JP2013192851A - Medicine solution administration apparatus - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a medicine solution administration apparatus which is used for administering insulin into the body and is capable of administering a medicine solution appropriately and accurately.SOLUTION: When a gasket 12 is located on the most distal part 11B side and abuts a projecting part 11F, a small space is formed by the projecting part 11F between an internal surface 11C of an outer tube 11 and the gasket 12. When air bubbles are present within a medicine solution storing space 13, the air bubbles affixed to a side surface of a main part 11A moves by being pushed by the gasket 12 while the medicine solution is delivered by movement of the gasket 12. When the gasket 12 abuts the projecting part 11F, the air bubbles is pooled within the space formed between the gasket 12 and the internal surface 11C. With such a configuration, the air bubbles are prevented from being delivered outside.

Description

  The present invention relates to a drug solution administration device, and is suitable for application when, for example, insulin is administered into the body.

  2. Description of the Related Art Conventionally, as a device for administering a drug solution (insulin), it is a portable device that is used by adhering to a patient's skin, and is administered into the body by pushing out a drug solution filled in an outer cylinder through a plunger. A so-called syringe pump type drug administration device has been proposed (see, for example, Patent Document 1).

Special table 2010-501283

  By the way, in a chemical | medical solution administration apparatus, sending a chemical | medical solution into a body by what is called a piston pump type delivery part is also considered. In a chemical solution administration device that uses a piston pump type delivery unit, if bubbles are delivered from the chemical storage unit that stores the chemical solution into the flow path, the specified amount of chemical solution cannot be delivered into the body, and the chemical solution is accurate. There is a risk of not being able to administer well.

  The present invention has been made in consideration of the above points, and an object of the present invention is to propose a drug solution administration device capable of accurately administering a drug solution.

  In order to solve this problem, the present invention is a chemical solution administration device that is used by being attached to the skin of a living body, and stores a chemical solution storage unit that stores the chemical solution and a chemical solution stored in the chemical solution storage unit into the living body. And a medical solution storage unit includes a main body part, a front end part that closes the front end of the main body part, and a hollow projecting part that projects from a surface of the front end part that contacts the space inside the main body part And a piston that abuts along the circumferential direction on a side surface that contacts the space in the main body portion and can slide in the main body portion in the cylinder axis direction, and the piston is moved to the tip of the outer cylinder. When this occurs, a space is formed between the tip and the piston.

  As a result, when bubbles are present in the internal space and the gasket moves and the chemical solution is delivered, the bubbles accumulate in the space between the syringe outer cylinder and the gasket. Can be prevented.

  According to the present invention, when bubbles are present in the internal space, the bubbles move in the space between the syringe outer tube and the gasket when the gasket moves and the chemical solution is delivered. Can be prevented from being delivered, and thus the medicinal solution can be administered with high accuracy.

It is a basic diagram which shows the structure of a chemical | medical solution administration apparatus. It is a disassembled perspective view of a chemical | medical solution administration apparatus. It is a basic diagram which shows the structure of a chemical | medical solution storage part. It is a basic diagram which shows the structure of a sending part. It is a basic diagram which shows the mode of the piston moved to the pressing position. It is a basic diagram which shows the structure (1) of a drive part. It is a basic diagram which shows the structure (2) of a drive part. It is a basic diagram which shows the structure of the sending part containing a film, and a drive part. It is a basic diagram which shows the electric constitution of a chemical | medical solution administration apparatus. It is a basic diagram which shows the structure (1) of the chemical | medical solution storage part in other embodiment. It is a basic diagram which shows the structure (2) of the chemical | medical solution storage part in other embodiment. It is a basic diagram which shows the structure (3) of the chemical | medical solution storage part in other embodiment. It is a basic diagram which shows the structure (4) of the chemical | medical solution storage part in other embodiment. It is a basic diagram which shows the structure (5) of the chemical | medical solution storage part in other embodiment. It is a basic diagram which shows the structure (6) of the chemical | medical solution storage part in other embodiment. It is a basic diagram which shows the structure (7) of the chemical | medical solution storage part in other embodiment.

  Hereinafter, an embodiment of the present invention will be described in detail with reference to the drawings.

[1. Overall configuration of drug solution administration device]
As shown in FIGS. 1 and 2, the drug solution administration device 1 is a portable device that is used by being attached to the skin of a patient, and is a lower casing that is open on the upper side and has a space inside. A flat, substantially rectangular parallelepiped shape is formed by the body portion 2 and the upper housing portion 3 that fits into the opening of the lower housing portion 2.

  The size of the drug administration device 1 may be reduced to such an extent that it can be affixed to the user's skin, and examples thereof include a substantially rectangular parallelepiped shape having a width of 32 mm, a length of 44 mm, and a height of 11 mm.

  The lower housing part 2 is provided with a sticking part 4 made of double-sided tape or the like on the bottom surface 2A. The medicinal-solution administration device 1 is held by the patient when the affixing unit 4 is affixed to the patient's skin.

