JP2012200417A - Liquid medicine administration apparatus - Google Patents

Abstract

PROBLEM TO BE SOLVED: To miniaturize an apparatus for administering a liquid medicine (insulin) on the whole.SOLUTION: The gap between a piston 11 and a cylinder is sealed with hydrophilic polymer 41, and the sliding resistance when the piston 11 slides within the cylinder can be greatly reduced. Accordingly, the power to be fed to a drive part for driving the piston 11 can be reduced, and therefore, a battery constituting a power supply part can be miniaturized. As a result, the apparatus on the whole can be miniaturized.

Description

  The present invention relates to a drug solution administration device, and is suitable for application when, for example, a drug solution is administered into a user's body.

  2. Description of the Related Art Conventionally, a device that administers a drug solution (insulin) is a portable device that is used by adhering to a user's skin. A so-called syringe pump type device has been proposed that is administered into the body by being pushed out (see, for example, Patent Document 1).

Special table 2010-501283 gazette

  By the way, in the apparatus mentioned above, in order to prevent a chemical | medical solution from leaking between the outer cylinder which is a chemical | medical solution container, and a piston, a piston is comprised, for example with a polymeric material (thermoplastic elastomer) etc., or at least outer peripheral part of a piston is made. A polymer material (thermoplastic elastomer) or the like is provided.

  On the other hand, it is required to further reduce the size of an apparatus that allows a user to hold it for a long time. In the case of downsizing the apparatus, the power source mounted inside must be reduced, and accordingly, the force for sending the drug solution to the outside must also be reduced.

  However, when a high-molecular material (thermoplastic elastomer) is used as the piston that is the seal member, the power supplied cannot be reduced due to the large sliding resistance between the piston and the outer cylinder. There is a problem that the power source to be used becomes large and cannot be reduced in size.

  The present invention has been made in consideration of the above points, and intends to propose a drug solution administration device that can be miniaturized.

  In order to solve this problem, the present invention provides a chemical solution administration device for administering a chemical solution into a user's body, the chemical solution storage unit storing the chemical solution, and the chemical solution being delivered from the chemical solution storage unit to the user's body. A flow path section that forms a flow path for liquid, a cylinder section provided in the middle of the flow path section, and a piston that slides in the cylinder section. The flow path section includes a chemical storage section and a cylinder section. The inflow path to be connected, and the outflow path to be connected to the cylinder part and the user's living body, the flow path part is provided on the inflow path so that the medicinal liquid flows from the medicinal liquid storage part to the cylinder part. A first restricting portion that controls the flow direction of the liquid and a second restricting portion that restricts the flow direction of the chemical solution provided on the outflow path so that the chemical solution flows from the cylinder portion into the living body of the user. The diameter of the piston is smaller than the diameter of the inner diameter part of the cylinder part. A volume changing member is provided between the piston and the cylinder to change the volume by contacting with the liquid.

  Thus, the volume change provided between the piston and the cylinder when the piston is slid in the cylinder part and the chemical liquid stored in the chemical liquid storage part is fed into the user's body through the flow path part. The hydrophilic polymer as a member can block the leakage of the chemical solution from between the piston and the cylinder and reduce the sliding resistance of the piston.

  According to the present invention, since the sliding resistance when the piston slides in the cylinder can be reduced, the power supplied to the drive unit for driving the piston can be reduced, and the power supply unit is It can be reduced in size, and thus the entire apparatus can be reduced in size.

It is a basic diagram which shows the structure of a chemical | medical solution administration apparatus. It is a disassembled perspective view of a chemical | medical solution administration apparatus. It is a basic diagram which shows the mode of the sending of the chemical | medical solution by a sending part. It is a basic diagram which shows the structure of a drive part. It is sectional drawing of a drive part. It is a basic diagram which shows the mode of a deformation | transformation of a vibrating body. It is a basic diagram which shows the relationship between a piston and a cylinder. It is a basic diagram which shows the mode of swelling of a hydrophilic polymer. It is a figure which shows an experimental result. It is a basic diagram which shows the electric constitution of a chemical | medical solution administration apparatus. It is a flowchart which shows a chemical | medical solution administration processing procedure. It is a basic diagram which shows the structure of the drive part in other embodiment. It is a basic diagram which shows the electric constitution of the chemical | medical solution administration apparatus in other embodiment.

