JP2012532117A5 - - Google Patents
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- JP2012532117A5 JP2012532117A5 JP2012517927A JP2012517927A JP2012532117A5 JP 2012532117 A5 JP2012532117 A5 JP 2012532117A5 JP 2012517927 A JP2012517927 A JP 2012517927A JP 2012517927 A JP2012517927 A JP 2012517927A JP 2012532117 A5 JP2012532117 A5 JP 2012532117A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- modified
- residue
- item
- fold
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 163
- 229920001184 polypeptide Polymers 0.000 claims description 162
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 162
- 239000011230 binding agent Substances 0.000 claims description 44
- 239000000203 mixture Substances 0.000 claims description 33
- 229960005486 vaccine Drugs 0.000 claims description 26
- 206010022000 influenza Diseases 0.000 claims description 24
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 20
- 239000008194 pharmaceutical composition Substances 0.000 claims description 9
- 241000712461 unidentified influenza virus Species 0.000 claims description 9
- 239000008280 blood Substances 0.000 claims description 8
- 210000004369 blood Anatomy 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- 230000002452 interceptive effect Effects 0.000 claims description 8
- 238000002255 vaccination Methods 0.000 claims description 6
- 241000700605 Viruses Species 0.000 claims description 5
- 230000002238 attenuated effect Effects 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 5
- 230000002265 prevention Effects 0.000 claims description 5
- 229940031626 subunit vaccine Drugs 0.000 claims description 5
- 239000002671 adjuvant Substances 0.000 claims description 4
- 238000006467 substitution reaction Methods 0.000 claims description 4
- 238000003745 diagnosis Methods 0.000 claims description 3
- 230000001747 exhibiting effect Effects 0.000 claims description 3
- 208000015181 infectious disease Diseases 0.000 claims description 3
- 230000003993 interaction Effects 0.000 claims description 3
- 238000013517 stratification Methods 0.000 claims description 3
- 101710154606 Hemagglutinin Proteins 0.000 claims description 2
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims description 2
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims description 2
- 101710176177 Protein A56 Proteins 0.000 claims description 2
- 239000000185 hemagglutinin Substances 0.000 claims description 2
- 230000004048 modification Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000035772 mutation Effects 0.000 description 8
- 238000000034 method Methods 0.000 description 7
- 241000282898 Sus scrofa Species 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 3
- 102220477627 Aldehyde oxidase_E227H_mutation Human genes 0.000 description 2
- 102200027276 rs267606877 Human genes 0.000 description 2
- 102200162557 rs73507527 Human genes 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 241000282412 Homo Species 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 102200050586 rs121912427 Human genes 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22288909P | 2009-07-02 | 2009-07-02 | |
| US61/222,889 | 2009-07-02 | ||
| PCT/US2010/040978 WO2011003100A2 (en) | 2009-07-02 | 2010-07-02 | Compositions and methods for diagnosing and/or treating influenza infection |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015224253A Division JP2016028107A (ja) | 2009-07-02 | 2015-11-16 | インフルエンザ感染の診断および／または処置のための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012532117A JP2012532117A (ja) | 2012-12-13 |
