JP2013095670A - Carbonic acid-containing internal liquid preparation - Google Patents
Carbonic acid-containing internal liquid preparation Download PDFInfo
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- JP2013095670A JP2013095670A JP2011236775A JP2011236775A JP2013095670A JP 2013095670 A JP2013095670 A JP 2013095670A JP 2011236775 A JP2011236775 A JP 2011236775A JP 2011236775 A JP2011236775 A JP 2011236775A JP 2013095670 A JP2013095670 A JP 2013095670A
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- carbon dioxide
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- carbonic acid
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- polyoxyethylene sorbitan
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- 239000007788 liquid Substances 0.000 title claims abstract description 40
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 title claims 4
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims abstract description 54
- 239000001569 carbon dioxide Substances 0.000 claims abstract description 25
- 229910002092 carbon dioxide Inorganic materials 0.000 claims abstract description 25
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims abstract description 20
- -1 fatty acid ester Chemical class 0.000 claims abstract description 16
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- 239000003814 drug Substances 0.000 claims abstract description 9
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- 238000000034 method Methods 0.000 claims description 2
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- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
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- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 2
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- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 2
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- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical class FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 1
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- 244000025254 Cannabis sativa Species 0.000 description 1
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 244000004281 Eucalyptus maculata Species 0.000 description 1
- 206010016326 Feeling cold Diseases 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
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- 208000002720 Malnutrition Diseases 0.000 description 1
- 208000000112 Myalgia Diseases 0.000 description 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 206010039897 Sedation Diseases 0.000 description 1
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 229930003779 Vitamin B12 Natural products 0.000 description 1
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- 210000003169 central nervous system Anatomy 0.000 description 1
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 description 1
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- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 1
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- HQPMKSGTIOYHJT-UHFFFAOYSA-N ethane-1,2-diol;propane-1,2-diol Chemical compound OCCO.CC(O)CO HQPMKSGTIOYHJT-UHFFFAOYSA-N 0.000 description 1
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Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
本発明は、外観が良好で、服用感に優れた炭酸含有内用液に関する。 The present invention relates to a carbonic acid-containing internal solution having a good appearance and excellent feeling of taking.
病中病後、肉体疲労、栄養障害、食欲不振等の場合の栄養補給や、肌荒れ、冷え症、神経痛、関節痛、筋肉痛等の諸症状の緩和や予防を期待して種々のビタミン類や生薬を配合した医薬品、医薬部外品等が数多く販売され、広く使用されている。これらの医薬品や医薬部外品等のうち、内用液は、固形物に比較し、服用に際して別に水も不要で、嚥下に問題が生じにくく摂取が容易であること、また服用量の調節が容易である等の理由から、広く採用されている。一方で、ビタミン類や生薬は、不快な味を有するものが多く、内用液に配合すると服用感を損なう場合がある。
After the disease, various vitamins and herbal medicines are provided for nutritional supplementation in the case of physical fatigue, malnutrition, loss of appetite, and relief and prevention of various symptoms such as rough skin, coldness, neuralgia, joint pain, and muscle pain. Many blended medicines and quasi-drugs are sold and widely used. Among these drugs and quasi-drugs, internal liquids do not require water separately when taken, are less likely to cause problems with swallowing, and are easy to ingest, and the dosage can be adjusted. It is widely used because it is easy. On the other hand, vitamins and herbal medicines often have an unpleasant taste, and when blended with an internal liquid, the feeling of taking may be impaired.
このような状況下、ビタミンＢ１の不快味や不快臭を二酸化炭素の配合により改善できることが報告されている（特許文献１）。 Under such circumstances, it has been reported that the unpleasant taste and unpleasant odor of vitamin B1 can be improved by blending carbon dioxide (Patent Document 1).
本発明者は、ショウキョウ、肝臓水解物、ゴミシ、シゴカ、イカリソウ等の生薬を含有する内用液の服用感を良好にすべく二酸化炭素の封入を試みた。ところが、これらの生薬を含有する液に二酸化炭素を封入すると泡状の着色物が発生し、得られた内用液の上部に着色物が残存し、外観上好ましくなく、製品価値及び生産適性を損なうことが判明した。
従って、本発明の課題は、前記の生薬と二酸化炭素を含有し、外観が良好で服用感にも優れた内用液を提供することにある。
The present inventor tried to enclose carbon dioxide in order to improve the feeling of taking a liquid for internal use containing herbal medicines such as ginger, liver hydrolyzate, rubbish, shigoka, and licorice. However, when carbon dioxide is enclosed in a liquid containing these herbal medicines, a foamy colored product is generated, and the colored product remains at the top of the obtained internal use liquid, which is not preferable in appearance, and has a product value and suitability for production. It turns out to be damaged.