  Hereinafter, an embodiment of the present invention will be described in detail with reference to the drawings.

[1. Configuration of drug administration device]
As shown in FIG. 1, the drug administration device 1 is a portable device that is used by being attached to a user's skin, and has a lower housing portion that is open on the upper side and has a space inside. 2 and the upper housing part 3 fitted in the opening of the lower housing part 2 are formed into a flat and substantially rectangular parallelepiped shape.

  The size of the drug solution administration device 1 may be reduced to such an extent that it can be attached to the user's skin, and examples thereof include a substantially rectangular parallelepiped shape having a width of 32 mm, a length of 44 mm, and a height of 11 mm.

  The lower housing part 2 is provided with a sticking part 4 made of double-sided tape or the like on the bottom surface 2A. The medicinal-solution administration device 1 is held by the user by attaching the adhesive portion 4 to the user's skin.

  The medicinal solution administration device 1 has a puncture portion made of a needle, a cannula or the like for puncturing the user's skin in order to administer the medicinal solution filled therein to the bottom surface 2A of the lower casing portion 2 into the user's body. 5 and an injection part 6 which is an injection path for injecting a chemical into a chemical storage part (FIG. 2) provided inside.

  As shown in FIG. 2, the drug solution administration device 1 includes an injection unit 6, a drug solution storage unit 7, a substrate unit 8, and a delivery unit 9 in a space formed by the lower housing unit 2 and the upper housing unit 3. The

  The chemical solution storage unit 7 is a container (2 mL in the present embodiment) formed of a flexible material. As a material constituting the chemical solution storage unit 7, for example, a material containing polyolefin is preferable, and particularly preferable examples include polyethylene or polypropylene, styrene-butadiene copolymer, styrene-ethylene-butylene-styrene block copolymer, and the like. And a soft resin obtained by blending and softening an olefinic thermoplastic elastomer such as an styrene thermoplastic elastomer or an ethylene-propylene copolymer, an ethylene-butene copolymer, or a propylene-α-olefin copolymer. And the chemical | medical solution storage part 7 is filled with a chemical | medical solution from the exterior through the injection | pouring part 6. FIG. Examples of the drug solution stored in the drug storage unit 7 include insulin, various hormones, analgesics such as morphine, or anti-inflammatory drugs. The substrate unit 8 is provided with a power supply unit 64 (FIG. 10) for supplying power supply power, a circuit for controlling the sending unit 9, and the like.

  As shown in FIGS. 2 and 3, the delivery unit 9 includes a piston 11, a drive unit 12 that reciprocates the piston 11 according to control of the CPU 61 (FIG. 6), and a drug solution from the drug solution storage unit 7 to the puncture unit 5. The flow path portion 13 that forms the flow path through which the gas flows, the cylinder 14 that has one end connected to the flow path portion 13 and the piston 11 that is inserted from the other end slides inside, and opens and closes the flow path of the flow path portion 13 It is set as the structure containing the limiting part 15 which restrict | limits the flow of a chemical | medical solution.

  The piston 11 is driven by the drive unit 12 and slides with a predetermined stroke in the cylinder 14. Examples of the material of the piston 11 include stainless steel, copper alloy, aluminum alloy, titanium material, thermoplastic elastomer such as polypropylene and polycarbonate, and the diameter thereof is, for example, about 0.8 mm. The piston 11 slides in the cylinder 14 to send a certain amount of chemical solution, and its stroke is, for example, about 2 mm.

  The flow path portion 13 includes a suction pipe 13A that forms an inflow path, a delivery pipe 13B that forms an outflow path, and a connection pipe 13C for connecting to a cylinder section. One end of the suction pipe 13A is connected to the medicine storage section 7, and the other end is connected to the connection pipe 13C. The delivery tube 13B has one end connected to the puncture unit 5 and the other end connected to the connection tube 13C. The connection pipe 13C has ends connected to the suction pipe 13A and the delivery pipe 13B, respectively, and the cylinder 14 is connected to the center portion.

  The restricting portion 15 includes a suction side lid portion 21 and a suction side pressing portion 23 constituting a first restriction portion, and a sending side lid portion 22 and a sending side pushing portion 24 constituting a second restriction portion.