  The medicinal solution administration device 1 includes a puncture mechanism 5, a medicinal solution storage unit 6, a flow channel unit 7, a delivery unit 8, a drive unit 9, a substrate unit 10, and the like in a space formed by the lower casing unit 2 and the upper casing unit 3. Is provided.

  The puncture mechanism 5 includes a puncture needle (not shown) made of a needle, a cannula or the like for puncturing the patient's skin in order to administer the drug solution stored in the drug solution storage unit 6 into the patient's body. It protrudes from the puncture needle hole 2B provided on the bottom surface 2A of the part 2.

  As will be described later in detail, the chemical solution storage unit 6 is filled with a chemical solution from the outside in a cylindrical outer cylinder 11 (FIG. 3).

  The flow path part 7 includes the suction pipe 7A, the delivery pipe 7B, the flow paths 22B, 23A, 24A formed in the delivery part 8 and the puncture needle of the puncture mechanism 5, and the flow of the drug solution from the drug solution storage unit 6 to the body. Form a road. The suction pipe 7A allows the chemical solution storage unit 6 and the flow path 23A formed in the delivery unit 8 to communicate with each other. The delivery tube 7B allows the flow path 24A formed in the delivery unit 8 to communicate with the puncture needle of the puncture mechanism 5.

  As will be described in detail later, the delivery unit 8 allows the chemical solution stored in the chemical solution storage unit 6 to flow through the flow path unit 7 when the piston 21 slides in the internal space 22A of the cylinder unit 22 (FIG. 4). To be delivered to the body.

  The drive unit 9 drives the piston 21 based on the control of the CPU 51 (FIG. 9), and slides the piston 21 in the internal space 22 </ b> A of the cylinder unit 22.

  The substrate unit 10 is provided with a power supply unit 54 (FIG. 9) for supplying power supply power, a circuit such as the CPU 51, and the like.

[2. (Composition of chemical storage part)
The chemical | medical solution storage part 6 inserts piston 12 from the open end side to the outer cylinder 11 formed in a cylindrical shape, as shown in FIG. The chemical liquid storage unit 6 stores the chemical liquid in a chemical liquid storage space 13 formed by the outer cylinder 11 and the piston 12.

  The outer cylinder 11 is provided with a distal end portion 11B that closes the distal end of the cylindrical main body portion 11A, and the main body portion 11A and the distal end portion 11B are integrally formed.

  The tip portion 11B is a surface (hereinafter referred to as an inscribed surface) that is in contact with the medicinal solution storage space 13 along a direction orthogonal to a direction along the axis of the main body portion 11A (hereinafter also referred to as a cylinder axis direction). A hollow protrusion 11D having an opening penetrating to the outside is provided at the center of 11C.

  Further, the distal end portion 11B communicates with the protruding portion 11D, and a connection port 11E protrudes in a direction opposite to the protruding portion 11D, and the suction pipe 7A is connected to the connecting port 11E.

  11 A of main-body parts are provided with the convex control part 11F which the part from the position which contact | connects the inscribed surface 11C to the position longer than the length of protrusion part 11D protruded inside. That is, the main body portion 11A is formed such that the inner diameter of the restricting portion 11F is shorter than the inner diameter of the main body portion 11A other than the restricting portion 11F.

  The piston 12 is inserted into the main body portion 11A from the end opposite to the tip portion 11B, contacts the inner surface of the main body portion 11A along the circumferential direction, and moves along the cylinder axis direction of the main body portion 11A. Closely slidable. The piston 12 is formed with a diameter larger than the inner diameter of the restricting portion 11F.

  The medicinal solution storage unit 6 has a slight space between the inscribed surface 11C of the outer cylinder 11 and the piston 12 with the restricting part 11F in a state where the piston 12 is positioned closest to the tip part 11B and in contact with the restricting part 11F. Is provided. In this state, the medicinal solution storage unit 6 injects the medicinal solution stored in the vial from the inlet (not shown) into the medicinal solution storage space 13.

  In the chemical solution storage unit 6, the piston 12 is moved to the end side as the chemical solution is injected, and a predetermined amount (for example, 2 ml) of the chemical solution is injected. At this time, bubbles that existed in the chemical solution storage space 13 remain as they are.

  When the chemical solution is delivered into the body by the delivery unit 8, the chemical solution storage unit 6 sucks the piston 12 through the protruding portion 11 </ b> D and the connection port 11 </ b> E while the piston 12 moves to the distal end portion 11 </ b> B side by the chemical solution suction pressure by the delivery unit 8. The chemical solution is sent to the tube 7A. And the chemical | medical solution storage part 6 sends out a chemical | medical solution until the piston 12 contact | abuts to the projection part 11F.