Accordingly, an object of the present invention is to provide a liquid for internal use which contains the above-mentioned herbal medicine and carbon dioxide, has a good appearance, and is excellent in feeling of administration.
そこで本発明者は、前記生薬含有液に二酸化炭素を封入する際の泡状の着色物の発生を抑制すべく種々検討した結果、数多くの非イオン性界面活性剤の中でポリオキシエチレンポリオキシプロピレングリコール又はポリオキシエチレンソルビタン脂肪酸エステルを添加した場合に、選択的に当該泡状の着色物の発生を防止できるとともに、服用感が良好で、かつ安定な内用液が得られることを見出し、本発明を完成した。 Therefore, as a result of various studies to suppress the generation of foamy colored substances when carbon dioxide is enclosed in the herbal medicine-containing liquid, the present inventors have found that among many nonionic surfactants, polyoxyethylene polyoxy When propylene glycol or polyoxyethylene sorbitan fatty acid ester is added, the generation of the foamy colored product can be selectively prevented, and the feeling of taking is good and a stable internal solution can be obtained, The present invention has been completed.
すなわち、本発明は、（Ａ）ショウキョウ、肝臓水解物、ゴミシ、シゴカ及びイカリソウから選ばれる１種又は２種以上、並びに（Ｂ）ポリオキシエチレンポリオキシプロピレングリコール及び／又はポリオキシエチレンソルビタン脂肪酸エステルを含有し、（Ｃ）二酸化炭素を封入してなる炭酸含有内用液を提供するものである。
また、本発明は、（Ａ）ショウキョウ、肝臓水解物、ゴミシ、シゴカ及びイカリソウから選ばれる１種又は２種以上、並びに（Ｂ）ポリオキシエチレンポリオキシプロピレングリコール及び／又はポリオキシエチレンソルビタン脂肪酸エステルを含有する内用液に、二酸化炭素を封入することを特徴とする炭酸含有内用液の泡状着色物の発生抑制方法を提供するものである。
That is, the present invention includes (A) one or more selected from (A) ginger, liver hydrolyzate, garbage, shigoka and icarius, and (B) polyoxyethylene polyoxypropylene glycol and / or polyoxyethylene sorbitan fatty acid. A carbonic acid-containing internal solution containing an ester and containing (C) carbon dioxide is provided.
The present invention also includes (A) one or more selected from (A) ginger, liver hydrolyzate, trash, shigoka and icarius, and (B) polyoxyethylene polyoxypropylene glycol and / or polyoxyethylene sorbitan fatty acid. The present invention provides a method for suppressing the generation of foamy colored substances in a carbonic acid-containing internal solution, wherein carbon dioxide is enclosed in an internal solution containing an ester.
本発明の炭酸含有内用液は、製造時に泡状着色物が生成しないため外観が良好で、かつ二酸化炭素の封入により服用感に優れ、かつ経時安定性も良好である。 The carbonic acid-containing internal solution of the present invention has a good appearance because no foamy colored product is produced during production, and is excellent in taking feeling due to the inclusion of carbon dioxide, and has good stability over time.
本発明の内用液は、（Ａ）ショウキョウ、肝臓水解物、ゴミシ、シゴカ及びイカリソウから選ばれる１種又は２種以上を含有する。これらの成分は、本発明内用液の有効成分である。 The internal use liquid of this invention contains 1 type (s) or 2 or more types chosen from (A) ginger, liver hydrolyzate, garbage, shigoka, and Ikarisou. These components are active ingredients of the internal use liquid of the present invention.
