JP2013515037A5 - - Google Patents
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- JP2013515037A5 JP2013515037A5 JP2012545292A JP2012545292A JP2013515037A5 JP 2013515037 A5 JP2013515037 A5 JP 2013515037A5 JP 2012545292 A JP2012545292 A JP 2012545292A JP 2012545292 A JP2012545292 A JP 2012545292A JP 2013515037 A5 JP2013515037 A5 JP 2013515037A5
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- JP
- Japan
- Prior art keywords
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- aryl
- alkyl
- Prior art date
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- 125000000217 alkyl group Chemical group 0.000 claims 8
- 125000000623 heterocyclic group Chemical group 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 7
- 125000003710 aryl alkyl group Chemical group 0.000 claims 6
- 125000004429 atom Chemical group 0.000 claims 6
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 4
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 1
- 125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000003902 lesion Effects 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000006413 ring segment Chemical group 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
- 0 CCC*N*N*(*)C(*)=O Chemical compound CCC*N*N*(*)C(*)=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09306294 | 2009-12-21 | ||
| EP09306294.1 | 2009-12-21 | ||
| PCT/EP2010/070359 WO2011076784A2 (en) | 2009-12-21 | 2010-12-21 | New inhibitors of cyclophilins and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016016491A Division JP2016128488A (ja) | 2009-12-21 | 2016-01-29 | シクロフィリンの新しいインヒビター及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013515037A JP2013515037A (ja) | 2013-05-02 |
| JP2013515037A5 true JP2013515037A5 (cg-RX-API-DMAC10.html) | 2013-09-26 |
| JP5947724B2 JP5947724B2 (ja) | 2016-07-06 |
Family
ID=42115490
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012545292A Active JP5947724B2 (ja) | 2009-12-21 | 2010-12-21 | シクロフィリンの新しいインヒビター及びその使用 |
| JP2016016491A Pending JP2016128488A (ja) | 2009-12-21 | 2016-01-29 | シクロフィリンの新しいインヒビター及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016016491A Pending JP2016128488A (ja) | 2009-12-21 | 2016-01-29 | シクロフィリンの新しいインヒビター及びその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US8802666B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP2516387B1 (cg-RX-API-DMAC10.html) |
| JP (2) | JP5947724B2 (cg-RX-API-DMAC10.html) |
| KR (1) | KR20120105041A (cg-RX-API-DMAC10.html) |
| CN (2) | CN102811998B (cg-RX-API-DMAC10.html) |
| CA (1) | CA2784600A1 (cg-RX-API-DMAC10.html) |
| ES (1) | ES2670394T3 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2011076784A2 (cg-RX-API-DMAC10.html) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102811998B (zh) * | 2009-12-21 | 2016-03-30 | 国家健康与医学研究院（Inserm） | 新的亲环素抑制剂及其用途 |
| US10501741B2 (en) | 2014-06-25 | 2019-12-10 | Cold Spring Harbor Laboratory | Methods and compositions for inhibiting growth and epithelial to mesenchymal transition (EMT) in cancer cells |
| AU2017244139A1 (en) * | 2016-03-31 | 2018-09-13 | Merck Patent Gmbh | Compounds for the inhibition of cyclophilins and uses thereof |
| JP2019510053A (ja) * | 2016-03-31 | 2019-04-11 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | シクロフィリンの阻害のための化合物及びその使用 |
| CA3016087A1 (en) | 2016-03-31 | 2017-10-05 | Merck Patent Gmbh | Compounds for the inhibition of cyclophilins and uses thereof |
