JP2013502928A5 - - Google Patents
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- JP2013502928A5 JP2013502928A5 JP2012526962A JP2012526962A JP2013502928A5 JP 2013502928 A5 JP2013502928 A5 JP 2013502928A5 JP 2012526962 A JP2012526962 A JP 2012526962A JP 2012526962 A JP2012526962 A JP 2012526962A JP 2013502928 A5 JP2013502928 A5 JP 2013502928A5
- Authority
- JP
- Japan
- Prior art keywords
- genetic
- variation
- item
- tissue
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 56
- 108090000623 proteins and genes Proteins 0.000 claims description 40
- 210000004027 cell Anatomy 0.000 claims description 21
- 230000007614 genetic variation Effects 0.000 claims description 20
- 102000004169 proteins and genes Human genes 0.000 claims description 16
- 230000002068 genetic effect Effects 0.000 claims description 7
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 6
- 230000001105 regulatory effect Effects 0.000 claims description 6
- 230000004069 differentiation Effects 0.000 claims description 4
- 230000035772 mutation Effects 0.000 claims description 4
- 239000002773 nucleotide Substances 0.000 claims description 4
- 125000003729 nucleotide group Chemical group 0.000 claims description 4
- 230000008672 reprogramming Effects 0.000 claims description 4
- 210000001082 somatic cell Anatomy 0.000 claims description 4
- 230000005856 abnormality Effects 0.000 claims description 3
- 108020004414 DNA Proteins 0.000 claims description 2
- 238000001712 DNA sequencing Methods 0.000 claims description 2
- 206010064571 Gene mutation Diseases 0.000 claims description 2
- 208000026350 Inborn Genetic disease Diseases 0.000 claims description 2
- 108700011259 MicroRNAs Proteins 0.000 claims description 2
- 238000003559 RNA-seq method Methods 0.000 claims description 2
- 108091027981 Response element Proteins 0.000 claims description 2
- 239000003623 enhancer Substances 0.000 claims description 2
- 230000001973 epigenetic effect Effects 0.000 claims description 2
- 208000016361 genetic disease Diseases 0.000 claims description 2
- 230000011987 methylation Effects 0.000 claims description 2
- 238000007069 methylation reaction Methods 0.000 claims description 2
- 239000002679 microRNA Substances 0.000 claims description 2
- 238000010208 microarray analysis Methods 0.000 claims description 2
- 210000001525 retina Anatomy 0.000 claims description 2
- 210000001116 retinal neuron Anatomy 0.000 claims description 2
- 230000003584 silencer Effects 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 238000007689 inspection Methods 0.000 claims 1
- 239000000790 retinal pigment Substances 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 description 8
- 210000003583 retinal pigment epithelium Anatomy 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23790809P | 2009-08-28 | 2009-08-28 | |
| US61/237,908 | 2009-08-28 | ||
| PCT/US2010/046735 WO2011025852A1 (en) | 2009-08-28 | 2010-08-26 | Identifying genetic variation in affected tissues |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015227384A Division JP2016028609A (ja) | 2009-08-28 | 2015-11-20 | 罹患組織における遺伝的変異の同定 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013502928A JP2013502928A (ja) | 2013-01-31 |
| JP2013502928A5 true JP2013502928A5 (https=) | 2013-09-19 |
| JP5885255B2 JP5885255B2 (ja) | 2016-03-15 |
Family
ID=42827374
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012526962A Active JP5885255B2 (ja) | 2009-08-28 | 2010-08-26 | 罹患組織における遺伝的変異の同定 |
| JP2015227384A Pending JP2016028609A (ja) | 2009-08-28 | 2015-11-20 | 罹患組織における遺伝的変異の同定 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015227384A Pending JP2016028609A (ja) | 2009-08-28 | 2015-11-20 | 罹患組織における遺伝的変異の同定 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US9506114B2 (https=) |
| EP (1) | EP2470673B1 (https=) |
| JP (2) | JP5885255B2 (https=) |
| CA (1) | CA2769862A1 (https=) |
| ES (1) | ES2509567T3 (https=) |
| WO (1) | WO2011025852A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE037509T2 (hu) | 2011-09-29 | 2018-09-28 | Cellsnap Llc | Készítmények és eljárások toxigenicitás meghatározására |
