JP2013528174A - オリゴベンズアミド化合物およびそれらの使用 - Google Patents

オリゴベンズアミド化合物およびそれらの使用 Download PDF

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JP2013528174A
JP2013528174A JP2013512048A JP2013512048A JP2013528174A JP 2013528174 A JP2013528174 A JP 2013528174A JP 2013512048 A JP2013512048 A JP 2013512048A JP 2013512048 A JP2013512048 A JP 2013512048A JP 2013528174 A JP2013528174 A JP 2013528174A
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compound
alkyl
alkenyl
arylalkyl
alkynyl
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JP2013528174A5 (OSRAM
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ジュン‐モ アーン
ガネーシュ ラジ
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University of Texas System
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University of Texas System
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/56—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
    • C07C217/66—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/06—Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/08—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2013512048A 2010-05-28 2011-05-27 オリゴベンズアミド化合物およびそれらの使用 Pending JP2013528174A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34955510P 2010-05-28 2010-05-28
US61/349,555 2010-05-28
PCT/US2011/038395 WO2011150360A1 (en) 2010-05-28 2011-05-27 Oligo-benzamide compounds and their use

Related Child Applications (1)

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JP2016122278A Division JP6385986B2 (ja) 2010-05-28 2016-06-21 オリゴベンズアミド化合物およびそれらの使用

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JP2013528174A true JP2013528174A (ja) 2013-07-08
JP2013528174A5 JP2013528174A5 (OSRAM) 2014-07-10

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JP2013512048A Pending JP2013528174A (ja) 2010-05-28 2011-05-27 オリゴベンズアミド化合物およびそれらの使用
JP2016122278A Active JP6385986B2 (ja) 2010-05-28 2016-06-21 オリゴベンズアミド化合物およびそれらの使用
JP2018097720A Pending JP2018131459A (ja) 2010-05-28 2018-05-22 オリゴベンズアミド化合物およびそれらの使用

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Country Status (14)

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US (3) US20130231385A1 (OSRAM)
EP (1) EP2575453B1 (OSRAM)
JP (3) JP2013528174A (OSRAM)
KR (1) KR20130115108A (OSRAM)
CN (1) CN102958364A (OSRAM)
AU (1) AU2011258009B2 (OSRAM)
BR (1) BR112012030298A2 (OSRAM)
CA (1) CA2800811C (OSRAM)
CL (1) CL2012003322A1 (OSRAM)
CO (1) CO6640301A2 (OSRAM)
EA (1) EA201291460A1 (OSRAM)
MX (1) MX2012013855A (OSRAM)
SG (1) SG186076A1 (OSRAM)
WO (1) WO2011150360A1 (OSRAM)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018515445A (ja) * 2015-05-18 2018-06-14 ネッレ セラピューティクス リミテッドＮｅｒｒｅ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ 性ホルモン依存性疾患を治療するためのｎｋ−１／ｎｋ−３受容体デュアルアンタゴニスト
JP2024178254A (ja) * 2018-12-03 2024-12-24 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム オリゴベンズアミド類似体およびがん処置におけるそれらの使用

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20130115108A (ko) 2010-05-28 2013-10-21 더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 올리고－벤즈아미드 화합물 및 이의 용도
CN103796680A (zh) * 2011-06-21 2014-05-14 约翰霍普金斯大学 用于增强针对赘生物的基于免疫的治疗的聚焦放射
WO2013078277A1 (en) 2011-11-23 2013-05-30 The Board Of Regents Of The University Of Texas System Oligo-benzamide compounds and their use in treating cancers
WO2013078288A1 (en) * 2011-11-23 2013-05-30 The Board Of Regents Of The University Of Texas System Oligo-benzamide compounds for use in treating cancers
CN103665043B (zh) 2012-08-30 2017-11-10 江苏豪森药业集团有限公司 一种替诺福韦前药及其在医药上的应用
US9827135B2 (en) 2015-09-15 2017-11-28 Savage Medical, Inc. Devices and methods for anchoring a sheath in a tissue cavity
USD874674S1 (en) * 2016-10-17 2020-02-04 Brandcore Limited Vibrator
US20250114313A1 (en) * 2022-02-11 2025-04-10 Board Of Regents, The University Of Texas System Oligo-benzamide analogs and their use in cancer treatment

