JP2013521058A5 - - Google Patents
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- JP2013521058A5 JP2013521058A5 JP2012556176A JP2012556176A JP2013521058A5 JP 2013521058 A5 JP2013521058 A5 JP 2013521058A5 JP 2012556176 A JP2012556176 A JP 2012556176A JP 2012556176 A JP2012556176 A JP 2012556176A JP 2013521058 A5 JP2013521058 A5 JP 2013521058A5
- Authority
- JP
- Japan
- Prior art keywords
- potential
- epidermal tissue
- electrode
- tissue
- voltage generator
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000001519 tissues Anatomy 0.000 claims 13
- 238000004520 electroporation Methods 0.000 claims 3
- 230000000451 tissue damage Effects 0.000 claims 2
- 231100000827 tissue damage Toxicity 0.000 claims 2
- 230000000007 visual effect Effects 0.000 claims 2
- 210000000434 stratum corneum Anatomy 0.000 claims 1
Claims (9)
- 電圧発生装置と；
前記電圧発生装置と電気的に連通した複数の電極を有するアレイと、
を含み、表皮組織への耐容性電位を対象へ送達して、前記組織内の細胞の電気穿孔をもたらすことが可能な電気穿孔装置であって、
前記複数の電極のそれぞれが、各隣接する電極から約０．５ｍｍ〜約２．５ｍｍの距離で離れており；そして
前記電圧発生装置が、電極を介して、約０．１〜約５０ボルトの電位を表皮組織へ送達し；さらに
前記電極が、鈍角であるが尖端のある遠端部の先端を有することで、角質層と基底層との間の表皮組織層に貫入することができ、かつ電圧発生装置から表皮組織へ電位を送達するか、
前記電極が、０．１ｍｍ以下の深さで表皮組織に貫入するように適合されているか、
前記電極が、ビジュアルアナログスケールにより測定されるとほぼ無痛となる耐容性電位を表皮組織の細胞へ送達するか、あるいは
前記電極が、表皮組織の細胞における最小限の組織障害を示す耐容性電位を前記細胞へ送達する
電気穿孔装置。 - 前記電極が、０．１ｍｍ以下の深さで表皮組織へ貫入するように適合されている、請求項１に記載の装置。
- 前記電極が、約０．０１ｍｍ〜約０．０４ｍｍの深さで表皮組織へ貫入するように適合されている、請求項１に記載の装置。
- 前記耐容性電位が、ビジュアルアナログスケールにより測定されると、前記対象によるほぼ無痛との疼痛評価を生じる、請求項１に記載の装置。
- 前記耐容性電位が、対象の前記細胞において最小限の組織障害をもたらす電位である、請求項１に記載の装置。
- 前記電極が、約１．５ｍｍの距離で各隣接する電極から離れている、請求項１〜５のいずれか１項に記載の装置。
- 前記電圧発生装置が、約１ボルト〜約１５ボルトの電位を表皮組織へ送達する、請求項１〜６のいずれか１項に記載の装置。
- 前記電圧発生装置が、約１ｍＡ〜約５０ｍＡの範囲内の電流で、電位を表皮組織へ送達する、請求項１〜７のいずれか１項に記載の装置。
- 前記電圧発生装置が、約５ｍ秒〜約２５０ｍ秒の範囲内の持続期間で、電位を表皮組織へ送達する、請求項１〜７のいずれか１項に記載の装置。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30942210P | 2010-03-01 | 2010-03-01 | |
| US61/309,422 | 2010-03-01 | ||
| PCT/US2011/026701 WO2011109406A1 (en) | 2010-03-01 | 2011-03-01 | A tolerable and minimally invasive skin electroporation device |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013521058A JP2013521058A (ja) | 2013-06-10 |
| JP2013521058A5 true JP2013521058A5 (ja) | 2014-04-17 |
| JP5706451B2 JP5706451B2 (ja) | 2015-04-22 |
Family
ID=44542539
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012556176A Active JP5706451B2 (ja) | 2010-03-01 | 2011-03-01 | 耐容性で最小侵襲性の皮膚電気穿孔装置 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US11565107B2 (ja) |
| EP (1) | EP2542300B1 (ja) |
| JP (1) | JP5706451B2 (ja) |
| KR (1) | KR101872408B1 (ja) |
| CN (1) | CN102905755B (ja) |
| AU (1) | AU2011223753B2 (ja) |
| BR (1) | BR112012021805A2 (ja) |
| CA (1) | CA2789736A1 (ja) |
| DK (1) | DK2542300T3 (ja) |
| EA (1) | EA025705B1 (ja) |
| ES (1) | ES2594498T3 (ja) |
