JP2013504599A - ランゲルハンス細胞に向けられたワクチン - Google Patents

Info

Publication number

JP2013504599A

JP2013504599A JP2012528993A JP2012528993A JP2013504599A JP 2013504599 A JP2013504599 A JP 2013504599A JP 2012528993 A JP2012528993 A JP 2012528993A JP 2012528993 A JP2012528993 A JP 2012528993A JP 2013504599 A JP2013504599 A JP 2013504599A

Authority

JP

Japan

Prior art keywords

seq

cancer

antigen

langerin

antibody

Prior art date

2009-09-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 229960005486 vaccine Drugs 0.000 title claims abstract description 69
• 210000001821 langerhans cell Anatomy 0.000 title description 29
• 239000000427 antigen Substances 0.000 claims abstract description 314
• 108091007433 antigens Proteins 0.000 claims abstract description 314
• 102000036639 antigens Human genes 0.000 claims abstract description 314
• 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 148
• 238000009739 binding Methods 0.000 claims abstract description 135
• 230000027455 binding Effects 0.000 claims abstract description 134
• 239000012634 fragment Substances 0.000 claims abstract description 99
• 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 74
• 238000000034 method Methods 0.000 claims abstract description 71
• 230000000890 antigenic effect Effects 0.000 claims abstract description 52
• 239000013598 vector Substances 0.000 claims abstract description 31
• 230000014509 gene expression Effects 0.000 claims abstract description 29
• 230000013595 glycosylation Effects 0.000 claims abstract description 15
• 238000006206 glycosylation reaction Methods 0.000 claims abstract description 15
• 210000004899 c-terminal region Anatomy 0.000 claims abstract description 14
• 206010028980 Neoplasm Diseases 0.000 claims description 80
• 150000007523 nucleic acids Chemical group 0.000 claims description 80
• 210000004027 cell Anatomy 0.000 claims description 77
• 108090000623 proteins and genes Proteins 0.000 claims description 77
• 210000001744 T-lymphocyte Anatomy 0.000 claims description 64
• 102000004169 proteins and genes Human genes 0.000 claims description 57
• 108091028043 Nucleic acid sequence Proteins 0.000 claims description 55
• 108020001507 fusion proteins Proteins 0.000 claims description 52
• 102000037865 fusion proteins Human genes 0.000 claims description 51
• 239000000203 mixture Substances 0.000 claims description 46
• 201000001441 melanoma Diseases 0.000 claims description 43
• 201000011510 cancer Diseases 0.000 claims description 38
• 102000007066 Prostate-Specific Antigen Human genes 0.000 claims description 35
• 108010072866 Prostate-Specific Antigen Proteins 0.000 claims description 35
• 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims description 32
• 210000003719 b-lymphocyte Anatomy 0.000 claims description 28
• 102000039446 nucleic acids Human genes 0.000 claims description 25
• 108020004707 nucleic acids Proteins 0.000 claims description 25
• 230000002163 immunogen Effects 0.000 claims description 20
• 210000002307 prostate Anatomy 0.000 claims description 18
• 101710205625 Capsid protein p24 Proteins 0.000 claims description 17
• 108010063954 Mucins Proteins 0.000 claims description 17
• 101710177166 Phosphoprotein Proteins 0.000 claims description 17
• 101710149279 Small delta antigen Proteins 0.000 claims description 17
• 230000003612 virological effect Effects 0.000 claims description 17
• 241000700605 Viruses Species 0.000 claims description 16
• 208000032839 leukemia Diseases 0.000 claims description 16
• 241000701806 Human papillomavirus Species 0.000 claims description 15
• 102100022430 Melanocyte protein PMEL Human genes 0.000 claims description 15
• 108700025647 major vault Proteins 0.000 claims description 15
• 102100035526 B melanoma antigen 1 Human genes 0.000 claims description 14
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 14
• 102000004127 Cytokines Human genes 0.000 claims description 14
• 108090000695 Cytokines Proteins 0.000 claims description 14
• 108010008655 Epstein-Barr Virus Nuclear Antigens Proteins 0.000 claims description 14
• 101000874316 Homo sapiens B melanoma antigen 1 Proteins 0.000 claims description 14
• 101710154606 Hemagglutinin Proteins 0.000 claims description 12
• 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims description 12
• 101710093908 Outer capsid protein VP4 Proteins 0.000 claims description 12
• 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims description 12
• 101710176177 Protein A56 Proteins 0.000 claims description 12
• 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims description 12
• 239000000185 hemagglutinin Substances 0.000 claims description 12
• 238000000338 in vitro Methods 0.000 claims description 12
• 238000002255 vaccination Methods 0.000 claims description 12
• 206010060862 Prostate cancer Diseases 0.000 claims description 11
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 11
• 208000020816 lung neoplasm Diseases 0.000 claims description 11
• 208000037797 influenza A Diseases 0.000 claims description 10
• 210000002966 serum Anatomy 0.000 claims description 9
• 206010069767 H1N1 influenza Diseases 0.000 claims description 8
• 208000017604 Hodgkin disease Diseases 0.000 claims description 8
• 208000010747 Hodgkins lymphoma Diseases 0.000 claims description 8
• 206010035226 Plasma cell myeloma Diseases 0.000 claims description 8
• 101800001271 Surface protein Proteins 0.000 claims description 8
• 239000002671 adjuvant Substances 0.000 claims description 8
• 230000016396 cytokine production Effects 0.000 claims description 8
• 210000003734 kidney Anatomy 0.000 claims description 8
• 210000004072 lung Anatomy 0.000 claims description 8
• 201000010740 swine influenza Diseases 0.000 claims description 8
• FFILOTSTFMXQJC-QCFYAKGBSA-N (2r,4r,5s,6s)-2-[3-[(2s,3s,4r,6s)-6-[(2s,3r,4r,5s,6r)-5-[(2s,3r,4r,5r,6r)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-[(2r,3s,4r,5r,6r)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(e)-3-hydroxy-2-(octadecanoylamino)octadec-4-enoxy]oxan-3-yl]oxy-3-hy Chemical compound O[C@@H]1[C@@H](O)[C@H](OCC(NC(=O)CCCCCCCCCCCCCCCCC)C(O)\C=C\CCCCCCCCCCCCC)O[C@H](CO)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@]2(O[C@@H]([C@@H](N)[C@H](O)C2)C(O)C(O)CO[C@]2(O[C@@H]([C@@H](N)[C@H](O)C2)C(O)C(O)CO)C(O)=O)C(O)=O)[C@@H](O[C@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](CO)O1 FFILOTSTFMXQJC-QCFYAKGBSA-N 0.000 claims description 7
• 102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 claims description 7
• 206010003571 Astrocytoma Diseases 0.000 claims description 7
• 108060000903 Beta-catenin Proteins 0.000 claims description 7
• 102000015735 Beta-catenin Human genes 0.000 claims description 7
• 206010006187 Breast cancer Diseases 0.000 claims description 7
• 208000026310 Breast neoplasm Diseases 0.000 claims description 7
• 206010008342 Cervix carcinoma Diseases 0.000 claims description 7
• 206010009944 Colon cancer Diseases 0.000 claims description 7
• 108010060385 Cyclin B1 Proteins 0.000 claims description 7
• 208000002699 Digestive System Neoplasms Diseases 0.000 claims description 7
• 101000971171 Homo sapiens Apoptosis regulator Bcl-2 Proteins 0.000 claims description 7
• 101000620359 Homo sapiens Melanocyte protein PMEL Proteins 0.000 claims description 7
• 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims description 7
• 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims description 7
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 7
• 206010025323 Lymphomas Diseases 0.000 claims description 7
• 208000032271 Malignant tumor of penis Diseases 0.000 claims description 7
• 108010008707 Mucin-1 Proteins 0.000 claims description 7
• 102100034256 Mucin-1 Human genes 0.000 claims description 7
• 208000034578 Multiple myelomas Diseases 0.000 claims description 7
• 206010033128 Ovarian cancer Diseases 0.000 claims description 7
• 206010061535 Ovarian neoplasm Diseases 0.000 claims description 7
• 108060006580 PRAME Proteins 0.000 claims description 7
• 102000036673 PRAME Human genes 0.000 claims description 7
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 7
• 208000002471 Penile Neoplasms Diseases 0.000 claims description 7
• 206010034299 Penile cancer Diseases 0.000 claims description 7
• 208000005718 Stomach Neoplasms Diseases 0.000 claims description 7
• 208000024313 Testicular Neoplasms Diseases 0.000 claims description 7
• 206010057644 Testis cancer Diseases 0.000 claims description 7
• 208000024770 Thyroid neoplasm Diseases 0.000 claims description 7
• 102000003425 Tyrosinase Human genes 0.000 claims description 7
• 108060008724 Tyrosinase Proteins 0.000 claims description 7
• 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 7
• 208000002495 Uterine Neoplasms Diseases 0.000 claims description 7
• 239000002253 acid Substances 0.000 claims description 7
• 210000003445 biliary tract Anatomy 0.000 claims description 7
• 210000004556 brain Anatomy 0.000 claims description 7
• 201000010881 cervical cancer Diseases 0.000 claims description 7
• 208000029742 colonic neoplasm Diseases 0.000 claims description 7
