JP2012527467A - 脂肪酸アミドヒドロラーゼ阻害薬としてのイソオキサゾリン - Google Patents

脂肪酸アミドヒドロラーゼ阻害薬としてのイソオキサゾリン Download PDF

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JP2012527467A
JP2012527467A JP2012511971A JP2012511971A JP2012527467A JP 2012527467 A JP2012527467 A JP 2012527467A JP 2012511971 A JP2012511971 A JP 2012511971A JP 2012511971 A JP2012511971 A JP 2012511971A JP 2012527467 A JP2012527467 A JP 2012527467A
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alkyl
independently
certain embodiments
aryl
carbocyclyl
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エル．べフンケ マルク
シー．カストロ アルフレド
ケー．チャン ルアウレンセ
エー．エブアンス カトヘリネ
グレニエル ロウイス
ジェイ．グロガン ミチャエル
ルエブルアンク イブエス
ルイウ タオ
ペルウソ ステプハネ
エー．スンイデル ダニエル
ティー．トイブビトトス トホマス
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インフイニトイ プハルマセウトイカルス インコーポレイテッド
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Pregnancy & Childbirth (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Otolaryngology (AREA)
  • Child & Adolescent Psychology (AREA)
JP2012511971A 2009-05-18 2010-05-18 脂肪酸アミドヒドロラーゼ阻害薬としてのイソオキサゾリン Ceased JP2012527467A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US17928309P 2009-05-18 2009-05-18
US17928009P 2009-05-18 2009-05-18
US17928509P 2009-05-18 2009-05-18
US61/179,283 2009-05-18
US61/179,280 2009-05-18
US61/179,285 2009-05-18
PCT/US2010/035309 WO2010135360A1 (en) 2009-05-18 2010-05-18 Isoxazolines as inhibitors of fatty acid amide hydrolase

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Publication Number Publication Date
JP2012527467A true JP2012527467A (ja) 2012-11-08
JP2012527467A5 JP2012527467A5 (https=) 2013-07-04

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JP2012511971A Ceased JP2012527467A (ja) 2009-05-18 2010-05-18 脂肪酸アミドヒドロラーゼ阻害薬としてのイソオキサゾリン

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EP (1) EP2432771A4 (https=)
JP (1) JP2012527467A (https=)
KR (1) KR20120042766A (https=)
CN (1) CN102459202B (https=)
AR (1) AR076687A1 (https=)
AU (1) AU2010249674A1 (https=)
BR (1) BRPI1011049A2 (https=)
CA (1) CA2762527A1 (https=)
IL (1) IL216420A0 (https=)
MX (1) MX2011012263A (https=)
NZ (2) NZ596585A (https=)
RU (1) RU2539595C2 (https=)
SG (2) SG176168A1 (https=)
TW (1) TW201043620A (https=)
WO (1) WO2010135360A1 (https=)
ZA (1) ZA201108657B (https=)

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WO2019031618A1 (ja) * 2017-08-10 2019-02-14 大正製薬株式会社 アゾールで置換されたピリジン化合物

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US10954231B2 (en) 2006-10-16 2021-03-23 Bionomics Limited Anxiolytic compounds
JP5373613B2 (ja) 2006-10-16 2013-12-18 バイオノミクス リミテッド 新規な抗不安薬化合物
US8927551B2 (en) 2009-05-18 2015-01-06 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
US9149465B2 (en) 2009-05-18 2015-10-06 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
WO2011085216A2 (en) 2010-01-08 2011-07-14 Ironwood Pharmaceuticals, Inc. Use of faah inhibitors for treating parkinson's disease and restless legs syndrome
WO2011123719A2 (en) 2010-03-31 2011-10-06 Ironwood Pharmaceuticals, Inc. Use of faah inhibitors for treating abdominal, visceral and pelvic pain
CA2828780A1 (en) 2011-03-02 2012-09-07 Bionomics Limited Novel small-molecules as therapeutics
EP2707367B1 (en) 2011-05-12 2019-10-09 Bionomics Limited Methods for preparing naphthyridines
WO2018112843A1 (en) 2016-12-22 2018-06-28 Merck Sharp & Dohme Corp. Heteroaryl piperidine ether allosteric modulators of the m4 muscarinic acetylcholine receptor
US10485790B1 (en) 2018-09-13 2019-11-26 Syneurx International (Taiwan) Corp. Salts of cycloserine compounds and applications thereof
WO2020081572A1 (en) * 2018-10-15 2020-04-23 Dana-Farber Cancer Institute, Inc. Transcriptional enhanced associate domain (tead) transcription factor inhibitors and uses thereof
CN110016142B (zh) * 2019-04-30 2021-08-03 合肥工业大学 一种含嘧啶硼酸结构的硅油及其制备方法
WO2020243423A1 (en) 2019-05-31 2020-12-03 Ikena Oncology, Inc. Tead inhibitors and uses thereof
KR20220030222A (ko) 2019-05-31 2022-03-10 이케나 온콜로지, 인코포레이티드 Tead 억제제 및 이의 용도
KR20230145066A (ko) 2021-02-11 2023-10-17 바스프 에스이 치환된 이속사졸린 유도체
EP4043444A1 (en) 2021-02-11 2022-08-17 Basf Se Substituted isoxazoline derivatives
CN116888101A (zh) * 2021-02-11 2023-10-13 巴斯夫欧洲公司 取代的异噁唑啉衍生物
JP2024539280A (ja) 2021-10-25 2024-10-28 カイメラ セラピューティクス， インコーポレイテッド Ｔｙｋ２分解剤およびそれらの使用
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