JP2013507945A5 - - Google Patents
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- Publication number
- JP2013507945A5 JP2013507945A5 JP2012534715A JP2012534715A JP2013507945A5 JP 2013507945 A5 JP2013507945 A5 JP 2013507945A5 JP 2012534715 A JP2012534715 A JP 2012534715A JP 2012534715 A JP2012534715 A JP 2012534715A JP 2013507945 A5 JP2013507945 A5 JP 2013507945A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- peripheral blood
- regulatory
- contacting
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 15
- 239000000427 antigen Substances 0.000 claims 12
- 102000036639 antigens Human genes 0.000 claims 12
- 108091007433 antigens Proteins 0.000 claims 12
- 210000000265 leukocyte Anatomy 0.000 claims 10
- 210000005259 peripheral blood Anatomy 0.000 claims 10
- 239000011886 peripheral blood Substances 0.000 claims 10
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 9
- 210000003289 regulatory T cell Anatomy 0.000 claims 9
- 210000002950 fibroblast Anatomy 0.000 claims 8
- 238000004519 manufacturing process Methods 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 4
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims 3
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 3
- 108090000978 Interleukin-4 Proteins 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 108010002350 Interleukin-2 Proteins 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 1
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 1
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims 1
- 210000000577 adipose tissue Anatomy 0.000 claims 1
- 208000037765 diseases and disorders Diseases 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0918615.6A GB0918615D0 (en) | 2009-10-23 | 2009-10-23 | Cell populations having immunoregulatory activity, methods for the preparation and uses thereof |
| GB0918615.6 | 2009-10-23 | ||
| PCT/EP2010/066007 WO2011048222A1 (en) | 2009-10-23 | 2010-10-22 | Cell populations having immunoregulatory activity, methods for the preparation and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013507945A JP2013507945A (ja) | 2013-03-07 |
| JP2013507945A5 true JP2013507945A5 (enExample) | 2013-12-12 |
Family
ID=41426608
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012534715A Pending JP2013507945A (ja) | 2009-10-23 | 2010-10-22 | 免疫調節活性を有する細胞集団、その製造方法及び使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9969976B2 (enExample) |
| EP (1) | EP2491115B1 (enExample) |
| JP (1) | JP2013507945A (enExample) |
| ES (1) | ES2479543T3 (enExample) |
| GB (1) | GB0918615D0 (enExample) |
| WO (1) | WO2011048222A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012156522A1 (en) | 2011-05-19 | 2012-11-22 | Tigenix Sa | Cell populations having immunoregulatory activity, methods for the preparation and uses thereof |
| ES2434853B1 (es) * | 2012-06-12 | 2014-09-30 | Fundación Centro Nacional De Investigaciones Cardiovasculares Carlos Iii | Marcador molecular de potencia terapéutica de células madre mesenquimales humanas y sus usos |
| CN108289937A (zh) * | 2015-06-03 | 2018-07-17 | 爱兰细胞技术公司 | 用于产生和递送来自干细胞的有益因子的方法和装置 |
| US11291689B2 (en) | 2015-06-03 | 2022-04-05 | Aelan Cell Technologies, Inc. | Methods and devices for the production and delivery of beneficial factors from adipose-derived stem cells |
| CN111601606A (zh) | 2017-11-29 | 2020-08-28 | 菲格内有限责任公司 | 用于活化的成纤维细胞与免疫细胞的相互作用及其用途 |
| WO2021076674A1 (en) * | 2019-10-15 | 2021-04-22 | Figene, Llc | Fibroblast-based immunotherapy of graves disease |
| CN111979186B (zh) * | 2020-08-21 | 2022-04-08 | 遵义医科大学附属医院 | 一种快速高效体外扩增人间充质干细胞的方法及应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7048922B2 (en) * | 2002-05-29 | 2006-05-23 | Demao Yang | Stimulation of hematopoiesis by ex vivo activated immune cells |
| AU2005228442A1 (en) * | 2004-03-29 | 2005-10-13 | Cytomatrix, Llc | Methods for production of regulatory T cells and uses thereof |
| JP2006280307A (ja) * | 2005-04-01 | 2006-10-19 | Kyoto Univ | 制御性ｔ細胞の製造方法 |
| JP5925408B2 (ja) | 2005-09-23 | 2016-05-25 | タイジェニックス、ソシエダッド、アノニマ、ウニペルソナルＴｉｇｅｎｉｘ Ｓ．Ａ．Ｕ． | 免疫調節活性を有する細胞集団、単離方法および使用 |
| US8241621B2 (en) * | 2006-12-18 | 2012-08-14 | Medistem Laboratories | Stem cell mediated treg activation/expansion for therapeutic immune modulation |
| GB0820397D0 (en) * | 2008-11-07 | 2008-12-17 | Cellerix Sa | Cells, nucleic acid constructs, cells comprising said constructs and methods utilizing said cells in the treatment of diseases |
-
2009
- 2009-10-23 GB GBGB0918615.6A patent/GB0918615D0/en not_active Ceased
-
2010
- 2010-10-22 JP JP2012534715A patent/JP2013507945A/ja active Pending
- 2010-10-22 US US13/503,542 patent/US9969976B2/en active Active
- 2010-10-22 EP EP10768496.1A patent/EP2491115B1/en active Active
- 2010-10-22 WO PCT/EP2010/066007 patent/WO2011048222A1/en not_active Ceased
- 2010-10-22 ES ES10768496.1T patent/ES2479543T3/es active Active
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