JP2013070790A - Drug solution delivery device - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a drug solution delivery device capable of correctly delivering a drug solution by having a function of preventing an unintendedly excessive amount of drug solution such as insulin from being delivered into a human body, for example, in such a case that the insulin is delivered into the human body.SOLUTION: The device includes a restricting section 9 which is provided between a drug solution storing section 7 for storing a drug solution and a sending section 10 for sending the drug solution to the outside and flows the drug solution when the sending section 10 has a negative pressure and stops the flow of the drug solution when the drug solution storing section 7 has a positive pressure. With this configuration, when the sending section 10 is driven to deliver the drug solution, the restricting section 9 communicates a flow path from the drug solution storing section 7 to the sending section 10 to enable the drug solution stored in the drug solution storing section 7 to be delivered to a user via the sending section 10. When a lower casing 2 or an upper casing 3 is deformed due to an applied external force and a positive pressure is applied to the drug solution storing section 7, the restricting section 9 closes a flow path from the drug solution storing section 7 to the sending section 10. Thus, even if a positive pressure is applied to the drug solution storing section 7, the drug solution can be prevented from being delivered into user's body via the sending section 10, resulting in correct delivery of the drug solution.

Description

  The present invention relates to a chemical solution administration device, and is suitable for application to, for example, administering insulin to a human body.

  2. Description of the Related Art Conventionally, as a device for administering a drug solution (insulin), a so-called piston pump that is a portable device that is used by being attached to a user's skin, and in which a drug solution filled in a storage container that is a drug solution container is administered into the body. A type device has been proposed (see, for example, Patent Document 1).

Special table 2010-501283

  By the way, when hold | maintaining by a user like the chemical | medical solution administration apparatus mentioned above, there exists a possibility that force (external force) may be applied with respect to a chemical | medical solution administration apparatus from the outside.

  Since the case is made of plastic or the like in order to reduce the weight because it is attached to and held on the user's skin, the drug solution administration device is a drug solution in which the case is deformed by external force and the drug solution is stored It is also conceivable that pressure is applied to the storage unit according to the deformation of the housing.

  At this time, in the drug solution administration device, the inside of the drug solution storage unit may become a positive pressure and the drug solution may be pushed out to the outside (the user's body).

  The present invention has been made in consideration of the above points, and an object of the present invention is to propose a drug solution administration device having a function of preventing an unintended excessive amount of drug solution from being administered into the body.

  In order to solve such a problem, the present invention is a portable chemical solution administration device for administering a chemical solution into a living body, and stores the chemical solution storage unit for storing the chemical solution, and the chemical solution is sent from the chemical solution storage unit to the user's body. A flow path section that forms a flow path for liquid, a delivery section that is provided in the middle of the flow path section and that stores the chemical liquid stored in the chemical liquid storage section into the living body via the flow path section, and a chemical liquid in the flow path section Provided between the storage part and the delivery part, and when the delivery part side becomes negative pressure, the flow path between the chemical solution storage part and delivery part is communicated, and when the chemical solution storage part side becomes positive pressure, the chemical solution storage part and delivery part And a restricting portion for closing the flow path between the two.

  As a result, when the delivery unit is driven to administer the drug solution into the living body, the restricting unit communicates the flow path from the drug solution storage unit to the delivery unit, so that the drug solution passes through the channel unit from the drug solution storage unit to the living body. Can be administered. On the other hand, when a positive pressure is applied to the chemical storage part by external force, the restricting part blocks the flow path between the chemical storage part and the delivery part and prevents the chemical liquid from flowing into the living body from the chemical storage part. can do.

  According to the present invention, when the delivery unit is driven to administer the chemical solution into the living body, the restriction unit communicates the flow path from the chemical solution storage unit to the delivery unit, so that the chemical solution passes from the chemical solution storage unit through the flow channel unit. On the other hand, when a positive pressure is applied to the chemical storage part by an external force, the restricting unit closes the flow path between the chemical storage part and the delivery part from the chemical storage part. The drug solution does not flow out into the living body, thus preventing an unintended excessive amount of the drug solution from being administered into the body.