• GIVLTTJNORAZON-HDBOBKCLSA-N ganglioside GM2 (18:0) Chemical compound O[C@@H]1[C@@H](O)[C@H](OC[C@H](NC(=O)CCCCCCCCCCCCCCCCC)[C@H](O)\C=C\CCCCCCCCCCCCC)O[C@H](CO)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@]2(O[C@H]([C@H](NC(C)=O)[C@@H](O)C2)[C@H](O)[C@H](O)CO)C(O)=O)[C@@H](O[C@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](CO)O1 GIVLTTJNORAZON-HDBOBKCLSA-N 0.000 claims description 7
• 206010017758 gastric cancer Diseases 0.000 claims description 7
• 208000005017 glioblastoma Diseases 0.000 claims description 7
• 208000014829 head and neck neoplasm Diseases 0.000 claims description 7
• 210000000867 larynx Anatomy 0.000 claims description 7
• 201000007270 liver cancer Diseases 0.000 claims description 7
• 208000014018 liver neoplasm Diseases 0.000 claims description 7
• 201000005202 lung cancer Diseases 0.000 claims description 7
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 7
• 210000000653 nervous system Anatomy 0.000 claims description 7
• 208000014500 neuronal tumor Diseases 0.000 claims description 7
• 208000008443 pancreatic carcinoma Diseases 0.000 claims description 7
• 201000011549 stomach cancer Diseases 0.000 claims description 7
• 201000003120 testicular cancer Diseases 0.000 claims description 7
• 201000002510 thyroid cancer Diseases 0.000 claims description 7
• 206010046766 uterine cancer Diseases 0.000 claims description 7
• 206010046885 vaginal cancer Diseases 0.000 claims description 7
• 208000013139 vaginal neoplasm Diseases 0.000 claims description 7
• 108090000259 Cyclin D Proteins 0.000 claims description 6
• 102000003910 Cyclin D Human genes 0.000 claims description 6
• 108010002350 Interleukin-2 Proteins 0.000 claims description 6
• 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims description 6
• 238000003306 harvesting Methods 0.000 claims description 6
• 201000010536 head and neck cancer Diseases 0.000 claims description 6
• 210000003932 urinary bladder Anatomy 0.000 claims description 6
• 101150029707 ERBB2 gene Proteins 0.000 claims description 5
• 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims description 5
• 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims description 5
• 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 claims description 5
• 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 claims description 5
• 208000002979 Influenza in Birds Diseases 0.000 claims description 5
• 102100034263 Mucin-2 Human genes 0.000 claims description 5
• 108010008705 Mucin-2 Proteins 0.000 claims description 5
• 241000193448 Ruminiclostridium thermocellum Species 0.000 claims description 5
• 206010064097 avian influenza Diseases 0.000 claims description 5
• 230000036755 cellular response Effects 0.000 claims description 5
• 210000003527 eukaryotic cell Anatomy 0.000 claims description 5
• 230000003053 immunization Effects 0.000 claims description 5
• 208000015181 infectious disease Diseases 0.000 claims description 5
• 108010061181 influenza matrix peptide (58-66) Proteins 0.000 claims description 5
• 229940021747 therapeutic vaccine Drugs 0.000 claims description 5
• 208000018084 Bone neoplasm Diseases 0.000 claims description 4
• 230000001093 anti-cancer Effects 0.000 claims description 4
• 210000000232 gallbladder Anatomy 0.000 claims description 4
• 108010072094 gp100(280-288) melanoma antigen peptide Proteins 0.000 claims description 4
• 210000000088 lip Anatomy 0.000 claims description 4
• 210000000214 mouth Anatomy 0.000 claims description 4
• 210000001989 nasopharynx Anatomy 0.000 claims description 4
• 201000002528 pancreatic cancer Diseases 0.000 claims description 4
• 239000008194 pharmaceutical composition Substances 0.000 claims description 4
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 4
• 210000003800 pharynx Anatomy 0.000 claims description 4
• 210000000664 rectum Anatomy 0.000 claims description 4
• 208000020416 vascular bone neoplasm Diseases 0.000 claims description 4
• 201000011531 vascular cancer Diseases 0.000 claims description 4
• 208000036142 Viral infection Diseases 0.000 claims description 3
• 230000002708 enhancing effect Effects 0.000 claims description 3
• 239000012678 infectious agent Substances 0.000 claims description 3
• 230000002062 proliferating effect Effects 0.000 claims description 3
• 230000009385 viral infection Effects 0.000 claims description 3
• 208000035473 Communicable disease Diseases 0.000 claims description 2
• 229960005475 antiinfective agent Drugs 0.000 claims description 2
• 239000004599 antimicrobial Substances 0.000 claims description 2
• 229940124531 pharmaceutical excipient Drugs 0.000 claims description 2
• 125000003275 alpha amino acid group Chemical group 0.000 claims 24
• 102000008178 Cyclin B1 Human genes 0.000 claims 3
• 210000003238 esophagus Anatomy 0.000 claims 3
• 238000004519 manufacturing process Methods 0.000 abstract description 6
• 150000001413 amino acids Chemical group 0.000 description 86
• 210000004443 dendritic cell Anatomy 0.000 description 84
• 101710183165 C-type lectin domain family 4 member K Proteins 0.000 description 73
• 102100028681 C-type lectin domain family 4 member K Human genes 0.000 description 73
• 241000282414 Homo sapiens Species 0.000 description 65
• 235000018102 proteins Nutrition 0.000 description 56
• 108020004414 DNA Proteins 0.000 description 29
• 235000001014 amino acid Nutrition 0.000 description 29
• 229940024606 amino acid Drugs 0.000 description 29
• 230000028993 immune response Effects 0.000 description 28
• 241000699666 Mus <mouse, genus> Species 0.000 description 26
• 230000001580 bacterial effect Effects 0.000 description 26
• 229920001184 polypeptide Polymers 0.000 description 22
• 108020004705 Codon Proteins 0.000 description 19
• 210000000612 antigen-presenting cell Anatomy 0.000 description 19
• 241000725303 Human immunodeficiency virus Species 0.000 description 18
• 108700018351 Major Histocompatibility Complex Proteins 0.000 description 18
• 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 description 16
• 239000012636 effector Substances 0.000 description 16
• 102000040430 polynucleotide Human genes 0.000 description 16
• 108091033319 polynucleotide Proteins 0.000 description 16
• 239000002157 polynucleotide Substances 0.000 description 16
• 230000004044 response Effects 0.000 description 16
• 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 description 16
• 102100022563 Tubulin polymerization-promoting protein Human genes 0.000 description 15
• 229940127121 immunoconjugate Drugs 0.000 description 15
• 239000013604 expression vector Substances 0.000 description 14
• 239000002773 nucleotide Substances 0.000 description 14
• 241001465754 Metazoa Species 0.000 description 12
• 238000003556 assay Methods 0.000 description 12
• 230000004069 differentiation Effects 0.000 description 12
• 206010022000 influenza Diseases 0.000 description 12
• 108091026890 Coding region Proteins 0.000 description 11
• 241000282412 Homo Species 0.000 description 11
• 102000015728 Mucins Human genes 0.000 description 11
• 239000011324 bead Substances 0.000 description 11
• 238000001727 in vivo Methods 0.000 description 11
• 210000001616 monocyte Anatomy 0.000 description 11
• 125000003729 nucleotide group Chemical group 0.000 description 11
• 239000000047 product Substances 0.000 description 11
• 102000004190 Enzymes Human genes 0.000 description 10
• 108090000790 Enzymes Proteins 0.000 description 10
• 108091007491 NSP3 Papain-like protease domains Proteins 0.000 description 10
• 210000003491 skin Anatomy 0.000 description 10
• 239000000126 substance Substances 0.000 description 10
• 230000001225 therapeutic effect Effects 0.000 description 10
• 108060003951 Immunoglobulin Proteins 0.000 description 9
• 239000003795 chemical substances by application Substances 0.000 description 9
• 230000000694 effects Effects 0.000 description 9
• 230000002538 fungal effect Effects 0.000 description 9
• 102000018358 immunoglobulin Human genes 0.000 description 9
• 208000023275 Autoimmune disease Diseases 0.000 description 8
• 230000005867 T cell response Effects 0.000 description 8
• 239000002299 complementary DNA Substances 0.000 description 8
• 201000010099 disease Diseases 0.000 description 8
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
• 210000004408 hybridoma Anatomy 0.000 description 8
• 102000005962 receptors Human genes 0.000 description 8
• 108020003175 receptors Proteins 0.000 description 8
• 102000013463 Immunoglobulin Light Chains Human genes 0.000 description 7
• 108010065825 Immunoglobulin Light Chains Proteins 0.000 description 7
• 108091008874 T cell receptors Proteins 0.000 description 7
• 102000016266 T-Cell Antigen Receptors Human genes 0.000 description 7
• 210000004369 blood Anatomy 0.000 description 7
• 239000008280 blood Substances 0.000 description 7
• 239000003153 chemical reaction reagent Substances 0.000 description 7
• -1 chimeric antibodies Proteins 0.000 description 7
• 230000002500 effect on skin Effects 0.000 description 7
• 238000009472 formulation Methods 0.000 description 7
• 210000002865 immune cell Anatomy 0.000 description 7
• 230000036039 immunity Effects 0.000 description 7
• 239000007924 injection Substances 0.000 description 7
• 238000002347 injection Methods 0.000 description 7
• 239000000463 material Substances 0.000 description 7
• 230000037361 pathway Effects 0.000 description 7
• 239000000243 solution Substances 0.000 description 7
