JP2013507383A5 - - Google Patents
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- Publication number
- JP2013507383A5 JP2013507383A5 JP2012533335A JP2012533335A JP2013507383A5 JP 2013507383 A5 JP2013507383 A5 JP 2013507383A5 JP 2012533335 A JP2012533335 A JP 2012533335A JP 2012533335 A JP2012533335 A JP 2012533335A JP 2013507383 A5 JP2013507383 A5 JP 2013507383A5
- Authority
- JP
- Japan
- Prior art keywords
- combination
- fluorophenyl
- amino
- chloro
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 2-Amino-4-pyrimidinyl Chemical group 0.000 claims 7
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 5
- YKGMKSIHIVVYKY-UHFFFAOYSA-N dabrafenib mesylate Chemical compound CS(O)(=O)=O.S1C(C(C)(C)C)=NC(C=2C(=C(NS(=O)(=O)C=3C(=CC=CC=3F)F)C=CC=2)F)=C1C1=CC=NC(N)=N1 YKGMKSIHIVVYKY-UHFFFAOYSA-N 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 4
- 208000011580 syndromic disease Diseases 0.000 claims 3
- DWBWMAAYLWUXQK-UHFFFAOYSA-N 2,3-difluorobenzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC(F)=C1F DWBWMAAYLWUXQK-UHFFFAOYSA-N 0.000 claims 2
- 238000012423 maintenance Methods 0.000 claims 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- 102000010400 1-phosphatidylinositol-3-kinase activity proteins Human genes 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 108091007960 PI3Ks Proteins 0.000 claims 1
- 102000014160 PTEN Phosphohydrolase Human genes 0.000 claims 1
- 108010011536 PTEN Phosphohydrolase Proteins 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- BFSMGDJOXZAERB-UHFFFAOYSA-N dabrafenib Chemical compound S1C(C(C)(C)C)=NC(C=2C(=C(NS(=O)(=O)C=3C(=CC=CC=3F)F)C=CC=2)F)=C1C1=CC=NC(N)=N1 BFSMGDJOXZAERB-UHFFFAOYSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- YFQJOPFTGMHYNV-YDALLXLXSA-N n-[(2s)-1-amino-3-(3-fluorophenyl)propan-2-yl]-5-chloro-4-(4-chloro-2-methylpyrazol-3-yl)thiophene-2-carboxamide;hydrochloride Chemical compound Cl.CN1N=CC(Cl)=C1C1=C(Cl)SC(C(=O)N[C@H](CN)CC=2C=C(F)C=CC=2)=C1 YFQJOPFTGMHYNV-YDALLXLXSA-N 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24980809P | 2009-10-08 | 2009-10-08 | |
| US61/249,808 | 2009-10-08 | ||
| PCT/US2010/051909 WO2011044415A1 (en) | 2009-10-08 | 2010-10-08 | Combination |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013507383A JP2013507383A (ja) | 2013-03-04 |
| JP2013507383A5 true JP2013507383A5 (enExample) | 2013-11-28 |
| JP5881607B2 JP5881607B2 (ja) | 2016-03-09 |
Family
ID=43857163
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012533335A Expired - Fee Related JP5881607B2 (ja) | 2009-10-08 | 2010-10-08 | 組合せ |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8796298B2 (enExample) |
| EP (1) | EP2485594B1 (enExample) |
| JP (1) | JP5881607B2 (enExample) |
| KR (1) | KR101696003B1 (enExample) |
| CN (1) | CN102647908B (enExample) |
| AU (1) | AU2010303364B2 (enExample) |
| BR (1) | BR112012008274A2 (enExample) |
| CA (1) | CA2777087C (enExample) |
| EA (1) | EA023018B1 (enExample) |
| ES (1) | ES2530436T3 (enExample) |
| IL (1) | IL219000A (enExample) |
| MX (1) | MX2012004140A (enExample) |
| WO (1) | WO2011044415A1 (enExample) |
| ZA (1) | ZA201202495B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20140053836A (ko) | 2011-01-11 | 2014-05-08 | 글락소스미스클라인 엘엘씨 | 조합물 |
| WO2015003571A1 (zh) * | 2013-07-08 | 2015-01-15 | 杭州普晒医药科技有限公司 | 达拉菲尼甲磺酸盐的新晶型及其制备方法 |
| EP4435112A3 (en) * | 2015-05-27 | 2025-02-26 | Quest Diagnostics Investments Incorporated | Compositions and methods for screening solid tumors |
| WO2020055760A1 (en) * | 2018-09-10 | 2020-03-19 | Mirati Therapeutics, Inc. | Combination therapies |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000042003A1 (en) * | 1999-01-13 | 2000-07-20 | Warner-Lambert Company | Benzenesulfonamide derivatives and their use as mek inhibitors |
| EP1601657A1 (en) * | 2003-03-12 | 2005-12-07 | Vertex Pharmaceuticals Incorporated | Pyrazole modulators of atp-binding cassette transporters |
| EP1981884B1 (en) * | 2006-01-18 | 2012-06-13 | Amgen, Inc | Thiazole compounds as protein kinase b (pkb) inhibitors |
| UY30892A1 (es) * | 2007-02-07 | 2008-09-02 | Smithkline Beckman Corp | Inhibidores de la actividad akt |
| UA103319C2 (en) * | 2008-05-06 | 2013-10-10 | Глаксосмитклайн Ллк | Thiazole- and oxazole-benzene sulfonamide compounds |
-
2010
- 2010-10-08 CA CA2777087A patent/CA2777087C/en not_active Expired - Fee Related
- 2010-10-08 WO PCT/US2010/051909 patent/WO2011044415A1/en not_active Ceased
- 2010-10-08 ES ES10822734T patent/ES2530436T3/es active Active
- 2010-10-08 AU AU2010303364A patent/AU2010303364B2/en not_active Ceased
- 2010-10-08 MX MX2012004140A patent/MX2012004140A/es active IP Right Grant
- 2010-10-08 EP EP10822734.9A patent/EP2485594B1/en active Active
- 2010-10-08 BR BR112012008274A patent/BR112012008274A2/pt active Search and Examination
- 2010-10-08 US US13/500,698 patent/US8796298B2/en not_active Expired - Fee Related
- 2010-10-08 EA EA201270527A patent/EA023018B1/ru not_active IP Right Cessation
- 2010-10-08 CN CN201080055874.7A patent/CN102647908B/zh not_active Expired - Fee Related
- 2010-10-08 JP JP2012533335A patent/JP5881607B2/ja not_active Expired - Fee Related
- 2010-10-08 KR KR1020127011759A patent/KR101696003B1/ko not_active Expired - Fee Related
-
2012
- 2012-04-02 IL IL219000A patent/IL219000A/en not_active IP Right Cessation
- 2012-04-05 ZA ZA2012/02495A patent/ZA201202495B/en unknown