It is a basic diagram which shows the structure of a chemical | medical solution administration apparatus. It is a disassembled perspective view of a chemical | medical solution administration apparatus. It is a basic diagram which shows the flow path of the chemical | medical solution in a chemical | medical solution administration apparatus. It is a disassembled perspective view which shows the structure of a restriction | limiting part. It is sectional drawing of a restriction | limiting part. It is a basic diagram which shows the mode of the control part at the time of making the sending part side into a negative pressure. It is a basic diagram which shows the mode of the control part at the time of making a chemical | medical solution storage part side into a positive pressure. It is a basic diagram which shows the electric constitution of a chemical | medical solution administration apparatus. It is a basic diagram which shows the analysis result at the time of changing the thickness of a diaphragm. It is a basic diagram which shows the analysis result at the time of changing the diameter of a metal plate. It is a basic diagram which shows the analysis result at the time of changing the hardness of a seal valve. It is a basic diagram which shows the analysis result of the pressure distribution at the time of setting the negative pressure of 5 kPa on the sending part side, and the displacement of a seal valve. It is a basic diagram which shows the analysis result of the pressure distribution at the time of making the chemical | medical solution storage part side into the positive pressure of 10 kPa, and a contact pressure.

  Hereinafter, an embodiment of the present invention will be described in detail with reference to the drawings.

[1. Configuration of drug administration device]
As shown in FIG. 1, the drug solution administration device 1 is a portable device that is used by being attached to an appropriate place on the skin of a user, and includes a lower housing portion 2 having a space inside and a lower housing portion 2. The upper casing 3 that fits into the opening of the casing 2 is formed into a flat, substantially rectangular parallelepiped shape. The lower housing 2 and the upper housing 3 are made of a material such as synthetic resin (plastic).

  The size of the drug solution administration device 1 may be reduced to such an extent that it can be attached to the user's skin, and examples thereof include a substantially rectangular parallelepiped shape having a width of 32 mm, a length of 44 mm, and a height of 11 mm.

  The lower housing part 2 is provided with a sticking part 4 made of double-sided tape or the like on the bottom surface 2A. The medicinal-solution administration device 1 is held by the user by attaching the adhesive portion 4 to the user's skin.

  The medicinal solution administration device 1 has a puncture portion made of a needle, a cannula or the like for puncturing the user's skin in order to administer the medicinal solution filled therein to the bottom surface 2A of the lower casing portion 2 into the user's body. 5 and an injection part 6 which is an injection port for injecting a chemical into a chemical storage part 7 (FIG. 2) provided therein.

  As shown in FIGS. 2 and 3, the drug solution administration device 1 includes an injection unit 6, a drug solution storage unit 7, a flow channel unit 8, and a restriction unit in a space formed by the lower casing unit 2 and the upper casing unit 3. 9, a delivery unit 10, a drive unit 11, a substrate unit 12, and the like are provided.

  The chemical solution storage unit 7 is a container (2 mL in the present embodiment) formed of a flexible material. As a material constituting the chemical solution storage unit 7, for example, a material containing polyolefin is preferable, and particularly preferable examples include polyethylene or polypropylene, styrene-butadiene copolymer, styrene-ethylene-butylene-styrene block copolymer, and the like. And a soft resin obtained by blending and softening an olefinic thermoplastic elastomer such as an styrene thermoplastic elastomer or an ethylene-propylene copolymer, an ethylene-butene copolymer, or a propylene-α-olefin copolymer. And the chemical | medical solution storage part 7 is filled with a chemical | medical solution from the exterior through the injection | pouring part 6. FIG. Examples of the drug solution stored in the drug solution storage unit 7 include analgesics such as insulin, various hormones, morphine, and anti-inflammatory drugs.

  The flow path portion 8 is constituted by a suction pipe 8A, a connection pipe 8B, and a delivery pipe 8C, and forms a flow path through which a chemical solution flows. The suction pipe 8A is a pipe that allows the chemical solution storage unit 7 and the restriction unit 9 to communicate with each other. The connection pipe 8 </ b> B is a pipe that allows the restriction unit 9 and the sending unit 10 to communicate with each other. The delivery tube 8C is a tube that allows the delivery unit 10 and the puncture unit 5 to communicate with each other, and includes a puncture unit 5 at the tip thereof.

  As will be described in detail later, the restricting unit 9 communicates that the discharge unit 10 side (connecting tube 8B side) has a negative pressure relative to the chemical solution storage unit 7 via the suction tube 8A and the connecting tube 8B. When the chemical solution storage unit 10 side (the suction pipe 8A side) becomes a positive pressure relative to the delivery unit 10 side, the chemical solution is blocked by closing the flow path from the chemical solution storage unit 7 to the delivery unit 10. Do not flow.

