JP2013505966A5 - - Google Patents
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- Publication number
- JP2013505966A5 JP2013505966A5 JP2012531124A JP2012531124A JP2013505966A5 JP 2013505966 A5 JP2013505966 A5 JP 2013505966A5 JP 2012531124 A JP2012531124 A JP 2012531124A JP 2012531124 A JP2012531124 A JP 2012531124A JP 2013505966 A5 JP2013505966 A5 JP 2013505966A5
- Authority
- JP
- Japan
- Prior art keywords
- lower alkyl
- group
- compound
- carbon atoms
- soluble non
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims description 102
- 150000001875 compounds Chemical class 0.000 claims description 50
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 29
- 125000004432 carbon atom Chemical group C* 0.000 claims description 28
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims description 10
- 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims description 10
- 125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 claims description 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- -1 2,4-butylene Chemical group 0.000 claims description 8
- 125000006850 spacer group Chemical group 0.000 claims description 8
- 229920000233 poly(alkylene oxides) Polymers 0.000 claims description 6
- 150000001413 amino acids Chemical class 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 125000003545 alkoxy group Chemical group 0.000 claims description 4
- 125000001188 haloalkyl group Chemical group 0.000 claims description 4
- 125000005843 halogen group Chemical group 0.000 claims description 4
- 239000000178 monomer Substances 0.000 claims description 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 2
- 125000002252 acyl group Chemical group 0.000 claims description 2
- 125000003282 alkyl amino group Chemical group 0.000 claims description 2
- 150000001408 amides Chemical class 0.000 claims description 2
- 125000003118 aryl group Chemical group 0.000 claims description 2
- 125000002527 bicyclic carbocyclic group Chemical group 0.000 claims description 2
- VDHAWDNDOKGFTD-MRXNPFEDSA-N cinacalcet Chemical group N([C@H](C)C=1C2=CC=CC=C2C=CC=1)CCCC1=CC=CC(C(F)(F)F)=C1 VDHAWDNDOKGFTD-MRXNPFEDSA-N 0.000 claims description 2
- 230000008878 coupling Effects 0.000 claims description 2
- 238000010168 coupling process Methods 0.000 claims description 2
- 238000005859 coupling reaction Methods 0.000 claims description 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims description 2
- 229910052736 halogen Inorganic materials 0.000 claims description 2
- 150000002367 halogens Chemical class 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 125000002950 monocyclic group Chemical group 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 125000001424 substituent group Chemical group 0.000 claims description 2
- 125000004001 thioalkyl group Chemical group 0.000 claims description 2
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims 1
- 241000124008 Mammalia Species 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24693109P | 2009-09-29 | 2009-09-29 | |
| US61/246,931 | 2009-09-29 | ||
| PCT/US2010/050761 WO2011056325A2 (en) | 2009-09-29 | 2010-09-29 | Oligomer-calcimimetic conjugates and related compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013505966A JP2013505966A (ja) | 2013-02-21 |
| JP2013505966A5 true JP2013505966A5 (https=) | 2013-11-14 |
| JP5792175B2 JP5792175B2 (ja) | 2015-10-07 |
Family
ID=43901165
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012531124A Active JP5792175B2 (ja) | 2009-09-29 | 2010-09-29 | オリゴマー−カルシミメティクスコンジュゲートおよび関連化合物 |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP2482855B1 (https=) |
| JP (1) | JP5792175B2 (https=) |
| KR (1) | KR101828613B1 (https=) |
| CN (1) | CN102573921B (https=) |
| AU (1) | AU2010315805B2 (https=) |
| CA (1) | CA2773353C (https=) |
| IL (1) | IL218869A (https=) |
| MX (1) | MX341690B (https=) |
| WO (1) | WO2011056325A2 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8722732B2 (en) | 2009-09-29 | 2014-05-13 | Nektar Therapeutics | Oligomer-calcimimetic conjugates and related compounds |
| JP2020105072A (ja) * | 2017-03-24 | 2020-07-09 | 協和キリン株式会社 | ポリエチレングリコール誘導体 |
| US20220040318A1 (en) * | 2018-09-28 | 2022-02-10 | Seikagaku Corporation | Primary amine compound or secondary amine compound-acidic polysaccharide conjugate and production method therefor |
| KR20230066044A (ko) * | 2020-09-10 | 2023-05-12 | 샨시 마이콧 테크놀로지 컴퍼니 리미티드 | 이중특이적 융합 폴리펩타이드 화합물 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4966988A (en) | 1989-02-17 | 1990-10-30 | Chevron Research Company | Process for preparing acetonitrile 3-trifluoromethyl benzene |
| US6011068A (en) | 1991-08-23 | 2000-01-04 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
| US6211244B1 (en) | 1994-10-21 | 2001-04-03 | Nps Pharmaceuticals, Inc. | Calcium receptor-active compounds |
| US5672662A (en) | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
| US5648541A (en) | 1995-09-28 | 1997-07-15 | Nps Pharmaceuticals, Inc. | Chiral reductions of imines leading to the syntheses of optically active amines |
| US6835802B2 (en) | 2001-06-04 | 2004-12-28 | Nobex Corporation | Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties |
| EP2905033B1 (en) * | 2003-12-16 | 2020-09-02 | Nektar Therapeutics | Monodisperse PEGylated naloxol compositions |
| WO2006125026A2 (en) | 2005-05-16 | 2006-11-23 | Teva Pharmaceutical Industries, Ltd. | Process for preparing cinacalcet hydrochloride |
| BRPI0611872B8 (pt) | 2005-06-16 | 2021-05-25 | Nektar Therapeutics | reagente polimérico, conjugado, método para preparação de um conjugado e composição farmacêutica |
| US7563930B2 (en) | 2005-11-22 | 2009-07-21 | Teva Pharmaceutical Industries Ltd | Crystal forms of Cinacalcet HCI and processes for their preparation |
| TW200811082A (en) | 2006-04-27 | 2008-03-01 | Teva Pharma | Process for the preparation of cinacalcet base |
| CA2681582C (en) * | 2007-03-30 | 2015-07-14 | Amgen Inc. | Methods of treating bowel disorders |
| WO2009151590A2 (en) * | 2008-06-09 | 2009-12-17 | Nektar Therapeutics | Methods of treating cyp2d6 alternative metabolizers |
-
2010
- 2010-09-29 KR KR1020127005885A patent/KR101828613B1/ko active Active
- 2010-09-29 MX MX2012003775A patent/MX341690B/es active IP Right Grant
- 2010-09-29 CA CA2773353A patent/CA2773353C/en active Active
- 2010-09-29 JP JP2012531124A patent/JP5792175B2/ja active Active
- 2010-09-29 EP EP10810996.8A patent/EP2482855B1/en active Active
- 2010-09-29 WO PCT/US2010/050761 patent/WO2011056325A2/en not_active Ceased
- 2010-09-29 CN CN201080043400.0A patent/CN102573921B/zh active Active
- 2010-09-29 AU AU2010315805A patent/AU2010315805B2/en active Active
-
2012
- 2012-03-27 IL IL218869A patent/IL218869A/en active IP Right Grant