ショウキョウは、ショウガの根茎であり、発汗作用、消化促進作用、鎮嘔作用、抗痙攣作用等を有し、寒気を伴う風邪の初期症状の治療、胃腸の冷え等による胃腸機能低下の治療等に用いられる生薬である。ショウキョウは、ショウガの根茎の粉砕物又はその抽出物として用いられる。ショウキョウエキスとしては、水抽出物、熱水抽出物、アルコール抽出物等が挙げられる。このうち、ショウキョウ流エキスを用いるのが好ましい。ショウキョウの含有量は、本発明の内用液中、原生薬換算で０．０１〜１．５ｗ／ｖ％が好ましく、０．０５〜１．３ｗ／ｖ％がより好ましく、０．１〜１ｗ／ｖ％がさらに好ましい。 Ginger is a rhizome of ginger and has sweating action, digestion promoting action, anti-emetic action, anticonvulsant action, etc., treatment of initial symptoms of cold with cold, treatment of gastrointestinal dysfunction due to gastrointestinal cold etc. Is a herbal medicine. Ginger is used as a ground product of ginger rhizome or an extract thereof. Examples of the pepper extract include a water extract, a hot water extract, and an alcohol extract. Among these, it is preferable to use a show flow extract. The content of ginger is preferably 0.01 to 1.5 w / v%, more preferably 0.05 to 1.3 w / v% in terms of the active ingredient in the internal use liquid of the present invention, 0.1 to 1 w / v% is more preferable.
肝臓水解物は、ウシ、ブタ等の肝臓の加水分解物であり、滋養強壮効果、肝機能改善効果等を有する。肝臓水解物の含有量は、本発明の内用液中、０．０１〜１．５ｗ／ｖ％が好ましく、０．０１〜１ｗ／ｖ％がより好ましく、０．０５〜０．５ｗ／ｖ％がさらに好ましい。 Liver hydrolyzate is a hydrolyzate of livers such as cattle and pigs, and has nourishing tonic effect, liver function improving effect and the like. The content of liver hydrolyzate is preferably 0.01 to 1.5 w / v%, more preferably 0.01 to 1 w / v%, and 0.05 to 0.5 w / v in the internal use liquid of the present invention. % Is more preferable.
ゴミシは、モクレン科地五味子の成熟果実を乾燥したものであり、強壮作用、神経興奮作用、鎮咳去痰作用、抗菌作用、抗疲労効果等を有する。ゴミシとしては、ゴミシの水抽出物、熱水抽出物、アルコール抽出物等が用いられる。ゴミシの含有量は、本発明内用液中、原生薬換算で０．０１〜１．５ｗ／ｖ％が好ましく、０．１〜１ｗ／ｖ％がより好ましく、０．３〜０．６ｗ／ｖ％がさらに好ましい。 Garbage is a dried fruit of magnolia field Gomi, which has tonicity, nerve excitement, antitussive expectorant, antibacterial, antifatigue and the like. As the garbage, a waste water extract, a hot water extract, an alcohol extract or the like is used. The content of the garbage is preferably 0.01 to 1.5 w / v%, more preferably 0.1 to 1 w / v%, and more preferably 0.3 to 0.6 w / v in terms of bulk drug in the internal use liquid of the present invention. v% is more preferable.
シゴカは、ウコギ科エゾウコギの根皮又は幹皮を乾燥させたものであり、滋養強壮、中枢神経系に対する鎮静、抗炎症、鎮痛、解熱、血圧降下、血糖降下作用等を有する。シゴカとしては、シゴカの水抽出物、熱水抽出物、アルコール抽出物等が挙げられる。シゴカの含有量は、本発明内用液中、原生薬換算で、０．０１〜１．５ｗ／ｖ％が好ましく、０．１〜１．５ｗ／ｖ％がより好ましく、０．２〜１．２ｗ／ｖ％がさらに好ましい。 Shigoka is dried from the root bark or stem bark of the urchinaceae, and has nourishing tonic, central nervous system sedation, anti-inflammatory, analgesic, antipyretic, hypotensive, hypoglycemic action and the like. Examples of Sigoka include water extract of Sigoka, hot water extract, alcohol extract and the like. The content of shigoka is preferably 0.01 to 1.5 w / v%, more preferably 0.1 to 1.5 w / v%, and more preferably 0.2 to 1 in terms of the drug substance in the internal use solution of the present invention. More preferably, 2 w / v%.
イカリソウは、メギ科イカリソウであり、全草や葉が用いられ、利尿作用、強精作用、強壮作用等を有する。イカリソウとしては、水抽出物、熱水抽出物、アルコール抽出物等が用いられる。イカリソウの含有量は、本発明内用液中、原生薬換算で０．０１〜１．５ｗ／ｖ％が好ましく、０．０５〜１．２ｗ／ｖ％がより好ましく、０．１〜１ｗ／ｖ％がさらに好ましい。 The licorice is the eucalyptus licorice, which uses whole grass and leaves, and has a diuretic action, a tonic action, a tonic action and the like. As the licorice, a water extract, a hot water extract, an alcohol extract and the like are used. The content of licorice is preferably 0.01 to 1.5 w / v%, more preferably 0.05 to 1.2 w / v%, and more preferably 0.1 to 1 w / v in terms of the active ingredient in the liquid for internal use of the present invention. v% is more preferable.
