JP2013516984A5 - - Google Patents
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- Publication number
- JP2013516984A5 JP2013516984A5 JP2012548931A JP2012548931A JP2013516984A5 JP 2013516984 A5 JP2013516984 A5 JP 2013516984A5 JP 2012548931 A JP2012548931 A JP 2012548931A JP 2012548931 A JP2012548931 A JP 2012548931A JP 2013516984 A5 JP2013516984 A5 JP 2013516984A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- abnormal
- sample
- body fluid
- polymerase chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000007523 nucleic acids Chemical class 0.000 claims description 103
- 102000039446 nucleic acids Human genes 0.000 claims description 103
- 108020004707 nucleic acids Proteins 0.000 claims description 103
- 238000000034 method Methods 0.000 claims description 74
- 230000002159 abnormal effect Effects 0.000 claims description 37
- 210000001124 body fluid Anatomy 0.000 claims description 24
- 230000003321 amplification Effects 0.000 claims description 22
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 22
- 239000010839 body fluid Substances 0.000 claims description 20
- 206010028980 Neoplasm Diseases 0.000 claims description 16
- 201000010099 disease Diseases 0.000 claims description 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 14
- 238000003753 real-time PCR Methods 0.000 claims description 14
- 201000011510 cancer Diseases 0.000 claims description 12
- 210000004369 blood Anatomy 0.000 claims description 10
- 239000008280 blood Substances 0.000 claims description 10
- 238000003752 polymerase chain reaction Methods 0.000 claims description 10
- 238000004445 quantitative analysis Methods 0.000 claims description 9
- 210000004185 liver Anatomy 0.000 claims description 8
- 210000003739 neck Anatomy 0.000 claims description 8
- 206010003445 Ascites Diseases 0.000 claims description 6
- 210000003567 ascitic fluid Anatomy 0.000 claims description 6
- 210000003756 cervix mucus Anatomy 0.000 claims description 6
- 239000012530 fluid Substances 0.000 claims description 6
- 210000002751 lymph Anatomy 0.000 claims description 6
- 210000003097 mucus Anatomy 0.000 claims description 6
- 210000002381 plasma Anatomy 0.000 claims description 6
- 210000003296 saliva Anatomy 0.000 claims description 6
- 210000000582 semen Anatomy 0.000 claims description 6
- 210000002966 serum Anatomy 0.000 claims description 6
- 210000002700 urine Anatomy 0.000 claims description 6
- 208000034578 Multiple myelomas Diseases 0.000 claims description 4
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 4
- 206010039491 Sarcoma Diseases 0.000 claims description 4
- 210000004100 adrenal gland Anatomy 0.000 claims description 4
- 210000004556 brain Anatomy 0.000 claims description 4
- 210000000481 breast Anatomy 0.000 claims description 4
- 210000001072 colon Anatomy 0.000 claims description 4
- 210000003238 esophagus Anatomy 0.000 claims description 4
- 210000001035 gastrointestinal tract Anatomy 0.000 claims description 4
- 208000005017 glioblastoma Diseases 0.000 claims description 4
- 210000003128 head Anatomy 0.000 claims description 4
- 210000003734 kidney Anatomy 0.000 claims description 4
- 210000004072 lung Anatomy 0.000 claims description 4
- 210000001672 ovary Anatomy 0.000 claims description 4
- 210000000496 pancreas Anatomy 0.000 claims description 4
- 210000002307 prostate Anatomy 0.000 claims description 4
- 210000000664 rectum Anatomy 0.000 claims description 4
- 210000003491 skin Anatomy 0.000 claims description 4
- 210000002784 stomach Anatomy 0.000 claims description 4
- 210000001685 thyroid gland Anatomy 0.000 claims description 4
- 210000001519 tissue Anatomy 0.000 claims description 4
- 210000003932 urinary bladder Anatomy 0.000 claims description 4
- 210000001215 vagina Anatomy 0.000 claims description 4
- 238000001514 detection method Methods 0.000 claims description 3
- 238000000605 extraction Methods 0.000 claims description 3
- 238000004458 analytical method Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/689,597 | 2010-01-19 | ||
| US12/689,597 US20110177512A1 (en) | 2010-01-19 | 2010-01-19 | Method for assuring amplification of an abnormal nucleic acid in a sample |
| PCT/US2010/050195 WO2011090517A1 (en) | 2010-01-19 | 2010-09-24 | Method for assuring amplification of an abnormal nucleic acid in a sample |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013516984A JP2013516984A (ja) | 2013-05-16 |
