JP2013505252A - 三環式タンパク質キナーゼ調節剤 - Google Patents
三環式タンパク質キナーゼ調節剤 Download PDFInfo
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Classifications
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- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
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- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Enzymes And Modification Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24310409P | 2009-09-16 | 2009-09-16 | |
| US61/243,104 | 2009-09-16 | ||
| PCT/US2010/049113 WO2011035019A1 (en) | 2009-09-16 | 2010-09-16 | Novel tricyclic protein kinase modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2013505252A true JP2013505252A (ja) | 2013-02-14 |
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| JP2012529900A Pending JP2013505252A (ja) | 2009-09-16 | 2010-09-16 | 三環式タンパク質キナーゼ調節剤 |
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Cited By (2)
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| JP2023520883A (ja) * | 2020-03-30 | 2023-05-22 | センホア・バイオサイエンシーズ・インコーポレイテッド | Ｒｎａウイルス感染症、特にｃｏｖｉｄ－１９を処置するための抗ウイルス化合物および方法 |
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| EA201891620A1 (ru) | 2016-02-05 | 2019-02-28 | Денали Терапьютикс Инк. | Ингибиторы взаимодействующей с рецептором протеинкиназы 1 |
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| EP3552017B1 (en) | 2016-12-09 | 2022-02-23 | Denali Therapeutics Inc. | Compounds useful as ripk1 inhibitors |
| EP3634370A4 (en) | 2017-06-06 | 2021-03-03 | Verrica Pharmaceuticals, Inc. | Treatment of cutaneous disorders |
| MX2019014908A (es) | 2017-06-15 | 2020-02-13 | Verrica Pharmaceuticals Inc | Dispositivos y metodos para el tratamiento de trastornos de la superficie corporal. |
| US11932606B2 (en) | 2017-07-31 | 2024-03-19 | The Regents Of The University Of California | Anti-cancer/anti-fibrosis compounds |
| IL273784B2 (en) | 2017-10-04 | 2024-02-01 | Verrica Pharmaceuticals Inc | Synthesis of cantharidin |
| CN109761902B (zh) * | 2017-11-09 | 2022-06-10 | 四川大学 | 6-菲啶酮衍生物及其制备方法和用途 |
| AR113922A1 (es) | 2017-12-08 | 2020-07-01 | Incyte Corp | Terapia de combinación de dosis baja para el tratamiento de neoplasias mieloproliferativas |
| US11071727B2 (en) | 2018-01-26 | 2021-07-27 | Northwestern University | Therapeutic targeting of proteolytic cleavage of the mixed lineage leukemia gene product (MLL1) by taspase1 using kinase inhibitors |
| EP3866804A4 (en) | 2018-10-19 | 2022-08-03 | Senhwa Biosciences, Inc. | Combinations for immune-modulation in cancer treatment |
| CN109369528B (zh) * | 2018-11-26 | 2022-03-04 | 天津医科大学 | 三氟甲基取代环戊酮并喹啉化合物及药学上可接受的盐、其制备方法及应用 |
| EP4146205A4 (en) | 2020-05-05 | 2024-05-29 | Nuvalent, Inc. | HETEROAROMATIC MACROCYCLIC ETHERS AS CHEMOTHERAPEUTIC AGENTS |
| PE20230608A1 (es) | 2020-05-05 | 2023-04-13 | Nuvalent Inc | Quimioterapicos de eter macrociclico heteroaromatico |
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| CN118234725A (zh) | 2021-10-01 | 2024-06-21 | 纽威伦特公司 | 杂芳族大环醚化合物的固体形式、药物组合物及制备 |
| KR20240132504A (ko) | 2022-01-12 | 2024-09-03 | 데날리 테라퓨틱스 인크. | (s)-5-벤질-n-(5-메틸-4-옥소-2,3,4,5-테트라하이드로피리도 [3,2-b][1,4]옥사제핀-3-일)-4h-1,2,4-트리아졸-3-카복사미드의 결정질 형태 |
| HUE072274T2 (hu) | 2022-04-28 | 2025-11-28 | Xinthera Inc | Triciklusos PARP1 inhibitorok és alkalmazásaik |
| CN115819436B (zh) * | 2022-11-03 | 2023-09-05 | 淮阴师范学院 | 喹啉并环丁砜衍生物的制备方法 |
| CN116947879B (zh) * | 2023-07-25 | 2025-10-31 | 沈阳药科大学 | 一种bbi608类衍生物及其制备方法和在制备治疗stat3介导疾病的药物中的应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005028624A2 (en) * | 2003-09-15 | 2005-03-31 | Plexxikon, Inc. | Molecular scaffolds for kinase ligand development |
| CA2974246C (en) * | 2006-09-01 | 2020-02-25 | Senhwa Biosciences, Inc. | Tricyclic heteroaryl compounds and their use as protein modulators |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017018060A1 (ja) * | 2015-07-27 | 2017-02-02 | 味の素株式会社 | システイン誘導体及びシステインスルホキシド誘導体の製造方法 |
| JPWO2017018060A1 (ja) * | 2015-07-27 | 2018-05-24 | 味の素株式会社 | システイン誘導体及びシステインスルホキシド誘導体の製造方法 |
| JP2023520883A (ja) * | 2020-03-30 | 2023-05-22 | センホア・バイオサイエンシーズ・インコーポレイテッド | Ｒｎａウイルス感染症、特にｃｏｖｉｄ－１９を処置するための抗ウイルス化合物および方法 |
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| IN2012DN03217A (cg-RX-API-DMAC7.html) | 2015-10-23 |
| KR20120104180A (ko) | 2012-09-20 |
| CA2774266A1 (en) | 2011-03-24 |
| SG179163A1 (en) | 2012-05-30 |
| IL218631A0 (en) | 2012-05-31 |
| EP2477493A1 (en) | 2012-07-25 |
| WO2011035019A1 (en) | 2011-03-24 |
| AU2010295619A1 (en) | 2012-05-10 |
| MX2012003322A (es) | 2012-07-23 |
| CN102647904A (zh) | 2012-08-22 |
| BR112012005970A2 (pt) | 2015-09-08 |
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