JP2013521786A - エンドヌクレアーゼ活性を有するインフルエンザａ２００９パンデミックｈ１ｎ１のポリペプチド断片、及びそれらの使用 - Google Patents

エンドヌクレアーゼ活性を有するインフルエンザａ２００９パンデミックｈ１ｎ１のポリペプチド断片、及びそれらの使用 Download PDF

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JP2013521786A
JP2013521786A JP2012557443A JP2012557443A JP2013521786A JP 2013521786 A JP2013521786 A JP 2013521786A JP 2012557443 A JP2012557443 A JP 2012557443A JP 2012557443 A JP2012557443 A JP 2012557443A JP 2013521786 A JP2013521786 A JP 2013521786A
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subunit
polypeptide fragment
seq
compound
amino acids
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JP2013521786A5 (enExample
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キューザック，ステファン
コワリンスキー，エヴァ
スビエタ，クロエ
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European Molecular Biology Laboratory
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    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
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    • A61P31/14—Antivirals for RNA viruses
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    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
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    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
    • C07D311/62—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2 with oxygen atoms directly attached in position 3, e.g. anthocyanidins
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    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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    • C07K16/108—Orthomyxoviridae (F), e.g. influenza virus
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    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

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JP2012557443A 2010-03-16 2011-03-15 エンドヌクレアーゼ活性を有するインフルエンザａ２００９パンデミックｈ１ｎ１のポリペプチド断片、及びそれらの使用 Withdrawn JP2013521786A (ja)

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US34033510P 2010-03-16 2010-03-16
US61/340,335 2010-03-16
PCT/EP2011/001274 WO2011113579A2 (en) 2010-03-16 2011-03-15 Influenza a 2009 pandemic h1n1 polypeptide fragments comprising endonuclease activity and their use

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JP2013521786A5 JP2013521786A5 (enExample) 2014-04-24

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JP2016053802A Pending JP2016189772A (ja) 2010-03-16 2016-03-17 エンドヌクレアーゼ活性を有するインフルエンザａ２００９パンデミックｈ１ｎ１のポリペプチド断片、及びそれらの使用

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CN (2) CN102803288B (enExample)
AU (1) AU2011229469B2 (enExample)
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JP2016189772A (ja) * 2010-03-16 2016-11-10 ヨーロピアン モレキュラー バイオロジー ラボラトリー エンドヌクレアーゼ活性を有するインフルエンザａ２００９パンデミックｈ１ｎ１のポリペプチド断片、及びそれらの使用
JP2018150260A (ja) * 2017-03-10 2018-09-27 地方独立行政法人神奈川県立産業技術総合研究所 インフルエンザウイルスの増殖を阻害するモノクローナル抗体

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US8859290B2 (en) * 2011-07-22 2014-10-14 Rutgers, The State University Of New Jersey Inhibitors of influenza endonuclease activity and tools for their discovery
CN112837764B (zh) * 2021-01-21 2023-07-07 北京晶泰科技有限公司 分子杂交方法及平台
WO2026071124A1 (ja) * 2024-09-30 2026-04-02 富士フイルム和光純薬株式会社 Ｒｎａ抽出方法及びｒｎａ抽出用試薬セット

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CN101514335B (zh) * 2008-02-22 2013-04-17 中国科学院生物物理研究所 流感病毒聚合酶亚基pa的表达纯化及pa氨基端及pa羧基端与pb1氨基端多肽复合体的晶体结构
EP2547696B1 (en) 2010-03-16 2018-05-23 European Molecular Biology Laboratory (Embl) Fragments of the pa subunit of rna dependent rna polymerase from pandemic influenza virus a 2009 h1n1, and their use

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016189772A (ja) * 2010-03-16 2016-11-10 ヨーロピアン モレキュラー バイオロジー ラボラトリー エンドヌクレアーゼ活性を有するインフルエンザａ２００９パンデミックｈ１ｎ１のポリペプチド断片、及びそれらの使用
US9783794B2 (en) 2010-03-16 2017-10-10 European Molecular Biology Laboratory (Embl) Influenza A 2009 pandemic H1N1 polypeptide fragments comprising endonuclease activity and their use
JP2018150260A (ja) * 2017-03-10 2018-09-27 地方独立行政法人神奈川県立産業技術総合研究所 インフルエンザウイルスの増殖を阻害するモノクローナル抗体

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IL260192A (en) 2018-07-31
AU2011229469A1 (en) 2012-09-06
EP2547696B1 (en) 2018-05-23
CN102803288B (zh) 2015-09-23
BR112012023166A2 (pt) 2020-08-25
CA2790183A1 (en) 2011-09-22
US9783794B2 (en) 2017-10-10
KR20130075726A (ko) 2013-07-05
EP2547696A2 (en) 2013-01-23
WO2011113579A3 (en) 2012-08-02
US20160053241A1 (en) 2016-02-25
AU2011229469B2 (en) 2015-01-22
JP2016189772A (ja) 2016-11-10
US20180044649A1 (en) 2018-02-15
SG10201703245SA (en) 2017-05-30
CN102803288A (zh) 2012-11-28
US20130023565A1 (en) 2013-01-24
SG10201601365RA (en) 2016-03-30
CN105273066A (zh) 2016-01-27
US9181307B2 (en) 2015-11-10
MX352906B (es) 2017-12-13
WO2011113579A2 (en) 2011-09-22
MX2012010652A (es) 2013-02-07
SG183375A1 (en) 2012-09-27

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