  By the way, in the chemical | medical solution storage part 6, when the bubble exists in the chemical | medical solution storage space 13, most of this bubble adheres to a wall surface. Therefore, in the chemical solution storage unit 6, when the piston 12 moves and the chemical solution is delivered, the bubbles attached to the side surface of the main body portion 11A move while being pushed by the piston 12, and the piston 12 comes into contact with the regulating portion 11F. At this time, since the air bubbles are accumulated in the space provided between the piston 12 and the inscribed surface 11C, it is possible to prevent the air bubbles from being sent to the outside.

  Further, since the chemical liquid storage unit 6 is provided with the protruding portion 11D protruding from the inscribed surface 11C on the chemical liquid storage space 13 side, bubbles attached to the side surface of the main body 11A when the chemical liquid is delivered. Can be prevented from being sent to the outside through the opening of the protrusion 11D.

[3. (Configuration of sending unit)
As shown in FIG. 4A, the delivery unit 8 includes a piston 21, a cylinder unit 22, lids 23 and 24, one-way valves 25 and 26, an X ring 27, an X ring fixing unit 28, and a fixing member 29. It is supposed to be configured.

  The piston 21 has a diameter of, for example, 1.03 mm, and is slid with a predetermined stroke in an internal space 22 </ b> A formed in a hollow cylindrical shape formed in the cylinder portion 22 by being driven by the drive portion 9. Examples of the material of the piston 21 include stainless steel, copper alloy, aluminum alloy, titanium material, thermoplastic elastomer such as polypropylene and polycarbonate, and the like.

  The cylinder portion 22 is provided with an internal space 22A in which the piston 21 is inserted from one end and slides. The cylinder portion 22 is provided such that a flow path 22B that is in contact with the other end of the internal space 22A and orthogonal to the internal space 22A penetrates between opposing side surfaces of the cylinder portion 22.

  The cylinder part 22 is provided with an X ring 27 for preventing leakage of a chemical solution between the piston 21 and an X ring fixing part 28 for fixing the X ring 27 at one end where the piston 21 is inserted in the internal space 22A. Examples of the member for preventing leakage of the chemical liquid include an O-ring.

  The X ring 27 is inserted into the cylinder portion 22 from the side of the cylinder portion 22 where the internal space 22A is provided, and is pressed and fixed by the X ring fixing portion 28. A part of the X ring fixing part 28 is fitted into the cylinder part 22 and the X ring 27 is fixed so that the remaining part is exposed to the outside.

  As shown in FIG. 4B, the flow path 22B is formed in a rectangular cross section whose horizontal width is the same as the diameter of the internal space 22A and whose height is shorter than the horizontal width. Hydrophilic processing is performed on the surfaces of the internal space 22A and the flow path 22B. As the hydrophilic processing, for example, plasma treatment or application of a surfactant (sodium stearate) or the like is applied. Note that hydrophilic processing may also be performed on the tip surface (upper surface) of the piston 21.

  In the cylinder portion 22, the diameter of the internal space 22A and the horizontal width of the flow path 22B are formed to have the same length, and the center position of the axis of the internal space 22A and the central position of the horizontal width of the flow path 22B are formed to coincide.

  The cylinder portion 22 has lid portions 23 and 24 connected to the side surface on which the flow path 22B is formed via a fixing member 29, respectively. The lid portions 23 and 24 are provided with flow passages 23A and 24A penetrating along the flow passage 22B at positions facing the flow passage 22B of the cylinder portion 22.

  One end of the flow path 23A is connected to the flow path 22B of the cylinder part 22, and the other end of the flow path 23A is connected to the suction pipe 7A to connect the suction pipe 7A and the flow path 22B.

  In the lid 24, one end of the flow path 24A is connected to the flow path 22B of the cylinder part 22, and the other end of the flow path 24A is connected to the delivery pipe 7B, thereby communicating the flow path 22B and the delivery pipe 7B.

  The delivery section 8 is provided with a one-way valve 25 between the flow path 23A of the lid section 23 and the flow path 22B of the cylinder section 22, and between the flow path 22B of the cylinder section 22 and the flow path 24A of the lid section 24. Is provided with a one-way valve 26.

  The one-way valve 25 allows the chemical liquid flowing from the flow path 23A of the lid portion 23 to the flow path 22B of the cylinder portion 22 to pass, and does not allow the chemical liquid to pass from the flow path 22B of the cylinder portion 22 to the flow path 23A of the lid portion 23. For example, an umbrella valve is applied.

  The one-way valve 26 allows the chemical liquid flowing from the flow path 22 of the cylinder portion 22 to the flow path 24AB of the lid section 24 to pass, and does not allow the chemical liquid to pass from the flow path 22B of the cylinder section 22 to the flow path 24A of the lid section 24. For example, an umbrella valve is applied.