• 230000008685 targeting Effects 0.000 description 7
• 210000001519 tissue Anatomy 0.000 description 7
• 241000712461 unidentified influenza virus Species 0.000 description 7
• 210000000605 viral structure Anatomy 0.000 description 7
• 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 description 6
• 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 description 6
• 241000282560 Macaca mulatta Species 0.000 description 6
• 108091036414 Polyinosinic:polycytidylic acid Proteins 0.000 description 6
• 241000725643 Respiratory syncytial virus Species 0.000 description 6
• 230000037396 body weight Effects 0.000 description 6
• 150000001875 compounds Chemical class 0.000 description 6
• 230000003389 potentiating effect Effects 0.000 description 6
• 238000011282 treatment Methods 0.000 description 6
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
• 108091032973 (ribonucleotides)n+m Proteins 0.000 description 5
• 102000053602 DNA Human genes 0.000 description 5
• 101000766965 Homo sapiens C-type lectin domain family 4 member K Proteins 0.000 description 5
• 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 description 5
• 102000006992 Interferon-alpha Human genes 0.000 description 5
• 108010047761 Interferon-alpha Proteins 0.000 description 5
• 102000043129 MHC class I family Human genes 0.000 description 5
• 108091054437 MHC class I family Proteins 0.000 description 5
• 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 description 5
• 239000002202 Polyethylene glycol Substances 0.000 description 5
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
• 230000004913 activation Effects 0.000 description 5
• 230000030741 antigen processing and presentation Effects 0.000 description 5
• 239000002158 endotoxin Substances 0.000 description 5
• 102000045167 human CD207 Human genes 0.000 description 5
• 229920006008 lipopolysaccharide Polymers 0.000 description 5
• 210000004698 lymphocyte Anatomy 0.000 description 5
• 210000004962 mammalian cell Anatomy 0.000 description 5
• 238000012737 microarray-based gene expression Methods 0.000 description 5
• 238000012243 multiplex automated genomic engineering Methods 0.000 description 5
• 244000052769 pathogen Species 0.000 description 5
• 229920001223 polyethylene glycol Polymers 0.000 description 5
• 229920000642 polymer Polymers 0.000 description 5
• 230000008569 process Effects 0.000 description 5
• 108010029697 CD40 Ligand Proteins 0.000 description 4
• 102100032937 CD40 ligand Human genes 0.000 description 4
• 238000002965 ELISA Methods 0.000 description 4
• 102100032340 G2/mitotic-specific cyclin-B1 Human genes 0.000 description 4
• 208000022072 Gallbladder Neoplasms Diseases 0.000 description 4
• 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 4
• 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 4
• 241000700721 Hepatitis B virus Species 0.000 description 4
• 108010065805 Interleukin-12 Proteins 0.000 description 4
• 102000000588 Interleukin-2 Human genes 0.000 description 4
• 241000710842 Japanese encephalitis virus Species 0.000 description 4
• 102000043131 MHC class II family Human genes 0.000 description 4
• 108091054438 MHC class II family Proteins 0.000 description 4
• 241000700159 Rattus Species 0.000 description 4
• 102100040247 Tumor necrosis factor Human genes 0.000 description 4
• 230000014102 antigen processing and presentation of exogenous peptide antigen via MHC class I Effects 0.000 description 4
• 208000020790 biliary tract neoplasm Diseases 0.000 description 4
• 210000000621 bronchi Anatomy 0.000 description 4
• 229940030156 cell vaccine Drugs 0.000 description 4
• 238000010367 cloning Methods 0.000 description 4
• 238000013270 controlled release Methods 0.000 description 4
• 239000003814 drug Substances 0.000 description 4
• 230000002255 enzymatic effect Effects 0.000 description 4
• 201000007487 gallbladder carcinoma Diseases 0.000 description 4
• 150000004676 glycans Chemical class 0.000 description 4
• 206010023841 laryngeal neoplasm Diseases 0.000 description 4
• 230000000670 limiting effect Effects 0.000 description 4
• 210000002540 macrophage Anatomy 0.000 description 4
• 230000007246 mechanism Effects 0.000 description 4
• 230000001404 mediated effect Effects 0.000 description 4
• 239000011859 microparticle Substances 0.000 description 4
• 230000004048 modification Effects 0.000 description 4
• 238000012986 modification Methods 0.000 description 4
• 229920001282 polysaccharide Polymers 0.000 description 4
• 239000005017 polysaccharide Substances 0.000 description 4
• 238000013207 serial dilution Methods 0.000 description 4
• 239000011780 sodium chloride Substances 0.000 description 4
• 235000002639 sodium chloride Nutrition 0.000 description 4
• 238000010561 standard procedure Methods 0.000 description 4
• 102100038222 60 kDa heat shock protein, mitochondrial Human genes 0.000 description 3
• 241000193738 Bacillus anthracis Species 0.000 description 3
• 241000282693 Cercopithecidae Species 0.000 description 3
• 102100035359 Cerebellar degeneration-related protein 2-like Human genes 0.000 description 3
• 108010058432 Chaperonin 60 Proteins 0.000 description 3
• 241000699800 Cricetinae Species 0.000 description 3
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
• 241000606768 Haemophilus influenzae Species 0.000 description 3
• 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 description 3
• 241000711549 Hepacivirus C Species 0.000 description 3
• 101000737792 Homo sapiens Cerebellar degeneration-related protein 2-like Proteins 0.000 description 3
• 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 description 3
• 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 description 3
• 241000701085 Human alphaherpesvirus 3 Species 0.000 description 3
• 206010020751 Hypersensitivity Diseases 0.000 description 3
• 102000004388 Interleukin-4 Human genes 0.000 description 3
• 108090000978 Interleukin-4 Proteins 0.000 description 3
• 241000712079 Measles morbillivirus Species 0.000 description 3
• 239000004698 Polyethylene Substances 0.000 description 3
• 206010037742 Rabies Diseases 0.000 description 3
• 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 description 3
• 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 3
• 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 3
• 241000606701 Rickettsia Species 0.000 description 3
• 241000702670 Rotavirus Species 0.000 description 3
• 241000710799 Rubella virus Species 0.000 description 3
• 241000700584 Simplexvirus Species 0.000 description 3
• 108060008682 Tumor Necrosis Factor Proteins 0.000 description 3
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 3
• 108010067390 Viral Proteins Proteins 0.000 description 3
• 239000004480 active ingredient Substances 0.000 description 3
• 230000004721 adaptive immunity Effects 0.000 description 3
• 230000007815 allergy Effects 0.000 description 3
• 239000008365 aqueous carrier Substances 0.000 description 3
• 239000012472 biological sample Substances 0.000 description 3
• 229910052799 carbon Inorganic materials 0.000 description 3
• 229940079593 drug Drugs 0.000 description 3
• 239000003937 drug carrier Substances 0.000 description 3
• 239000003623 enhancer Substances 0.000 description 3
• 125000000524 functional group Chemical group 0.000 description 3
• 230000004927 fusion Effects 0.000 description 3
• 230000036541 health Effects 0.000 description 3
• 210000002443 helper t lymphocyte Anatomy 0.000 description 3
• 208000006454 hepatitis Diseases 0.000 description 3
• 231100000283 hepatitis Toxicity 0.000 description 3
• 210000000987 immune system Anatomy 0.000 description 3
• 238000002649 immunization Methods 0.000 description 3
• 230000001939 inductive effect Effects 0.000 description 3
• 238000001802 infusion Methods 0.000 description 3
• 230000015788 innate immune response Effects 0.000 description 3
• 230000003834 intracellular effect Effects 0.000 description 3
• 239000002502 liposome Substances 0.000 description 3
• 239000007788 liquid Substances 0.000 description 3
• 239000003094 microcapsule Substances 0.000 description 3
• 239000004005 microsphere Substances 0.000 description 3
• 239000002105 nanoparticle Substances 0.000 description 3
• 239000002245 particle Substances 0.000 description 3
• 210000005134 plasmacytoid dendritic cell Anatomy 0.000 description 3
• 230000037452 priming Effects 0.000 description 3
• 238000012545 processing Methods 0.000 description 3
• 230000002285 radioactive effect Effects 0.000 description 3
• 150000003384 small molecules Chemical class 0.000 description 3
• 238000010186 staining Methods 0.000 description 3
• 239000000758 substrate Substances 0.000 description 3
• 241000701161 unidentified adenovirus Species 0.000 description 3
• 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 description 2
• 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 description 2
• 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 description 2
• 101150013553 CD40 gene Proteins 0.000 description 2
• 108010009685 Cholinergic Receptors Proteins 0.000 description 2
• 241000223203 Coccidioides Species 0.000 description 2
• 201000004624 Dermatitis Diseases 0.000 description 2
• 206010012438 Dermatitis atopic Diseases 0.000 description 2
• 108010053187 Diphtheria Toxin Proteins 0.000 description 2