| GB2561540A (en) | 2017-03-13 | 2018-10-24 | Nodthera Ltd | Chemical compounds |
| GB201814067D0 (en) | 2018-08-29 | 2018-10-10 | Univ Edinburgh | Compounds for the inhibition of cyclophilins |
| CN112794860B (zh) * | 2021-03-24 | 2021-06-29 | 上海肇钰医药科技有限公司 | 噁唑嘧啶酮酰胺类化合物或其可药用盐，制备方法及用途 |
| GB202407295D0 (en) * | 2024-05-22 | 2024-07-03 | Univ Liverpool | Compounds for the inhibition of cyclophilin d |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4970210A (en) * | 1987-07-17 | 1990-11-13 | Abbott Laboratories | Triazinone lipoxygenase compounds |
| AU635403B2 (en) * | 1990-02-15 | 1993-03-18 | Teijin Limited | 4h-3,1-benzoxazin-4-one compound and elastase inhibitor composition containing the same |
| DE69124459T3 (de) * | 1990-11-02 | 2001-05-31 | Novartis Ag, Basel | Zyklosporine |
| CZ146196A3 (en) * | 1995-06-02 | 1997-05-14 | American Cyanamid Co | 1-(3-heterocyclylphenyl)-s-triazin-2,4,6-oxo or thiotriones and herbicidal agent based thereon |
| BR9911724A (pt) | 1998-07-01 | 2001-03-20 | Debiopharm Sa | Ciclosporina que tem um perfil de atividade melhorado |
| US6423519B1 (en) * | 1998-07-15 | 2002-07-23 | Gpc Biotech Inc. | Compositions and methods for inhibiting fungal growth |
| US20020107262A1 (en) * | 2000-12-08 | 2002-08-08 | 3M Innovative Properties Company | Substituted imidazopyridines |
| US6593362B2 (en) * | 2001-05-21 | 2003-07-15 | Guilford Pharmaceuticals Inc. | Non-peptidic cyclophilin binding compounds and their use |
| US20040204340A1 (en) * | 2003-04-11 | 2004-10-14 | Guilford Pharmaceuticals, Inc. | Polyprolyl inhibitors of cyclophilin |
| CN1590378A (zh) * | 2003-08-29 | 2005-03-09 | 中国科学院上海药物研究所 | 一类喹喔啉衍生物及其制备方法和用途 |
| GB0509223D0 (en) * | 2005-05-05 | 2005-06-15 | Chroma Therapeutics Ltd | Enzyme inhibitors |
| EP1910279A2 (en) * | 2005-06-24 | 2008-04-16 | Migenix Inc. | Non-nucleoside anti-hepacivirus agents and uses thereof |
| WO2007106854A2 (en) * | 2006-03-15 | 2007-09-20 | Coley Pharmaceutical Group, Inc. | Hydroxy and alkoxy substituted 1h-imidazonaphthyridines and methods |
| MX2010006209A (es) * | 2007-12-05 | 2010-08-10 | Enanta Pharm Inc | Derivados de quinoxalinilo. |
| TWI437986B (zh) * | 2008-01-31 | 2014-05-21 | R Tech Ueno Ltd | 噻唑衍生物及使用該衍生物作為ｖａｐ－１抑制劑之用途 |
| CN102811998B (zh) * | 2009-12-21 | 2016-03-30 | 国家健康与医学研究院（Inserm） | 新的亲环素抑制剂及其用途 |
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2010
- 2010-12-21 CN CN201080062786.XA patent/CN102811998B/zh not_active Expired - Fee Related
- 2010-12-21 ES ES10798084.9T patent/ES2670394T3/es active Active
- 2010-12-21 CN CN201510863716.9A patent/CN105693597A/zh active Pending
- 2010-12-21 WO PCT/EP2010/070359 patent/WO2011076784A2/en not_active Ceased
- 2010-12-21 KR KR1020127019386A patent/KR20120105041A/ko not_active Ceased
- 2010-12-21 CA CA2784600A patent/CA2784600A1/en not_active Abandoned
- 2010-12-21 EP EP10798084.9A patent/EP2516387B1/en active Active
- 2010-12-21 JP JP2012545292A patent/JP5947724B2/ja active Active
- 2010-12-21 US US13/517,148 patent/US8802666B2/en active Active
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2014
- 2014-02-21 US US14/186,432 patent/US8901295B2/en active Active
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2016
- 2016-01-29 JP JP2016016491A patent/JP2016128488A/ja active Pending