| KR20150087321A (ko) | 2012-11-21 | 2015-07-29 | 메르츠 파마 게엠베하 운트 코. 카가아 | 보툴리눔 신경독소 생물학적 활성의 결정을 위한 수단 및 방법 |
| PL3014267T3 (pl) | 2013-06-28 | 2019-05-31 | Merz Pharma Gmbh & Co Kgaa | Środki i sposoby określania aktywności biologicznej polipeptydów neurotoksyny w komórkach |
| AU2015367329B2 (en) | 2014-12-19 | 2021-02-18 | Merz Pharma Gmbh & Co. Kgaa | Means and methods for the determination of the biological activity of BoNT/E in cells |
| TWI704156B (zh) | 2015-03-04 | 2020-09-11 | 德商曼茲法瑪股份有限公司 | 用於增進肉毒桿菌神經毒素進入細胞之特定攝取的方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US172079A (en) | 1876-01-11 | Improvement in grinding-disks | ||
| US4863849A (en) * | 1985-07-18 | 1989-09-05 | New York Medical College | Automatable process for sequencing nucleotide |
| US5800992A (en) * | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
| GB9223084D0 (en) | 1992-11-04 | 1992-12-16 | Imp Cancer Res Tech | Compounds to target cells |
| CA2216439A1 (en) | 1996-09-25 | 1998-03-25 | Derek Van Der Kooy | Pharmaceuticals containing retinal stem cells |
| US6391622B1 (en) * | 1997-04-04 | 2002-05-21 | Caliper Technologies Corp. | Closed-loop biochemical analyzers |
| AU729377B2 (en) | 1997-10-23 | 2001-02-01 | Asterias Biotherapeutics, Inc. | Methods and materials for the growth of primate-derived primordial stem cells in feeder-free culture |
| EP1274865B1 (en) | 2000-04-06 | 2007-02-14 | Epigenomics AG | Diagnosis of diseases associated with apoptosis by means of assessing the methylation status of genes associated with apoptosis |
| US20030211603A1 (en) | 2001-08-14 | 2003-11-13 | Earp David J. | Reprogramming cells for enhanced differentiation capacity using pluripotent stem cells |
| WO2004098490A2 (en) | 2002-05-17 | 2004-11-18 | Mount Sinai School Of Medicine Of New York University | Mesoderm and definitive endoderm cell populations |
| US20060046258A1 (en) * | 2004-02-27 | 2006-03-02 | Lapidus Stanley N | Applications of single molecule sequencing |
| US7452718B2 (en) | 2004-03-26 | 2008-11-18 | Geron Corporation | Direct differentiation method for making cardiomyocytes from human embryonic stem cells |
| US20080038820A1 (en) | 2004-06-22 | 2008-02-14 | Rudy-Reil Diane E | Induction of pluripotent stem cells into mesodermal lineages |
| AU2005282414C1 (en) | 2004-09-08 | 2011-04-07 | Wisconsin Alumni Research Foundation | Culturing human embryonic stem cells |
| WO2006066320A1 (en) | 2004-12-22 | 2006-06-29 | Es Cell International Pte Ltd | Differentiation of human embryonic stem cells and cardiomyocytes and cardiomyocyte progenitors derived therefrom |
| US7606580B2 (en) | 2005-05-11 | 2009-10-20 | Aol Llc | Personalized location information for mobile devices |
| ES2527444T5 (es) | 2007-04-18 | 2018-05-17 | Hadasit Medical Research Services & Development Limited | Células del epitelio pigmentario de la retina derivadas de células madre |
| IL292561A (en) * | 2007-10-12 | 2022-06-01 | Astellas Inst For Regenerative Medicine | Improved methods of rpe cell production and rpe cell preparations |
| US20110151447A1 (en) | 2007-11-06 | 2011-06-23 | Children's Medical Center Corporation | Method to produce induced pluripotent stem (ips) cells from non-embryonic human cells |
| US8669048B2 (en) * | 2008-06-24 | 2014-03-11 | Parkinson's Institute | Pluripotent cell lines and methods of use thereof |
-
2010
- 2010-08-26 US US13/392,776 patent/US9506114B2/en active Active
- 2010-08-26 ES ES10748206.9T patent/ES2509567T3/es active Active
- 2010-08-26 EP EP10748206.9A patent/EP2470673B1/en active Active
- 2010-08-26 US US13/392,776 patent/US20120322670A1/en active Granted
- 2010-08-26 WO PCT/US2010/046735 patent/WO2011025852A1/en not_active Ceased
- 2010-08-26 JP JP2012526962A patent/JP5885255B2/ja active Active
- 2010-08-26 CA CA2769862A patent/CA2769862A1/en not_active Abandoned
-
2015
- 2015-11-20 JP JP2015227384A patent/JP2016028609A/ja active Pending
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