• 102000016607 Diphtheria Toxin Human genes 0.000 description 2
• AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 2
• 206010014596 Encephalitis Japanese B Diseases 0.000 description 2
• 238000012413 Fluorescence activated cell sorting analysis Methods 0.000 description 2
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
• 102100028972 HLA class I histocompatibility antigen, A alpha chain Human genes 0.000 description 2
• 108010075704 HLA-A Antigens Proteins 0.000 description 2
• 102000006354 HLA-DR Antigens Human genes 0.000 description 2
• 108010058597 HLA-DR Antigens Proteins 0.000 description 2
• 241000228402 Histoplasma Species 0.000 description 2
• 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 description 2
• 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 description 2
• 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 description 2
• 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 description 2
• 101000946843 Homo sapiens T-cell surface glycoprotein CD8 alpha chain Proteins 0.000 description 2
• 241000371980 Influenza B virus (B/Shanghai/361/2002) Species 0.000 description 2
• 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 description 2
• 102100037850 Interferon gamma Human genes 0.000 description 2
• 108010074328 Interferon-gamma Proteins 0.000 description 2
• 102000003812 Interleukin-15 Human genes 0.000 description 2
• 108090000172 Interleukin-15 Proteins 0.000 description 2
• 108091092195 Intron Proteins 0.000 description 2
• 201000005807 Japanese encephalitis Diseases 0.000 description 2
• 241000222722 Leishmania <genus> Species 0.000 description 2
• 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 description 2
• 101710085938 Matrix protein Proteins 0.000 description 2
• 101710127721 Membrane protein Proteins 0.000 description 2
• 241000699670 Mus sp. Species 0.000 description 2
• 125000003047 N-acetyl group Chemical group 0.000 description 2
• 108091034117 Oligonucleotide Proteins 0.000 description 2
• 102000035195 Peptidases Human genes 0.000 description 2
• 108091005804 Peptidases Proteins 0.000 description 2
• 102000007079 Peptide Fragments Human genes 0.000 description 2
• 108010033276 Peptide Fragments Proteins 0.000 description 2
• 241000709664 Picornaviridae Species 0.000 description 2
• 241000223960 Plasmodium falciparum Species 0.000 description 2
• WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
• 239000004365 Protease Substances 0.000 description 2
• 102000004245 Proteasome Endopeptidase Complex Human genes 0.000 description 2
• 108090000708 Proteasome Endopeptidase Complex Proteins 0.000 description 2
• 241000711798 Rabies lyssavirus Species 0.000 description 2
• 208000021386 Sjogren Syndrome Diseases 0.000 description 2
• 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 description 2
• MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
• 206010043376 Tetanus Diseases 0.000 description 2
• 102000011923 Thyrotropin Human genes 0.000 description 2
• 108010061174 Thyrotropin Proteins 0.000 description 2
• 241000223996 Toxoplasma Species 0.000 description 2
• 206010052779 Transplant rejections Diseases 0.000 description 2
• 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 description 2
• 241000700647 Variola virus Species 0.000 description 2
• JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 2
• 102000034337 acetylcholine receptors Human genes 0.000 description 2
• 230000003213 activating effect Effects 0.000 description 2
• 238000007792 addition Methods 0.000 description 2
• 208000026935 allergic disease Diseases 0.000 description 2
• 230000000735 allogeneic effect Effects 0.000 description 2
• 125000003277 amino group Chemical group 0.000 description 2
• 230000005875 antibody response Effects 0.000 description 2
• 206010003246 arthritis Diseases 0.000 description 2
• 208000006673 asthma Diseases 0.000 description 2
• 201000008937 atopic dermatitis Diseases 0.000 description 2
• 230000008901 benefit Effects 0.000 description 2
• 239000007975 buffered saline Substances 0.000 description 2
• 150000001720 carbohydrates Chemical class 0.000 description 2
• 235000014633 carbohydrates Nutrition 0.000 description 2
• 238000004113 cell culture Methods 0.000 description 2
• 230000024245 cell differentiation Effects 0.000 description 2
• 230000001413 cellular effect Effects 0.000 description 2
• 230000008859 change Effects 0.000 description 2
• 238000007385 chemical modification Methods 0.000 description 2
• 238000003776 cleavage reaction Methods 0.000 description 2
• 108010045512 cohesins Proteins 0.000 description 2
• 239000012228 culture supernatant Substances 0.000 description 2
• 231100000433 cytotoxic Toxicity 0.000 description 2
• 230000001472 cytotoxic effect Effects 0.000 description 2
• 238000011161 development Methods 0.000 description 2
• 230000018109 developmental process Effects 0.000 description 2
• 206010012601 diabetes mellitus Diseases 0.000 description 2
• 206010013023 diphtheria Diseases 0.000 description 2
• LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
• 235000013601 eggs Nutrition 0.000 description 2
• 239000000839 emulsion Substances 0.000 description 2
• 238000005516 engineering process Methods 0.000 description 2
• 238000003114 enzyme-linked immunosorbent spot assay Methods 0.000 description 2
• 230000034964 establishment of cell polarity Effects 0.000 description 2
• 210000004700 fetal blood Anatomy 0.000 description 2
• 239000012530 fluid Substances 0.000 description 2
• 239000007850 fluorescent dye Substances 0.000 description 2
• 230000006870 function Effects 0.000 description 2
• 230000003394 haemopoietic effect Effects 0.000 description 2
• 229940088597 hormone Drugs 0.000 description 2
• 239000005556 hormone Substances 0.000 description 2
• 230000001900 immune effect Effects 0.000 description 2
• 230000005847 immunogenicity Effects 0.000 description 2
• 229940099472 immunoglobulin a Drugs 0.000 description 2
• 238000011534 incubation Methods 0.000 description 2
• 239000004615 ingredient Substances 0.000 description 2
• 230000005764 inhibitory process Effects 0.000 description 2
• 238000003780 insertion Methods 0.000 description 2
• 230000037431 insertion Effects 0.000 description 2
• 230000019734 interleukin-12 production Effects 0.000 description 2
• 238000001990 intravenous administration Methods 0.000 description 2
• 238000002955 isolation Methods 0.000 description 2
• 206010023332 keratitis Diseases 0.000 description 2
• 201000010666 keratoconjunctivitis Diseases 0.000 description 2
• 239000003446 ligand Substances 0.000 description 2
• 150000002632 lipids Chemical class 0.000 description 2
• 238000011068 loading method Methods 0.000 description 2
• 230000007774 longterm Effects 0.000 description 2
• 230000003211 malignant effect Effects 0.000 description 2
• 230000035772 mutation Effects 0.000 description 2
• 239000002088 nanocapsule Substances 0.000 description 2
• 239000002077 nanosphere Substances 0.000 description 2
• 238000007911 parenteral administration Methods 0.000 description 2
• 230000007170 pathology Effects 0.000 description 2
• 210000005259 peripheral blood Anatomy 0.000 description 2
• 239000011886 peripheral blood Substances 0.000 description 2
• 239000002953 phosphate buffered saline Substances 0.000 description 2
• 238000003752 polymerase chain reaction Methods 0.000 description 2
• 239000002243 precursor Substances 0.000 description 2
• 210000001236 prokaryotic cell Anatomy 0.000 description 2
• 230000000069 prophylactic effect Effects 0.000 description 2
• 230000002797 proteolythic effect Effects 0.000 description 2
• 230000009467 reduction Effects 0.000 description 2
• 230000001177 retroviral effect Effects 0.000 description 2
• 239000000523 sample Substances 0.000 description 2
• 201000004409 schistosomiasis Diseases 0.000 description 2
• 230000007017 scission Effects 0.000 description 2
• 230000003248 secreting effect Effects 0.000 description 2
• 230000028327 secretion Effects 0.000 description 2
• 239000007787 solid Substances 0.000 description 2
• 230000003393 splenic effect Effects 0.000 description 2
• 210000000130 stem cell Anatomy 0.000 description 2
• 210000005127 stratified epithelium Anatomy 0.000 description 2
• 208000024891 symptom Diseases 0.000 description 2
• 201000000596 systemic lupus erythematosus Diseases 0.000 description 2
• 238000012360 testing method Methods 0.000 description 2
• MPLHNVLQVRSVEE-UHFFFAOYSA-N texas red Chemical compound [O-]S(=O)(=O)C1=CC(S(Cl)(=O)=O)=CC=C1C(C1=CC=2CCCN3CCCC(C=23)=C1O1)=C2C1=C(CCC1)C3=[N+]1CCCC3=C2 MPLHNVLQVRSVEE-UHFFFAOYSA-N 0.000 description 2
• 125000003396 thiol group Chemical group [H]S* 0.000 description 2
• 239000003053 toxin Substances 0.000 description 2
• 231100000765 toxin Toxicity 0.000 description 2
• 108700012359 toxins Proteins 0.000 description 2
• 230000009261 transgenic effect Effects 0.000 description 2
• 241001430294 unidentified retrovirus Species 0.000 description 2
• 239000000080 wetting agent Substances 0.000 description 2
• NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 description 1