  The delivery unit 8 is a position where the piston 21 is most retracted (hereinafter also referred to as a push-off position) when delivering a chemical solution from the chemical solution storage unit 6 into the living body (hereinafter also referred to as a withdrawal position). The chemical solution that has been moved by the drive unit 9 in the internal space 22A and stored in the chemical solution storage unit 6 is sucked into the internal space 22A.

  And the delivery part 8 sends out the chemical | medical solution suck | inhaled by 22 A of internal spaces in the living body, when the piston 21 is moved by the drive part 9 from a retracted position to a pushing position.

  The delivery unit 8 can administer about 1 to 2 μL of a chemical solution into the patient's body by reciprocating the piston 21 once. By repeating this operation at a set period and interval, a desired administration rate and dosage can be obtained. The drug solution can be administered to the patient.

  By the way, the pressing position is set to a position where the tip of the piston 21 is on the same plane as the bottom surface of the flow path 22B (the surface to which the internal space 22A is connected) or a position within the flow path 22B. That is, as shown in FIG. 5, when the drive unit 9 moves the piston 21 to the pressing position, the position where the tip of the piston 21 is on the same plane as the bottom surface of the flow path 22B or within the flow path 22B from the position. Move to the position.

  As a result, when air bubbles are present in the internal space 22A, the delivery unit 8 causes the air bubbles present in the internal space 22A to move into the flow path 22B at the tip surface (upper surface) of the piston 21 when the piston 21 moves to the push-off position. Since it can push out, when the piston 21 is moved to the retracted position thereafter, the possibility that the bubbles are pulled back into the internal space 22A can be greatly reduced.

  On the other hand, in an apparatus that does not move the piston tip into the flow path, for example, bubbles adhere to the side surface of the cylinder part that contacts the internal space or the tip surface of the piston, and the air bubbles present in the internal space cause the piston to slide. In some cases, it may not be pushed into the flow path.

  In this case, the bubble repeatedly expands and contracts due to a change in the internal pressure that changes according to the movement of the piston, thereby changing the amount of the drug solution sucked into the internal space, and sending the set drug solution amount into the living body. Can not do. Therefore, with such a device, there is a possibility that the drug solution cannot be administered with high accuracy.

  On the other hand, since the drug solution administration device 1 pushes out the air bubbles existing in the internal space 22A into the flow path 22B when the piston 21 moves to the push-off position in the delivery unit 8, the piston 21 moves to the retract position thereafter. In doing so, only the chemical solution can be sucked into the internal space 22A. Thus, the drug solution administration device 1 can accurately administer the drug solution.

  Further, in the drug solution administration device 1, since the hydrophilic processing is applied to the front end surface of the piston 21, and the surfaces of the internal space 22A and the flow path 22B, it is possible to prevent air bubbles from remaining in the internal space 22A and the flow path 22B. can do.

[4. (Configuration of drive unit)
As shown in FIG. 6, the drive unit 9 includes a base unit 31, a motor 32, a motor support unit 34, a motor fixing plate 35, a fixed plate support unit 36, a bearing unit 37, a coupling 38, and a bearing support unit 39. It is said.

  Each part of the drive unit 9 is arranged on the base unit 31. The motor 32 is sandwiched between a motor support portion 34 and a motor fixing plate 35 supported by the fixing plate support portion 36 and fixed to the base portion 31.

  The motor 32 is provided with a motor shaft 33 that protrudes from the side surface on the motor fixing plate 35 side. A screw groove 33 </ b> A is formed on the side surface of the motor shaft 33.

  The bearing portion 37 has a substantially rectangular parallelepiped shape that is elongated along the axial direction of the motor 32 and has a hollow interior. The bearing portion 37 is provided with a screw hole 37A at the center of the side surface corresponding to the short side of the substantially rectangular parallelepiped shape, through which the motor shaft 33 of the motor 32 is inserted and screwed into the screw groove 33A.

  In the bearing portion 37, the piston 21 is coaxially connected to the motor shaft 33 via a coupling 38 on a side surface facing a side surface provided with a screw hole 37 </ b> A corresponding to a short side of a substantially rectangular parallelepiped shape. The bearing portion 37 is supported by the bearing support portion 39. As the coupling 38, for example, a coupling that absorbs axial displacement between the motor shaft 33 and the piston 21 is applied.

  As shown in FIGS. 6 and 7, the drive unit 9 rotates the motor shaft 33 when the motor 32 is driven, and the bearing unit 37 screwed to the motor shaft 33 in the axial direction is driven in accordance with the rotation. Move and reciprocate the piston 21 in the axial direction. As a result, the drive unit 9 slides the piston 21 in the internal space 22 </ b> A of the cylinder unit 22. 6A and 6B, the piston 21 is in the retracted position, and in FIG. 7, the piston 21 is in the push-off position.

  Thus, since the motor shaft 33 of the motor 32 is arranged coaxially with the piston 21, the drive unit 9 has a force applied to the bearing portion 37 by the rotation of the motor shaft 33 and the force applied to the piston 21. The applied force is in the same direction, and the thrust loss of the piston 21 is eliminated.

