JP2013521268A5 - - Google Patents
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- Publication number
- JP2013521268A5 JP2013521268A5 JP2012555480A JP2012555480A JP2013521268A5 JP 2013521268 A5 JP2013521268 A5 JP 2013521268A5 JP 2012555480 A JP2012555480 A JP 2012555480A JP 2012555480 A JP2012555480 A JP 2012555480A JP 2013521268 A5 JP2013521268 A5 JP 2013521268A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- complex
- group
- unsubstituted
- hydroxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003446 ligand Substances 0.000 claims 24
- HZVOZRGWRWCICA-UHFFFAOYSA-N methanediyl Chemical compound [CH2] HZVOZRGWRWCICA-UHFFFAOYSA-N 0.000 claims 20
- 125000000623 heterocyclic group Chemical group 0.000 claims 14
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 14
- -1 cyano, cyanato, thiocyanato, amino Chemical group 0.000 claims 11
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 150000001450 anions Chemical class 0.000 claims 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
- HVLLSGMXQDNUAL-UHFFFAOYSA-N triphenyl phosphite Chemical compound C=1C=CC=CC=1OP(OC=1C=CC=CC=1)OC1=CC=CC=C1 HVLLSGMXQDNUAL-UHFFFAOYSA-N 0.000 claims 8
- 125000005843 halogen group Chemical group 0.000 claims 7
- QFAKXSUNHTXHAE-UHFFFAOYSA-N OS(=O)(=O)S(=O)(=O)ON=O Chemical compound OS(=O)(=O)S(=O)(=O)ON=O QFAKXSUNHTXHAE-UHFFFAOYSA-N 0.000 claims 6
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 claims 6
- 125000002178 anthracenyl group Chemical group C1(=CC=CC2=CC3=CC=CC=C3C=C12)* 0.000 claims 6
- 125000000707 boryl group Chemical group B* 0.000 claims 6
- 229910021505 gold(III) hydroxide Inorganic materials 0.000 claims 6
- WDZVNNYQBQRJRX-UHFFFAOYSA-K gold(iii) hydroxide Chemical compound O[Au](O)O WDZVNNYQBQRJRX-UHFFFAOYSA-K 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 125000001624 naphthyl group Chemical group 0.000 claims 6
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 6
- 125000004469 siloxy group Chemical group [SiH3]O* 0.000 claims 6
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 6
- 125000000524 functional group Chemical group 0.000 claims 5
- MPOKJOWFCMDRKP-UHFFFAOYSA-N gold;hydrate Chemical compound O.[Au] MPOKJOWFCMDRKP-UHFFFAOYSA-N 0.000 claims 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 239000003054 catalyst Substances 0.000 claims 4
- 150000002148 esters Chemical class 0.000 claims 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 claims 4
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims 3
- 239000010931 gold Substances 0.000 claims 3
- 229910052737 gold Inorganic materials 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 229910000073 phosphorus hydride Inorganic materials 0.000 claims 3
- LDHHXVZBJSYNKB-UHFFFAOYSA-N C1(=CC=CC=C1)C1=C(C(=C(C=C1)P(C1=CC=CC=C1)C1=CC=CC=C1)C1=CC=CC=C1)C1=CC=CC=C1 Chemical class C1(=CC=CC=C1)C1=C(C(=C(C=C1)P(C1=CC=CC=C1)C1=CC=CC=C1)C1=CC=CC=C1)C1=CC=CC=C1 LDHHXVZBJSYNKB-UHFFFAOYSA-N 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims 2
- 229910018286 SbF 6 Inorganic materials 0.000 claims 2
- 125000002015 acyclic group Chemical group 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 125000002837 carbocyclic group Chemical group 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 230000008707 rearrangement Effects 0.000 claims 2
- 238000007363 ring formation reaction Methods 0.000 claims 2
- QRTHECVGSAZOPL-UHFFFAOYSA-N thiocyanato cyanate Chemical compound N#COSC#N QRTHECVGSAZOPL-UHFFFAOYSA-N 0.000 claims 2
- UQRONKZLYKUEMO-UHFFFAOYSA-N 4-methyl-1-(2,4,6-trimethylphenyl)pent-4-en-2-one Chemical group CC(=C)CC(=O)Cc1c(C)cc(C)cc1C UQRONKZLYKUEMO-UHFFFAOYSA-N 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- CLMJEWSUQLNMEF-UHFFFAOYSA-N B(O)(O)OP(=O)(O)P(=O)(O)O Chemical compound B(O)(O)OP(=O)(O)P(=O)(O)O CLMJEWSUQLNMEF-UHFFFAOYSA-N 0.000 claims 1
- 238000006237 Beckmann rearrangement reaction Methods 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 claims 1
- 150000001345 alkine derivatives Chemical class 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000000746 allylic group Chemical group 0.000 claims 1