• KISWVXRQTGLFGD-UHFFFAOYSA-N 2-[[2-[[6-amino-2-[[2-[[2-[[5-amino-2-[[2-[[1-[2-[[6-amino-2-[(2,5-diamino-5-oxopentanoyl)amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-(diaminomethylideneamino)p Chemical compound C1CCN(C(=O)C(CCCN=C(N)N)NC(=O)C(CCCCN)NC(=O)C(N)CCC(N)=O)C1C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(CC(C)C)C(O)=O)CC1=CC=C(O)C=C1 KISWVXRQTGLFGD-UHFFFAOYSA-N 0.000 description 1
• FWBHETKCLVMNFS-UHFFFAOYSA-N 4',6-Diamino-2-phenylindol Chemical compound C1=CC(C(=N)N)=CC=C1C1=CC2=CC=C(C(N)=N)C=C2N1 FWBHETKCLVMNFS-UHFFFAOYSA-N 0.000 description 1
• CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
• 108010088751 Albumins Proteins 0.000 description 1
• 102000009027 Albumins Human genes 0.000 description 1
• 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
• 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
• 102100035248 Alpha-(1,3)-fucosyltransferase 4 Human genes 0.000 description 1
• 208000032467 Aplastic anaemia Diseases 0.000 description 1
• 101100446590 Arabidopsis thaliana FIM5 gene Proteins 0.000 description 1
• 206010003399 Arthropod bite Diseases 0.000 description 1
• 206010003445 Ascites Diseases 0.000 description 1
• DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
• 102100022717 Atypical chemokine receptor 1 Human genes 0.000 description 1
• 208000032116 Autoimmune Experimental Encephalomyelitis Diseases 0.000 description 1
• 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 description 1
• 241000304886 Bacilli Species 0.000 description 1
• 241000894006 Bacteria Species 0.000 description 1
• 102100021663 Baculoviral IAP repeat-containing protein 5 Human genes 0.000 description 1
• 208000008439 Biliary Liver Cirrhosis Diseases 0.000 description 1
• 208000033222 Biliary cirrhosis primary Diseases 0.000 description 1
• 108010006654 Bleomycin Proteins 0.000 description 1
• 241000283690 Bos taurus Species 0.000 description 1
• 208000003174 Brain Neoplasms Diseases 0.000 description 1
• 208000014644 Brain disease Diseases 0.000 description 1
• 102100028667 C-type lectin domain family 4 member A Human genes 0.000 description 1
• 102100040840 C-type lectin domain family 7 member A Human genes 0.000 description 1
• 102100032912 CD44 antigen Human genes 0.000 description 1
• 102100035793 CD83 antigen Human genes 0.000 description 1
• UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
• 241000222120 Candida <Saccharomycetales> Species 0.000 description 1
• 241000283707 Capra Species 0.000 description 1
• BQENDLAVTKRQMS-SBBGFIFASA-L Carbenoxolone sodium Chemical compound [Na+].[Na+].C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C([O-])=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](OC(=O)CCC([O-])=O)C1(C)C BQENDLAVTKRQMS-SBBGFIFASA-L 0.000 description 1
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
• 208000017897 Carcinoma of esophagus Diseases 0.000 description 1
• 102000014914 Carrier Proteins Human genes 0.000 description 1
• 102000011727 Caspases Human genes 0.000 description 1
• 108010076667 Caspases Proteins 0.000 description 1
• 241000700199 Cavia porcellus Species 0.000 description 1
• 241000218645 Cedrus Species 0.000 description 1
• 241000242722 Cestoda Species 0.000 description 1
• 101710098119 Chaperonin GroEL 2 Proteins 0.000 description 1
• 102000019034 Chemokines Human genes 0.000 description 1
• 108010012236 Chemokines Proteins 0.000 description 1
• 241000606161 Chlamydia Species 0.000 description 1
• 208000002691 Choroiditis Diseases 0.000 description 1
• 206010008909 Chronic Hepatitis Diseases 0.000 description 1
• 241000193403 Clostridium Species 0.000 description 1
• 108700010070 Codon Usage Proteins 0.000 description 1
• 208000015943 Coeliac disease Diseases 0.000 description 1
• 206010009900 Colitis ulcerative Diseases 0.000 description 1
• 206010010741 Conjunctivitis Diseases 0.000 description 1
• 101710139375 Corneodesmosin Proteins 0.000 description 1
• 102100031673 Corneodesmosin Human genes 0.000 description 1
• 241000711573 Coronaviridae Species 0.000 description 1
• 241000557626 Corvus corax Species 0.000 description 1
• 208000011231 Crohn disease Diseases 0.000 description 1
• 241001337994 Cryptococcus <scale insect> Species 0.000 description 1
• 241000724252 Cucumber mosaic virus Species 0.000 description 1
• 241000701022 Cytomegalovirus Species 0.000 description 1
• 230000006820 DNA synthesis Effects 0.000 description 1
• 206010011891 Deafness neurosensory Diseases 0.000 description 1
• 208000001490 Dengue Diseases 0.000 description 1
• 206010012310 Dengue fever Diseases 0.000 description 1
• 229920002307 Dextran Polymers 0.000 description 1
• BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 1
• 102000003779 Dipeptidyl-peptidases and tripeptidyl-peptidases Human genes 0.000 description 1
• 108090000194 Dipeptidyl-peptidases and tripeptidyl-peptidases Proteins 0.000 description 1
• 208000019872 Drug Eruptions Diseases 0.000 description 1
• 102100023431 E3 ubiquitin-protein ligase TRIM21 Human genes 0.000 description 1
• 101710164941 E3 ubiquitin-protein ligase TRIM21 Proteins 0.000 description 1
• 238000012286 ELISA Assay Methods 0.000 description 1
• 208000032274 Encephalopathy Diseases 0.000 description 1
• 101001095863 Enterobacteria phage T4 RNA ligase 1 Proteins 0.000 description 1
• 241000991587 Enterovirus C Species 0.000 description 1
• 101710126487 Envelope glycoprotein B Proteins 0.000 description 1
• 101710204837 Envelope small membrane protein Proteins 0.000 description 1
• 206010015226 Erythema nodosum Diseases 0.000 description 1
• 241000588724 Escherichia coli Species 0.000 description 1
• 208000000461 Esophageal Neoplasms Diseases 0.000 description 1
• 241000206602 Eukaryota Species 0.000 description 1
• 101150106011 FIM2 gene Proteins 0.000 description 1
• 101150048576 FIM3 gene Proteins 0.000 description 1
• 241000282326 Felis catus Species 0.000 description 1
• 102000012673 Follicle Stimulating Hormone Human genes 0.000 description 1
• 108010079345 Follicle Stimulating Hormone Proteins 0.000 description 1
• 102100021260 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 Human genes 0.000 description 1
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
• 102000008214 Glutamate decarboxylase Human genes 0.000 description 1
• 108091022930 Glutamate decarboxylase Proteins 0.000 description 1
• WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
• 108010070675 Glutathione transferase Proteins 0.000 description 1
• 239000004471 Glycine Substances 0.000 description 1
• 229930186217 Glycolipid Natural products 0.000 description 1
• 102000003886 Glycoproteins Human genes 0.000 description 1
• 108090000288 Glycoproteins Proteins 0.000 description 1
• 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 description 1
• 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 description 1
• 206010072579 Granulomatosis with polyangiitis Diseases 0.000 description 1
• 108010043121 Green Fluorescent Proteins Proteins 0.000 description 1
• 102000004144 Green Fluorescent Proteins Human genes 0.000 description 1
• 108010051696 Growth Hormone Proteins 0.000 description 1
• HVLSXIKZNLPZJJ-TXZCQADKSA-N HA peptide Chemical compound C([C@@H](C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](C)C(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 HVLSXIKZNLPZJJ-TXZCQADKSA-N 0.000 description 1
• 208000030836 Hashimoto thyroiditis Diseases 0.000 description 1
• 241000590002 Helicobacter pylori Species 0.000 description 1
• 102100029100 Hematopoietic prostaglandin D synthase Human genes 0.000 description 1
• 206010019755 Hepatitis chronic active Diseases 0.000 description 1
• 241000709721 Hepatovirus A Species 0.000 description 1
• 208000021519 Hodgkin lymphoma Diseases 0.000 description 1
• 101001022185 Homo sapiens Alpha-(1,3)-fucosyltransferase 4 Proteins 0.000 description 1
• 101000678879 Homo sapiens Atypical chemokine receptor 1 Proteins 0.000 description 1
• 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 description 1
• 101000766908 Homo sapiens C-type lectin domain family 4 member A Proteins 0.000 description 1
• 101000868273 Homo sapiens CD44 antigen Proteins 0.000 description 1
• 101000946856 Homo sapiens CD83 antigen Proteins 0.000 description 1
• 101000894906 Homo sapiens Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 Proteins 0.000 description 1
• 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 description 1
• 101000935043 Homo sapiens Integrin beta-1 Proteins 0.000 description 1
• 101000935040 Homo sapiens Integrin beta-2 Proteins 0.000 description 1
• 101000599852 Homo sapiens Intercellular adhesion molecule 1 Proteins 0.000 description 1
• 101000853002 Homo sapiens Interleukin-25 Proteins 0.000 description 1
• 101000608935 Homo sapiens Leukosialin Proteins 0.000 description 1
• 101000972485 Homo sapiens Lupus La protein Proteins 0.000 description 1
• 101001063392 Homo sapiens Lymphocyte function-associated antigen 3 Proteins 0.000 description 1
• 101001128431 Homo sapiens Myeloid-derived growth factor Proteins 0.000 description 1
• 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 description 1
• 101000934346 Homo sapiens T-cell surface antigen CD2 Proteins 0.000 description 1
• 108010001336 Horseradish Peroxidase Proteins 0.000 description 1
• 108010084873 Human Immunodeficiency Virus nef Gene Products Proteins 0.000 description 1
• 108090000144 Human Proteins Proteins 0.000 description 1