  The suction-side lid portion 21 and the delivery-side lid portion 22 are elastically deformable members, and are spaced apart from each other end of the suction tube 13A and the delivery tube 13B by a predetermined distance. The suction-side pressing portion 23 and the delivery-side pressing portion 24 are actuators that operate according to the control of the CPU 61 (FIG. 10). The suction-side lid portion 21 and the delivery-side lid portion 22 are connected to the suction pipe 13A and the delivery pipe 13B. By pressing against the ends, the other ends of the suction pipe 13A and the delivery pipe 13B are respectively closed.

  The cylinder 14 has an inner diameter larger than the diameter of the piston 11, one end is connected to the connection pipe 13 </ b> C, and the piston 11 is inserted from the other end side to slide inside. The difference in diameter between the cylinder 14 and the piston 11 is, for example, about 0.01 mm.

  When sending the chemical solution from the chemical solution storage unit 7 to the outside, the delivery unit 9, as shown in FIG. 3, when the piston 11 comes to the most pushed position (hereinafter also referred to as the most pushed position), the suction side pressing unit. 23 is separated from the suction side lid 21 to open the flow path between the suction pipe 13A and the connection pipe 13C, and the delivery side pressing part 24 is pressed against the other end of the delivery pipe 13B by the delivery side pressing part 24. The flow path between 13B and the connecting pipe 13C is closed (FIG. 3A).

  The delivery section 9 slides the piston 11 in the cylinder 14 to the position where the piston 11 is most retracted from the most pushed position (hereinafter also referred to as the most retracted position) (hereinafter, this sliding direction is also referred to as the retracting direction). ), And the chemical stored in the chemical storage 7 is sucked into the cylinder 14 through the suction pipe 13A and the connection pipe 13C (FIG. 3B).

  When the piston 11 is moved to the most retracted position, the delivery part 9 presses the suction side cover part 21 against the other end of the suction pipe 13A by the suction side pressing part 23, thereby causing the flow between the suction pipe 13A and the connection pipe 13C. The path is closed (FIG. 3C), the sending side pressing part 24 is separated from the sending side cover part 22, and the flow path between the sending pipe 13B and the connecting pipe 13C is opened (FIG. 3D).

  The delivery unit 9 slides the piston 11 in the cylinder 14 from the most retracted position to the most pushed position (hereinafter, this sliding direction is also referred to as the pushing direction), and connects the chemical solution sucked into the cylinder 14. It sends out into a user's body via the pipe | tube 13C, the delivery pipe | tube 13B, and the puncture part 5 (FIG.3 (E) and (F)).

  The delivery unit 9 can administer a predetermined amount of chemical into the user's body by the operation of reciprocating the piston 11 (FIGS. 3A to 3F), and repeatedly performs this operation at a set cycle and interval. Thus, the drug solution can be administered to the user at a desired administration rate and dosage.

  As shown in FIG. 4 and FIG. 5 which is a cross-sectional view thereof, the drive unit 12 includes a support body 31, a shaft support body 32, a shaft body 33, a vibrating body 34, a moving body 35, a shaft contact body 36, and a tightening body. 37.

  The support 31 supports each part of the drive unit 12 via a shaft support 32 provided on one end side thereof. The support 31 is provided with movement restricting portions 31A and 31B projecting in the direction of the moving body 35 such that opposing surfaces are separated by a predetermined distance (a distance obtained by combining the stroke of the piston 11 and the width of the protruding portion 35B). The movement restricting portions 31A and 31B restrict the movement of the piston 11.

  The shaft support 32 is provided with a hole through which the shaft 33 is inserted. The shaft 33 has a substantially cylindrical shape, is inserted through the hole of the shaft support 32, and is supported so as to be movable in the axial direction. A vibrating body 34 made of, for example, a voltage element is brought into contact with one end of the shaft body 33.

  When a voltage is applied based on the control of the CPU 41 (FIG. 7), the vibrating body 34 is bent so that the central portion is pushed out with respect to the peripheral portion. At this time, the bending direction differs depending on the direction of the applied voltage. Specifically, for example, when a voltage is not applied, the surface is planar, and a voltage is applied in the direction of (FIG. 6A) and FIG. 6B (this direction is assumed to be a positive direction). Then, the shaft body 33 is deformed so as to be pushed out, and the shaft body 33 is deformed so as to be pulled back by applying a voltage in a direction opposite to that shown in FIG. 6 (C)).