- 125000001626 borono group Chemical group [H]OB([*])O[H] 0.000 claims 1
- ZBKIUFWVEIBQRT-UHFFFAOYSA-N gold(1+) Chemical compound [Au+] ZBKIUFWVEIBQRT-UHFFFAOYSA-N 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 230000036571 hydration Effects 0.000 claims 1
- 238000006703 hydration reaction Methods 0.000 claims 1
- 238000005913 hydroamination reaction Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 150000002825 nitriles Chemical class 0.000 claims 1
- FVZVCSNXTFCBQU-UHFFFAOYSA-N phosphanyl Chemical group [PH2] FVZVCSNXTFCBQU-UHFFFAOYSA-N 0.000 claims 1
- ACVYVLVWPXVTIT-UHFFFAOYSA-M phosphinate Chemical compound [O-][PH2]=O ACVYVLVWPXVTIT-UHFFFAOYSA-M 0.000 claims 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims 1
- 125000001476 phosphono group Chemical group [H]OP(*)(=O)O[H] 0.000 claims 1
- RIZZXCJMFIGMON-UHFFFAOYSA-N prop-2-ynyl acetate Chemical compound CC(=O)OCC#C RIZZXCJMFIGMON-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1003483.3A GB201003483D0 (en) | 2010-03-02 | 2010-03-02 | Gold complexes |
| GB1003483.3 | 2010-03-02 | ||
| PCT/GB2011/000284 WO2011107736A1 (en) | 2010-03-02 | 2011-03-02 | Gold complexes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013521268A JP2013521268A (ja) | 2013-06-10 |
| JP2013521268A5 true JP2013521268A5 (enExample) | 2014-04-17 |
| JP5806686B2 JP5806686B2 (ja) | 2015-11-10 |
Family
ID=42125868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012555480A Expired - Fee Related JP5806686B2 (ja) | 2010-03-02 | 2011-03-02 | 金錯体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9464097B2 (enExample) |
| EP (1) | EP2542342A1 (enExample) |
| JP (1) | JP5806686B2 (enExample) |
| CN (1) | CN102821849B (enExample) |
| CA (1) | CA2791747A1 (enExample) |
| GB (1) | GB201003483D0 (enExample) |
| WO (1) | WO2011107736A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104163824B (zh) * | 2014-07-04 | 2017-05-03 | 南开大学 | 一种金‑{2‑(9‑蒽苯基)二环己基膦}‑乙腈的络合物的合成及应用 |
| CN104926650B (zh) * | 2015-05-06 | 2016-08-24 | 中国石油大学(北京) | 二氧化铈负载金纳米颗粒催化烯炔环异构化反应的方法 |
| EP3847180A1 (en) * | 2018-09-03 | 2021-07-14 | Universiteit Gent | Method of preparing metal complexes of formula z-m, in particular carbene-metal complexes |
| EP3972981A4 (en) * | 2019-05-22 | 2023-05-24 | Board of Regents, The University of Texas System | Functionalized gold carbene naphthoquinone complexes for use in the treatment of cancer |
| EP4122940A1 (en) * | 2021-07-19 | 2023-01-25 | Versitech Limited | Binuclear gold(i) compounds for photocatalysis applications |
| CN116407545A (zh) * | 2023-04-03 | 2023-07-11 | 深圳市人民医院 | 一种新型聚集诱导发光物质靶向递送用于肿瘤化疗放疗免疫治疗三联疗法 |
| CN118852216A (zh) * | 2024-07-03 | 2024-10-29 | 中山大学 | 一种金(i)配合物及其制备方法和应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3574143D1 (de) * | 1985-03-19 | 1989-12-14 | Engelhard Corp | Trihalo(amine)gold(iii) complexes |
| GB0329416D0 (en) * | 2003-12-19 | 2004-01-21 | Univ Salford The | Treatment of cancer |
| JP2006063000A (ja) * | 2004-08-25 | 2006-03-09 | Nard Inst Ltd | ポルフィリンリン酸誘導体およびその製造方法 |
| JP4815586B2 (ja) * | 2005-08-12 | 2011-11-16 | 国立大学法人 筑波大学 | Ａｕ２５クラスターの選択的大量合成方法 |
| EP2338593B1 (de) | 2006-01-31 | 2013-06-19 | Basf Se | Verfahren zur Herstellung von Übergangsmetall-Carbenkomplexen |
| US7470337B2 (en) | 2006-03-21 | 2008-12-30 | Autoliv Asp, Inc. | Gas generation with copper complexed imidazole and derivatives |
| GB201009656D0 (en) | 2010-06-09 | 2010-07-21 | Univ St Andrews | Carboxylation catalysts |
-
2010
- 2010-03-02 GB GBGB1003483.3A patent/GB201003483D0/en not_active Ceased
-
2011
- 2011-03-02 US US13/580,772 patent/US9464097B2/en not_active Expired - Fee Related
- 2011-03-02 WO PCT/GB2011/000284 patent/WO2011107736A1/en not_active Ceased
- 2011-03-02 CN CN201180011955.1A patent/CN102821849B/zh not_active Expired - Fee Related
- 2011-03-02 CA CA2791747A patent/CA2791747A1/en not_active Abandoned
- 2011-03-02 JP JP2012555480A patent/JP5806686B2/ja not_active Expired - Fee Related
- 2011-03-02 EP EP11709760A patent/EP2542342A1/en not_active Withdrawn
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