JP2012526832A5 - - Google Patents
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- Publication number
- JP2012526832A5 JP2012526832A5 JP2012510964A JP2012510964A JP2012526832A5 JP 2012526832 A5 JP2012526832 A5 JP 2012526832A5 JP 2012510964 A JP2012510964 A JP 2012510964A JP 2012510964 A JP2012510964 A JP 2012510964A JP 2012526832 A5 JP2012526832 A5 JP 2012526832A5
- Authority
- JP
- Japan
- Prior art keywords
- transnorsertraline
- pharmaceutical composition
- serotonin receptor
- disorder
- antagonist
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102100022738 5-hydroxytryptamine receptor 1A Human genes 0.000 claims 7
- 101710138638 5-hydroxytryptamine receptor 1A Proteins 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 239000005557 antagonist Substances 0.000 claims 5
- 239000000556 agonist Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000012453 solvate Substances 0.000 claims 4
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 230000036651 mood Effects 0.000 claims 3
- XIGAHNVCEFUYOV-BTJKTKAUSA-N (z)-but-2-enedioic acid;n-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-n-pyridin-2-ylcyclohexanecarboxamide Chemical compound OC(=O)\C=C/C(O)=O.COC1=CC=CC=C1N1CCN(CCN(C(=O)C2CCCCC2)C=2N=CC=CC=2)CC1 XIGAHNVCEFUYOV-BTJKTKAUSA-N 0.000 claims 2
- NRPQELCNMADTOZ-OAQYLSRUSA-N 4-cyano-n-[(2r)-2-[4-(2,3-dihydro-1,4-benzodioxin-5-yl)piperazin-1-yl]propyl]-n-pyridin-2-ylbenzamide Chemical compound C([C@@H](C)N1CCN(CC1)C=1C=2OCCOC=2C=CC=1)N(C=1N=CC=CC=1)C(=O)C1=CC=C(C#N)C=C1 NRPQELCNMADTOZ-OAQYLSRUSA-N 0.000 claims 2
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 2
- 208000012902 Nervous system disease Diseases 0.000 claims 2
- 208000025966 Neurological disease Diseases 0.000 claims 2
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 2
- QWCRAEMEVRGPNT-UHFFFAOYSA-N buspirone Chemical group C1C(=O)N(CCCCN2CCN(CC2)C=2N=CC=CN=2)C(=O)CC21CCCC2 QWCRAEMEVRGPNT-UHFFFAOYSA-N 0.000 claims 2
- 229960002495 buspirone Drugs 0.000 claims 2
- SRPXSILJHWNFMK-MEDUHNTESA-N dasotraline Chemical group C1([C@@H]2CC[C@H](C3=CC=CC=C32)N)=CC=C(Cl)C(Cl)=C1 SRPXSILJHWNFMK-MEDUHNTESA-N 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- WVLHGCRWEHCIOT-UHFFFAOYSA-N eltoprazine Chemical compound C1CNCCN1C1=CC=CC2=C1OCCO2 WVLHGCRWEHCIOT-UHFFFAOYSA-N 0.000 claims 2
- 229950006047 eltoprazine Drugs 0.000 claims 2
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 claims 2
- 229950007396 lecozotan Drugs 0.000 claims 2
- PHUTUTUABXHXLW-UHFFFAOYSA-N pindolol Chemical group CC(C)NCC(O)COC1=CC=CC2=NC=C[C]12 PHUTUTUABXHXLW-UHFFFAOYSA-N 0.000 claims 2
- 229960002508 pindolol Drugs 0.000 claims 2
- 208000012672 seasonal affective disease Diseases 0.000 claims 2
- 208000011117 substance-related disease Diseases 0.000 claims 2
- CEIJFEGBUDEYSX-FZDBZEDMSA-N tandospirone Chemical compound O=C([C@@H]1[C@H]2CC[C@H](C2)[C@@H]1C1=O)N1CCCCN(CC1)CCN1C1=NC=CC=N1 CEIJFEGBUDEYSX-FZDBZEDMSA-N 0.000 claims 2
- 229950000505 tandospirone Drugs 0.000 claims 2
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 claims 1
- 208000028698 Cognitive impairment Diseases 0.000 claims 1
- 206010013654 Drug abuse Diseases 0.000 claims 1
- 208000001640 Fibromyalgia Diseases 0.000 claims 1
- 206010026749 Mania Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 208000005793 Restless legs syndrome Diseases 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 206010013663 drug dependence Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 208000028173 post-traumatic stress disease Diseases 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 230000001457 vasomotor Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17799709P | 2009-05-13 | 2009-05-13 | |
