JP2012525201A5 - - Google Patents
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- JP2012525201A5 JP2012525201A5 JP2012508432A JP2012508432A JP2012525201A5 JP 2012525201 A5 JP2012525201 A5 JP 2012525201A5 JP 2012508432 A JP2012508432 A JP 2012508432A JP 2012508432 A JP2012508432 A JP 2012508432A JP 2012525201 A5 JP2012525201 A5 JP 2012525201A5
- Authority
- JP
- Japan
- Prior art keywords
- ions
- layer
- ion
- range
- coating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000011248 coating agent Substances 0.000 claims description 33
- 238000000576 coating method Methods 0.000 claims description 33
- 238000000034 method Methods 0.000 claims description 17
- 239000000758 substrate Substances 0.000 claims description 15
- 150000002500 ions Chemical group 0.000 claims description 10
- 239000007864 aqueous solution Substances 0.000 claims description 9
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 9
- 239000001506 calcium phosphate Substances 0.000 claims description 9
- 235000011010 calcium phosphates Nutrition 0.000 claims description 9
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 9
- 229910052710 silicon Inorganic materials 0.000 claims description 8
- 239000010703 silicon Substances 0.000 claims description 8
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 7
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 7
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 7
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 7
- 239000000243 solution Substances 0.000 claims description 7
- 238000006467 substitution reaction Methods 0.000 claims description 7
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims description 6
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 claims description 6
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 6
- 229910001424 calcium ion Inorganic materials 0.000 claims description 6
- 229910001425 magnesium ion Inorganic materials 0.000 claims description 6
- 229910052712 strontium Inorganic materials 0.000 claims description 6
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 claims description 6
- 229910001414 potassium ion Inorganic materials 0.000 claims description 5
- 229910001415 sodium ion Inorganic materials 0.000 claims description 5
- 230000015572 biosynthetic process Effects 0.000 claims description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 3
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 3
- 229910052791 calcium Inorganic materials 0.000 claims description 3
- 239000011575 calcium Substances 0.000 claims description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
- 229910019142 PO4 Inorganic materials 0.000 claims description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 238000002048 anodisation reaction Methods 0.000 claims description 2
- 125000002091 cationic group Chemical group 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- 230000007062 hydrolysis Effects 0.000 claims description 2
- 238000006460 hydrolysis reaction Methods 0.000 claims description 2
- 238000007654 immersion Methods 0.000 claims description 2
- 230000003647 oxidation Effects 0.000 claims description 2
- 238000007254 oxidation reaction Methods 0.000 claims description 2
- 239000010452 phosphate Substances 0.000 claims description 2
- 239000011591 potassium Substances 0.000 claims description 2
- 229910052700 potassium Inorganic materials 0.000 claims description 2
- 239000011734 sodium Substances 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 238000011282 treatment Methods 0.000 claims description 2
- 238000009281 ultraviolet germicidal irradiation Methods 0.000 claims description 2
- -1 silicon ions Chemical class 0.000 claims 2
- 229910001427 strontium ion Inorganic materials 0.000 claims 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 1
- 150000001805 chlorine compounds Chemical group 0.000 claims 1
- 239000011777 magnesium Substances 0.000 claims 1
- 229910052749 magnesium Inorganic materials 0.000 claims 1
- 238000002203 pretreatment Methods 0.000 claims 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 5
- 239000011701 zinc Substances 0.000 description 4
- NPYPAHLBTDXSSS-UHFFFAOYSA-N Potassium ion Chemical compound [K+] NPYPAHLBTDXSSS-UHFFFAOYSA-N 0.000 description 3
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 description 3
- 229940085991 phosphate ion Drugs 0.000 description 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 229910052788 barium Inorganic materials 0.000 description 1
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 1