  The delivery unit 10 includes a piston 21, a cylinder unit 22, one-way valves 23 and 24, and O-rings 25 and 26.

  The piston 21 is driven by the drive unit 11 and slides with a predetermined stroke in contact with the inner wall in the substantially cylindrical internal space 22 </ b> A formed in the cylinder unit 22. Examples of the material of the piston 11 include stainless steel, copper alloy, aluminum alloy, titanium material, thermoplastic elastomer such as polypropylene and polycarbonate.

  The cylinder part 22 is provided with an internal space 22A in which the piston 11 is inserted and slid from one end, and the other end of the internal space 22A is connected to the connection pipe 8B and the delivery pipe 8C to form a flow path through which the chemical solution flows. A flow path 22B is formed.

  The one-way valve 23 is provided between the connection pipe 8B and the flow path 22B, allows the chemical liquid flowing from the connection pipe 8B to the flow path 22B to pass therethrough, and does not allow the chemical liquid to pass from the flow path 22B to the connection portion 8B. For example, an umbrella valve is applied.

  The one-way valve 24 is provided between the flow path 22B and the delivery pipe 8C, allows the chemical liquid flowing from the flow path 22B to the delivery pipe 8C to pass, and does not allow the chemical liquid to pass from the delivery pipe 8C to the flow path 22B. For example, an umbrella valve is applied.

  The O-ring 25 is arranged between the connection pipe 8B and the cylinder part 22 so as to surround the outer periphery of the one-way valve 23, and the chemical liquid leaks to the outside from between the connection pipe 8B and the cylinder part 22. To prevent.

  The O-ring 26 is arranged between the cylinder portion 22 and the delivery pipe 8C so as to surround the outer periphery of the one-way valve 24, and the chemical liquid leaks to the outside from between the cylinder portion 22 and the delivery pipe 8C. To prevent.

  The drive unit 11 drives the piston 21 to reciprocate according to the control of the CPU 41 (FIG. 8). The substrate unit 12 is provided with a power supply unit 44 (FIG. 8) that supplies power supply power, a circuit that controls the drive unit 11, and the like.

[2. (Configuration of restriction part)
As shown in FIGS. 4 and 5, the limiting portion 9 includes a lid portion 31, a metal plate 32, a diaphragm 33, a main body portion 34, a seal valve 35, and an input port 36, and is formed in a substantially cylindrical shape as a whole. Is about 8 mm and the thickness is about 3 mm.

  The lid portion 31 is made of a material such as resin (PMMA), for example, and is formed in a flat disk shape having a diameter of about 8 mm. The lid portion 31 is provided with a hole 31 </ b> A penetrating in the center thereof, and a groove 31 </ b> B larger than the diameter of the metal plate 32 and deeper than the thickness of the metal plate 32 is provided on the surface on the diaphragm 33 side.

  The metal plate 32 is made of a material such as stainless steel, for example, and is formed in a flat disk shape with a diameter of 2 to 5 mm. The metal plate 32 is a surface on the lid portion 31 side of the diaphragm 33 and is bonded to the center thereof.

  The diaphragm 33 is made of a material such as silicone rubber, for example, and is formed in a flat disk shape having a diameter of about 8 mm and a thickness of about 0.1 to 0.2 mm. The diaphragm 33 is fixed in a liquid-tight manner with no gap between the outer periphery of the lid 31 and the main body 34 so as to be sandwiched over the entire circumference, and is not sandwiched between the lid 31 and the main body 34. The portion is elastically deformed by applying a predetermined pressure (a pressure of 5 [kPa] or less in the present embodiment).

  The main body 34 is made of a material such as resin (PMMA), for example, and is formed in a substantially cylindrical shape having a diameter of about 8 mm. The main body portion 34 is provided with a groove 34A on the upper surface on the diaphragm 33 side that is larger than the diameter of the metal plate 32 and deeper than the distance at which the diaphragm 33 moves downward (in the direction toward the main body portion 34 with respect to the diaphragm 33). It is done.

  The main body portion 34 is provided with a hole 34 </ b> B penetrating in the vertical direction having a diameter larger than the outer diameter of the column portion 35 </ b> D of the seal valve 35 at the center in the vertical direction.

