JP2012522809A5 - - Google Patents
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- Publication number
- JP2012522809A5 JP2012522809A5 JP2012503772A JP2012503772A JP2012522809A5 JP 2012522809 A5 JP2012522809 A5 JP 2012522809A5 JP 2012503772 A JP2012503772 A JP 2012503772A JP 2012503772 A JP2012503772 A JP 2012503772A JP 2012522809 A5 JP2012522809 A5 JP 2012522809A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- bound
- nanoparticles
- polymer
- nanoparticle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920000642 polymer Polymers 0.000 claims description 26
- 230000000694 effects Effects 0.000 claims description 14
- 229920001553 poly(ethylene glycol)-block-polylactide methyl ether Polymers 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 13
- 102100028496 Galactocerebrosidase Human genes 0.000 claims description 10
- 238000002360 preparation method Methods 0.000 claims description 4
- 229920001184 polypeptide Polymers 0.000 claims 56
- 102000004196 processed proteins & peptides Human genes 0.000 claims 56
- 108090000765 processed proteins & peptides Proteins 0.000 claims 56
- 239000002105 nanoparticle Substances 0.000 claims 45
- 238000000034 method Methods 0.000 claims 27
- 108090000790 Enzymes Proteins 0.000 claims 11
- 102000004190 Enzymes Human genes 0.000 claims 11
- 108010042681 Galactosylceramidase Proteins 0.000 claims 4
- 230000002255 enzymatic effect Effects 0.000 claims 4
- 210000002966 serum Anatomy 0.000 claims 3
- 238000004220 aggregation Methods 0.000 claims 2
- 230000002776 aggregation Effects 0.000 claims 2
- 230000009920 chelation Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 101000860395 Homo sapiens Galactocerebrosidase Proteins 0.000 description 6
- 238000004630 atomic force microscopy Methods 0.000 description 4
- 238000000338 in vitro Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 239000010445 mica Substances 0.000 description 2
- 229910052618 mica group Inorganic materials 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- WYTZZXDRDKSJID-UHFFFAOYSA-N (3-aminopropyl)triethoxysilane Chemical compound CCO[Si](OCC)(OCC)CCCN WYTZZXDRDKSJID-UHFFFAOYSA-N 0.000 description 1
- 208000034530 PLAA-associated neurodevelopmental disease Diseases 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000010079 rubber tapping Methods 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16692909P | 2009-04-06 | 2009-04-06 | |
| US61/166,929 | 2009-04-06 | ||
| PCT/US2010/029985 WO2010117957A2 (en) | 2009-04-06 | 2010-04-05 | Methods and materials for delivering molecules |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015032550A Division JP2015098484A (ja) | 2009-04-06 | 2015-02-23 | 分子を送達するための方法および材料 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012522809A JP2012522809A (ja) | 2012-09-27 |
| JP2012522809A5 true JP2012522809A5 (cg-RX-API-DMAC10.html) | 2015-04-16 |
| JP5866117B2 JP5866117B2 (ja) | 2016-02-17 |
Family
ID=42936837
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012503772A Active JP5866117B2 (ja) | 2009-04-06 | 2010-04-05 | 分子を送達するための方法および材料 |
| JP2015032550A Withdrawn JP2015098484A (ja) | 2009-04-06 | 2015-02-23 | 分子を送達するための方法および材料 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015032550A Withdrawn JP2015098484A (ja) | 2009-04-06 | 2015-02-23 | 分子を送達するための方法および材料 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9636384B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP2416763B1 (cg-RX-API-DMAC10.html) |