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006044379A2 (en) * 2004-10-15 2006-04-27 University Of North Carolina At Chapel Hill Novel curcumin analogues and uses thereof
WO2008112941A1 (en) * 2007-03-13 2008-09-18 Board Of Regents The University Of Texas System Composition and method for the treatment of diseases affected by a peptide receptor
WO2009055053A2 (en) * 2007-10-26 2009-04-30 The Regents Of The University Of California Diarylhydantoin compounds as androgen receptor modulators
WO2009105214A2 (en) * 2008-02-22 2009-08-27 Radius Health, Inc. Selective androgen receptor modulators
WO2010015212A1 (zh) * 2008-08-07 2010-02-11 浙江海正药业股份有限公司 一种对δ亚型过氧化物酶增殖物激活受体具有激动作用的化合物、其制备方法和应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1903899A (en) 1933-04-18 Cabboxylic acid abylides oe the benzene sebies and process oe making
US3951914A (en) 1974-07-30 1976-04-20 E. I. Du Pont De Nemours And Company Process for preparing poly(1,4-benzamide) in cyclic sulfone media
US5212203A (en) 1986-01-21 1993-05-18 Centre International De Recherches Dermatogologiques (C.I.R.D.) Aromatic benzamido compounds; their preparation and their use in human or veterinary medicine or in cosmetic preparations
US5734081A (en) 1994-08-05 1998-03-31 Warner-Lambert Company Arylthio compounds
DK1259485T3 (da) 2000-02-29 2006-04-10 Millennium Pharm Inc Benzamider og beslægtede inhibitorer for faktor Xa
CA2537663A1 (en) * 2003-09-10 2005-03-24 Merck & Co., Inc. 17-heterocyclic-4-azasteroid derivatives as androgen receptor modulators
JP2007528725A (ja) 2004-02-20 2007-10-18 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア 結合ペルオキシダーゼ模倣物及びその使用
US20070248535A1 (en) 2005-02-07 2007-10-25 The Trustees Of Columbia University In The City Of New York Methods to treat or prevent hormone-resistant prostate cancer using siRNA specific for protocadherin-PC, or other inhibitors of protocadherin-PC expression or activity
WO2007056593A2 (en) 2005-11-08 2007-05-18 Choongwae Pharma Corporation α-HELIX MIMETICS AND METHOD RELATING TO THE TREATMENT OF CANCER STEM CELLS
US8236983B2 (en) 2008-03-13 2012-08-07 Board Of Regents, The University Of Texas System Composition and method for the treatment of diseases affected by apoptosis
CN101980718A (zh) 2008-02-08 2011-02-23 爱勒让治疗公司 治疗性的拟肽大环化合物
US8188098B2 (en) 2008-05-19 2012-05-29 Hoffmann-La Roche Inc. GPR119 receptor agonists
JP5657549B2 (ja) 2008-10-17 2015-01-21 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド 癌の阻害剤としてのｍｕｃ−１細胞質ドメインペプチド
CA2749947A1 (en) 2009-01-30 2010-08-05 Bayer Healthcare Llc Methods for treating estrogen receptor positive cancer by x-box binding protein 1 inhibition
KR20120095402A (ko) 2009-10-23 2012-08-28 파나셀라 랩스, 아이엔씨. 안드로겐 수용체 양성 암의 치료 방법
KR20130115108A (ko) * 2010-05-28 2013-10-21 더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 올리고－벤즈아미드 화합물 및 이의 용도
WO2013078288A1 (en) * 2011-11-23 2013-05-30 The Board Of Regents Of The University Of Texas System Oligo-benzamide compounds for use in treating cancers
WO2013078277A1 (en) 2011-11-23 2013-05-30 The Board Of Regents Of The University Of Texas System Oligo-benzamide compounds and their use in treating cancers

