technologies Consulting Ltd | Banking of stem cells and business methods related to the same |
| US10221395B2 (en) | 2016-06-16 | 2019-03-05 | Cedars-Sinai Medical Center | Efficient method for reprogramming blood to induced pluripotent stem cells |
| US11572545B2 (en) | 2016-06-16 | 2023-02-07 | Cedars-Sinai Medical Center | Efficient method for reprogramming blood to induced pluripotent stem cells |
| WO2018026576A1 (en) * | 2016-08-04 | 2018-02-08 | Good Start Genetics, Inc. | Genomic analysis of cord blood |
| WO2018027116A1 (en) * | 2016-08-05 | 2018-02-08 | Jay Yadav | Plasma banking to mitigate aging |
| US10772986B2 (en) | 2017-01-26 | 2020-09-15 | Allosource | Fascia fibrous compositions and methods for their use and manufacture |
| TW201835798A (zh) * | 2017-03-14 | 2018-10-01 | 美商歐瑞３恩公司 | 誘導多能幹細胞之以人類白細胞索引之抗原儲存庫及誘導多能幹細胞衍生之幹細胞及相關系統及方法 |
| WO2019045774A1 (en) * | 2017-09-01 | 2019-03-07 | Orig3N, Inc. | ALLOGENEIC CAR-T PLATFORM USING INDUCED PLURIPOTENT STEM CELL BANK CORRESPONDING TO HLA SYSTEM, AND RELATED COMPOSITIONS, SYSTEMS, AND METHODS |
| KR20200064077A (ko) * | 2017-09-01 | 2020-06-05 | 오리그3엔, 인코포레이티드 | Ipsc-유래 분비단백체 조성물, 및 관련된 시스템 및 방법 |
| WO2019050958A2 (en) * | 2017-09-06 | 2019-03-14 | Nant Holdings Ip, Llc | CORRESPONDENCE OF HLA FABRIC AND ASSOCIATED METHODS |
| US20190338244A1 (en) * | 2017-11-30 | 2019-11-07 | New York Medical College | Multipotent adult stem cells: characterization and use |
| US20220076839A1 (en) * | 2018-12-21 | 2022-03-10 | I Peace, Inc. | Health risk information management device, health risk information management method, and program |
| CN114242191A (zh) * | 2021-10-29 | 2022-03-25 | 南京国青血液净化科技有限公司 | 干细胞自助配型方法及配型装置 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040258673A1 (en) * | 2003-04-03 | 2004-12-23 | Hirose Thomas Gordon | Elective collection and banking of autologous peripheral blood stem cells |
| US20070116691A1 (en) * | 2005-10-18 | 2007-05-24 | National Jewish Medical And Research Center | Conditionally immortalized long-term stem cells and methods of making and using such cells |
| WO2007059084A2 (en) * | 2005-11-14 | 2007-05-24 | The New England Medical Center Hospitals, Inc. | Methods for preparing cord matrix stem cells (cmsc) for long term storage and for preparing a segment of umbilical cord for cryopreservation |
| WO2008127670A1 (en) * | 2007-04-11 | 2008-10-23 | Alecia Hathaway | Autologous/allogeneic human dna grafting, anti-and reserve aging stem cell, and bone marrow compositions/methods |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040091936A1 (en) * | 2002-05-24 | 2004-05-13 | Michael West | Bank of stem cells for producing cells for transplantation having HLA antigens matching those of transplant recipients, and methods for making and using such a stem cell bank |
| BRPI0509141A (pt) * | 2004-03-26 | 2007-09-04 | Celgene Corp | método para manter um registro de células-tronco, produto de programa de computação para uso junto com um sistema de computador, sistema de computador, e, meio legìvel por computador |
| US20090227032A1 (en) * | 2005-12-13 | 2009-09-10 | Kyoto University | Nuclear reprogramming factor and induced pluripotent stem cells |