  The shaft body 33 is sandwiched by a predetermined frictional force so as to be surrounded by the moving body 35 and the shaft contact body 36 via the fastening body 37 on the opposite side of the vibration body 34 with the shaft support body 32 interposed therebetween. .

  The moving body 35 is connected to the piston 11 on the side opposite to the shaft facing portion 35 </ b> A facing the shaft contact body 36.

  The movable body 35 is a protrusion having a predetermined width so as to come into contact with the opposing surfaces of the movement restriction portions 31A and 31B when the movement body 35 moves between the movement restriction portions 31A and 31B of the support 31. 35B is provided.

  When the voltage applied to the vibrating body 34 gradually changes in the positive direction, the driving unit 12 extends the vibrating body 34 and moves the shaft body 33 in the pushing direction. At this time, the moving body 35, the shaft contact body 36, the tightening body 37, and the piston 11 move in the pushing direction together with the shaft body 33 by the frictional force between the shaft body 33, the moving body 35, and the shaft contact body 36.

  Thereafter, when the voltage applied to the vibrating body 34 suddenly changes in the negative direction, the driving unit 12 contracts the vibrating body 34 and moves the shaft body 33 in the retracting direction. At this time, the moving body 35, the shaft abutting body 36, the tightening body 37, and the piston 11 are slipped by the inertial force overcoming the frictional force between the shaft body 33 and the moving body 35 and the shaft abutting body 36. , Stay in that position.

  In this manner, the drive unit 12 moves the piston 11 by a minute amount in the pushing direction by this one operation. The minute amount is, for example, about 0.2 μm. The drive unit 12 repeats this a predetermined number of times to move the piston 11 from the most retracted position to the most pushed position. For example, the drive unit 12 can be moved 2 mm by moving 10,000 times. At this time, the drive unit 12 can prevent the piston 11 from moving in the pressing direction from the most pressed position by the protrusion 35B coming into contact with the movement limiting unit 31A.

  On the other hand, when the voltage applied to the vibrating body 34 suddenly changes in the positive direction, the driving unit 12 extends the vibrating body 34 and moves the shaft body 33 in the pushing direction. At this time, the moving body 35, the shaft abutting body 36, the tightening body 37, and the piston 11 are slipped by the inertial force overcoming the frictional force between the shaft body 33 and the moving body 35 and the shaft abutting body 36. , Stay in that position.

  When the voltage applied to the vibrating body 34 gradually changes in the negative direction, the driving unit 12 contracts the vibrating body 34 and moves the shaft body 33 in the retracting direction. At this time, the moving body 35, the shaft contact body 36, the tightening body 37, and the piston 11 move in the retracting direction together with the shaft body 33 due to the frictional force between the shaft body 33, the moving body 35, and the shaft contact body 36.

  In this way, the drive unit 12 moves the piston 11 by a small amount in the pullback direction by this single operation. The minute amount is, for example, about 0.2 μm. The drive unit 12 repeats this a predetermined number of times to move the piston 11 from the most pushed position to the most retracted position. The predetermined number of times is, for example, 10,000 times, whereby the 2 mm piston 11 can be moved. At this time, the drive unit 12 can prevent the piston 11 from moving in the retracting direction from the most retracted position by the protrusion 35B coming into contact with the movement restricting unit 31B.

  Incidentally, as shown in FIG. 7, the diameter of the piston 11 is 0.8 mm, whereas the inner diameter of the cylinder 14 is 0.81 mm, and the piston 11 and the cylinder 14 are spaced by 5 μm.

  Therefore, as shown in FIG. 8A, a hydrophilic polymer 41 that swells by contact with the liquid is applied to the piston 11 through a primer as a volume changing member that changes its volume by contacting the liquid. This hydrophilic polymer 41 is set to be thinner than the gap between the piston 11 and the cylinder 14 before coming into contact with the liquid, and thicker than the gap between the piston 11 and the cylinder 14 after coming into contact with the liquid. Is done. An example of the volume changing member is a dimethylacrylamide-glycidyl methacrylate copolymer.