| JP2012532117A5 true JP2012532117A5 (https=) | 2013-08-15 |
| JP5886194B2 JP5886194B2 (ja) | 2016-03-16 |
Family
ID=43411785
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012517927A Active JP5886194B2 (ja) | 2009-07-02 | 2010-07-02 | インフルエンザ感染の診断および／または処置のための組成物および方法 |
| JP2015224253A Withdrawn JP2016028107A (ja) | 2009-07-02 | 2015-11-16 | インフルエンザ感染の診断および／または処置のための組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015224253A Withdrawn JP2016028107A (ja) | 2009-07-02 | 2015-11-16 | インフルエンザ感染の診断および／または処置のための組成物および方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US9278998B2 (https=) |
| EP (1) | EP2448596B1 (https=) |
| JP (2) | JP5886194B2 (https=) |
| AU (1) | AU2010266129B2 (https=) |
| CA (1) | CA2766899C (https=) |
| ES (1) | ES2566361T3 (https=) |
| WO (1) | WO2011003100A2 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9278998B2 (en) | 2009-07-02 | 2016-03-08 | Massachusetts Institute Of Technology | Compositions and methods for diagnosing and/or treating influenza infection |
| WO2011094445A1 (en) * | 2010-01-27 | 2011-08-04 | Massachusetts Institute Of Technology | Engineered polypeptide agents for targeted broad spectrum influenza neutralization |
| WO2012040406A2 (en) | 2010-09-21 | 2012-03-29 | Massachusetts Institute Of Technology | Influenza treatment and/or characterization; human-adapted ha polypeptides; vaccines |
| BR112013007946B1 (pt) | 2010-10-04 | 2022-07-12 | Massachusetts Institute Of Technology | Composições farmacêuticas e imunogênicas compreendendo polipeptídeos de hemaglutinina |
| US9969794B2 (en) | 2012-05-10 | 2018-05-15 | Visterra, Inc. | HA binding agents |
| US10022434B2 (en) | 2013-03-15 | 2018-07-17 | The Trustees Of The University Of Pennsylvania | Influenza nucleic acid molecules and vaccines made therefrom |
| WO2014179464A1 (en) * | 2013-04-30 | 2014-11-06 | Massachusetts Institute Of Technology | Human adaptation of h3 influenza |
| WO2017083627A1 (en) | 2015-11-13 | 2017-05-18 | Visterra, Inc. | Compositions and methods for treating and preventing influenza |
| CN109195629A (zh) | 2016-02-24 | 2019-01-11 | 威特拉公司 | 流行性感冒抗体分子制剂 |
| US11781112B2 (en) | 2016-03-06 | 2023-10-10 | Kareem Thomas Robinson | Method of generating antigen-specific immunological memory in a subject that rejects classical vaccines |
| MX2020004151A (es) | 2017-10-30 | 2020-08-13 | Takeda Pharmaceuticals Co | Detergentes compatibles con el medio ambiente para la inactivacion de virus envueltos en lipidos. |
| CN113924147A (zh) | 2019-03-25 | 2022-01-11 | 威特拉公司 | 用于治疗和预防流感的组合物和方法 |
| BR112022021208A8 (pt) * | 2020-04-22 | 2023-02-23 | Medicago Inc | Supraestrutura compreendendo hemaglutinina de influenza modificada com interação reduzida com ácido siálico |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4166452A (en) | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4692411A (en) | 1983-09-06 | 1987-09-08 | Ghose Rabindra N | Separation of specific biological cells by a biochemical filter |
| US5698390A (en) | 1987-11-18 | 1997-12-16 | Chiron Corporation | Hepatitis C immunoassays |
| SG46445A1 (en) | 1990-01-26 | 1998-02-20 | Immunomedics Inc | Vaccines against cancer and infectious diseases |
| US5500161A (en) | 1993-09-21 | 1996-03-19 | Massachusetts Institute Of Technology And Virus Research Institute | Method for making hydrophobic polymeric microparticles |
| US6085349A (en) * | 1997-08-27 | 2000-07-04 | Qualcomm Incorporated | Method for selecting cyclic redundancy check polynomials for linear coded systems |