本発明の内用液においては、これらの成分の１種又は２種以上を含有するが、これらの成分のうち、ショウキョウ、肝臓水解物及びシゴカを含有するのが好ましく、ショウキョウ及び肝臓水解物を含有するのがより好ましい。成分（Ａ）の合計含有量は、有効性及び服用感の点から本発明の内用液中、肝臓水解物を除く生薬の原生薬換算量及び／又は肝臓水解物の含有量の合計で０．０１〜１．５ｗ／ｖ％が好ましく、０．０５〜１．５ｗ／ｖ％がより好ましく、０．１〜１．５ｗ／ｖ％がさらに好ましい。 The liquid for internal use of the present invention contains one or more of these components, and among these components, it is preferable to contain gyoza, liver hydrolyzate, and shigoka. It is more preferable to contain a product. The total content of component (A) is 0 in terms of effectiveness and ingestion in the total amount of crude drug equivalents and / or liver hydrolyzate content excluding liver hydrolyzate in the internal use liquid of the present invention. 0.01 to 1.5 w / v% is preferable, 0.05 to 1.5 w / v% is more preferable, and 0.1 to 1.5 w / v% is more preferable.
本発明の内用液に用いられる（Ｂ）ポリオキシエチレンポリオキシプロピレングリコール及び／又はポリオキシエチレンソルビタン脂肪酸エステルは、成分（Ａ）を含有する内用液に二酸化炭素を封入した際の泡状着色物の発生を防止し、かつ本発明の内用液の経時安定性を向上させる作用を有する。二酸化炭素封入時の泡状着色物の発生に関しては、後記実施例に示すように、種々の非イオン性界面活性剤や消泡剤及び増粘剤の添加によっても十分に防止できないにもかかわらず、これら成分（Ｂ）が特異的に効果を有する。
ポリオキシエチレンポリオキシプロピレングリコールのポリオキシエチレン数は２０〜２００が好ましく、ポリオキシプロピレン数は２０〜７０が好ましい。ポリオキシエチレンソルビタン脂肪酸エステルとしては、ポリオキシエチレンソルビタンＣ8-22脂肪酸エステルが好ましく、ポリオキシエチレンソルビタンモノＣ8-22脂肪酸エステルがより好ましい。またポリオキシエチレンソルビタン脂肪酸エステルのポリオキシエチレン数は、１０〜４０が好ましく、１０〜３０がより好ましく、約２０が特に好ましい。より具体例にはポリオキシエチレンソルビタンモノラウリン酸エステル、ポリオキシエチレンソルビタンモノステアリン酸エステル、ポリオシキエチレンソルビタントリステアリン酸エステル、ポリオキシエチレンソルビタンモノオレイン酸エステルが挙げられ、ポリオキシエチレンソルビタンモノオレイン酸エステルが特に好ましい。
これらの成分は、１種を用いてもよいし、２種を組み合わせて用いてもよい。
The (B) polyoxyethylene polyoxypropylene glycol and / or polyoxyethylene sorbitan fatty acid ester used in the internal use liquid of the present invention is foamed when carbon dioxide is sealed in the internal use liquid containing the component (A). It has the effect of preventing the occurrence of colored substances and improving the temporal stability of the internal use liquid of the present invention. Regarding the generation of foamy colored substances when carbon dioxide is encapsulated, as shown in the examples below, even though various nonionic surfactants, antifoaming agents and thickeners cannot be sufficiently prevented. These components (B) have a specific effect.
20-200 are preferable and, as for the polyoxyethylene number of polyoxyethylene polyoxypropylene glycol, 20-70 are preferable. As the polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbitan C 8-22 fatty acid ester is preferable, and polyoxyethylene sorbitan mono C 8-22 fatty acid ester is more preferable. Further, the polyoxyethylene number of the polyoxyethylene sorbitan fatty acid ester is preferably 10 to 40, more preferably 10 to 30, and particularly preferably about 20. More specific examples include polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan tristearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monooleate Esters are particularly preferred.
These components may be used alone or in combination of two.