  The main body 34 is sealed at the center of the bottom surface opposite to the surface on the diaphragm 33 side at the same thickness as the total thickness of the input port 36 and the thickness from the bottom surface of the seal valve 35 to the upper end of the base portion 35A. A groove 34C having a diameter slightly larger than the diameter of the valve 35 is provided.

  In the main body 34, a flange groove 34 </ b> D that matches the diameter and thickness of the flange 36 </ b> B of the input port 36 is integrally formed with the groove 34 </ b> C at the center of the bottom surface.

  The main body portion 34 is provided with a hole 34E that communicates with the groove 34A at a position that is the bottom surface and does not interfere with the hole 34B, the groove 34C, and the flange groove 34D.

  The seal valve 35 is made of a material such as silicone having a hardness of 30 to 70, and a base portion 35A, a deformable portion 35B, an abutting portion 35C, and a column portion 35D are integrally formed.

  The base portion 35 </ b> A has a substantially cylindrical shape with a diameter smaller than the diameter of the groove 34 </ b> C of the main body portion 34 and a predetermined thickness, and the bottom surface is bonded to the input port 36.

  The deformable portion 35B is a deformable thin annular portion that connects the base portion 35A and the abutting portion 35C above the inner side of the base portion 35A, penetrates in the vertical direction, and has a plurality of intervals in the circumferential direction. A hole 35E is provided. An internal space 35F is formed inside the base portion 35A and below the deformable portion 35B.

  The contact portion 35C is provided inside the deformable portion 35B, and an annular portion 35G having a semicircular cross section (a semicircle having a rounded portion facing upward) is integrally formed above the cylindrical portion. In the contact portion 35C, the upper surface of the annular portion is in contact with the upper surface 34F of the groove 34A of the main body portion 34 without any gap in the circumferential direction in a state where the diaphragm 33 and the deformation portion 35B are not deformed.

  The column portion 35D is provided at a position that is the center of the upper surface of the abutting portion 35C and does not interfere with the semicircular annular portion. The column portion 35 </ b> D is formed in a cylindrical shape, and the upper surface is bonded to the diaphragm 33.

  The input port 36C is made of a material such as resin (PMMA), for example, and has a support portion 36A having a diameter smaller than the diameter of the groove 34C of the main body portion 34 and a diameter of the flange groove 34D of the main body portion 34 below the support portion 36A. A flange 36B having a smaller diameter is integrally formed.

  The input port 36 is provided with a hole 36C penetrating in the vertical direction in the center. Further, the input port 36 is provided with a groove 36D having a predetermined depth with a surface on the seal valve 35 side having the same diameter as the internal space 35F, and a protrusion 36E protruding in the direction of the seal valve is provided in the groove 36D. 36A and the flange 36B are integrally formed.

  In the restricting portion 9, the suction pipe 8 </ b> A is connected to the hole 36 </ b> C of the input port 36, and the connection pipe 8 </ b> B is connected to the hole 34 </ b> E of the main body portion 34. That is, in the restricting section 9, the chemical liquid storage section 7 and the hole 36C of the input port 36 are communicated with each other through the suction pipe 8A, and the delivery section 10 and the hole 34E of the main body section 34 are communicated with each other through the connection pipe 8B.

  The control unit 9 has a flow path (hereinafter referred to as a flow path) through which a chemical solution flows by the hole 36C of the input port 36, the internal space 35F of the seal valve 35, the hole 35E, and the groove 34C, hole 34B, groove 34A and hole 34E of the main body 34. An internal flow path).

  Therefore, the restriction unit 9 can communicate the chemical solution storage unit 7 and the delivery unit 10 via the suction pipe 8A, the internal flow path, and the connection pipe 8B.

  In the state where the pressure is not applied, that is, in the state where the diaphragm 33 and the deformed portion 35B of the seal valve 35 are not deformed, the restricting portion 9 is configured so that the contact portion 35C of the seal valve 35 is the upper surface 34F of the groove 34D of the main body portion 34. The inner flow path is closed and the flow path from the chemical solution storage section 7 to the delivery section 10 is closed.

  On the other hand, when the drive unit 11 is driven and the piston 21 is moved in the direction of expanding the internal space 22A, the limiting unit 9 is a contact portion of the seal valve 35 from the hole 34E connected to the connection portion 8B in the main body portion 34. The internal flow path up to 35C becomes negative pressure.