| HK (1) | HK1181339A1 (ja) |
| MX (1) | MX2012009986A (ja) |
| PL (1) | PL2542300T3 (ja) |
| PT (1) | PT2542300T (ja) |
| WO (1) | WO2011109406A1 (ja) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20230156804A (ko) * | 2011-06-28 | 2023-11-14 | 이노비오 파마수티컬즈, 인크. | 최소 침습 피부 전기천공 장치 |
| AU2015203882C1 (en) * | 2011-06-28 | 2017-09-21 | Inovio Pharmaceuticals, Inc. | A minimally invasive dermal electroporation device |
| EP3010582B1 (en) | 2013-06-21 | 2021-04-28 | Newsouth Innovations Pty Limited | Method and apparatus for close-field electroporation |
| CN104689478A (zh) * | 2013-12-09 | 2015-06-10 | 深圳市瑞吉思科技有限公司 | 细胞再生仪 |
| CN103861202B (zh) * | 2014-03-18 | 2016-06-01 | 苏州壹达生物科技有限公司 | 一种利用空心电极针电穿孔给药的装置 |
| CA2981474A1 (en) * | 2015-03-31 | 2016-10-06 | Oncosec Medical Incorporated | Systems and methods for improved tissue-sensing based electroporation |
| CN109414580B (zh) | 2015-12-30 | 2022-09-20 | 因诺维奥制药公司 | 具有带锁住系统的可拆卸针阵列的电穿孔装置 |
| WO2018064463A1 (en) * | 2016-09-30 | 2018-04-05 | University Of Florida Research Foundation, Inc. | Systems and methods including porous membrane for low-voltage continuous cell electroporation |
| CN107890608A (zh) * | 2017-12-01 | 2018-04-10 | 王嘉浩 | 淋巴细胞增升仪 |
| KR102601524B1 (ko) * | 2019-02-04 | 2023-11-14 | 루트거스, 더 스테이트 유니버시티 오브 뉴 저지 | 미세전극을 사용한 조직 전기이동을 위한 소자 |
| US11071860B2 (en) | 2019-02-06 | 2021-07-27 | Oncosec Medical Incorporated | Systems and methods for detecting fault conditions in electroporation therapy |
| BR102019013578A2 (pt) * | 2019-06-28 | 2021-01-05 | Eqt Equipamentos E Tecnologia Ltda. | Ponta aplicadora de eletroporação para procedimento de eletroquimioterapia |
| KR102576604B1 (ko) | 2021-02-16 | 2023-09-08 | 주식회사 밀알 | 의료용 정밀 약물주입 및 전기천공 융합 전극 |
| KR20220159203A (ko) | 2021-05-25 | 2022-12-02 | 주식회사 밀알 | 의료용 정밀 약물주입 및 전기천공 융합 전극 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3994287A (en) * | 1974-07-01 | 1976-11-30 | Centre De Recherche Industrielle Du Quebec | Trocar |
| US6277116B1 (en) * | 1994-05-06 | 2001-08-21 | Vidaderm | Systems and methods for shrinking collagen in the dermis |
| AU3880697A (en) * | 1996-07-03 | 1998-01-21 | Altea Technologies, Inc. | Multiple mechanical microporation of skin or mucosa |
| US6241701B1 (en) * | 1997-08-01 | 2001-06-05 | Genetronics, Inc. | Apparatus for electroporation mediated delivery of drugs and genes |
| TW368420B (en) | 1997-11-04 | 1999-09-01 | Genetronics Inc | Apparatus and method for transdermal molecular delivery by applying sufficient amplitude of electric field to induce migration of molecules through pores in the stratum corneum |
| US7922709B2 (en) * | 1998-07-13 | 2011-04-12 | Genetronics, Inc. | Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation |