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006044379A2 (en) * 2004-10-15 2006-04-27 University Of North Carolina At Chapel Hill Novel curcumin analogues and uses thereof
WO2008112941A1 (en) * 2007-03-13 2008-09-18 Board Of Regents The University Of Texas System Composition and method for the treatment of diseases affected by a peptide receptor
WO2008112938A2 (en) * 2007-03-13 2008-09-18 New England Medical Center Hospitals, Inc. Composition and method for the treatment of diseases affected by a peptide receptor
WO2008112939A2 (en) * 2007-03-13 2008-09-18 Board Of Regents, The University Of Texas System Composition and method for making oligo-benzamide compounds
US20090012141A1 (en) * 2007-03-13 2009-01-08 Board Of Regents, The University Of Texas System Composition and Method for Making Oligo-Benzamide Compounds
WO2009055053A2 (en) * 2007-10-26 2009-04-30 The Regents Of The University Of California Diarylhydantoin compounds as androgen receptor modulators
WO2009105214A2 (en) * 2008-02-22 2009-08-27 Radius Health, Inc. Selective androgen receptor modulators
WO2010015212A1 (zh) * 2008-08-07 2010-02-11 浙江海正药业股份有限公司 一种对δ亚型过氧化物酶增殖物激活受体具有激动作用的化合物、其制备方法和应用

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, vol. 49(4), JPN6015011805, 8 January 2010 (2010-01-08), pages 736 - 739, ISSN: 0003039460 *
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 131(15), JPN6015011806, 2009, pages 5564 - 5572, ISSN: 0003039461 *
ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 6(1), JPN6015011809, 2008, pages 138 - 146, ISSN: 0003039462 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018515445A (ja) * 2015-05-18 2018-06-14 ネッレ セラピューティクス リミテッドＮｅｒｒｅ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ 性ホルモン依存性疾患を治療するためのｎｋ−１／ｎｋ−３受容体デュアルアンタゴニスト
JP2024178254A (ja) * 2018-12-03 2024-12-24 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム オリゴベンズアミド類似体およびがん処置におけるそれらの使用
JP7770716B2 (ja) 2018-12-03 2025-11-17 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム オリゴベンズアミド類似体およびがん処置におけるそれらの使用

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EP2575453B1 (en) 2018-08-01
KR20130115108A (ko) 2013-10-21
EP2575453A4 (en) 2015-12-23
WO2011150360A1 (en) 2011-12-01
JP2018131459A (ja) 2018-08-23
EA201291460A1 (ru) 2013-11-29
AU2011258009A1 (en) 2013-01-10
AU2011258009B2 (en) 2016-04-21
CA2800811C (en) 2019-02-26
EP2575453A1 (en) 2013-04-10
MX2012013855A (es) 2013-04-08
US20160130217A1 (en) 2016-05-12
JP2017019769A (ja) 2017-01-26
US20180230087A1 (en) 2018-08-16
US20130231385A1 (en) 2013-09-05
BR112012030298A2 (pt) 2015-09-29
CA2800811A1 (en) 2011-12-01
US10618869B2 (en) 2020-04-14
US9856206B2 (en) 2018-01-02
SG186076A1 (en) 2013-01-30
CO6640301A2 (es) 2013-03-22
CL2012003322A1 (es) 2014-03-28
CN102958364A (zh) 2013-03-06
JP6385986B2 (ja) 2018-09-05

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Tulunay et al. 894 Primary Ovarian Carcinosarcomas
Lehnen CNS, GPN, RNP, PhD. National PRO-Irish Practice Nurses Association

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