• 102000003839 Human Proteins Human genes 0.000 description 1
• 102000008100 Human Serum Albumin Human genes 0.000 description 1
• 108091006905 Human Serum Albumin Proteins 0.000 description 1
• 241000701044 Human gammaherpesvirus 4 Species 0.000 description 1
• 241000726041 Human respirovirus 1 Species 0.000 description 1
• 241000712003 Human respirovirus 3 Species 0.000 description 1
• 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 description 1
• 108010073807 IgG Receptors Proteins 0.000 description 1
• 102000009490 IgG Receptors Human genes 0.000 description 1
• 108700005091 Immunoglobulin Genes Proteins 0.000 description 1
• 102100034349 Integrase Human genes 0.000 description 1
• 102100034353 Integrase Human genes 0.000 description 1
• 102100022338 Integrin alpha-M Human genes 0.000 description 1
• 102100025304 Integrin beta-1 Human genes 0.000 description 1
• 102100025390 Integrin beta-2 Human genes 0.000 description 1
• 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 description 1
• 102000003996 Interferon-beta Human genes 0.000 description 1
• 108090000467 Interferon-beta Proteins 0.000 description 1
• 102000014150 Interferons Human genes 0.000 description 1
• 108010050904 Interferons Proteins 0.000 description 1
• 108010002352 Interleukin-1 Proteins 0.000 description 1
• 108050003558 Interleukin-17 Proteins 0.000 description 1
• 102000013691 Interleukin-17 Human genes 0.000 description 1
• 102000010789 Interleukin-2 Receptors Human genes 0.000 description 1
• 108010038453 Interleukin-2 Receptors Proteins 0.000 description 1
• 108010002386 Interleukin-3 Proteins 0.000 description 1
• 108010002616 Interleukin-5 Proteins 0.000 description 1
• 108090001005 Interleukin-6 Proteins 0.000 description 1
• 208000029523 Interstitial Lung disease Diseases 0.000 description 1
• 208000003456 Juvenile Arthritis Diseases 0.000 description 1
• 206010059176 Juvenile idiopathic arthritis Diseases 0.000 description 1
• 208000008839 Kidney Neoplasms Diseases 0.000 description 1
• QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
• DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 1
• CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
• ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
• 108090001090 Lectins Proteins 0.000 description 1
• 102000004856 Lectins Human genes 0.000 description 1
• 241000222732 Leishmania major Species 0.000 description 1
• 206010024229 Leprosy Diseases 0.000 description 1
• 102100039564 Leukosialin Human genes 0.000 description 1
• 241000209082 Lolium Species 0.000 description 1
• 102100022742 Lupus La protein Human genes 0.000 description 1
• 102000009151 Luteinizing Hormone Human genes 0.000 description 1
• 108010073521 Luteinizing Hormone Proteins 0.000 description 1
• 208000016604 Lyme disease Diseases 0.000 description 1
• 102100033486 Lymphocyte antigen 75 Human genes 0.000 description 1
• 101710157884 Lymphocyte antigen 75 Proteins 0.000 description 1
• 102100030984 Lymphocyte function-associated antigen 3 Human genes 0.000 description 1
• 241000282553 Macaca Species 0.000 description 1
• 241000282567 Macaca fascicularis Species 0.000 description 1
• 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 description 1
• 102000007651 Macrophage Colony-Stimulating Factor Human genes 0.000 description 1
• 101710175243 Major antigen Proteins 0.000 description 1
• 241000124008 Mammalia Species 0.000 description 1
• 201000005505 Measles Diseases 0.000 description 1
• 102000018697 Membrane Proteins Human genes 0.000 description 1
• 108010052285 Membrane Proteins Proteins 0.000 description 1
• 108010057081 Merozoite Surface Protein 1 Proteins 0.000 description 1
• 101000749307 Mus musculus C-type lectin domain family 4 member K Proteins 0.000 description 1
• 241000187479 Mycobacterium tuberculosis Species 0.000 description 1
• 101000944608 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) Chaperonin GroEL 2 Proteins 0.000 description 1
• 241000204031 Mycoplasma Species 0.000 description 1
• 102000047918 Myelin Basic Human genes 0.000 description 1
• 102000055324 Myelin Proteolipid Human genes 0.000 description 1
• 101710107068 Myelin basic protein Proteins 0.000 description 1
• 101710094913 Myelin proteolipid protein Proteins 0.000 description 1
• 108091061960 Naked DNA Proteins 0.000 description 1
• 241000588652 Neisseria gonorrhoeae Species 0.000 description 1
• 241000588650 Neisseria meningitidis Species 0.000 description 1
• 241000244206 Nematoda Species 0.000 description 1
• 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 description 1
• 108010006232 Neuraminidase Proteins 0.000 description 1
• 102000005348 Neuraminidase Human genes 0.000 description 1
• 102000011931 Nucleoproteins Human genes 0.000 description 1
• 108010061100 Nucleoproteins Proteins 0.000 description 1
• 108010038807 Oligopeptides Proteins 0.000 description 1
• 102000015636 Oligopeptides Human genes 0.000 description 1
• 108700020796 Oncogene Proteins 0.000 description 1
• 102000043276 Oncogene Human genes 0.000 description 1
• 241000713112 Orthobunyavirus Species 0.000 description 1
• 241000150452 Orthohantavirus Species 0.000 description 1
• 241000283973 Oryctolagus cuniculus Species 0.000 description 1
• 229930012538 Paclitaxel Natural products 0.000 description 1
• 241000282577 Pan troglodytes Species 0.000 description 1
• 241001631646 Papillomaviridae Species 0.000 description 1
• 241001494479 Pecora Species 0.000 description 1
• 229930182555 Penicillin Natural products 0.000 description 1
• JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
• 241000009328 Perro Species 0.000 description 1
• 201000005702 Pertussis Diseases 0.000 description 1
• 108010081690 Pertussis Toxin Proteins 0.000 description 1
• 241000224016 Plasmodium Species 0.000 description 1
• 102100024616 Platelet endothelial cell adhesion molecule Human genes 0.000 description 1
• 101710183389 Pneumolysin Proteins 0.000 description 1
• RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
• 206010065159 Polychondritis Diseases 0.000 description 1
• 108010039918 Polylysine Proteins 0.000 description 1
• 239000004743 Polypropylene Substances 0.000 description 1
• 239000004793 Polystyrene Substances 0.000 description 1
• 241000605862 Porphyromonas gingivalis Species 0.000 description 1
• 208000003971 Posterior uveitis Diseases 0.000 description 1
• 208000012654 Primary biliary cholangitis Diseases 0.000 description 1
• 241000288906 Primates Species 0.000 description 1
• 206010036774 Proctitis Diseases 0.000 description 1
• 102000003946 Prolactin Human genes 0.000 description 1
• 108010057464 Prolactin Proteins 0.000 description 1
• 101710194807 Protective antigen Proteins 0.000 description 1
• 102000001253 Protein Kinase Human genes 0.000 description 1
• 101710192141 Protein Nef Proteins 0.000 description 1
• 241000125945 Protoparvovirus Species 0.000 description 1
• 101000762949 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) Exotoxin A Proteins 0.000 description 1
• 201000004681 Psoriasis Diseases 0.000 description 1
• 201000001263 Psoriatic Arthritis Diseases 0.000 description 1
• 208000036824 Psoriatic arthropathy Diseases 0.000 description 1
• 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 1
• 108020004511 Recombinant DNA Proteins 0.000 description 1
• 208000015634 Rectal Neoplasms Diseases 0.000 description 1
• 208000035415 Reinfection Diseases 0.000 description 1
• 241000702263 Reovirus sp. Species 0.000 description 1
• 101710088839 Replication initiation protein Proteins 0.000 description 1
• 108010081734 Ribonucleoproteins Proteins 0.000 description 1
• 102000004389 Ribonucleoproteins Human genes 0.000 description 1
• 108091028664 Ribonucleotide Chemical group 0.000 description 1
• 101000999689 Saimiriine herpesvirus 2 (strain 11) Transcriptional regulator ICP22 homolog Proteins 0.000 description 1
• 241000607142 Salmonella Species 0.000 description 1
• 206010039710 Scleroderma Diseases 0.000 description 1
• 208000009966 Sensorineural Hearing Loss Diseases 0.000 description 1
• 241000607768 Shigella Species 0.000 description 1
• 108010003723 Single-Domain Antibodies Proteins 0.000 description 1
• VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
• 102100038803 Somatotropin Human genes 0.000 description 1
• 101001039853 Sonchus yellow net virus Matrix protein Proteins 0.000 description 1
• 206010042033 Stevens-Johnson syndrome Diseases 0.000 description 1
• 231100000168 Stevens-Johnson syndrome Toxicity 0.000 description 1
• 241000193998 Streptococcus pneumoniae Species 0.000 description 1
• 101710137302 Surface antigen S Proteins 0.000 description 1
• 108010002687 Survivin Proteins 0.000 description 1
• 230000006044 T cell activation Effects 0.000 description 1
• 102100025237 T-cell surface antigen CD2 Human genes 0.000 description 1
• 108010055044 Tetanus Toxin Proteins 0.000 description 1
• 210000000447 Th1 cell Anatomy 0.000 description 1
• 210000004241 Th2 cell Anatomy 0.000 description 1
• 108010034949 Thyroglobulin Proteins 0.000 description 1
• 102000009843 Thyroglobulin Human genes 0.000 description 1
• 208000002474 Tinea Diseases 0.000 description 1
• 108700019146 Transgenes Proteins 0.000 description 1
• 241000893966 Trichophyton verrucosum Species 0.000 description 1
