JP2012524103A5 - - Google Patents

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Publication number
JP2012524103A5
JP2012524103A5 JP2012506209A JP2012506209A JP2012524103A5 JP 2012524103 A5 JP2012524103 A5 JP 2012524103A5 JP 2012506209 A JP2012506209 A JP 2012506209A JP 2012506209 A JP2012506209 A JP 2012506209A JP 2012524103 A5 JP2012524103 A5 JP 2012524103A5
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JP
Japan
Prior art keywords
phenyl
azabicyclo
oxa
alkyl
oct
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JP2012506209A
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English (en)
Japanese (ja)
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JP5649643B2 (ja
JP2012524103A (ja
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Priority claimed from PCT/US2010/031191 external-priority patent/WO2010120998A1/en
Publication of JP2012524103A publication Critical patent/JP2012524103A/ja
Publication of JP2012524103A5 publication Critical patent/JP2012524103A5/ja
Application granted granted Critical
Publication of JP5649643B2 publication Critical patent/JP5649643B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2012506209A 2009-04-17 2010-04-15 ピリミジン化合物、ｍＴＯＲキナーゼおよびＰＩ３キナーゼ阻害剤としてのそれらの使用、ならびにそれらの合成 Expired - Fee Related JP5649643B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17013809P 2009-04-17 2009-04-17
US61/170,138 2009-04-17
PCT/US2010/031191 WO2010120998A1 (en) 2009-04-17 2010-04-15 Pyrimidine compounds, their use as mtor kinase and pi3 kinase inhibitors, and their syntheses

Publications (3)

Publication Number Publication Date
JP2012524103A JP2012524103A (ja) 2012-10-11
JP2012524103A5 true JP2012524103A5 (enExample) 2013-04-04
JP5649643B2 JP5649643B2 (ja) 2015-01-07

Family

ID=42269326

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012506209A Expired - Fee Related JP5649643B2 (ja) 2009-04-17 2010-04-15 ピリミジン化合物、ｍＴＯＲキナーゼおよびＰＩ３キナーゼ阻害剤としてのそれらの使用、ならびにそれらの合成

Country Status (6)

Country Link
US (1) US8835429B2 (enExample)
EP (1) EP2419432B9 (enExample)
JP (1) JP5649643B2 (enExample)
CA (1) CA2755554C (enExample)
ES (1) ES2439793T3 (enExample)
WO (1) WO2010120998A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9249129B2 (en) 2010-03-04 2016-02-02 Cellzome Limited Morpholino substituted urea derivatives as mTOR inhibitors
JP2014511395A (ja) * 2011-03-09 2014-05-15 セルジーン アヴィロミクス リサーチ， インコーポレイテッド Ｐｉ３キナーゼインヒビターおよびその使用
US20140163023A1 (en) 2011-04-04 2014-06-12 Cellzome Limited Dihydropyrrolo pyrimidine derivatives as mtor inhibitors
US9175011B2 (en) 2011-09-21 2015-11-03 Cellzone Limited Morpholino substituted urea or carbamate derivatives as MTOR inhibitors
CN103946222B (zh) 2011-10-07 2016-12-28 塞尔佐姆有限公司 作为mtor抑制剂的吗啉代取代的双环嘧啶脲或氨基甲酸衍生物
AU2012332486A1 (en) * 2011-11-01 2014-06-19 Arthur Decillis N- (3- { [ (3- { [2-chloro-5- (methoxy) phenyl] amino} quinoxalin- 2 -yl) amino] sulfonyl} phe nyl) - 2 -methylalaninamide as phosphatidylinositol 3 - kinase inhibitor for the treatment of lymphoproliferative malignancies
CN104230952B (zh) * 2014-08-16 2017-02-01 沈阳药科大学 含有嘧啶骨架的化合物及其制备方法和用途
JP6397577B2 (ja) * 2014-12-17 2018-09-26 シャンハイ ハイヤン ファーマシューティカル テクノロジー カンパニー リミテッドＳｈａｎｇｈａｉ Ｈａｉｙａｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏ．， Ｌｔｄ． ２−モルホリノ−４，６−二置換ピリミジン誘導体、その製法および医薬における使用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9009A (en) * 1852-06-08 Bat-trap
WO2004108130A1 (en) * 2003-06-03 2004-12-16 Beth Israel Deaconess Medical Center Methods and compounds for the treatment of vascular stenosis
GB0520657D0 (en) * 2005-10-11 2005-11-16 Ludwig Inst Cancer Res Pharmaceutical compounds
GB0525083D0 (en) * 2005-12-09 2006-01-18 Astrazeneca Ab Pyrimidine derivatives
CA2660758A1 (en) * 2006-08-24 2008-02-27 Astrazeneca Ab Morpholino pyrimidine derivatives useful in the treatment of proliferative disorders
AU2008255005B2 (en) * 2007-05-18 2013-05-02 Merck Sharp & Dohme Corp. OXO bridged diazepan orexin receptor antagonists
CN101883774A (zh) * 2007-10-16 2010-11-10 惠氏有限责任公司 噻吩并嘧啶和吡唑并嘧啶化合物及其用作mtor激酶和pi3激酶抑制剂的用途

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