  In the drug solution administration device 1, the piston 11 is inserted into the cylinder 14 with the hydrophilic polymer 41 applied through a primer. Thereafter, when the chemical solution is put into the cylinder 14, the hydrophilic polymer 41 swells by contacting with the chemical solution, and completely fills the space between the piston 11 and the cylinder 14. Thereby, it is possible to prevent the chemical liquid filled in the cylinder 14 from leaking outside through the space.

  In order to confirm the leakage of the chemical solution when the space between the piston 11 and the cylinder 14 is sealed with the hydrophilic polymer 41, the diameter of the piston 11 is 1 mm, and the distance between the piston 11 and the cylinder 14 is changed to 5 μm, 10 μm, 15 μm, and 20 μm. Then, an experiment of sliding the piston 11 was performed.

  As shown in the experimental results in FIG. 9, when the distance between the piston 11 and the cylinder 14 is 10 μm, it greatly exceeds the 2000 times that is the number of sliding times required to send out all the chemical liquid filled in the chemical liquid storage unit 7. Even when the piston 11 was slid 6000 times, it was confirmed that the chemical liquid did not leak from between the piston 11 and the cylinder 14.

  Further, the sliding resistance of the piston 11 to which the hydrophilic polymer 41 was applied was measured. In addition, for comparison with this experiment, the sliding resistance of a syringe in which a gap between the cylinder and a piston with a diameter of about 3 mm was sealed with a polymer material (thermoplastic elastomer) coated with silicone oil was also measured.

  In this experiment, the sliding resistance of the piston 11 coated with the hydrophilic polymer 41 was about 5 gf, whereas the sliding resistance when using a polymer material (thermoplastic elastomer) was about 50 gf. It was. Thus, by using the hydrophilic polymer 41 to seal between the piston 11 and the cylinder 14, the sliding resistance can be greatly reduced.

[2. Electrical configuration of drug solution administration device]
As shown in FIG. 10, the drug solution administration device 1 includes a CPU (Central Processing Unit) 61, a ROM (Read Only Memory) 62, a RAM (Random Access Memory) 63, a power supply unit 64, and an interface unit (I / F unit) 65. The notification unit 66, the drive unit 12, and the restriction unit 15 are connected via a bus 67.

  The CPU 61, the ROM 62, the RAM 63, the power supply unit 64, and the notification unit 66 are arranged on the substrate unit 8 (not shown). A battery is applied to the power supply unit 64. As the notification unit 66, for example, a speaker for notification by voice, an LED for notification by light, or the like is applied.

  The interface unit 65 is arranged on the upper housing unit 3 or the lower housing unit 2 and is adapted with a button (not shown) for receiving a user input command. In addition, a communication unit including an antenna and a communication circuit for performing wireless communication instead of the interface unit 45 is installed, and an input command by wireless communication is received from an operation unit (not shown) separate from the pump. But you can.

  The CPU 61 performs overall control by reading and executing the basic program stored in the ROM 62 to the RAM 63, and executes various processes by reading and executing various application programs stored in the ROM 62 to the RAM 63. The user operates the drug solution administration device 1 and issues a command to the CPU 61 that is a control unit. The CPU 61 reads the basic program and controls the drive unit 12 and the restriction unit 15 to administer the drug to the user. The

  When the medical solution is administered to the user, the CPU 61 reads out the chemical solution administration program to the RAM 63 and executes it, thereby executing the chemical solution administration process according to the flowchart shown in FIG.

  When the CPU 61 executes the chemical solution administration process, the chemical solution is filled from the outside through the injection unit 6 (step SP1), the application unit 2 is applied to the user's skin, and the puncture unit 5 punctures the user's skin. After that (step SP2), parameters such as the dose and the dose rate input via the interface unit 65 are set (step SP3).

  Then, the CPU 61 controls the driving unit 12 and the limiting unit 15 based on the set parameters to start administration of the chemical solution (step SP4), and when all of the chemical solution stored in the chemical solution storage unit 7 has been administered (step SP4) The processing is terminated.

  Since the amount of chemical stored in the chemical storage 7 and the amount of chemical delivered when the piston 11 reciprocates once are determined, the CPU 61 stores in the chemical storage 7 based on the number of reciprocations of the piston 11. It is determined whether or not all the liquid medicines that have been delivered have been delivered (administered).