| JP (2) | JP5866117B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2757645C (cg-RX-API-DMAC10.html) |
| IL (1) | IL215455B (cg-RX-API-DMAC10.html) |
| WO (1) | WO2010117957A2 (cg-RX-API-DMAC10.html) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013524811A (ja) * | 2010-04-20 | 2013-06-20 | ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド | ナノザイム、ナノザイムの製造方法、およびナノザイムの使用方法 |
| JP2014522649A (ja) * | 2011-07-06 | 2014-09-08 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 多酵素ナノ複合体 |
| US8871189B2 (en) * | 2011-11-30 | 2014-10-28 | Mallinckrodt Llc | MMP-targeted therapeutic and/or diagnostic nanocarriers |
| US20130323221A1 (en) * | 2012-05-30 | 2013-12-05 | Biostrategies LC | Plant lectins as carriers of associated drug substances into animal and human cells |
| US10413606B2 (en) | 2012-10-01 | 2019-09-17 | Mayo Foundation For Medical Education And Research | Methods for treating cancer with nanoparticle complexes of albumin-bound paclitaxel and anti-VEGF antibodies |
| EP2910632B1 (en) * | 2012-10-19 | 2017-07-05 | Tokushima University | Highly functional enzyme having modified substrate specificity of human beta-hexosaminidase b and exhibiting protease resistance |
| WO2015023715A1 (en) | 2013-08-14 | 2015-02-19 | The University Of Florida Research Foundation, Inc. | Nanozymes, methods of making nanozymes, and methods of using nanozymes |
| EP3154586B1 (en) | 2014-06-13 | 2020-05-27 | Mayo Foundation for Medical Education and Research | Treating lymphomas |
| US10213513B2 (en) | 2014-06-16 | 2019-02-26 | Mayo Foundation For Medical Education And Research | Treating myelomas |
| CN107073132B (zh) | 2014-10-06 | 2021-08-27 | 梅约医学教育与研究基金会 | 载体-抗体组合物及其制备和使用方法 |
| TW201707725A (zh) | 2015-08-18 | 2017-03-01 | 美國馬友醫藥教育研究基金會 | 載體－抗體組合物及其製造及使用方法 |
| TW201713360A (en) | 2015-10-06 | 2017-04-16 | Mayo Foundation | Methods of treating cancer using compositions of antibodies and carrier proteins |
| WO2017120501A1 (en) | 2016-01-07 | 2017-07-13 | Mayo Foundation For Medical Education And Research | Methods of treating cancer with interferon |
| US11351254B2 (en) | 2016-02-12 | 2022-06-07 | Mayo Foundation For Medical Education And Research | Hematologic cancer treatments |
| WO2017165440A1 (en) | 2016-03-21 | 2017-09-28 | Mayo Foundation For Medical Education And Research | Methods for reducing toxicity of a chemotherapeutic drug |
| EP3432928A4 (en) | 2016-03-21 | 2019-11-20 | Mayo Foundation for Medical Education and Research | PROCESS FOR IMPROVING THE THERAPEUTIC INDEX FOR CHEMOTHERAPEUTIC |
| US10618969B2 (en) | 2016-04-06 | 2020-04-14 | Mayo Foundation For Medical Education And Research | Carrier-binding agent compositions and methods of making and using the same |
| CN109843336A (zh) | 2016-09-01 | 2019-06-04 | 梅约医学教育与研究基金会 | 用于靶向t细胞癌症的方法和组合物 |
| CN109890419A (zh) | 2016-09-01 | 2019-06-14 | 梅约医学教育与研究基金会 | 用于治疗癌症的载体-pd-l1结合剂组合物 |
| US11590098B2 (en) | 2016-09-06 | 2023-02-28 | Mayo Foundation For Medical Education And Research | Methods of treating triple-negative breast cancer using compositions of antibodies and carrier proteins |
| CN109843924A (zh) | 2016-09-06 | 2019-06-04 | 梅约医学教育与研究基金会 | 治疗表达pd-l1的癌症的方法 |
| AU2017324947A1 (en) | 2016-09-06 | 2019-03-28 | Mayo Foundation For Medical Education And Research | Paclitaxel-albumin-binding agent compositions and methods for using and making the same |