• 102000005937 Tropomyosin Human genes 0.000 description 1
• 108010030743 Tropomyosin Proteins 0.000 description 1
• 241000223104 Trypanosoma Species 0.000 description 1
• 241000223109 Trypanosoma cruzi Species 0.000 description 1
• 241001467018 Typhis Species 0.000 description 1
• 201000006704 Ulcerative Colitis Diseases 0.000 description 1
• 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 1
• 206010046914 Vaginal infection Diseases 0.000 description 1
• 201000008100 Vaginitis Diseases 0.000 description 1
• 241000607626 Vibrio cholerae Species 0.000 description 1
• 108010059722 Viral Fusion Proteins Proteins 0.000 description 1
• 241000710886 West Nile virus Species 0.000 description 1
• 208000003152 Yellow Fever Diseases 0.000 description 1
• 241000607479 Yersinia pestis Species 0.000 description 1
• 230000021736 acetylation Effects 0.000 description 1
• 238000006640 acetylation reaction Methods 0.000 description 1
• 230000002378 acidificating effect Effects 0.000 description 1
• 230000009471 action Effects 0.000 description 1
• 239000012190 activator Substances 0.000 description 1
• 239000011149 active material Substances 0.000 description 1
• 230000001154 acute effect Effects 0.000 description 1
• 102000030621 adenylate cyclase Human genes 0.000 description 1
• 108060000200 adenylate cyclase Proteins 0.000 description 1
• 239000000443 aerosol Substances 0.000 description 1
• 235000004279 alanine Nutrition 0.000 description 1
• 239000013566 allergen Substances 0.000 description 1
• 201000009961 allergic asthma Diseases 0.000 description 1
• 208000004631 alopecia areata Diseases 0.000 description 1
• 230000003321 amplification Effects 0.000 description 1
• 238000004458 analytical method Methods 0.000 description 1
• 208000002399 aphthous stomatitis Diseases 0.000 description 1
• 235000009582 asparagine Nutrition 0.000 description 1
• 229960001230 asparagine Drugs 0.000 description 1
• 235000003704 aspartic acid Nutrition 0.000 description 1
• 208000010668 atopic eczema Diseases 0.000 description 1
• 230000006472 autoimmune response Effects 0.000 description 1
• 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 description 1
• 201000004982 autoimmune uveitis Diseases 0.000 description 1
• 230000005784 autoimmunity Effects 0.000 description 1
• 230000004888 barrier function Effects 0.000 description 1
• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
• OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
• 230000002146 bilateral effect Effects 0.000 description 1
• 108091008324 binding proteins Proteins 0.000 description 1
• 238000004166 bioassay Methods 0.000 description 1
• 230000004071 biological effect Effects 0.000 description 1
• 230000008827 biological function Effects 0.000 description 1
• 230000005540 biological transmission Effects 0.000 description 1
• 238000001574 biopsy Methods 0.000 description 1
• 230000015572 biosynthetic process Effects 0.000 description 1
• 229960001561 bleomycin Drugs 0.000 description 1
• OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 description 1
• 229920001400 block copolymer Polymers 0.000 description 1
• 230000000903 blocking effect Effects 0.000 description 1
• 210000000601 blood cell Anatomy 0.000 description 1
• 230000036760 body temperature Effects 0.000 description 1
• 210000002798 bone marrow cell Anatomy 0.000 description 1
• 239000000872 buffer Substances 0.000 description 1
• 239000006172 buffering agent Substances 0.000 description 1
• 239000001110 calcium chloride Substances 0.000 description 1
• 229910001628 calcium chloride Inorganic materials 0.000 description 1
• 208000020670 canker sore Diseases 0.000 description 1
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
• 125000002843 carboxylic acid group Chemical group 0.000 description 1
• 125000002091 cationic group Chemical group 0.000 description 1
• 210000003855 cell nucleus Anatomy 0.000 description 1
• 230000007969 cellular immunity Effects 0.000 description 1
• 108091008394 cellulose binding proteins Proteins 0.000 description 1
• 238000006243 chemical reaction Methods 0.000 description 1
• 239000007795 chemical reaction product Substances 0.000 description 1
• 230000000973 chemotherapeutic effect Effects 0.000 description 1
• 210000004978 chinese hamster ovary cell Anatomy 0.000 description 1
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol group Chemical group [C@@H]1(CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)[C@H](C)CCCC(C)C HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 1
• 208000019069 chronic childhood arthritis Diseases 0.000 description 1
• 230000001684 chronic effect Effects 0.000 description 1
• 238000003501 co-culture Methods 0.000 description 1
• 230000008045 co-localization Effects 0.000 description 1
• 238000012875 competitive assay Methods 0.000 description 1
• 230000006957 competitive inhibition Effects 0.000 description 1
• 230000000295 complement effect Effects 0.000 description 1
• 239000000470 constituent Substances 0.000 description 1
• 239000000599 controlled substance Substances 0.000 description 1
• 238000007796 conventional method Methods 0.000 description 1
• 230000009260 cross reactivity Effects 0.000 description 1
• 238000012258 culturing Methods 0.000 description 1
• 208000004921 cutaneous lupus erythematosus Diseases 0.000 description 1
• 235000018417 cysteine Nutrition 0.000 description 1
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
• 210000000805 cytoplasm Anatomy 0.000 description 1
• 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 1
• 210000004544 dc2 Anatomy 0.000 description 1
• 108010025838 dectin 1 Proteins 0.000 description 1
• 230000003412 degenerative effect Effects 0.000 description 1
• 238000012217 deletion Methods 0.000 description 1
• 230000037430 deletion Effects 0.000 description 1
• 238000002716 delivery method Methods 0.000 description 1
• 239000003398 denaturant Substances 0.000 description 1
• 208000025729 dengue disease Diseases 0.000 description 1
• 239000005547 deoxyribonucleotide Substances 0.000 description 1
• 125000002637 deoxyribonucleotide group Chemical group 0.000 description 1
• 230000001419 dependent effect Effects 0.000 description 1
• 238000001212 derivatisation Methods 0.000 description 1
• 238000013461 design Methods 0.000 description 1
• 239000008121 dextrose Substances 0.000 description 1
• 238000010586 diagram Methods 0.000 description 1
• 230000029087 digestion Effects 0.000 description 1
• 239000003085 diluting agent Substances 0.000 description 1
• 238000010790 dilution Methods 0.000 description 1
• 239000012895 dilution Substances 0.000 description 1
• XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 description 1
• 229960003983 diphtheria toxoid Drugs 0.000 description 1
• 238000010494 dissociation reaction Methods 0.000 description 1
• 230000005593 dissociations Effects 0.000 description 1
• 238000009826 distribution Methods 0.000 description 1
• 229960004679 doxorubicin Drugs 0.000 description 1
• 238000012377 drug delivery Methods 0.000 description 1
• 239000000428 dust Substances 0.000 description 1
• 239000000975 dye Substances 0.000 description 1
• 239000003995 emulsifying agent Substances 0.000 description 1
• 206010014599 encephalitis Diseases 0.000 description 1
• 108010078428 env Gene Products Proteins 0.000 description 1
• 108700004025 env Genes Proteins 0.000 description 1
• 101150030339 env gene Proteins 0.000 description 1
• 210000002919 epithelial cell Anatomy 0.000 description 1
• 210000005081 epithelial layer Anatomy 0.000 description 1
• 230000017214 establishment of T cell polarity Effects 0.000 description 1
• VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 description 1
• 229960005420 etoposide Drugs 0.000 description 1
• 238000010195 expression analysis Methods 0.000 description 1
• 208000030533 eye disease Diseases 0.000 description 1
• 230000001605 fetal effect Effects 0.000 description 1
• 238000000684 flow cytometry Methods 0.000 description 1
• MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 1
• 238000001943 fluorescence-activated cell sorting Methods 0.000 description 1
• 238000001215 fluorescent labelling Methods 0.000 description 1
• 229940028334 follicle stimulating hormone Drugs 0.000 description 1
• 230000003325 follicular Effects 0.000 description 1
• 238000010230 functional analysis Methods 0.000 description 1
• 108700004026 gag Genes Proteins 0.000 description 1
• 101150098622 gag gene Proteins 0.000 description 1
• 210000004602 germ cell Anatomy 0.000 description 1
• 239000011521 glass Substances 0.000 description 1
• 235000013922 glutamic acid Nutrition 0.000 description 1
• 239000004220 glutamic acid Substances 0.000 description 1
• ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
• 235000004554 glutamine Nutrition 0.000 description 1
• PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
• 210000003714 granulocyte Anatomy 0.000 description 1
• 239000005090 green fluorescent protein Substances 0.000 description 1
• 239000000122 growth hormone Substances 0.000 description 1
• 229940047650 haemophilus influenzae Drugs 0.000 description 1
• 210000002768 hair cell Anatomy 0.000 description 1
• 210000003128 head Anatomy 0.000 description 1
• 229940037467 helicobacter pylori Drugs 0.000 description 1