  CPU61 repeats step SP5-SP7 until the chemical | medical solution of the dosage set by step SP3 is administered, when all the chemical | medical solutions stored in the chemical | medical solution storage part 7 are not sent out (it is NO at step SP5).

  CPU61 waits until the input command which administers a chemical | medical solution next is input via the interface part 65, when the chemical | medical solution of the dosage set by step SP3 is administered (it is YES at step SP6) (step SP8).

[3. Operation and effect)
In the above configuration, the drug solution administration device 1 is configured such that the other end of the cylinder 14 to which one end is connected to the flow path unit 13 for sending the drug solution from the drug solution storage unit in which the drug solution (drug solution) is stored to the user's body. When the piston 11 slides on the side, the drug solution is delivered into the user's body.

  In the drug solution administration device 1, a hydrophilic polymer 41 is provided between the piston 11 and the cylinder 14. By sealing between the piston 11 and the cylinder 14 with the hydrophilic polymer 41, the piston 11 slides in the cylinder 14 without passing between the piston 11 and the cylinder 14 and leaking outside. The resistance can be greatly reduced as compared with the conventional case of sealing with a polymer material (thermoplastic elastomer).

  Thereby, in the chemical solution administration device 1, the power supplied to the drive unit 12 that drives the piston 11 can be reduced, and the battery constituting the power supply unit 45 can be reduced accordingly. Thus, the drug solution administration device 1 can be downsized as a whole.

  By the way, in the syringe pump that directly pushes the chemical solution with the plunger in the outer cylinder filled with the chemical solution, the cross-sectional area of the syringe and the plunger is the piston 11 and the cylinder of the present invention in order to secure the volume for filling the syringe with the chemical solution. 14 is larger than the cross-sectional area.

  Therefore, since the force applied to the plunger and the internal pressure increase when pushing out the chemical liquid, the chemical liquid is likely to leak if there is a gap between the syringe and the plunger, so it is completely sealed with a polymer material (thermoplastic elastomer). To prevent leakage.

  As described above, in the syringe pump, if the polymer material (thermoplastic elastomer) is sealed, the sliding resistance of the plunger increases. Therefore, in order to reduce the sliding resistance, silicone oil is applied to the inner surface of the outer cylinder or the outer periphery of the plunger. May be applied.

  However, as long as a polymer material (thermoplastic elastomer) is used, the sliding resistance cannot be reduced as in the present invention as shown in the above experimental results.

  On the other hand, in the chemical solution administration device 1, the hydrophilic polymer 41 functions as a lubricant that seals between the piston 11 and the cylinder 14 and reduces sliding resistance, so that the piston 11 slides in the cylinder 14. The sliding resistance can be greatly reduced.

  According to the above configuration, since the hydrophilic polymer 41 seals between the piston 11 and the cylinder 14, the sliding resistance when the piston 11 slides in the cylinder 14 can be greatly reduced. Accordingly, the power supplied to the drive unit 12 for driving the power source 11 can be reduced, and accordingly, the battery constituting the power supply unit 45 can be reduced, and thus the entire apparatus can be reduced in size.

[4. Other Embodiments]
In the embodiment described above, the case where the diameter of the piston 11 is 0.8 mm, the inner diameter of the cylinder 14 is 0.81 mm, and the distance between the piston 11 and the cylinder 14 is 10 μm has been described. The present invention is not limited to this, and the inner diameter of the cylinder 14 is set to 0.7 mm to 3 mm, and the space between the piston 11 and the cylinder 14 is set to 2 to 20 μm. It was confirmed that the sliding resistance at the time of sealing can be reduced to several gf to 30 gf.

  In the embodiment described above, the case where the hydrophilic polymer 41 is applied to the piston 11 has been described. However, the present invention is not limited to this, and the hydrophilic polymer 41 is applied to the inner surface of the cylinder 14. May be.

  In the above-described embodiment, the case where the drive unit 12 is applied as a reciprocating movement of the piston 11 has been described. However, if the reciprocating movement of the piston 11 is performed, for example, a gear is used as a rotating shaft. The attached DC motor may be rotated, and the piston 11 may be reciprocated by a feed screw via the gear.