本発明の内用液中の成分（Ｂ）の含有量は、泡状着色物の発生防止効果及び経時安定性の点から、０．００１〜１．０ｗ／ｖ％が好ましい。ポリオキシエチレンポリオキシプロピレングリコールの含有量は、０．０１〜０．５ｗ／ｖ％が好ましく、０．０５〜０．２ｗ／ｖ％がさらに好ましい。ポリオキシエチレンソルビタン脂肪酸エステルの含有量は０．００１〜０．５ｗ／ｖ％が好ましく、０．０１〜０．１ｗ／ｖ％がさらに好ましい。 The content of the component (B) in the internal use liquid of the present invention is preferably 0.001 to 1.0 w / v% from the viewpoint of the effect of preventing generation of foamy colored products and the stability over time. The content of polyoxyethylene polyoxypropylene glycol is preferably 0.01 to 0.5 w / v%, more preferably 0.05 to 0.2 w / v%. The content of the polyoxyethylene sorbitan fatty acid ester is preferably 0.001 to 0.5 w / v%, and more preferably 0.01 to 0.1 w / v%.
本発明の内用液には二酸化炭素が封入される。二酸化炭素の封入により、成分（Ａ）の苦味等がマスキングされ、服用感が良好になる。本発明の内用液への二酸化炭素の封入量は、ガスボリューム［内用液中に溶解している二酸化炭素量（ｖ／ｖ）］が、１〜４が好ましく、１．２〜４．０がより好ましく、１．５〜４．０がさらに好ましい。なお、本発明におけるガスボリュームとは、１気圧１５．６℃において、内用液中に溶解している炭酸ガスの体積を内用液の体積で割ったものである。 Carbon dioxide is enclosed in the internal liquid of the present invention. Encapsulation of carbon dioxide masks the bitterness of component (A) and improves the feeling of dosing. As for the amount of carbon dioxide enclosed in the internal liquid of the present invention, the gas volume [the amount of carbon dioxide dissolved in the internal liquid (v / v)] is preferably 1 to 4, preferably 1.2 to 4. 0 is more preferable, and 1.5 to 4.0 is more preferable. The gas volume in the present invention is obtained by dividing the volume of carbon dioxide dissolved in the internal liquid at 1 atm 15.6 ° C. by the volume of the internal liquid.
本発明の内用液には、前記成分の他に、他の有効成分、矯味剤、甘味剤、安定化剤、増粘剤、溶解補助剤、ｐＨ調節剤、着色剤、香料、水、エタノール、プロピレングリコール、グリセリン等を配合することができる。他の有効成分としては、ビタミンＢ１、ビタミンＢ２、ビタミンＢ６、ナイアシン、パントテン酸、ビタミンＢ１２、ビタミンＣ、タウリン、コンドロイチン硫酸等が挙げられる。このうち、ビタミンＢ１は０．００１〜０．０３ｗ／ｖ％含有するのが好ましく、ビタミンＢ２は０．００１〜０．０３ｗ／ｖ％含有するのが好ましく、ビタミンＢ６は０．０１〜０．１ｗ／ｖ％含有するのが好ましく、コンドロイチン硫酸は０．１〜１ｗ／ｖ％含有するのが好ましい。 In addition to the above components, the internal use liquid of the present invention includes other active ingredients, flavoring agents, sweeteners, stabilizers, thickeners, solubilizers, pH adjusters, colorants, fragrances, water, ethanol , Propylene glycol, glycerin and the like can be blended. Examples of other active ingredients include vitamin B1, vitamin B2, vitamin B6, niacin, pantothenic acid, vitamin B12, vitamin C, taurine, chondroitin sulfate and the like. Of these, vitamin B1 is preferably contained in an amount of 0.001 to 0.03 w / v%, vitamin B2 is preferably contained in an amount of 0.001 to 0.03 w / v%, and vitamin B6 is contained in an amount of 0.01 to 0.03. It is preferable to contain 1 w / v%, and it is preferable to contain chondroitin sulfate 0.1 to 1 w / v%.
本発明の内用液のｐＨとしては２〜５が好ましく、２．５〜４がさらに好ましい。 The pH of the internal use liquid of the present invention is preferably 2 to 5, and more preferably 2.5 to 4.
本発明の内用液は、成分（Ａ）及び成分（Ｂ）を含有する液を調製し、二酸化炭素ガスを所定量封入することにより製造するのが好ましい。 The internal liquid of the present invention is preferably produced by preparing a liquid containing the component (A) and the component (B) and enclosing a predetermined amount of carbon dioxide gas.