• 244000000013 helminth Species 0.000 description 1
• 230000002489 hematologic effect Effects 0.000 description 1
• 210000003958 hematopoietic stem cell Anatomy 0.000 description 1
• 230000002008 hemorrhagic effect Effects 0.000 description 1
• 208000002672 hepatitis B Diseases 0.000 description 1
• 108700017737 hepatitis B virus L Proteins 0.000 description 1
• 230000005745 host immune response Effects 0.000 description 1
• 210000005260 human cell Anatomy 0.000 description 1
• 102000007579 human kallikrein-related peptidase 3 Human genes 0.000 description 1
• 108010071652 human kallikrein-related peptidase 3 Proteins 0.000 description 1
• 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
• 230000000984 immunochemical effect Effects 0.000 description 1
• 238000003125 immunofluorescent labeling Methods 0.000 description 1
• 230000016784 immunoglobulin production Effects 0.000 description 1
• 239000007943 implant Substances 0.000 description 1
• 230000006872 improvement Effects 0.000 description 1
• 239000012535 impurity Substances 0.000 description 1
• 238000011503 in vivo imaging Methods 0.000 description 1
• 230000006698 induction Effects 0.000 description 1
• 239000003978 infusion fluid Substances 0.000 description 1
• 230000000977 initiatory effect Effects 0.000 description 1
• 230000003993 interaction Effects 0.000 description 1
• 229940079322 interferon Drugs 0.000 description 1
• 229940028885 interleukin-4 Drugs 0.000 description 1
• 230000000968 intestinal effect Effects 0.000 description 1
• 150000002500 ions Chemical class 0.000 description 1
• 201000004614 iritis Diseases 0.000 description 1
• 201000002215 juvenile rheumatoid arthritis Diseases 0.000 description 1
• 238000002372 labelling Methods 0.000 description 1
• 239000004816 latex Substances 0.000 description 1
• 229920000126 latex Polymers 0.000 description 1
• 239000002523 lectin Substances 0.000 description 1
• 210000000265 leukocyte Anatomy 0.000 description 1
• 230000021633 leukocyte mediated immunity Effects 0.000 description 1
• 201000011486 lichen planus Diseases 0.000 description 1
• 239000006193 liquid solution Substances 0.000 description 1
• 239000006194 liquid suspension Substances 0.000 description 1
• 210000004185 liver Anatomy 0.000 description 1
• 238000004020 luminiscence type Methods 0.000 description 1
• 229940040129 luteinizing hormone Drugs 0.000 description 1
• 230000002132 lysosomal effect Effects 0.000 description 1
• 201000004792 malaria Diseases 0.000 description 1
• 238000002844 melting Methods 0.000 description 1
• 230000008018 melting Effects 0.000 description 1
• 108020004999 messenger RNA Proteins 0.000 description 1
• 230000001617 migratory effect Effects 0.000 description 1
• 108091005601 modified peptides Proteins 0.000 description 1
• 229940051875 mucins Drugs 0.000 description 1
• 201000006417 multiple sclerosis Diseases 0.000 description 1
• 238000002703 mutagenesis Methods 0.000 description 1
• 231100000350 mutagenesis Toxicity 0.000 description 1
• 206010028417 myasthenia gravis Diseases 0.000 description 1
• 201000000050 myeloid neoplasm Diseases 0.000 description 1
• OHDXDNUPVVYWOV-UHFFFAOYSA-N n-methyl-1-(2-naphthalen-1-ylsulfanylphenyl)methanamine Chemical compound CNCC1=CC=CC=C1SC1=CC=CC2=CC=CC=C12 OHDXDNUPVVYWOV-UHFFFAOYSA-N 0.000 description 1
• 230000002956 necrotizing effect Effects 0.000 description 1
• 210000005036 nerve Anatomy 0.000 description 1
• 210000003924 normoblast Anatomy 0.000 description 1
• 238000003199 nucleic acid amplification method Methods 0.000 description 1
• 238000011330 nucleic acid test Methods 0.000 description 1
• 210000004940 nucleus Anatomy 0.000 description 1
• 230000003287 optical effect Effects 0.000 description 1
• 210000003463 organelle Anatomy 0.000 description 1
• 239000003002 pH adjusting agent Substances 0.000 description 1
• 239000006179 pH buffering agent Substances 0.000 description 1
• 229960001592 paclitaxel Drugs 0.000 description 1
• 244000045947 parasite Species 0.000 description 1
• 230000003071 parasitic effect Effects 0.000 description 1
• 230000036961 partial effect Effects 0.000 description 1
• 229940049954 penicillin Drugs 0.000 description 1
• XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
• 230000000737 periodic effect Effects 0.000 description 1
• 108010021711 pertactin Proteins 0.000 description 1
• 230000026731 phosphorylation Effects 0.000 description 1
• 238000006366 phosphorylation reaction Methods 0.000 description 1
• 230000004962 physiological condition Effects 0.000 description 1
• 239000002504 physiological saline solution Substances 0.000 description 1
• 239000013612 plasmid Substances 0.000 description 1
• 210000004180 plasmocyte Anatomy 0.000 description 1
• 239000004033 plastic Substances 0.000 description 1
• 229920003023 plastic Polymers 0.000 description 1
• 108700004029 pol Genes Proteins 0.000 description 1
• 101150088264 pol gene Proteins 0.000 description 1
• 229920001992 poloxamer 407 Polymers 0.000 description 1
• 229940044476 poloxamer 407 Drugs 0.000 description 1
• 229920000656 polylysine Polymers 0.000 description 1
• 229920001155 polypropylene Polymers 0.000 description 1
• 229920002223 polystyrene Polymers 0.000 description 1
• 230000004481 post-translational protein modification Effects 0.000 description 1
• 239000001103 potassium chloride Substances 0.000 description 1
• 235000011164 potassium chloride Nutrition 0.000 description 1
• 238000007781 pre-processing Methods 0.000 description 1
• 238000002360 preparation method Methods 0.000 description 1
• 230000000750 progressive effect Effects 0.000 description 1
• 229940097325 prolactin Drugs 0.000 description 1
• XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 description 1
• 235000019419 proteases Nutrition 0.000 description 1
• 230000001681 protective effect Effects 0.000 description 1
• 108060006633 protein kinase Proteins 0.000 description 1
• 229940023143 protein vaccine Drugs 0.000 description 1
• 230000005180 public health Effects 0.000 description 1
• 238000012205 qualitative assay Methods 0.000 description 1
• 239000009342 ragweed pollen Substances 0.000 description 1
• 238000010188 recombinant method Methods 0.000 description 1
• 230000002829 reductive effect Effects 0.000 description 1
• 210000003289 regulatory T cell Anatomy 0.000 description 1
• 238000011160 research Methods 0.000 description 1
• 206010039073 rheumatoid arthritis Diseases 0.000 description 1
• PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
• 239000002336 ribonucleotide Chemical group 0.000 description 1
• 125000002652 ribonucleotide group Chemical group 0.000 description 1
• 201000000306 sarcoidosis Diseases 0.000 description 1
• 231100000879 sensorineural hearing loss Toxicity 0.000 description 1
• 208000023573 sensorineural hearing loss disease Diseases 0.000 description 1
• 230000035939 shock Effects 0.000 description 1
• 238000002741 site-directed mutagenesis Methods 0.000 description 1
• 239000001632 sodium acetate Substances 0.000 description 1
• 235000017281 sodium acetate Nutrition 0.000 description 1
• 239000001540 sodium lactate Substances 0.000 description 1
• 229940005581 sodium lactate Drugs 0.000 description 1
• 235000011088 sodium lactate Nutrition 0.000 description 1
• 238000001179 sorption measurement Methods 0.000 description 1
• 125000006850 spacer group Chemical group 0.000 description 1
• 230000009870 specific binding Effects 0.000 description 1
• 210000003046 sporozoite Anatomy 0.000 description 1
• 239000008227 sterile water for injection Substances 0.000 description 1
• 230000001954 sterilising effect Effects 0.000 description 1
• 238000004659 sterilization and disinfection Methods 0.000 description 1
• 150000003431 steroids Chemical class 0.000 description 1
• 230000004936 stimulating effect Effects 0.000 description 1
• 230000000638 stimulation Effects 0.000 description 1
• 229940031000 streptococcus pneumoniae Drugs 0.000 description 1
• 238000006467 substitution reaction Methods 0.000 description 1
• 238000003786 synthesis reaction Methods 0.000 description 1
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
• 229960003604 testosterone Drugs 0.000 description 1
• 229940118376 tetanus toxin Drugs 0.000 description 1
• 229960000814 tetanus toxoid Drugs 0.000 description 1
• 229960002175 thyroglobulin Drugs 0.000 description 1
• 231100000331 toxic Toxicity 0.000 description 1
• 230000002588 toxic effect Effects 0.000 description 1
• 231100000419 toxicity Toxicity 0.000 description 1
• 230000001988 toxicity Effects 0.000 description 1
• 238000013518 transcription Methods 0.000 description 1
• 230000035897 transcription Effects 0.000 description 1
• 230000032258 transport Effects 0.000 description 1
• 238000011269 treatment regimen Methods 0.000 description 1
• 231100000402 unacceptable toxicity Toxicity 0.000 description 1
• 241001529453 unidentified herpesvirus Species 0.000 description 1
• 210000003462 vein Anatomy 0.000 description 1
• 229940118696 vibrio cholerae Drugs 0.000 description 1
• 239000013603 viral vector Substances 0.000 description 1
• 238000005406 washing Methods 0.000 description 1
• 238000009736 wetting Methods 0.000 description 1
• 210000005253 yeast cell Anatomy 0.000 description 1