| JP5008244B2 (ja) | 2000-06-23 | 2012-08-22 | ワイス・ホールディングズ・コーポレイション | 野性型およびキメラのインフルエンザウイルス様粒子（ｖｌｐ）のアセンブリー |
| US20040242518A1 (en) * | 2002-09-28 | 2004-12-02 | Massachusetts Institute Of Technology | Influenza therapeutic |
| US8592197B2 (en) | 2003-07-11 | 2013-11-26 | Novavax, Inc. | Functional influenza virus-like particles (VLPs) |
| WO2006108226A1 (en) | 2005-04-12 | 2006-10-19 | The University Of Queensland | Vaccine delivery system |
| SG169996A1 (en) | 2006-02-16 | 2011-04-29 | Us Gov Health & Human Serv | Antiviral agents and vaccines against influenza |
| US9101578B2 (en) | 2006-05-01 | 2015-08-11 | Technovax, Inc. | Polyvalent influenza virus-like particle (VLP) compositions |
| US8778353B2 (en) | 2006-05-01 | 2014-07-15 | Technovax, Inc. | Influenza virus-like particle (VLP) compositions |
| EP1998814A4 (en) | 2006-05-11 | 2010-06-16 | Novavax Inc | NEW VACCINES AGAINST INFLUENZA M2 |
| US9511134B2 (en) * | 2006-05-18 | 2016-12-06 | Epimmune Inc. | Inducing immune responses to influenza virus using polypeptide and nucleic acid compositions |
| WO2008005777A2 (en) | 2006-06-30 | 2008-01-10 | Novavax, Inc. | Methods of enhancing protein incorporation into virus like particles |
| WO2008094200A2 (en) | 2006-07-27 | 2008-08-07 | Ligocyte Pharmaceuticals, Inc | Chimeric virus-like particles |
| US9439959B2 (en) | 2006-07-27 | 2016-09-13 | Takeda Vaccines, Inc. | Chimeric influenza virus-like particles |
| US20090081193A1 (en) * | 2006-08-14 | 2009-03-26 | Massachusetts Institute Of Technology | Hemagglutinin polypeptides, and reagents and methods relating thereto |
| US20080241918A1 (en) * | 2006-08-14 | 2008-10-02 | Ram Sasisekharan | Hemagglutinin polypeptides, and reagents and methods relating thereto |
| US20090269342A1 (en) | 2006-08-14 | 2009-10-29 | Massachusetts Institute Of Technology | Hemagglutinin Polypeptides, and Reagents and Methods Relating Thereto |
| WO2008040060A1 (en) | 2006-10-04 | 2008-04-10 | The University Of Queensland | Vlp based vaccine delivery system |
| US20080233150A1 (en) | 2006-11-16 | 2008-09-25 | Gale Smith | Respiratory syncytial virus-virus like particle (vlps) |
| WO2008148104A1 (en) | 2007-05-25 | 2008-12-04 | Novavax, Inc. | Novel vlps derived from cells that do not express a viral matrix or core protein |
| CA2615372A1 (en) | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
| HUE025702T2 (en) | 2007-07-19 | 2016-04-28 | Novavax Inc | Avian Flu Chimeric VLPs |
| CA2711330A1 (en) | 2008-01-03 | 2009-07-16 | Massachusetts Institute Of Technology | Decoy influenza therapies |
| MX370690B (es) | 2008-07-18 | 2019-12-19 | Medicago Inc | Epitopo de inmunizacion de nuevo virus de la influenza. |
| US9278998B2 (en) | 2009-07-02 | 2016-03-08 | Massachusetts Institute Of Technology | Compositions and methods for diagnosing and/or treating influenza infection |
-
2010
- 2010-07-02 US US12/829,931 patent/US9278998B2/en active Active
- 2010-07-02 EP EP10794834.1A patent/EP2448596B1/en active Active
- 2010-07-02 CA CA2766899A patent/CA2766899C/en active Active
- 2010-07-02 AU AU2010266129A patent/AU2010266129B2/en active Active
- 2010-07-02 ES ES10794834.1T patent/ES2566361T3/es active Active
- 2010-07-02 JP JP2012517927A patent/JP5886194B2/ja active Active
- 2010-07-02 WO PCT/US2010/040978 patent/WO2011003100A2/en not_active Ceased
-
2015
- 2015-11-16 JP JP2015224253A patent/JP2016028107A/ja not_active Withdrawn
-
2016
- 2016-01-28 US US15/009,270 patent/US9709567B2/en active Active
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