| US61/177,997 | 2009-05-13 | ||
| PCT/US2010/034473 WO2010132521A1 (en) | 2009-05-13 | 2010-05-12 | Compositions comprising transnorsertraline and serotonin receptor 1a agonists/ antagonists and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015113773A Division JP2015180673A (ja) | 2009-05-13 | 2015-06-04 | トランスノルセルトラリン及びセロトニン受容体１ａ作動剤／拮抗剤を含む組成物及びその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012526832A JP2012526832A (ja) | 2012-11-01 |
| JP2012526832A5 true JP2012526832A5 (OSRAM) | 2013-06-27 |
Family
ID=42306730
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012510964A Pending JP2012526832A (ja) | 2009-05-13 | 2010-05-12 | トランスノルセルトラリン及びセロトニン受容体１ａ作動剤／拮抗剤を含む組成物及びその使用 |
| JP2015113773A Pending JP2015180673A (ja) | 2009-05-13 | 2015-06-04 | トランスノルセルトラリン及びセロトニン受容体１ａ作動剤／拮抗剤を含む組成物及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015113773A Pending JP2015180673A (ja) | 2009-05-13 | 2015-06-04 | トランスノルセルトラリン及びセロトニン受容体１ａ作動剤／拮抗剤を含む組成物及びその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20120077818A1 (OSRAM) |
| EP (1) | EP2429514A1 (OSRAM) |
| JP (2) | JP2012526832A (OSRAM) |
| CN (1) | CN102573823B (OSRAM) |
| CA (1) | CA2759180A1 (OSRAM) |
| WO (1) | WO2010132521A1 (OSRAM) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8134029B2 (en) | 2002-09-16 | 2012-03-13 | Sunovion Pharmaceuticals Inc. | Treatment of CNS disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine |
| WO2007006003A2 (en) | 2005-07-06 | 2007-01-11 | Sepracor Inc. | Combinations of eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders |
| WO2011064769A1 (en) * | 2009-11-24 | 2011-06-03 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Methods and pharmaceutical compositions for the treatment of hot flashes |
| CA2782240A1 (en) | 2009-12-04 | 2011-06-09 | Sunovion Pharmaceuticals Inc. | Formulations, salts and polymorphs of transnorsertraline and uses thereof |
| JP6436024B2 (ja) | 2015-09-14 | 2018-12-12 | 住友電気工業株式会社 | 炭化珪素エピタキシャル基板の製造方法 |
| US20200405867A1 (en) * | 2018-01-19 | 2020-12-31 | Sunovion Pharmaceuticals Inc. | Oral dosage forms |
| US12150777B2 (en) * | 2018-03-19 | 2024-11-26 | The Board Of Trustees Of The Leland Stanford Junior University | Treatment of depression |
| EP3870292A4 (en) | 2018-10-26 | 2022-11-09 | The Research Foundation for The State University of New York | COMBINATION OF SEROTONIN-SPECIFIC RESUPPUT INHIBITOR AND SEROTONIN 1A RECEPTOR PARTIAL AGONIST TO REDUCE L-DOPA-INDUCED DYSKINESIA |
| WO2020092496A1 (en) * | 2018-10-31 | 2020-05-07 | Sunovion Pharmaceuticals Inc. | Methods of treating central nervous system disorders |
| WO2025049588A1 (en) * | 2023-08-29 | 2025-03-06 | The Trustees Of Indiana University | Novel treatments for optic neuropathies and glaucoma |
| US11977085B1 (en) | 2023-09-05 | 2024-05-07 | Elan Ehrlich | Date rape drug detection device and method of using same |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5810518A (ja) * | 1981-07-14 | 1983-01-21 | Kowa Yakuhin Kogyo Kk | アルコ−ル中毒または鎮静催眠薬中毒治療剤 |
| US4634703A (en) * | 1985-10-25 | 1987-01-06 | Bristol-Myers Company | Method for alleviation of panic disorders |
| US4687772A (en) * | 1986-10-07 | 1987-08-18 | Bristol-Myers Company | Method for improvement of short term memory |
| US4777173A (en) * | 1987-03-25 | 1988-10-11 | Bristol-Myers Company | Method for treatment of alcohol abuse |