  Therefore, the drive unit 9 can slide the piston 21 with a stable stroke distance in the internal space 22 </ b> A of the cylinder unit 22. In addition, since the driving unit 9 can drive the piston 21 with a smaller force by eliminating the loss of thrust of the piston 21, the motor 32, the battery, and the like can be reduced, and the entire apparatus can be downsized. Can do. The side surface of the piston 21 may be coated with diamond-like carbon to reduce sliding resistance.

  On the other hand, in a device in which the piston and the shaft portion of the motor are not arranged coaxially, the force applied to the bearing portion by the rotation of the shaft portion and the force applied to the piston by the force are offset, The loss of thrust of the piston increases, and the sliding resistance of the bearing portion and the piston increases due to the offset of the force, which not only stabilizes the stroke of the piston but also increases the size of the entire apparatus.

  By the way, in the chemical solution administration device 1, as shown in FIG. 8, the space between the X ring fixing portion 28 and the coupling 38 is covered with a tube-like flexible film 40. As the material of the film 40, for example, polyethylene or the like is applied.

  The film 40 is fixed to the X ring fixing portion 28 and the coupling 38 without gaps in the circumferential direction by film fixing portions 41 and 42 having both ends made of, for example, O-rings.

  Since the film 40 has flexibility, the piston 21 is always in the range from the state where the piston 21 shown in FIG. 8A is in the retracted position to the state where the piston 21 shown in FIG. Can be kept covered.

  Therefore, in the chemical solution administration device 1, the piston 21 can be slid within the internal space 22 </ b> A of the cylinder portion 22 without touching the air outside the film 40. Thereby, the chemical solution administration device 1 can further maintain the cleanliness of the piston 21 entering the internal space 22A.

[5. Electrical configuration of drug solution administration device]
As shown in FIG. 9, the drug solution administration device 1 includes a CPU (Central Processing Unit) 51, a ROM (Read Only Memory) 52, a RAM (Random Access Memory) 53, a power supply unit 54, and an interface unit (I / F unit) 55. The notification unit 56 and the drive unit 9 are connected via a bus 57.

  The CPU 51, ROM 52, RAM 53, power supply unit 54 and notification unit 56 are arranged on the substrate unit 10. A battery is applied to the power supply unit 54. The interface unit 55 is provided with a button (not shown) or the like that is arranged in the upper casing unit 3 or the lower casing unit 2 and receives a user input command. The notification unit 56 is a speaker.

  The CPU 51 performs overall control by reading the basic program stored in the ROM 52 into the RAM 53 and executing it, and executes various processes by reading out and executing the various application programs stored in the ROM 52 into the RAM 53.

  The CPU 51 fills the drug solution storage unit 6 from the outside, the drug solution administration device 1 is affixed to the patient's skin via the affixing unit 4, and the puncture mechanism 5 punctures the patient's skin. When an input command to start administration of a chemical solution is given by a user operation on the interface unit 55, a chemical solution administration process is executed.

  Specifically, the CPU 51 reads the drug solution administration program into the RAM 53, executes the drug solution administration process, and sets parameters such as the dose and the administration rate input via the interface unit 55. And CPU51 controls the drive part 9 based on the set parameter, and starts administration of a chemical | medical solution.

[6. Other Embodiments]
[6-1. Other Embodiment 1]
In the embodiment described above, when the piston 21 is moved to the pressing position, the piston 21 is moved to a position where the tip of the piston 21 is on the same plane as the bottom surface of the flow path 22B or to a position in the flow path 22B from the position. Although the case has been described, the present invention is not limited to this.

  The distance between the pressing position and the upper surface of the flow path 22B (hereinafter also referred to as the opposing surface) 22C (FIG. 4B) facing the tip surface (upper surface) of the piston 21 is allowed to maintain the flow rate accuracy. It may be set so as to be narrower than the diameter of the largest bubble (hereinafter also referred to as allowable maximum bubble).

  For example, when the piston 21 has a diameter of 1.03 mm, the discharge amount when the piston 21 makes one reciprocation is 1 μl, and the allowable maximum bubble diameter is 0.065 μl, the front end surface of the piston 21 and the opposing surface 22C as the pressing position. Is set to 0.078 mm. That is, the drive unit 9 moves the piston 21 to a position where the distance between the tip surface of the piston 21 and the facing surface 22C becomes 0.078 mm.

  As another example, when the piston 21 has a diameter of 1.03 mm, the discharge amount when the piston 21 makes one reciprocation is 2 μl, and the allowable maximum bubble diameter is 0.13 μl, The distance from the facing surface 22C is set to 0.156 mm. That is, the drive unit 9 moves the piston 21 to a position where the distance between the tip surface of the piston 21 and the facing surface 22C is 0.156 mm.