| NZ568618A (en) * | 2005-12-29 | 2011-10-28 | Anthrogenesis Corp | Co-culture of placental stem cells and stem cells from a second source |
| EP2032691A2 (en) * | 2006-06-15 | 2009-03-11 | Neostem, Inc | Processing procedure for peripheral blood stem cells |
-
2011
- 2011-05-05 US US13/696,383 patent/US20130052169A1/en not_active Abandoned
- 2011-05-05 JP JP2013508612A patent/JP2013528368A/ja active Pending
- 2011-05-05 EP EP11777360.6A patent/EP2566955A4/en not_active Withdrawn
- 2011-05-05 AU AU2011249406A patent/AU2011249406B2/en not_active Ceased
- 2011-05-05 CA CA2798571A patent/CA2798571A1/en not_active Abandoned
- 2011-05-05 WO PCT/IL2011/000362 patent/WO2011138786A2/en not_active Ceased
- 2011-05-05 CN CN2011800335103A patent/CN103025865A/zh active Pending
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2016
- 2016-01-15 US US14/996,408 patent/US20160122709A1/en not_active Abandoned
- 2016-06-01 JP JP2016109872A patent/JP2016189783A/ja active Pending
-
2018
- 2018-04-04 JP JP2018072255A patent/JP2018121650A/ja active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040258673A1 (en) * | 2003-04-03 | 2004-12-23 | Hirose Thomas Gordon | Elective collection and banking of autologous peripheral blood stem cells |
| US20070116691A1 (en) * | 2005-10-18 | 2007-05-24 | National Jewish Medical And Research Center | Conditionally immortalized long-term stem cells and methods of making and using such cells |
| WO2007059084A2 (en) * | 2005-11-14 | 2007-05-24 | The New England Medical Center Hospitals, Inc. | Methods for preparing cord matrix stem cells (cmsc) for long term storage and for preparing a segment of umbilical cord for cryopreservation |
| WO2008127670A1 (en) * | 2007-04-11 | 2008-10-23 | Alecia Hathaway | Autologous/allogeneic human dna grafting, anti-and reserve aging stem cell, and bone marrow compositions/methods |
Non-Patent Citations (1)
| Title |
|---|
| JPN6015027730; Ｎａｔｕｒｅ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ Ｖｏｌ．２６, 2008, ｐ．７３９-７４０ * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015030149A1 (ja) * | 2013-08-29 | 2015-03-05 | 国立大学法人鳥取大学 | 細胞のアンチエイジングに関連する生体分子群 |
| JPWO2015030149A1 (ja) * | 2013-08-29 | 2017-03-02 | 国立大学法人鳥取大学 | 細胞のアンチエイジングに関連する生体分子群 |
| US10265347B2 (en) | 2013-08-29 | 2019-04-23 | Norimasa Miura | Biomolecular group related to cell anti-aging |
| WO2017090509A1 (ja) * | 2015-11-24 | 2017-06-01 | ロート製薬株式会社 | 脂肪組織由来間質細胞を含む肝疾患治療剤およびその製造方法 |
| JPWO2017090509A1 (ja) * | 2015-11-24 | 2018-09-06 | ロート製薬株式会社 | 脂肪組織由来間質細胞を含む肝疾患治療剤およびその製造方法 |
| JP7244991B2 (ja) | 2015-11-24 | 2023-03-23 | ロート製薬株式会社 | 脂肪組織由来間質細胞を含む肝疾患治療剤およびその製造方法 |
Also Published As
| Publication number | Publication date |
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| JP2016189783A (ja) | 2016-11-10 |
| EP2566955A4 (en) | 2014-10-29 |
| EP2566955A2 (en) | 2013-03-13 |
| US20160122709A1 (en) | 2016-05-05 |
| WO2011138786A2 (en) | 2011-11-10 |
| JP2018121650A (ja) | 2018-08-09 |
| CA2798571A1 (en) | 2011-11-10 |
| AU2011249406B2 (en) | 2015-05-14 |
| AU2011249406A1 (en) | 2012-11-29 |
| WO2011138786A3 (en) | 2012-04-12 |
| CN103025865A (zh) | 2013-04-03 |
| US20130052169A1 (en) | 2013-02-28 |
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