  At this time, in the restricting portion 9, as shown in FIG. 6, the diaphragm 33 is deformed downward by the negative pressure by the piston 21 (indicated by the white arrow in the drawing), and the contact portion 35C of the seal valve 35 and the support column are correspondingly deformed. The part 35D also moves downward. In the seal valve 35, the deforming portion 35B is deformed in accordance with the downward movement of the contact portion 35C and the column portion 35D.

  Therefore, in the restricting portion 9, the contact portion 35C of the seal valve 35 is separated from the upper surface 34F of the groove 34D of the main body portion 34 to open the internal flow path, and from the chemical solution storage section 7 to the delivery section 10 via the internal flow path. The chemical liquid flows through the internal flow path as shown by arrows in the figure. Thereby, in the chemical solution administration device 1, the chemical solution is drawn from the chemical solution storage unit 7 to the delivery unit 10 by the negative pressure by the piston 21, and when the piston is moved in a direction to shrink the internal space 22A (see FIG. 3), the delivery pipe 8C and The drug solution is administered into the user's body through the puncture unit 5.

  By the way, since the lower housing | casing part 2 and the upper housing | casing part 3 are formed with the thin synthetic resin, when the external force is applied, the lower housing | casing part 2 and the upper housing | casing part 3 will deform | transform. Therefore, pressure is also applied to the chemical solution storage unit 7, and the chemical solution storage unit 7 may become positive pressure (a state where the pressure is higher than the outside).

  As shown in FIG. 7, when the chemical solution storage unit 7 reaches a positive pressure, the restricting unit 9 has a contact portion 35 </ b> C of the seal valve 35 via the suction pipe 8 </ b> A, the hole 36 </ b> C of the input port 36, and the internal space 35 </ b> F of the seal valve 35. An upward pressure is applied to the contact portion 35C, and the contact portion 35C is pressed against the upper surface 34F of the groove 34C of the main body portion 34 by the pressure. In FIG. 7, the pressure is indicated by a white arrow.

  Therefore, the restricting portion 9 closes the internal flow path when the annular portion 35G of the contact portion 35C is pressed against the upper surface 34F on the outer periphery of the groove 34C of the main body portion 34, and the flow path from the chemical solution storage portion 7 to the delivery portion 10 is closed. Block. Thereby, in the chemical solution administration device 1, even if the chemical solution storage unit 7 becomes positive pressure, the chemical solution does not flow downstream from the restriction unit 9 due to the positive pressure, so that the chemical solution is administered into the user's body. To prevent that.

[3. Electrical configuration of drug solution administration device]
As shown in FIG. 8, the drug solution administration device 1 includes a CPU (Central Processing Unit) 41, a ROM (Read Only Memory) 42, a RAM (Random Access Memory) 43, a power supply unit 44, and an interface unit (I / F unit) 45. The notification unit 46 and the drive unit 11 are connected via a bus 47.

  The CPU 41, ROM 42, RAM 43, power supply unit 44 and notification unit 46 are arranged on the substrate unit 12. A battery is applied to the power supply unit 44. As the notification unit 46, for example, a speaker for notification by voice, an LED for notification by light, or the like is applied.

  The interface unit 45 is provided with a button (not shown) that is arranged in the upper casing unit 3 or the lower casing unit 2 and receives a user input command. In addition, a communication unit including an antenna and a communication circuit for performing wireless communication instead of the interface unit 45 is installed, and an input command by wireless communication is received from an operation unit (not shown) separate from the pump. But you can.

  The CPU 41 performs overall control by reading the basic program stored in the ROM 42 into the RAM 43 and executing it, and executes various processes by reading out and executing various application programs stored in the ROM 42 into the RAM 43. The user operates the drug solution administration device 1 and issues a command to the CPU 41 that is a restriction unit, whereby the CPU 41 reads the basic program and controls the drive unit 11 to start administration of the drug solution to the user.

[4. Analysis and analysis results)
[4-1. Analysis and results of optimization)
First, the diameter and thickness of the entire restricting portion 9 are 8 mm and 3 mm, respectively, and as shown in FIG. 9A, the thickness of the diaphragm 33 (hardness 50), the diameter of the metal plate 32, and the hardness of the seal valve 35 are set. The displacement amount of the contact portion 35C when changed was analyzed by the finite element method. As an external load at the time of analysis, a negative pressure of 5 kPa was applied to the delivery unit 10 side.