  In this way, when the pressing position is set so that the distance between the tip surface of the piston 21 and the facing surface 22C is narrower than the diameter of the allowable maximum bubble, the delivery unit 8 is more than the allowable maximum bubble existing in the internal space 22A. When the piston 21 moves to the pressing position, the air bubbles having a diameter are crushed by the front end surface of the piston 21 and the opposing surface 22C and pushed out to the downstream side of the flow path 22B.

  As a result, when the piston 21 is subsequently moved to the retracted position, the delivery unit 8 can suck only the chemical liquid into the internal space 22A, and thus bubbles having a diameter larger than the maximum allowable bubble in the internal space 22A. Since it does not remain, a chemical | medical solution can be administered accurately.

  The pressing position may be set such that the distance between the tip surface of the piston 21 and the facing surface 22C is narrower than the diameter of the allowable maximum bubble.

[6-2. Other Embodiment 2]
In the embodiment described above, the diameter of the internal space 22A and the lateral width of the flow path 22B may be different.

[6-3. Other Embodiment 3]
In the above-described embodiment, the case where the cross section of the flow path 22B is rectangular has been described. However, the present invention is not limited to this, and the cross section of the flow path may be circular or elliptical.

[6-4. Other Embodiment 4]
In the above-described embodiment, the case where the cross section of the internal space 22A has a circular shape has been described. However, the present invention is not limited thereto, and the cross section of the internal space may be elliptical.

[6-5. Other Embodiment 5]
In the embodiment described above, the film 40 has been described as having both ends fixed to the X-ring fixing portion 28 and the coupling 38, respectively, but the present invention is not limited to this, and covers the piston 21. For example, one end may be fixed to the cylinder portion 22 and the other end may be fixed to the bearing portion 37.

[6-6. Other Embodiment 6]
In the above-described embodiment, the case where the respective parts (11A to 11F) of the outer cylinder 11 are integrally formed has been described, but the present invention is not limited thereto.

  As an example, as shown in FIG. 10, the chemical solution storage unit 100 is provided with a stainless pipe 104 instead of the protruding portion 11 </ b> D and the external port 11 </ b> E of the chemical solution storage unit 6. The piston 102 is the same as the piston 12.

  In the chemical solution storage unit 100, a stainless steel pipe 104 is provided in an opening 101G provided in the center of the distal end portion 101B of the outer cylinder 101. The stainless steel pipe 104 is fixed to the opening 101G so that the length of the portion inserted into the chemical solution storage space 103 is shorter than the length of the limiting portion 101F.

  As shown in FIG. 10 (B), the chemical solution storage unit 100 having such a configuration contacts the limiting portion 101F when the piston 102 moves to the most distal end portion 102B side, and contacts the inscribed surface 101C and the piston 102. There is a space between them.

  Accordingly, in the chemical solution storage unit 100, as with the chemical solution storage unit 6, when the chemical solution is delivered, bubbles attached to the side surface of the main body 101 </ b> A accumulate in a space provided between the piston 102 and the protrusion 101 </ b> F, It can prevent being sent to the outside through the opening of the stainless steel pipe 104.

  Further, since the diameter of the opening of the stainless steel pipe 104 can be made thinner than that of the synthetic resin, it is possible to make it difficult to send out the bubbles to the outside.

[6-7. Other Embodiment 7]
In the above-described embodiment, the case where the inner peripheral surface of the main body portion 11A of the outer cylinder 11 is provided with the restricting portion 11F protruding inward has been described, but the present invention is not limited thereto, and the piston is not limited to this. A restricting portion having another structure that restricts the movement of the piston may be provided so that the piston and the inscribed surface do not come into contact with each other when moved to the most distal end side.

  As an example, as shown in FIG. 11, the chemical storage unit 110 is provided with a protrusion 111 </ b> D that has an opening and protrudes toward the chemical storage space 113 on the inscribed surface 111 </ b> C of the outer cylinder 111. An external port 111E is protruded on the opposite side so as to communicate with 111D.

  The outer cylinder 111 is provided with a rib-shaped restricting portion 111F formed in an annular shape on the outer peripheral side of the protruding portion 111D and on the inner peripheral side of the main body portion 111A. The restricting portion 111F is formed longer than the protruding portion 111D.

  In the chemical liquid storage unit 110 having such a configuration, as shown in FIG. 11 (B), when the piston 112 moves to the most distal end portion 112B side, it comes into contact with the limiting portion 111F, and the inscribed surface 111C and the piston 112 There is a space between them.

  Therefore, as with the chemical solution storage unit 6, when the chemical solution is delivered, the chemical solution storage unit 110 generates bubbles in the space provided between the piston 112 and the restriction unit 111 </ b> F. It is possible to prevent accumulation and delivery to the outside through the opening of the protrusion 111D. The piston 112 is the same as the piston 12.