- KVEAILYLMGOETO-UHFFFAOYSA-H dicalcium magnesium diphosphate Chemical compound P(=O)([O-])([O-])[O-].[Mg+2].[Ca+2].[Ca+2].P(=O)([O-])([O-])[O-] KVEAILYLMGOETO-UHFFFAOYSA-H 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0900560-4 | 2009-04-27 | ||
| SE0900560A SE535536C2 (sv) | 2009-04-27 | 2009-04-27 | Jonsubstituerade hydroxiapatitytbeläggningar |
| PCT/SE2010/050461 WO2010126436A1 (en) | 2009-04-27 | 2010-04-26 | Ion substituted calcium phosphate coatings |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012525201A JP2012525201A (ja) | 2012-10-22 |
| JP2012525201A5 true JP2012525201A5 (enExample) | 2013-06-20 |
Family
ID=43032394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012508432A Pending JP2012525201A (ja) | 2009-04-27 | 2010-04-26 | イオン置換されたリン酸カルシウムコーティング |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20120087954A1 (enExample) |
| EP (1) | EP2424580A4 (enExample) |
| JP (1) | JP2012525201A (enExample) |
| CN (1) | CN102438671A (enExample) |
| SE (1) | SE535536C2 (enExample) |
| WO (1) | WO2010126436A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101423982B1 (ko) | 2012-08-10 | 2014-08-13 | 서울대학교산학협력단 | 휘트록카이트 및 그 제조 방법 |
| ES2717678T3 (es) * | 2013-04-22 | 2019-06-24 | Stryker European Holdings I Llc | Procedimiento para la carga de fármacos sobre superficies de implantes recubiertos de hidroxiapatita |
| EP3010557B1 (en) | 2013-06-21 | 2019-08-21 | Stryker European Holdings I, LLC | Co-precipitation of tobramycin into hydroxyapatite coatings |
| EP3019101B1 (en) | 2013-07-11 | 2018-02-21 | Stryker European Holdings I, LLC | Fixation assembly with a flexible elongated member for securing parts of a sternum |
| EP3041521B1 (en) | 2013-09-02 | 2017-08-30 | Stryker European Holdings I, LLC | Method of manufacturing an implant for use in a surgical procedure |
| EP3042622B1 (en) | 2015-01-09 | 2018-05-09 | Stryker European Holdings I, LLC | Implant for bone fixation |
| BR102016012926B1 (pt) * | 2016-06-06 | 2019-04-02 | Brunella Sily De Assis Bumachar | Processo de deposição nanométrica de fosfato de cálcio na superfície de implante de titânio anodizado |
| IT201600091766A1 (it) * | 2016-09-12 | 2018-03-12 | Innovaplants Srl | Dispositivi medici impiantabili aventi uno strato di rivestimento con proprieta' antimicrobiche a base di idrossiapatite nanostrutturata. |
| EP3320868B1 (en) | 2016-11-11 | 2019-05-01 | Stryker European Holdings I, LLC | Implant for bone fixation |
| WO2020146600A1 (en) * | 2019-01-10 | 2020-07-16 | University Of Utah Research Foundation | Fluorapatite coated implants and related methods statement regarding federally sponsored research |
| CN110302424A (zh) * | 2019-07-29 | 2019-10-08 | 西南交通大学 | 一种高通量仿生矿化多元素掺杂钙磷涂层的制备方法 |
| CN111467573A (zh) * | 2020-04-21 | 2020-07-31 | 上海交通大学医学院附属第九人民医院 | 一种用于预防种植体周围炎发生的口腔种植体 |
| CN112723315A (zh) * | 2020-11-16 | 2021-04-30 | 山东和创智云环保装备有限公司 | 一种臭氧发生用金属及其原位生长陶瓷介电体一体化电极及其制作工艺 |
| CN116732483A (zh) * | 2023-05-19 | 2023-09-12 | 武汉理工大学深圳研究院 | 一种表面磁控溅射制备掺锶磷酸钙生物涂层的方法、生物涂层及生物医用材料 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1288038B1 (it) * | 1996-04-30 | 1998-09-10 | Flametal S P A | Procedimento per la preparazione di rivestimenti di idrossiapatite |
| GB2316940A (en) * | 1996-08-30 | 1998-03-11 | Queen Mary & Westfield College | Silicon-substituted hydroxyapatite |
| US6013591A (en) * | 1997-01-16 | 2000-01-11 | Massachusetts Institute Of Technology | Nanocrystalline apatites and composites, prostheses incorporating them, and method for their production |
| US6139585A (en) * | 1998-03-11 | 2000-10-31 | Depuy Orthopaedics, Inc. | Bioactive ceramic coating and method |
| US6736849B2 (en) * | 1998-03-11 | 2004-05-18 | Depuy Products, Inc. | Surface-mineralized spinal implants |
| CA2277732A1 (en) * | 1998-09-15 | 2000-03-15 | Isotis B.V. | Method for coating medical implants |
| US6905723B2 (en) * | 2003-05-30 | 2005-06-14 | Depuy Products, Inc. | Strontium-substituted apatite coating |
| DK1786483T3 (da) * | 2004-08-10 | 2011-01-31 | Yekimed Ag | Biomimetisk fremgangsmåde til coating af substrater |
| ITMI20051966A1 (it) * | 2005-10-18 | 2007-04-19 | C N R Consiglio Naz Delle Ri C | Una idrossiapatite plurisostituita ed il relativo composito con un polimero naturale e-o sintetico loro preparazione e usi |
-
2009
- 2009-04-27 SE SE0900560A patent/SE535536C2/sv not_active IP Right Cessation
-
2010
- 2010-04-26 CN CN2010800188222A patent/CN102438671A/zh active Pending
- 2010-04-26 US US13/266,533 patent/US20120087954A1/en not_active Abandoned
- 2010-04-26 EP EP10770028.8A patent/EP2424580A4/en not_active Withdrawn
- 2010-04-26 WO PCT/SE2010/050461 patent/WO2010126436A1/en not_active Ceased
- 2010-04-26 JP JP2012508432A patent/JP2012525201A/ja active Pending
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