  FIGS. 9B and 9C show the analysis results when the thickness of the diaphragm 33 is 0.1 mm and 0.2 mm, respectively. As is apparent from the drawing, it can be seen that the thinner the diaphragm 33, the easier it is to deform.

  Next, the analysis results when the diameter of the metal plate 32 is 2 mm, 4 mm, and 5 mm are shown in FIGS. 10A, 10B, and 10C, respectively. As is apparent from the figure, the diaphragm 33 is most deformed when the diameter of the metal plate 32 is 4 mm, and it can be seen that there is a size of the metal plate 32 suitable for the deformation of the diaphragm 33.

  Next, the analysis results when the hardness of the seal valve 35 is 30 and 70 are shown in FIGS. As is apparent from the figure, it can be seen that the seal valve 35 is more easily deformed as it is softer.

[4-2. Analysis and analysis results of seal valve deformation and contact pressure
Next, the pressure distribution and deformation of the seal valve 35 when a negative pressure of 5 kPa is applied from the delivery unit 10 side, and the pressure distribution and the contact pressure when a positive pressure of 10 kPa is applied from the chemical solution storage unit 7 side are analyzed. The finite element method was used.

  The analysis was performed assuming that the thickness of the diaphragm 33 is 0.1 mm, the diameter of the metal plate 32 is 4 mm, and the hardness of the seal valve 35 is 30.

  First, FIGS. 12A and 12B show analysis results of pressure distribution and deformation of the seal valve 35 when a negative pressure of 5 kPa is applied from the delivery unit 10 side. 12A shows that the contact portion 35C of the seal valve 35 is separated from the upper surface 34F of the groove 34D of the main body portion 34 by about 0.04 mm.

  Next, the pressure distribution when a positive pressure of 10 kPa is applied from the chemical solution storage unit 7 side, and the contact pressure between the contact portion 35C of the seal valve 35 and the upper surface 34F of the groove 34D of the main body 34 are shown in FIG. And (B). In FIG. 13A, it can be seen that a pressure of 10 kPa is applied to the upper surface and the bottom surface of the contact portion 35B of the seal valve 35. In FIG. 13B, the maximum contact pressure between the contact portion 35C of the seal valve 35 and the upper surface 34F of the groove 34D of the main body 34 is about 30 kPa, and the internal flow path can be closed by the seal valve 35. I understood.

[5. Experiment and experimental result)
Next, in the restriction part 9 created by the inventor, it is confirmed that when a negative pressure of 2 kPa is applied from the hole 34E side (the delivery part 10 side) of the main body part 34, the liquid imitating the chemical liquid starts to flow through the internal flow path. It was.

  Therefore, the limiting portion 9 confirms that the hole 34E side (the delivery portion 10 side) of the main body portion 34 is 5 kPa or less, the seal valve 35 is separated from the upper surface 34F of the groove 34D of the main body portion 34, and the internal flow path is communicated. It was done.

  Moreover, in the restriction part 9 created by the inventor, it is confirmed that even if a positive pressure of 50 kPa is applied from the hole 36C side (chemical liquid storage part 7 side) of the input port 36, the liquid imitating the chemical liquid does not flow through the internal flow path. It was done. Therefore, it was confirmed that the limiting portion 9 closed the internal flow path with the seal valve 35 even when a positive pressure of at least 50 kPa was applied to the hole 36C side (the sending portion 10 side) of the input port 36.

[6. Effect etc.)
In the above configuration, the drug solution administration device 1 causes the drug solution to flow between the drug solution storage unit 7 that stores the drug solution and the delivery unit 10 that sends the drug solution to the outside when the delivery unit 10 side becomes negative pressure, and the drug solution storage unit 7 side A limiting portion 9 is provided to stop the flow of the chemical solution when the positive pressure is reached.

  Thereby, in the chemical solution administration device 1, when the delivery unit 10 is driven to administer the chemical solution, the restriction unit 9 communicates the flow path from the chemical solution storage unit 7 to the delivery unit 10 and is stored in the chemical solution storage unit 7. The medicinal solution can be administered to the user via the delivery unit 10.