[6-8. Other Embodiment 8]
In the above-described embodiment, the case where the inner peripheral surface of the main body portion 11A of the outer cylinder 11 is provided with the restricting portion 11F protruding inward has been described, but the present invention is not limited to this, and FIG. As shown in FIG. 4, the restriction portion may not be provided.

  The medicinal solution storage part 120 is provided with a projecting part 121D having an opening on the inscribed surface 121C of the outer cylinder 121 and projecting to the medicinal solution storage space 123 side, and communicates with the projecting part 121D on the opposite side. An external port 121E is projected.

  In the chemical solution storage unit 120 having such a configuration, as shown in FIG. 12 (B), when the piston 122 moves to the most distal end portion 122B side, it comes into contact with the protruding portion 121D, and the inscribed surface 121C and the piston 122 There is a space between them.

  Therefore, as in the case of the chemical solution storage unit 6, when the chemical solution is sent out, the chemical solution storage unit 120 causes bubbles attached to the side surface of the main body 121A to be generated in the space provided between the piston 122 and the protrusion 121D. It is possible to prevent the liquid from being collected and sent to the outside through the opening of the protrusion 131D. The piston 122 is the same as the piston 12.

[6-9. Other Embodiment 9]
In the above-described embodiment, the case where the surface of the piston 12 in contact with the chemical solution storage space 13 is flat has been described. However, the present invention is not limited to this, and the piston is provided with a groove portion for the protruding portion of the main body portion to enter. It may be done.

  As an example, as shown in FIG. 13, the chemical solution storage unit 130 has an opening on the inscribed surface 131 </ b> C of the outer cylinder 131, and a protrusion 131 </ b> D protrudes from the chemical solution storage space 133, and communicates with the protrusion 131 </ b> D. In this way, the external port 131E is provided on the opposite side.

  In addition, the tip 131B is provided with a protrusion 131F formed on the inscribed surface 11C that is shorter than the length of the protrusion 131D.

  The piston 132 is inserted into the outer cylinder 131 from the end opposite to the tip 131B, contacts the inner surface of the main body 131A along the circumferential direction, and is liquid-tight along the cylinder axis direction of the main body 131A. It is slidably arranged.

  The piston 132 is provided with a groove 132A into which the protrusion 131D can be inserted at a position facing the protrusion 131D. The groove 132A is a cylindrical space having a diameter larger than the outer shape of the protrusion 131D, shallower than the length of the protrusion 131D, and deeper than the difference between the length of the protrusion 131D and the height of the protrusion 131F.

  When the piston 132 is positioned closest to the distal end portion 131B, the chemical solution storage unit 130 contacts the protrusion 131F. At this time, in the chemical solution storage unit 130, a slight space is formed between the inscribed surface 131C of the outer cylinder 131 and the piston 132 by the protrusion 131F.

  Therefore, as in the case of the chemical solution storage unit 6, the chemical solution storage unit 130 causes bubbles attached to the side surface of the main body 131A to be generated in the space provided between the piston 132 and the protrusion 131D when the chemical solution is delivered. It is possible to prevent the liquid from being collected and sent to the outside through the opening of the protrusion 131D.

  As another example, as shown in FIG. 14, the chemical storage part 140 is provided with a protrusion 141 </ b> D having an opening on the inscribed surface 141 </ b> C of the outer cylinder 141 and protruding toward the chemical storage space 143. An external port 141E is provided on the opposite side so as to communicate with the portion 141D.

  The piston 142 abuts on the inner side surface of the main body 141A along the circumferential direction, and is slidably arranged along the cylinder axis direction of the main body 141A.

  The piston 142 is provided with a groove 142A into which the protrusion 141D can be inserted at a position facing the protrusion 141D. The piston 142 has the same surface as the surface on which the groove 142A is provided, and a protrusion 142B is provided around the groove 142A.

  The piston 142 is set such that the sum of the depth of the groove 142A and the height of the protrusion 142B is longer than the length of the protrusion 141D.

  In the chemical solution storage unit 140 configured as described above, the protrusion 142B abuts on the inscribed surface 141C when the piston 142 is positioned closest to the tip end 141B. At this time, in the chemical solution storage unit 140, a slight space is formed between the inscribed surface 141C of the outer cylinder 141 and the piston 142.

  Therefore, as with the chemical solution storage unit 6, when the chemical solution is delivered, the bubbles attached to the side surface of the main body 141A accumulate in the space provided between the piston 142 and the projection 141F, and the protrusion 141D It can prevent being sent to the outside through the opening.

  As another example, as shown in FIG. 15, the chemical solution storage unit 150 is provided with a stainless steel pipe 154 penetrating through an opening 150 </ b> G provided at the center of the distal end portion 151 </ b> B of the outer cylinder 151.

  The stainless steel pipe 154 is fixed to the opening 101G so that the length of the portion inserted into the chemical solution storage space 153 is shorter than the total length of the height of the protrusion 151F and the depth of the groove 152A of the piston 152.