| JP2013516984A5 true JP2013516984A5 (https=) | 2013-11-07 |
Family
ID=44277844
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012548931A Pending JP2013516984A (ja) | 2010-01-19 | 2010-09-24 | 試料中の異常核酸の増幅を確実にするための方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20110177512A1 (https=) |
| EP (1) | EP2526202A4 (https=) |
| JP (1) | JP2013516984A (https=) |
| WO (1) | WO2011090517A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1712639B1 (en) | 2005-04-06 | 2008-08-27 | Maurice Stroun | Method for the diagnosis of cancer by detecting circulating DNA and RNA |
| US11913065B2 (en) | 2012-09-04 | 2024-02-27 | Guardent Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| GB2533006B (en) | 2012-09-04 | 2017-06-07 | Guardant Health Inc | Systems and methods to detect copy number variation |
| US20160040229A1 (en) | 2013-08-16 | 2016-02-11 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| US10876152B2 (en) | 2012-09-04 | 2020-12-29 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| EP3077072B1 (en) | 2013-12-02 | 2019-03-06 | Biocartis N.V. | Extraction of circulating nucleic acids |
| ES2660989T3 (es) | 2013-12-28 | 2018-03-27 | Guardant Health, Inc. | Métodos y sistemas para detectar variantes genéticas |
| WO2017106768A1 (en) | 2015-12-17 | 2017-06-22 | Guardant Health, Inc. | Methods to determine tumor gene copy number by analysis of cell-free dna |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US5994056A (en) * | 1991-05-02 | 1999-11-30 | Roche Molecular Systems, Inc. | Homogeneous methods for nucleic acid amplification and detection |
| US5567583A (en) * | 1991-12-16 | 1996-10-22 | Biotronics Corporation | Methods for reducing non-specific priming in DNA detection |
| US5348853A (en) * | 1991-12-16 | 1994-09-20 | Biotronics Corporation | Method for reducing non-specific priming in DNA amplification |
| US6033854A (en) * | 1991-12-16 | 2000-03-07 | Biotronics Corporation | Quantitative PCR using blocking oligonucleotides |
| CH686982A5 (fr) * | 1993-12-16 | 1996-08-15 | Maurice Stroun | Méthode pour le diagnostic de cancers. |
| US5670325A (en) * | 1996-08-14 | 1997-09-23 | Exact Laboratories, Inc. | Method for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample |
| EP1033411B1 (en) * | 1996-06-04 | 2006-02-22 | University of Utah Research Foundation | Fluorescent donor-acceptor pair |
| US6117635A (en) * | 1996-07-16 | 2000-09-12 | Intergen Company | Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon |
| US6100029A (en) * | 1996-08-14 | 2000-08-08 | Exact Laboratories, Inc. | Methods for the detection of chromosomal aberrations |
| US5928870A (en) * | 1997-06-16 | 1999-07-27 | Exact Laboratories, Inc. | Methods for the detection of loss of heterozygosity |
| US6203993B1 (en) * | 1996-08-14 | 2001-03-20 | Exact Science Corp. | Methods for the detection of nucleic acids |
| US5989823A (en) * | 1998-09-18 | 1999-11-23 | Nexstar Pharmaceuticals, Inc. | Homogeneous detection of a target through nucleic acid ligand-ligand beacon interaction |
| GB9812768D0 (en) * | 1998-06-13 | 1998-08-12 | Zeneca Ltd | Methods |
| DE19935772C2 (de) * | 1999-07-26 | 2002-11-07 | Epigenomics Ag | Verfahren zur relativen Quantifizierung der Methylierung von Cytosin Basen in DNA-Proben |
| WO2006059132A1 (en) * | 2004-12-03 | 2006-06-08 | Forensic Science Service Limited | Method of optimizing parameters in the entire process of analysing a dna containing sample and method of modeling said process |
| WO2008103770A2 (en) * | 2007-02-20 | 2008-08-28 | Applera Corporation | Multiplex compositions and methods for quantification of human nuclear dna and human male dna and detection of pcr inhibitors |
| JP2010528585A (ja) * | 2007-02-26 | 2010-08-26 | ジョン ウェイン キャンサー インスティテュート | 癌の診断および治療におけるｂ−ｒａｆｄｎａ変異の有用性 |
| US20090203015A1 (en) * | 2008-02-13 | 2009-08-13 | Celera Corporation | Multiplex assays for hormonal and growth factor receptors, and uses thereof |
-
2010
- 2010-01-19 US US12/689,597 patent/US20110177512A1/en not_active Abandoned
- 2010-09-24 JP JP2012548931A patent/JP2013516984A/ja active Pending
- 2010-09-24 WO PCT/US2010/050195 patent/WO2011090517A1/en not_active Ceased
- 2010-09-24 EP EP10844135.3A patent/EP2526202A4/en not_active Withdrawn
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