  In the above-described embodiment, the case where the movement of the piston 11 is restricted by the protrusion 35B of the moving body 35 coming into contact with the movement restricting portions 31A and 31B of the support 31 has been described. Is not limited to this.

  For example, as shown in FIG. 12 in which parts corresponding to those in FIG. 4 are assigned the same reference numerals, the drive unit 112 is replaced by a support 31 and a piston position detection unit 131A is replaced by a moving body instead of the movement restriction units 31A and 31B. A support 131 is provided at a position facing 35.

  The piston position detector 131A only needs to be able to detect the position of the piston 11 by detecting the position of the moving body 35, and a magnetic sensor, an ultrasonic sensor, an optical sensor (laser distance meter), or the like is applied. In addition, what is necessary is just to make the protrusion part 35B into a magnetic body, when a magnetic sensor is applied.

  In the drug solution administration device 100 using the drive unit 112, the piston position detection unit 131A is connected to each unit via a bus 67, as shown in FIG. The piston position detector 131A detects the position of the moving body 35 at predetermined intervals, and sends a signal indicating the position of the piston 11 to the CPU 61 based on the moving body 35. The CPU 61 executes the above-described drug administration program and the like based on a signal indicating the position of the piston 11 supplied from the piston position detection unit 131A.

  In the above-described embodiment, the restricting portion 15 includes the suction side lid portion 21, the delivery side lid portion 22, the suction side pressing portion 23, and the sending side pressing portion 24, and the suction side pressing portion 23 and the sending side pressing portion. The suction side lid part 21 and the delivery side lid part 22 are pressed against the other ends of the suction pipe 13A and the delivery pipe 13B via 24, and the chemical liquid flows from the chemical liquid storage part 7 into the user's body through the flow path part 13. The case where the restriction was made was described. The present invention is not limited to this, but an automatic valve or a one-way valve is provided in place of the restriction unit 15, and the flow path of the flow path section 13 is limited to flow from the chemical solution storage section 7 to the user's body. Also good.

  The present invention can be applied to the medical field, for example.

  DESCRIPTION OF SYMBOLS 1 ... Chemical solution administration apparatus, 2 ... Lower housing | casing part, 3 ... Upper housing | casing part, 4 ... Pasting part, 5 ... Puncture part, 6 ... Injection | pouring part, 7 ... Chemical liquid storage part, 8 ... ... substrate part, 9 ... delivery part, 11 ... piston, 12 ... drive part, 13 ... flow path part, 14 ... cylinder, 15 ... restricting part, 31 ... support, 32 ... shaft support Body 33... Shaft body 33... Vibrating body 35. Mobile body 41. Hydrophilic polymer 41 and 50 Experimental apparatus 61 CPU and 62 ROM and 63 RAM and 64 ... power supply unit, 65 ... interface unit, 66 ... notification unit, 67 ... bus.

Claims (4)

A drug solution administration device for administering a drug solution into a user's body,
A chemical solution storage section for storing the chemical solution;
A flow path portion that forms a flow path for sending a chemical liquid from the chemical liquid storage section to the user's body; and
A cylinder part provided in the middle of the flow path part;
A piston sliding in the cylinder part,
The flow path section includes an inflow path connecting the chemical solution storage section and the cylinder section,
The cylinder part and the outflow path connected to the user's living body,
The flow path unit includes a first restriction unit that restricts a flow direction of the chemical solution provided on the inflow path so that the chemical solution flows from the chemical solution storage unit to the cylinder unit, and the cylinder unit to the user. A second restricting portion for restricting a flow direction of the chemical solution provided on the outflow path so that the chemical solution flows into the living body of
The piston has a diameter smaller than the diameter of the inner diameter portion of the cylinder portion,
A drug solution administration device, wherein a volume changing member is provided between the piston and the cylinder to change the volume of the piston by contacting the liquid.   2. The drug solution administration device according to claim 1, wherein the volume changing member is made of a hydrophilic polymer that swells when in contact with a liquid. The drug solution administration device according to claim 1, wherein an inner diameter of the cylinder portion is 0.7 mm or more and 3 mm or less. 2. The drug solution administration device according to claim 1, wherein a distance between the piston and the cylinder portion is 2 μm or more and 20 μm or less.

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