  When the piston 152 moves to the most distal end portion 152 </ b> B side, the chemical solution storage unit 150 having such a configuration makes contact with the protrusion 151 </ b> F, and a space is formed between the inscribed surface 151 </ b> C and the piston 152.

  Accordingly, in the chemical solution storage unit 150, as with the chemical solution storage unit 6, when the chemical solution is delivered, bubbles attached to the side surface of the main body 151A accumulate in a space provided between the piston 152 and the protrusion 151F. It can prevent being sent to the outside through the opening of the stainless steel pipe 154.

  Since the diameter of the opening of the stainless steel pipe 154 can be made smaller than that of the synthetic resin, it is possible to make it difficult to send out the bubbles to the outside. The piston 152 is the same as the piston 132.

  As another example, as shown in FIG. 16, the chemical solution storage unit 160 is provided with a protruding portion 161 </ b> D having an opening and protruding toward the chemical solution storage space 163 on the inscribed surface 161 </ b> C of the distal end portion 161 </ b> B of the outer cylinder 161. The external port 161E is provided on the opposite side so as to communicate with the protruding portion 161D.

  The piston 162 is provided with a groove 162A into which the protrusion 161D can be inserted at a position facing the protrusion 161D. The length of the protrusion 161D is longer than the depth of the groove 162A. As a result, in the chemical storage unit 160, even if the piston 162 moves to the most distal end portion 161B side, the distal end of the protruding portion 161D abuts on the bottom surface of the groove 162A, and the piston 162 does not abut on the inscribed surface 161C.

  Therefore, when the piston 162 is moved to the most distal end portion 161B side, a space is created between the piston 162 and the inscribed surface 161C, so that the chemical solution storage unit 160 has air bubbles in the chemical solution storage space 163. It is possible to prevent bubbles from being accumulated in the space between the piston 162 and the inscribed surface 161C and being sent to the outside through the opening of the protrusion 161D.

  The present invention can be applied to the medical field, for example.

  DESCRIPTION OF SYMBOLS 1 ... Chemical solution administration apparatus 1 ... Lower housing | casing part, 3 ... Upper housing | casing part, 4 ... Pasting part, 5 ... Puncture mechanism, 6 ... Chemical solution storage part, 7 ... Channel part, 8 ... ··· Delivery portion, 9 ··· Drive portion, 10 ··· substrate portion, 11 ··· outer cylinder, 11D ··· projection portion, 11F ··· projection portion, 12 ··· piston, 12A ··· groove portion, 13 ··· chemical solution storage space , 21 ... piston, 22 ... cylinder part, 22A ... internal space, 22B ... flow path, 22C ... facing surface, 23, 24 ... lid part, 25, 26 ... one-way valve, 27 ... X ring, 28 ... X ring fixing part, 31 ... Base part, 32 ... Motor, 33 ..., 33 ... Motor shaft, 37 ... Bearing part, 38 ... Coupling, 40 ... Film, 51 …… CPU, 52 …… ROM, 53 …… RAM, 54 …… Power supply unit, 55 …… Interface unit, 56 …… Notification unit, 5 ...... bus.

Claims (8)

A chemical liquid administration device used by being attached to the skin of a living body,
A chemical storage section for storing the chemical,
A delivery part for delivering the chemical stored in the chemical storage part into the living body,
The chemical storage unit
An outer cylinder having a main body part, a front end part closing the front end of the main body part, and a hollow projecting part projecting from a surface in contact with the space inside the main body part at the front end part;
Abutting along the circumferential direction on the side surface of the main body portion that contacts the space, and having a piston that can slide in the main body portion in the cylinder axis direction,
A space is formed between the tip and the piston when the piston is moved to the tip of the outer cylinder. The outer cylinder is
2. The drug solution administration device according to claim 1, further comprising: a restricting portion that restricts the piston from moving further to a tip side than a predetermined position when the piston moves to the tip of the outer cylinder. The drug solution administration device according to claim 2, wherein the restricting portion is a convex portion provided on an inner peripheral surface of the main body portion. The drug solution administration device according to claim 2, wherein the restricting portion is a rib that is provided on the outer peripheral side of the protruding portion, and is a surface in contact with the space inside the outer cylinder at the tip portion. The medicinal-solution administration device according to any one of claims 1 to 4, wherein the piston is formed with a groove part into which the projecting part can be inserted at a position facing the projecting part. The medicinal-solution administration device according to claim 5, wherein a length of the protruding portion in the cylinder axis direction is longer than a depth of the groove portion in the cylinder axis direction. The outer cylinder is
The medicinal-solution administration device according to any one of claims 1 to 6, wherein a protruding portion is formed on a surface of the tip portion that contacts a space inside the main body. The piston is
The medicinal-solution administration device according to claim 7, wherein a protruding portion is provided on a surface facing the tip portion.

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