次に実施例を挙げて本発明をさらに詳細に説明するが、本発明はこれに何ら限定されるものではない。 EXAMPLES Next, although an Example is given and this invention is demonstrated further in detail, this invention is not limited to this at all.
実施例１
ショウキョウ流エキス５ｍＬ、ポリオキシエチレンポリオキシプロピレングリコール（プルロニックＦ６８）０．５ｇ、クエン酸７ｇ、水酸化ナトリウム適量、果糖ブドウ糖液糖４０ｇ、香料適量を精製水１０００ｍＬに溶解し、これに二酸化炭素をガスボリュームが２．５となるように封入して内用液を得た。
Example 1
Dissolve 5 mL of Pepper extract, 0.5 g of polyoxyethylene polyoxypropylene glycol (Pluronic F68), 7 g of citric acid, appropriate amount of sodium hydroxide, 40 g of fructose-glucose liquid sugar, and appropriate amount of fragrance in 1000 mL of purified water. Was sealed so that the gas volume was 2.5 to obtain an internal solution.
実施例２〜６１及び比較例１〜６１
実施例１と同様にして、表１〜表１２の内用液を製造した。
Examples 2 to 61 and Comparative Examples 1 to 61
In the same manner as in Example 1, internal liquids shown in Tables 1 to 12 were produced.
（試験及び評価）
（１）二酸化炭素封入時の泡状着色物の発生の有無
二酸化炭素封入時の着色物の発生の有無を以下の基準で評価した。着色物が発生した状態の写真を図１に、着色物の発生が抑制された状態の写真を図２に示す。
(Test and evaluation)
(1) Presence / absence of generation of foamy colored substance at the time of carbon dioxide encapsulation The presence / absence of colored substance at the time of carbon dioxide encapsulation was evaluated according to the following criteria. FIG. 1 shows a photograph in a state where a colored material is generated, and FIG. 2 shows a photograph in a state where the generation of the colored material is suppressed.
着色物の析出が多い：×
着色物の析出が認められる：△
着色物の析出がほとんどない：○
着色物の析出が全くない：◎
There is much precipitation of coloring matter: ×
Precipitation of coloring matter is observed:
There is almost no precipitation of colored matter: ○
There is no precipitation of coloring matter: ◎
（２）服用感
得られた内用液を５名のパネラーが服用し、その服用感を評価した。
(2) Taking feeling Five panelists took the obtained internal liquid and evaluated the taking feeling.
服用しにくい：×
やや服用しにくい：△
服用しやすい：○
非常に服用しやすい：◎
Difficult to take: ×
Slightly difficult to take: △
Easy to take: ○
Very easy to take: ◎
（３）経時安定性
得られた内用液を６０℃に３週間保存後、２ヶ月冷蔵保存し、外観を評価した。
(3) Stability over time The obtained internal use solution was stored at 60 ° C. for 3 weeks and then refrigerated for 2 months to evaluate the appearance.
著しい外観の劣化を生じる ：×
外観の劣化を生じる ：△
ほとんど外観の劣化を生じない：○
外観の劣化を生じない ：◎
Significant deterioration in appearance: x
Deterioration of appearance: △
Almost no deterioration of appearance: ○
Appearance does not deteriorate: ◎
得られた結果を表１〜表１２に示す。 The obtained results are shown in Tables 1 to 12.
表１〜表１２に記載のように、成分（Ａ）の含有液に二酸化炭素を封入すると泡状着色物が発生するが、これに（Ｂ）ポリオキシエチレンポリオキシプロピレングリコール又はポリオキシエチレンソルビタン脂肪酸エステルを添加すると当該着色物の発生は顕著に抑制されることがわかる。また、得られた内用液は、服用感が良好で、かつ経時安定性も良好であった。
一方、成分（Ｂ）に代えて、種々の非イオン性界面活性剤、消泡剤や増粘剤を添加しても十分な効果は得られなかった。
As shown in Tables 1 to 12, when carbon dioxide is encapsulated in the component (A) containing liquid, a foamy colored product is generated, and (B) polyoxyethylene polyoxypropylene glycol or polyoxyethylene sorbitan It turns out that generation | occurrence | production of the said coloring matter is suppressed notably when fatty acid ester is added. Further, the obtained liquid for internal use had a good feeling of dosing and good stability over time.
On the other hand, in place of the component (B), even when various nonionic surfactants, antifoaming agents and thickeners were added, sufficient effects were not obtained.
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