  On the other hand, when the external force is applied and the lower housing part 2 or the upper housing part 3 is deformed and a positive pressure is applied to the chemical liquid storage unit 7, the chemical liquid administration device 1 is configured so that the restricting unit 9 moves from the chemical liquid storage unit 7. Since the flow path to the delivery unit 10 is closed, it is possible to prevent the chemical solution from being administered into the user's body via the delivery unit 10 even if a positive pressure is applied to the chemical solution storage unit 7. Thus, the drug solution administration device 1 can accurately administer the drug solution.

  The restricting unit 9 is a diaphragm 33 that is deformed by the negative pressure generated when the delivery unit 10 is driven, and a main body part that is in contact with one surface of the diaphragm 33 and forms an internal flow path that communicates the drug solution storage unit 7 and the delivery unit 10. 34 and a seal valve 35 that is bonded to the diaphragm 33 in the internal flow path in the main body 34 and moves in accordance with the deformation of the diaphragm 33 to close and open the flow path in the main body 34.

  Thereby, since the restricting unit 9 does not use a complicated configuration, the entire drug solution administration device 1 can be reduced in size and weight. This is particularly useful when applied to a drug solution administration device that is carried on a user's skin.

  The present invention can be applied to the medical field, for example.

  DESCRIPTION OF SYMBOLS 1 ... Chemical solution administration apparatus, 2 ... Lower housing | casing part, 3 ... Upper housing | casing part, 4 ... Pasting part, 5 ... Puncture part, 6 ... Injection | pouring part, 7 ... Chemical liquid storage part, 8 ... ... Flow path part, 9 ... Limiting part, 10 ... Sending part, 11 ... Drive part, 12 ... Substrate part, 21 ... Piston, 22 ... Cylinder part, 23, 24 ... One-way valve, 25 , 26... O-ring, 31... Lid, 32 .. metal plate, 33... Diaphragm, 34 .. main body, 35 .. seal valve, 36 .. input port, 41. ROM, 43... RAM, 44... Power supply unit, 45... Interface unit, 46.

Claims (4)

A portable drug administration device for administering a drug solution to a living body,
A chemical storage section for storing the chemical,
A flow path section that forms a flow path for feeding a chemical liquid from the chemical liquid storage section into the living body;
A delivery part that is provided in the middle of the flow path part, and sends out the chemical liquid stored in the chemical liquid storage part to the user's body via the flow path part;
Provided between the chemical solution storage part and the delivery part in the flow path part, and when the delivery part side becomes negative pressure, the flow path between the chemical solution storage part and the delivery part is communicated, and the chemical solution storage part side is A chemical solution administration device comprising: a restriction unit that blocks a flow path between the drug solution storage unit and the delivery unit when positive pressure is reached. The delivery part has a cylinder part and a piston that slides in the internal space of the cylinder part, and the chemical solution stored in the chemical solution storage part is absorbed in the living body by sliding the piston in the internal space. To
The restriction unit is
When the piston is moved in the direction in which it is pulled out from the internal space, the flow path between the drug solution storage unit and the delivery unit is communicated by negative pressure, and the drug solution storage side becomes positive pressure by the external force. 2. The medicinal-solution administration device according to claim 1, wherein a flow path between the unit and the delivery unit is blocked. The restriction unit is
A diaphragm that is deformed by a negative pressure due to the operation of the delivery unit;
A main body portion formed so that an internal flow path for communicating the chemical solution storage section and the delivery section via the flow path section is in contact with one surface of the diaphragm;
The medicinal-solution administration device according to claim 1, further comprising: a seal valve that is connected to the diaphragm within the internal flow path and moves according to deformation of the diaphragm to open the internal flow path. The main body is
The diaphragm is brought into contact with one surface, and the chemical solution storage unit and the delivery unit are connected from the surface different from the one surface through the internal flow channel and the flow channel unit, respectively. The internal flow path is expanded on the chemical solution storage side than the position in contact with the diaphragm,
The seal valve is
An abutting portion that abuts the inner channel from the side of the chemical solution storage unit along the circumferential direction on the inner surface at the spread position in the inner channel,
A strut portion that connects the diaphragm and the contact portion,
The diaphragm is deformed to the internal flow path side by the negative pressure due to the operation of the delivery section, the contact section is separated from the inner surface, and the contact section is brought to the inner surface when the chemical solution storage section side becomes positive pressure. The drug solution administration device according to claim 3, wherein the drug solution administration device is pressed.