JP2012532167A - インターフェロンβの精製方法 - Google Patents
インターフェロンβの精製方法 Download PDFInfo
- Publication number
- JP2012532167A JP2012532167A JP2012518819A JP2012518819A JP2012532167A JP 2012532167 A JP2012532167 A JP 2012532167A JP 2012518819 A JP2012518819 A JP 2012518819A JP 2012518819 A JP2012518819 A JP 2012518819A JP 2012532167 A JP2012532167 A JP 2012532167A
- Authority
- JP
- Japan
- Prior art keywords
- ifn
- chromatography
- container
- affinity chromatography
- hydrophobic interaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/565—IFN-beta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102009032179A DE102009032179A1 (de) | 2009-07-07 | 2009-07-07 | Verfahren zur Reinigung von Interferon beta |
DE102009032179.9 | 2009-07-07 | ||
PCT/EP2010/004130 WO2011003600A1 (en) | 2009-07-07 | 2010-07-07 | METHOD FOR THE PURIFICATION OF INTERFERON-β |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2012532167A true JP2012532167A (ja) | 2012-12-13 |
Family
ID=42562473
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012518819A Pending JP2012532167A (ja) | 2009-07-07 | 2010-07-07 | インターフェロンβの精製方法 |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP2451470A1 (de) |
JP (1) | JP2012532167A (de) |
DE (1) | DE102009032179A1 (de) |
EA (1) | EA201290040A1 (de) |
WO (1) | WO2011003600A1 (de) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021010638A1 (ko) * | 2019-07-18 | 2021-01-21 | 에이비온 주식회사 | 2당화된 인터페론-베타 단백질의 정제 방법 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009505645A (ja) * | 2005-08-26 | 2009-02-12 | アレス トレーディング ソシエテ アノニム | グリコシル化されたインターフェロンベータの調製方法 |
JP2009518361A (ja) * | 2005-12-09 | 2009-05-07 | アレス トレーディング ソシエテ アノニム | Fsh又はfsh変異体を精製するための方法 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5564799A (en) | 1978-11-07 | 1980-05-15 | Toray Ind Inc | Multi-stage concentration and purification of interferon originated from human fibroblast |
CH648331A5 (de) | 1979-07-31 | 1985-03-15 | Hoffmann La Roche | Homogenes fibroblasten-interferon und dessen herstellung. |
US4278661A (en) | 1979-10-12 | 1981-07-14 | E. I. Du Pont De Nemours And Company | Purification of interferon |
NL7907791A (nl) | 1979-10-23 | 1981-04-27 | Stichting Rega V Z W | Werkwijze voor het zuiveren van interferon. |
AU538665B2 (en) | 1979-10-30 | 1984-08-23 | Juridical Foundation, Japanese Foundation For Cancer Research | Human interferon dna |
DK170476B1 (da) | 1980-04-03 | 1995-09-11 | Biogen Inc | Rekombinant DNA-molekyle, uni-cellulær vært transformeret med mindst ét rekombinant DNA-molekyle, fremgangsmåde til transformering af en uni-cellulær vært, samt fremgangsmåder til fremstilling af et polpeptid, der udviser den immunologiske eller biologiske aktivitet af human beta-interferon |
DE3273787D1 (en) | 1981-02-04 | 1986-11-20 | Japan Found Cancer | Human interferon-beta gene |
JPS58201794A (ja) | 1982-05-17 | 1983-11-24 | Toray Ind Inc | ヒトインターフェロンβの濃縮精製法 |
US4992271A (en) | 1982-09-23 | 1991-02-12 | Cetus Corporation | Formulation for lipophilic IL-2 proteins |
CA1231306A (en) | 1983-03-03 | 1988-01-12 | Erich Hochuli | Purification of interferon |
US4894330A (en) | 1986-12-23 | 1990-01-16 | Cetus Corporation | Purification of recombinant beta-interferon incorporating RP-HPLC |
DE3712564A1 (de) | 1987-04-14 | 1988-11-24 | Bioferon Biochem Substanz | Verfahren zur konstruktion einer animalen zellinie fuer die herstellung von humanem interferon-beta |