| EP1163024B1 (en) * | 1999-01-28 | 2003-12-17 | Cyto Pulse Sciences, Inc. | Delivery of macromolecules into cells |
| US6678558B1 (en) * | 1999-03-25 | 2004-01-13 | Genetronics, Inc. | Method and apparatus for reducing electroporation-mediated muscle reaction and pain response |
| US7113821B1 (en) * | 1999-08-25 | 2006-09-26 | Johnson & Johnson Consumer Companies, Inc. | Tissue electroperforation for enhanced drug delivery |
| US20070016268A1 (en) | 2000-01-07 | 2007-01-18 | John Carter | Percutaneous electrode array |
| US7245963B2 (en) * | 2002-03-07 | 2007-07-17 | Advisys, Inc. | Electrode assembly for constant-current electroporation and use |
| US6912417B1 (en) | 2002-04-05 | 2005-06-28 | Ichor Medical Systmes, Inc. | Method and apparatus for delivery of therapeutic agents |
| AU2003226605A1 (en) * | 2002-04-19 | 2003-11-03 | Transpharma Medical Ltd. | Handheld transdermal drug delivery and analyte extraction |
| US20060036210A1 (en) | 2004-06-30 | 2006-02-16 | Lei Zhang | Modular electroporation device with disposable electrode and drug delivery components |
| US20100168501A1 (en) * | 2006-10-02 | 2010-07-01 | Daniel Rogers Burnett | Method and apparatus for magnetic induction therapy |
| WO2007095140A2 (en) * | 2006-02-11 | 2007-08-23 | Genetronics, Inc. | Device and method for single-needle in vivo electroporation |
| CN101563132A (zh) * | 2006-10-17 | 2009-10-21 | Vgx药品公司 | 电穿孔装置及用其进行哺乳动物细胞电穿孔的方法 |
| WO2008094663A2 (en) | 2007-01-31 | 2008-08-07 | Adam Heller | Electrochemical management of pain |
-
2011
- 2011-03-01 KR KR1020127025208A patent/KR101872408B1/ko active IP Right Grant
- 2011-03-01 BR BR112012021805A patent/BR112012021805A2/pt not_active Application Discontinuation
- 2011-03-01 WO PCT/US2011/026701 patent/WO2011109406A1/en active Application Filing
- 2011-03-01 JP JP2012556176A patent/JP5706451B2/ja active Active
- 2011-03-01 US US13/581,702 patent/US11565107B2/en active Active
- 2011-03-01 CA CA2789736A patent/CA2789736A1/en active Pending
- 2011-03-01 ES ES11751208.7T patent/ES2594498T3/es active Active
- 2011-03-01 PT PT117512087T patent/PT2542300T/pt unknown
- 2011-03-01 CN CN201180011473.6A patent/CN102905755B/zh active Active
- 2011-03-01 AU AU2011223753A patent/AU2011223753B2/en active Active
- 2011-03-01 EP EP11751208.7A patent/EP2542300B1/en active Active
- 2011-03-01 DK DK11751208.7T patent/DK2542300T3/en active
- 2011-03-01 EA EA201201203A patent/EA025705B1/ru not_active IP Right Cessation
- 2011-03-01 MX MX2012009986A patent/MX2012009986A/es active IP Right Grant
- 2011-03-01 PL PL11751208T patent/PL2542300T3/pl unknown
-
2013
- 2013-07-29 HK HK13108852.5A patent/HK1181339A1/zh unknown
-
2022
- 2022-07-25 US US17/814,703 patent/US20230145532A1/en active Pending
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