| WO2022006271A2 (en) * | 2020-06-30 | 2022-01-06 | Hillstream Biopharma Inc. | Nanoparticles and methods of manufacture thereof |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US5122614A (en) * | 1989-04-19 | 1992-06-16 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
| US5766897A (en) | 1990-06-21 | 1998-06-16 | Incyte Pharmaceuticals, Inc. | Cysteine-pegylated proteins |
| US5621039A (en) * | 1993-06-08 | 1997-04-15 | Hallahan; Terrence W. | Factor IX- polymeric conjugates |
| US5565215A (en) | 1993-07-23 | 1996-10-15 | Massachusettes Institute Of Technology | Biodegradable injectable particles for imaging |
| US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| KR19990085365A (ko) * | 1998-05-16 | 1999-12-06 | 허영섭 | 지속적으로 약물 조절방출이 가능한 생분해성 고분자 미립구 및그 제조방법 |
| KR100566911B1 (ko) | 2001-06-25 | 2006-04-03 | 주식회사 삼양사 | 약물 전달체용 음이온기-함유 양친성 블록 공중합체 및 그의 양이온성 약물과의 복합체 |
| WO2003057179A2 (en) * | 2002-01-11 | 2003-07-17 | Biomarin Pharmaceutical, Inc. | Use of p97 as an enzyme delivery system for the delivery of therapeutic lysosomal enzymes |
| US20080014188A1 (en) | 2004-02-06 | 2008-01-17 | Zankel Todd C | Manufacture of Highly Phosphorylated Lysosomal Enzymes and Uses Thereof |
| EP1794590B1 (en) | 2004-09-08 | 2014-02-26 | Rensselaer Polytechnic Institute | Enhanced stability of proteins immobilized on nanoparticles |
| JP2009501237A (ja) * | 2005-03-14 | 2009-01-15 | ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム | 生物活性ｆｕｓ１ペプチドおよびナノ粒子−ポリペプチド複合体 |
| US20070059775A1 (en) | 2005-03-29 | 2007-03-15 | The Trustees Of Columbia University In The City Of New York | Synthesis and conjugation of iron oxide nanoparticles to antibodies for targeting specific cells using fluorescence and MR imaging techniques |
| JP5137814B2 (ja) | 2005-04-06 | 2013-02-06 | ジェンザイム・コーポレーション | 治療ターゲティングのための酸不安定リンカーを介するｐｅｇおよびポリシアルリソソーム酵素のコンジュゲート |
| US8246995B2 (en) * | 2005-05-10 | 2012-08-21 | The Board Of Trustees Of The Leland Stanford Junior University | Hydrophobic nanotubes and nanoparticles as transporters for the delivery of drugs into cells |
| FR2889362B1 (fr) | 2005-08-01 | 2007-10-19 | Thomson Licensing Sas | Systeme d'antennes a diversite de type dipole |
| JP2009508936A (ja) * | 2005-09-20 | 2009-03-05 | イッサム リサーチ ディベロップメント カンパニー | 活性物質の標的化送達用ナノ粒子 |
| EP1818395A1 (en) * | 2006-02-08 | 2007-08-15 | Diatos | Compositions and methods for treating lysosomal storage diseases |
| WO2008105773A2 (en) | 2006-03-31 | 2008-09-04 | Massachusetts Institute Of Technology | System for targeted delivery of therapeutic agents |
| US20100015050A1 (en) | 2006-12-21 | 2010-01-21 | Wayne State University | Peg and targeting ligands on nanoparticle surface |
| ATE539089T1 (de) * | 2007-03-21 | 2012-01-15 | Raptor Pharmaceutical Inc | Cyclische rezeptor-assoziierte-proteine (rap)- peptide |
-
2010
- 2010-04-05 CA CA2757645A patent/CA2757645C/en active Active
- 2010-04-05 EP EP10762266.4A patent/EP2416763B1/en active Active
- 2010-04-05 WO PCT/US2010/029985 patent/WO2010117957A2/en not_active Ceased
- 2010-04-05 JP JP2012503772A patent/JP5866117B2/ja active Active
- 2010-04-05 US US13/263,052 patent/US9636384B2/en active Active
-
2011
- 2011-10-02 IL IL215455A patent/IL215455B/en active IP Right Grant
-
2015
- 2015-02-23 JP JP2015032550A patent/JP2015098484A/ja not_active Withdrawn
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