JP2013505945A5 - - Google Patents
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- JP2013505945A5 JP2013505945A5 JP2012531042A JP2012531042A JP2013505945A5 JP 2013505945 A5 JP2013505945 A5 JP 2013505945A5 JP 2012531042 A JP2012531042 A JP 2012531042A JP 2012531042 A JP2012531042 A JP 2012531042A JP 2013505945 A5 JP2013505945 A5 JP 2013505945A5
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- JP
- Japan
- Prior art keywords
- substituted
- moiety
- unsubstituted
- propylene
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims description 46
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 claims description 46
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 claims description 36
- 125000003545 alkoxy group Chemical group 0.000 claims description 34
- -1 perhaloalkyl Chemical group 0.000 claims description 34
- 125000000217 alkyl group Chemical group 0.000 claims description 31
- 239000005977 Ethylene Substances 0.000 claims description 28
- VGGSQFUCUMXWEO-UHFFFAOYSA-N ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims description 28
- 125000001072 heteroaryl group Chemical group 0.000 claims description 27
- 150000003839 salts Chemical class 0.000 claims description 25
- 239000011780 sodium chloride Substances 0.000 claims description 25
- 125000001475 halogen functional group Chemical group 0.000 claims description 23
- 125000003118 aryl group Chemical group 0.000 claims description 22
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 20
- 125000000623 heterocyclic group Chemical group 0.000 claims description 20
- 229910052799 carbon Inorganic materials 0.000 claims description 18
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 18
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims description 18
- 125000004442 acylamino group Chemical group 0.000 claims description 16
- OKTJSMMVPCPJKN-UHFFFAOYSA-N carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 16
- 125000005102 carbonylalkoxy group Chemical group 0.000 claims description 16
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 16
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 16
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 16
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims description 14
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 12
- 125000004423 acyloxy group Chemical group 0.000 claims description 12
- 125000000266 alpha-aminoacyl group Chemical group 0.000 claims description 12
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 12
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims description 8
- 125000002252 acyl group Chemical group 0.000 claims description 8
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 8
- 125000004104 aryloxy group Chemical group 0.000 claims description 8
- 125000005589 carbonylalkylenealkoxy group Chemical group 0.000 claims description 8
- 125000000392 cycloalkenyl group Chemical group 0.000 claims description 8
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 8
- 125000004001 thioalkyl group Chemical group 0.000 claims description 8
- 206010057668 Cognitive disease Diseases 0.000 claims description 5
- 206010061920 Psychotic disease Diseases 0.000 claims description 5
- 201000010099 disease Diseases 0.000 claims description 5
- 230000001404 mediated Effects 0.000 claims description 5
- 239000002858 neurotransmitter agent Substances 0.000 claims description 5
- 208000009025 Nervous System Disease Diseases 0.000 claims description 4
- 206010029305 Neurological disorder Diseases 0.000 claims description 4
- 241000282941 Rangifer tarandus Species 0.000 claims description 4
- 125000005121 aminocarbonylalkoxy group Chemical group 0.000 claims description 4
- 125000004432 carbon atoms Chemical group C* 0.000 claims description 4
- 125000005243 carbonyl alkyl group Chemical group 0.000 claims description 4
- 125000003107 substituted aryl group Chemical group 0.000 claims description 4
- 150000003573 thiols Chemical class 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- 125000006319 alkynyl amino group Chemical group 0.000 claims description 2
- 125000000304 alkynyl group Chemical group 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 2
- 125000005418 aryl aryl group Chemical group 0.000 claims 1
- 206010029331 Neuropathy peripheral Diseases 0.000 description 1
- 201000001119 neuropathy Diseases 0.000 description 1
- 239000000546 pharmaceutic aid Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24514009P | 2009-09-23 | 2009-09-23 | |
| US24525909P | 2009-09-23 | 2009-09-23 | |
