JP2012524103A5 - - Google Patents

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Publication number
JP2012524103A5
JP2012524103A5 JP2012506209A JP2012506209A JP2012524103A5 JP 2012524103 A5 JP2012524103 A5 JP 2012524103A5 JP 2012506209 A JP2012506209 A JP 2012506209A JP 2012506209 A JP2012506209 A JP 2012506209A JP 2012524103 A5 JP2012524103 A5 JP 2012524103A5
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JP
Japan
Prior art keywords
phenyl
azabicyclo
oxa
alkyl
oct
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JP2012506209A
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English (en)
Japanese (ja)
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JP2012524103A (ja
JP5649643B2 (ja
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Priority claimed from PCT/US2010/031191 external-priority patent/WO2010120998A1/en
Publication of JP2012524103A publication Critical patent/JP2012524103A/ja
Publication of JP2012524103A5 publication Critical patent/JP2012524103A5/ja
Application granted granted Critical
Publication of JP5649643B2 publication Critical patent/JP5649643B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2012506209A 2009-04-17 2010-04-15 ピリミジン化合物、ｍＴＯＲキナーゼおよびＰＩ３キナーゼ阻害剤としてのそれらの使用、ならびにそれらの合成 Expired - Fee Related JP5649643B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17013809P 2009-04-17 2009-04-17
US61/170,138 2009-04-17
PCT/US2010/031191 WO2010120998A1 (en) 2009-04-17 2010-04-15 Pyrimidine compounds, their use as mtor kinase and pi3 kinase inhibitors, and their syntheses

Publications (3)

Publication Number Publication Date
JP2012524103A JP2012524103A (ja) 2012-10-11
JP2012524103A5 true JP2012524103A5 (https=) 2013-04-04
JP5649643B2 JP5649643B2 (ja) 2015-01-07

Family

ID=42269326

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012506209A Expired - Fee Related JP5649643B2 (ja) 2009-04-17 2010-04-15 ピリミジン化合物、ｍＴＯＲキナーゼおよびＰＩ３キナーゼ阻害剤としてのそれらの使用、ならびにそれらの合成

Country Status (6)

Country Link
US (1) US8835429B2 (https=)
EP (1) EP2419432B9 (https=)
JP (1) JP5649643B2 (https=)
CA (1) CA2755554C (https=)
ES (1) ES2439793T3 (https=)
WO (1) WO2010120998A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2542536B1 (en) 2010-03-04 2015-01-21 Cellzome Limited Morpholino substituted urea derivatives as mtor inhibitors
CA2829558A1 (en) * 2011-03-09 2012-09-13 Celgene Avilomics Research, Inc. Pi3 kinase inhibitors and uses thereof
WO2012136622A1 (en) 2011-04-04 2012-10-11 Cellzome Limited Dihydropyrrolo pyrimidine derivatives as mtor inhibitors
WO2013041652A1 (en) 2011-09-21 2013-03-28 Cellzome Limited Morpholino substituted urea or carbamate derivatives as mtor inhibitors
KR20140084130A (ko) 2011-10-07 2014-07-04 셀좀 리미티드 Mtor 억제제로서의 모르폴리노 치환된 바이사이클릭 피리미딘 우레아 또는 카르바메이트 유도체
CN107375289A (zh) * 2011-11-01 2017-11-24 埃克塞利希斯股份有限公司 用于治疗淋巴组织增生性恶性肿瘤的作为磷脂酰肌醇3‑激酶抑制剂的化合物
CN104230952B (zh) * 2014-08-16 2017-02-01 沈阳药科大学 含有嘧啶骨架的化合物及其制备方法和用途
CN107001348B (zh) * 2014-12-17 2019-10-11 上海海雁医药科技有限公司 2-吗啉-4,6-二取代的嘧啶衍生物、其制法与医药上的用途
GB202415232D0 (en) 2024-10-16 2024-11-27 Nacamed As Composition

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9009A (en) * 1852-06-08 Bat-trap
EP1635815A4 (en) * 2003-06-03 2009-03-25 Beth Israel Hospital METHOD AND COMPOUNDS FOR TREATING TISSUE TESTS
GB0520657D0 (en) * 2005-10-11 2005-11-16 Ludwig Inst Cancer Res Pharmaceutical compounds
GB0525083D0 (en) * 2005-12-09 2006-01-18 Astrazeneca Ab Pyrimidine derivatives
AU2007287428B2 (en) * 2006-08-24 2011-08-11 Astrazeneca Ab Morpholino pyrimidine derivatives useful in the treatment of proliferative disorders
JP2010527924A (ja) * 2007-05-18 2010-08-19 メルク・シャープ・エンド・ドーム・コーポレイション オキソ架橋ジアゼパンオレキシン受容体アンタゴニスト
EA201000484A1 (ru) * 2007-10-16 2010-12-30 ВАЙЕТ ЭлЭлСи Тиенопиримидиновые и пиразолопиримидиновые соединения и их применение в качестве ингибиторов киназы mtor и киназы pi3

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