| IL91451A0 (en) * | 1988-08-30 | 1990-04-29 | Bristol Myers Co | Pharmaceutical compositions comprising azapiron compounds and their use in the treatment of addiction |
| US5468749A (en) * | 1988-08-30 | 1995-11-21 | Gawin; Frank H. | Method for treatment of substance addiction |
| IL97054A (en) * | 1990-02-12 | 1995-10-31 | Bristol Meyers Squibb Co | Pharmaceutical preparations containing bospirone for the treatment of coma |
| JPH03246225A (ja) * | 1990-02-20 | 1991-11-01 | Bristol Myers Squibb Co | メランコリーうつ病の治療法 |
| JPH04327532A (ja) * | 1991-01-31 | 1992-11-17 | Bristol Myers Squibb Co | 活動過剰を伴う注意力欠乏疾患の治療に使用する医薬製剤 |
| US5330762A (en) * | 1992-02-27 | 1994-07-19 | Alza Corporation | Tandospiaine antidepressive therapy |
| US5858407A (en) * | 1992-02-27 | 1999-01-12 | Alza Corporation | Method for administering tandospirone |
| DE69607904T2 (de) * | 1995-08-16 | 2000-10-05 | Eli Lilly And Co., Indianapolis | Potenzierung von Serotonin-Wirkstoffresponz |
| EP0792649A1 (en) * | 1996-02-29 | 1997-09-03 | Eli Lilly And Company | Treatment of sleep disorders |
| EP0818198A1 (en) * | 1996-07-09 | 1998-01-14 | Lilly S.A. | Potentiation of drug response by increasing serotonin availability |
| PT1075264E (pt) * | 1998-05-08 | 2005-01-31 | Upjohn Co | Novas combinacoes farmacologicas de reboxetina e pindolol |
| US6500827B2 (en) * | 1998-05-08 | 2002-12-31 | Pharmacia & Upjohn Company | Drug combinations |
| JP2002020291A (ja) * | 2000-06-30 | 2002-01-23 | Sumitomo Pharmaceut Co Ltd | 認知機能障害の治療剤 |
| DE60229123D1 (de) * | 2001-02-20 | 2008-11-13 | Dinan Timothy Gerard | Behandlung von fibromyalgie mit pindolol |
| US20020183306A1 (en) * | 2001-05-30 | 2002-12-05 | Pfizer Inc. | Combination treatment for sleep disorders including sleep apnea |
| AU2002322539B2 (en) * | 2001-07-20 | 2007-09-27 | Psychogenics Inc. | Treatment for attention-deficit hyperactivity disorder |
| JP2003335678A (ja) * | 2002-05-17 | 2003-11-25 | Sumitomo Pharmaceut Co Ltd | 神経因性疼痛治療薬 |
| BRPI0314377B8 (pt) * | 2002-09-16 | 2021-05-25 | Sepracor Inc | composto, composição farmacêutica, tablete ou cápsula, uso de uma quantidade terapeuticamente eficaz, e, processo para preparar um composto |
| US20080262071A1 (en) * | 2004-09-17 | 2008-10-23 | Timothy Dinan | Pindolol for the Treating Premenstrual Syndrome and Premenstrual Dysphoric Disorder |
| WO2006030306A2 (en) * | 2004-09-17 | 2006-03-23 | Neurocure Ltd | Pindolol for treating premenstrual syndrome and premenstrual dysphoric disorder |
| WO2007006003A2 (en) * | 2005-07-06 | 2007-01-11 | Sepracor Inc. | Combinations of eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders |
| KR20080043855A (ko) * | 2005-09-09 | 2008-05-19 | 와이어쓰 | 레코조탄을 포함하는 약학적 제형 및 조성물 |
| JP2009538925A (ja) * | 2006-05-31 | 2009-11-12 | セプラコール， インク． | ｔｒａｎｓ４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロ−１−ナフタレンアミン及びそのホルムアミドを用いる疼痛性障害の治療 |
-
2010
- 2010-05-12 CN CN201080019852.5A patent/CN102573823B/zh not_active Expired - Fee Related
- 2010-05-12 WO PCT/US2010/034473 patent/WO2010132521A1/en not_active Ceased
- 2010-05-12 US US13/320,246 patent/US20120077818A1/en not_active Abandoned
- 2010-05-12 CA CA2759180A patent/CA2759180A1/en not_active Abandoned
- 2010-05-12 JP JP2012510964A patent/JP2012526832A/ja active Pending
- 2010-05-12 EP EP10719204A patent/EP2429514A1/en not_active Withdrawn
-
2015
- 2015-06-04 JP JP2015113773A patent/JP2015180673A/ja active Pending
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