| US61/245,259 | 2009-09-23 | ||
| US61/245,140 | 2009-09-23 | ||
| PCT/US2010/050078 WO2011038161A1 (en) | 2009-09-23 | 2010-09-23 | Pyrido[4,3-b]indoles and methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013505945A JP2013505945A (ja) | 2013-02-21 |
| JP2013505945A5 true JP2013505945A5 (US20040106767A1-20040603-C00005.png) | 2013-11-07 |
| JP5779183B2 JP5779183B2 (ja) | 2015-09-16 |
Family
ID=43796209
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012531042A Expired - Fee Related JP5779183B2 (ja) | 2009-09-23 | 2010-09-23 | ピリド［４，３−ｂ］インドールおよび使用方法 |
Country Status (9)
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2007139634A (ru) | 2007-10-25 | 2009-04-27 | Сергей Олегович Бачурин (RU) | Новые тиазол-, триазол- или оксадиазол-содержащие тетрациклические соединения |
| RU2544856C2 (ru) | 2008-01-25 | 2015-03-20 | Сергей Олегович Бачурин | НОВЫЕ ПРОИЗВОДНЫЕ 2,3,4,5-ТЕТРАГИДРО-1-ПИРИДО[4,3-b]ИНДОЛА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ |
| CN102083830B (zh) | 2008-03-24 | 2014-11-12 | 梅迪维新技术公司 | 吡啶并[3,4-b]吲哚和应用方法 |
| JP5586577B2 (ja) * | 2008-03-24 | 2014-09-10 | メディベイション テクノロジーズ， インコーポレイテッド | 架橋複素環化合物およびその使用 |
| JP5551708B2 (ja) * | 2008-10-31 | 2014-07-16 | メディベイション テクノロジーズ， インコーポレイテッド | アゼピノ［４，５−ｂ］インドール化合物およびその使用方法 |
| JP5588991B2 (ja) | 2008-10-31 | 2014-09-10 | メディベイション テクノロジーズ， インコーポレイテッド | 剛性の部分を有するピリド［４，３−ｂ］インドール |
| BRPI1006602A2 (pt) | 2009-04-29 | 2019-01-15 | Medivation Technologies Inc | composto, método para modular um receptor de histamina em um indivíduo, composição farmacêutica, kit e método para tratar um distúrbio cognitivo ou um distúrbio induzido por pelo menos um sintoma associado com a alteração da cognição |
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| CN102724875B (zh) | 2009-09-23 | 2015-05-27 | 梅迪维新技术公司 | 吡啶并[3,4-b]吲哚化合物及其使用方法 |
| JP5779183B2 (ja) | 2009-09-23 | 2015-09-16 | メディベイション テクノロジーズ， インコーポレイテッド | ピリド［４，３−ｂ］インドールおよび使用方法 |
| WO2011038164A1 (en) | 2009-09-23 | 2011-03-31 | Medivation Technologies, Inc. | Bridged heterocyclic compounds and methods of use |
| US9040519B2 (en) | 2010-02-18 | 2015-05-26 | Medivation Technologies, Inc. | Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use |
| WO2011103460A1 (en) | 2010-02-18 | 2011-08-25 | Medivation Technologies, Inc. | Fused tetracyclic pyrido[4,3-b]indole and pyrido[3,4-b]ondole derivatives and methods of use |
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| AU2012254158B2 (en) | 2011-02-18 | 2016-02-04 | Medivation Technologies, Inc. | Compounds and methods of treating diabetes |
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| US9199985B2 (en) | 2011-02-18 | 2015-12-01 | Medivation Technologies, Inc. | Compounds and methods for treatment of hypertension |
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| EP3704271A4 (en) * | 2017-11-02 | 2021-09-08 | California Institute of Technology | NEUROKININ ANTAGONISTS AND RELATED USES |
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| WO2014031170A1 (en) | 2012-08-22 | 2014-02-27 | Medivation Technologies, Inc. | Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use |
| EP2925129A4 (en) | 2012-08-24 | 2016-06-08 | Univ Texas | PRO-NEUROGENIC COMPOUNDS |
| US9422267B2 (en) | 2012-12-26 | 2016-08-23 | Medivation Technologies, Inc. | Fused pyrimidine compounds and use thereof |
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2010
- 2010-09-23 JP JP2012531042A patent/JP5779183B2/ja not_active Expired - Fee Related
- 2010-09-23 BR BR112012006640A patent/BR112012006640A2/pt not_active IP Right Cessation
- 2010-09-23 AU AU2010298166A patent/AU2010298166B2/en not_active Ceased
- 2010-09-23 WO PCT/US2010/050078 patent/WO2011038161A1/en active Application Filing
- 2010-09-23 CA CA2775328A patent/CA2775328A1/en not_active Abandoned
- 2010-09-23 EP EP10819490A patent/EP2480078A4/en not_active Withdrawn
- 2010-09-23 CN CN201080052847.4A patent/CN102711468B/zh not_active Expired - Fee Related
- 2010-09-23 US US12/889,338 patent/US8859561B2/en not_active Expired - Fee Related
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2013
- 2013-03-08 US US13/791,874 patent/US9199996B2/en not_active Expired - Fee Related
- 2013-03-08 US US13/791,570 patent/US20130184303A1/en not_active Abandoned
- 2013-03-08 US US13/791,871 patent/US9045482B2/en not_active Expired - Fee Related
- 2013-04-02 HK HK13104012.1A patent/HK1176811A1/xx not_active IP Right Cessation
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2014
- 2014-09-12 US US14/485,238 patent/US9580425B2/en not_active Expired - Fee Related
