JP2012524112A - 統合失調症および双極性障害を治療するための組織カリクレイン - Google Patents

統合失調症および双極性障害を治療するための組織カリクレイン Download PDF

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JP2012524112A
JP2012524112A JP2012506296A JP2012506296A JP2012524112A JP 2012524112 A JP2012524112 A JP 2012524112A JP 2012506296 A JP2012506296 A JP 2012506296A JP 2012506296 A JP2012506296 A JP 2012506296A JP 2012524112 A JP2012524112 A JP 2012524112A
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klk1
schizophrenia
variant
disorder
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JP2012524112A5 (https=
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マーク・ウィリアムズ
マシュー・チャールズ
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サノミューン・インコーポレイテッド
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482Serine endopeptidases (3.4.21)
    • A61K38/4853Kallikrein (3.4.21.34 or 3.4.21.35)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Psychiatry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2012506296A 2009-04-21 2010-04-21 統合失調症および双極性障害を治療するための組織カリクレイン Pending JP2012524112A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17118909P 2009-04-21 2009-04-21
US61/171,189 2009-04-21
PCT/CA2010/000561 WO2010121358A1 (en) 2009-04-21 2010-04-21 Tissue kallikrein for the treatment of schizophrenia and bipolar disorder

Publications (2)

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JP2012524112A true JP2012524112A (ja) 2012-10-11
JP2012524112A5 JP2012524112A5 (https=) 2013-05-30

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ID=43010629

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JP2012506296A Pending JP2012524112A (ja) 2009-04-21 2010-04-21 統合失調症および双極性障害を治療するための組織カリクレイン

Country Status (6)

Country Link
US (1) US20120201804A1 (https=)
EP (1) EP2421553A4 (https=)
JP (1) JP2012524112A (https=)
CN (1) CN102458453A (https=)
CA (1) CA2759481A1 (https=)
WO (1) WO2010121358A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016195088A1 (ja) * 2015-06-04 2016-12-08 国立研究開発法人 国立精神・神経医療研究センター Il-6阻害剤を有効成分とする精神疾患治療剤
JP2025504043A (ja) * 2022-01-28 2025-02-06 江蘇衆紅生物工程創薬研究院有限公司 Vci、psciまたはcsvdの治療におけるカリクレイン1またはその誘導体の使用

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2182978A4 (en) 2007-07-20 2012-03-21 Sanomune Inc TISSUE KALLIKREIN FOR THE TREATMENT OF DISEASES ASSOCIATED WITH AMYLOID PROTEIN
US20130315891A1 (en) 2012-05-25 2013-11-28 Matthew Charles Formulations of human tissue kallikrein-1 for parenteral delivery and related methods
US20130323222A1 (en) 2012-06-04 2013-12-05 Matthew Charles Human tissue kallikrein 1 glycosylation isoforms
EP3558276B1 (en) 2016-12-20 2024-11-06 LTS Lohmann Therapie-Systeme AG Transdermal therapeutic system containing asenapine and polysiloxane or polyisobutylene
CN115813888A (zh) 2016-12-20 2023-03-21 罗曼治疗系统股份公司 包含阿塞那平的透皮治疗系统
AU2018230478B2 (en) 2017-03-09 2025-01-23 Diamedica Inc. Dosage forms of tissue kallikrein 1
WO2019002204A1 (en) 2017-06-26 2019-01-03 Lts Lohmann Therapie-Systeme Ag TRANSDERMAL THERAPEUTIC SYSTEM CONTAINING ASENAPINE AND SILICONE-TYPE ACRYLIC HYBRID POLYMER
AU2019291060B2 (en) 2018-06-20 2024-09-05 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system containing asenapine
US12329862B2 (en) 2018-06-20 2025-06-17 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system containing asenapine
CN109091667B (zh) * 2018-09-18 2020-05-05 广东天普生化医药股份有限公司 人尿激肽原酶在制备治疗偏头痛药物中的用途及其组合物
CN116554267A (zh) * 2022-01-30 2023-08-08 江苏众红生物工程创药研究院有限公司 聚乙二醇修饰的激肽或其变体和药物应用
CN116549599A (zh) * 2022-01-30 2023-08-08 江苏众红生物工程创药研究院有限公司 激肽及其衍生物在治疗vci、psci或csvd中的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2182978A4 (en) * 2007-07-20 2012-03-21 Sanomune Inc TISSUE KALLIKREIN FOR THE TREATMENT OF DISEASES ASSOCIATED WITH AMYLOID PROTEIN
WO2010009557A1 (en) * 2008-07-25 2010-01-28 Sanomune Inc. Tissue kallikrein for the treatment of parkinson's disease

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
JPN6014016633; Neuropsychopharmacology Vol.33,No.6, 2008, p1343-1353 *
JPN6014016636; Journal of Neurochemistry [online], 20090310, doi:10.1111/j.1471-4159.2009.06030.x *
JPN6014016639; Human Gene Therapy Vol.17,No.2, 2006, p206-219 *
JPN6014016642; Hypertension Vol.43,No.2, 2004, p452-459 *
JPN6014016645; Journal of Pharmacology and Experimental Therapeut Vol.326,No.3, 2008, p838-848 *
JPN6014016649; 脳と精神の医学 Vol.19,No.1, 2008, p31-40 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016195088A1 (ja) * 2015-06-04 2016-12-08 国立研究開発法人 国立精神・神経医療研究センター Il-6阻害剤を有効成分とする精神疾患治療剤
JPWO2016195088A1 (ja) * 2015-06-04 2018-03-29 国立研究開発法人国立精神・神経医療研究センター Il−6阻害剤を有効成分とする精神疾患治療剤
JP2021073245A (ja) * 2015-06-04 2021-05-13 国立研究開発法人国立精神・神経医療研究センター Il−6阻害剤を有効成分とする精神疾患治療剤
US11174317B2 (en) 2015-06-04 2021-11-16 National Center Of Neurology And Psychiatry Therapeutic agent for mental illness comprising IL-6 inhibitor as active ingredient
JP7128460B2 (ja) 2015-06-04 2022-08-31 国立研究開発法人国立精神・神経医療研究センター Il-6阻害剤を有効成分とする精神疾患治療剤
JP2025504043A (ja) * 2022-01-28 2025-02-06 江蘇衆紅生物工程創薬研究院有限公司 Vci、psciまたはcsvdの治療におけるカリクレイン1またはその誘導体の使用

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Publication number Publication date
EP2421553A1 (en) 2012-02-29
CA2759481A1 (en) 2010-10-28
WO2010121358A1 (en) 2010-10-28
CN102458453A (zh) 2012-05-16
US20120201804A1 (en) 2012-08-09
EP2421553A4 (en) 2012-11-28

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