US5169936A (en) * | 1989-04-14 | 1992-12-08 | Biogen, Inc. | Protein purification on immobilized metal affinity resins effected by elution using a weak ligand |
IT1240612B (it) | 1990-03-16 | 1993-12-17 | Sclavo Spa | Procedimento di purificazione del b-interferone umano ricombinante |
DE4128319A1 (de) | 1991-08-27 | 1993-03-04 | Bioferon Biochem Substanz | Neues rekombinantes human-ifn-beta, verfahren zu dessen herstellung und dieses enthaltende pharmazeutische zubereitungen |
TR199901968T2 (xx) | 1996-12-24 | 1999-12-21 | Biogen, Inc. | Sabit s�v� interferon form�lleri. |
EP1224940B2 (de) | 1997-09-23 | 2010-08-11 | Rentschler Biotechnologie GmbH | Flüssige Interferon-Beta Formulierungen |
SK286217B6 (sk) * | 1998-04-28 | 2008-05-06 | Laboratoires Serono Sa | Polyol-interferón-ß konjugát, spôsob jeho výroby a farmaceutický prostriedok s jeho obsahom |
ITBO20010426A1 (it) | 2001-07-06 | 2003-01-06 | Alfa Wassermann Spa | Processo per la purificazione di proteine farmacologicamente attive mediante cromatografia in scambio cationico |
AU2003303635B2 (en) * | 2002-12-26 | 2009-07-23 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates of interferon-beta with enhanced biological potency |
DE102007050165B4 (de) * | 2007-10-19 | 2010-06-17 | Stiftung Tierärztliche Hochschule Hannover | Stabilisierte Lösung, Verfahren zu deren Herstellung sowie deren Verwendung und Arzneimittel in Form einer stabilisierten Lösung |
EP2245044A2 (de) * | 2008-01-18 | 2010-11-03 | F. Hoffmann-La Roche AG | Reinigung nicht-glycosylierter proteine |
DE102008051574A1 (de) * | 2008-10-14 | 2010-04-15 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren zur Herstellung von Interferon-beta und deren Varianten |
-
2009
- 2009-07-07 DE DE102009032179A patent/DE102009032179A1/de not_active Withdrawn
-
2010
- 2010-07-07 EP EP10737494A patent/EP2451470A1/de not_active Withdrawn
- 2010-07-07 EA EA201290040A patent/EA201290040A1/ru unknown
- 2010-07-07 WO PCT/EP2010/004130 patent/WO2011003600A1/en active Application Filing
- 2010-07-07 JP JP2012518819A patent/JP2012532167A/ja active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009505645A (ja) * | 2005-08-26 | 2009-02-12 | アレス トレーディング ソシエテ アノニム | グリコシル化されたインターフェロンベータの調製方法 |
JP2009518361A (ja) * | 2005-12-09 | 2009-05-07 | アレス トレーディング ソシエテ アノニム | Fsh又はfsh変異体を精製するための方法 |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021010638A1 (ko) * | 2019-07-18 | 2021-01-21 | 에이비온 주식회사 | 2당화된 인터페론-베타 단백질의 정제 방법 |
JP2022541112A (ja) * | 2019-07-18 | 2022-09-22 | アビオン インク. | 二糖化インターフェロンβタンパク質の精製方法 |
JP7425936B2 (ja) | 2019-07-18 | 2024-02-01 | アビオン インク. | 二糖化インターフェロンβタンパク質の精製方法 |
Also Published As
Publication number | Publication date |
---|---|
EP2451470A1 (de) | 2012-05-16 |
DE102009032179A1 (de) | 2011-01-13 |
WO2011003600A8 (en) | 2011-09-01 |
WO2011003600A1 (en) | 2011-01-13 |
EA201290040A1 (ru) | 2012-07-30 |
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JP2012532167A (ja) | インターフェロンβの精製方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20130531 |
|
A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A712 Effective date: 20140808 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20140916 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20150303 |