JP2012522785A - メントール有り無しのニコチン溶解フィルム - Google Patents
メントール有り無しのニコチン溶解フィルム Download PDFInfo
- Publication number
- JP2012522785A JP2012522785A JP2012503593A JP2012503593A JP2012522785A JP 2012522785 A JP2012522785 A JP 2012522785A JP 2012503593 A JP2012503593 A JP 2012503593A JP 2012503593 A JP2012503593 A JP 2012503593A JP 2012522785 A JP2012522785 A JP 2012522785A
- Authority
- JP
- Japan
- Prior art keywords
- nicotine
- substrate
- smoker
- container
- film
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
Abstract
Description
[0010] 探索研究はまた、パーキンソン病、アルツハイマー病、統合失調症、及び注意欠陥多動性障害のような広範囲の疾患及び精神病に罹患している患者に対して治療上有用であり得て、減量を促進する食欲制限の手段にもなり得ることを観測した。
Claims (12)
- ヒトの口腔に受容される大きさで、粘膜との接触時に速やかに溶ける低水分で非粘着性の材料から作られる薄い基質と、0.1mg〜10mgのニコチン又はニコチン類似体を含んでなり、それにより該基質の溶解時にニコチンがヒトの粘膜を通して血流へ入る、所望の物質をヒトの血流へ粘膜を介して送達するための薄型フィルム。
- 基質に存在するニコチンが純粋なニコチン又はニコチン類似体である、請求項1に記載の薄型フィルム。
- 1重量%と10重量%の間のメントール又はメントール類似体が基質に含まれる、請求項1に記載の薄型フィルム。
- 基質が植物成分から作られる、請求項1に記載の薄型フィルム。
- 基質にいくらかの動物副産物が含まれる、請求項1に記載の薄型フィルム。
- 基質に人工甘味料が含まれる、請求項1に記載の薄型フィルム。
- 基質に香味物質が含まれる、請求項1に記載の薄型フィルム。
- 該フィルムを環境から密封するホイルラップ外部カバーが含まれる、請求項1に記載の薄型フィルム。
- 該フィルムの厚さよりごくわずかに大きい厚さを有する容器と、該容器の上に配置されて該容器中の該フィルムをその外部から密封する除去可能カバーが含まれる、請求項1に記載の薄型フィルム。
- 喫煙者が喫煙し得ない時間の間、該喫煙者に一時的なニコチンブリッジを提供する方法であって、
水和したときに溶解する、低水分含量で非粘着性の材料から作られて、ヒトの口腔中に置くことができるような大きさである薄い基質を提供すること、
該基質へ0.1mg〜10mgのニコチン又はニコチン類似体を加えること、
喫煙者が遭遇するニコチン渇望の時間の間に、ニコチン又はニコチン類似体が含まれる該基質を該喫煙者の口腔中の粘膜に接触させて置くこと、及び
該基質が粘膜と接触している間にそれを溶解させて、それによりニコチン又はニコチン類似体を該基質より解放して、ニコチン又はニコチン類似体が粘膜を介して該喫煙者の血流に入ることを可能にすることを含んでなる、前記方法。 - 喫煙が可能でない時間と場所と、喫煙者が再び喫煙し得る時間の間のニコチン渇望を一時的にブリッジすることを喫煙者に可能にする方法であって、
水和したときに溶解する、低水分で非粘着性の材料から作られて、ヒトの口腔中に置くことができるような大きさである薄い基質を提供すること、
該基質へ0.1mg〜10mgのニコチン又はニコチン類似体を加えること、
該基質を平らな容器に包装すること、
容易に除去可能な密封膜を該容器上に適用して、該基質を環境より密封すること、
該密封容器を喫煙者が携帯するポケットの中へ目立たずに入れて、該容器が喫煙者に容易にアクセス可能であるようにすること、
喫煙が可能でない、喫煙者が遭遇するニコチン渇望の時間の間に、該基質を該容器より取り出すこと、
該基質を該喫煙者の口腔中へ置いて、該基質を該喫煙者の口腔中の粘膜と接触させて、それによって該基質を水和させること、及び
溶解中の基質より解放されるニコチンが粘膜を介して該喫煙者の血流に入るのを待って、それによって該喫煙者のニコチン渇望を一時的に満足させることを含んでなる、前記方法。 - 該基質を取り出すことが、その膜を該容器から少なくとも一部引き離して、その後で該基質を該容器より取り出すことを含む、請求項11に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/417,540 US20100256197A1 (en) | 2009-04-02 | 2009-04-02 | Nicotine Dissolving Film With Or Without Menthol |
US12/417,540 | 2009-04-02 | ||
PCT/US2010/029152 WO2010114816A1 (en) | 2009-04-02 | 2010-03-30 | Nicotine dissolving film with or without menthol |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2012522785A true JP2012522785A (ja) | 2012-09-27 |
Family
ID=42826712
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012503593A Pending JP2012522785A (ja) | 2009-04-02 | 2010-03-30 | メントール有り無しのニコチン溶解フィルム |
Country Status (7)
Country | Link |
---|---|
US (1) | US20100256197A1 (ja) |
EP (1) | EP2413919A4 (ja) |
JP (1) | JP2012522785A (ja) |
CN (1) | CN102625698A (ja) |
CA (1) | CA2757446A1 (ja) |
SG (1) | SG174619A1 (ja) |
WO (1) | WO2010114816A1 (ja) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9907748B2 (en) | 2011-10-21 | 2018-03-06 | Niconovum Usa, Inc. | Excipients for nicotine-containing therapeutic compositions |
US20140255452A1 (en) * | 2013-03-11 | 2014-09-11 | Niconovum Usa, Inc. | Method and apparatus for differentiating oral pouch products |
US20170165252A1 (en) | 2015-12-10 | 2017-06-15 | Niconovum Usa Inc. | Protein-enriched therapeutic composition |
EP3807260A1 (en) | 2018-06-15 | 2021-04-21 | R. J. Reynolds Tobacco Company | Purification of nicotine |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
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US7029A (en) * | 1850-01-15 | Winnowing-machike | ||
WO2004054551A1 (de) * | 2002-12-05 | 2004-07-01 | Lts Lohmann Therapie-Systeme Ag | Filmförmige zubereitungen zur transmucosalen verabreichung von nicotin, sowie verfahren zu deren herstellung |
JP2005247876A (ja) * | 1996-11-11 | 2005-09-15 | Lts Lohmann Therapie-Systeme Ag | 口部に適用される組成物及びその製造方法 |
JP2006528636A (ja) * | 2003-07-24 | 2006-12-21 | スミスクライン・ビーチャム・コーポレイション | 経口溶解性フィルム |
WO2007095600A2 (en) * | 2006-02-17 | 2007-08-23 | Novartis Ag | Disintegrable oral films |
WO2007131615A1 (de) * | 2006-05-12 | 2007-11-22 | Lts Lohmann Therapie-Systeme Ag | Beutel-sammelpackung |
WO2008028560A1 (de) * | 2006-09-07 | 2008-03-13 | Lts Lohmann Therapie-Systeme Ag | Verpackung für wirkstoffhaltige filme und verfahren für deren herstellung |
JP2008538782A (ja) * | 2005-04-25 | 2008-11-06 | バイオプログレス・テクノロジー・リミテッド | ニコチンを含む水溶性フィルム |
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US4933184A (en) * | 1983-12-22 | 1990-06-12 | American Home Products Corp. (Del) | Menthol enhancement of transdermal drug delivery |
US4927631A (en) * | 1986-11-28 | 1990-05-22 | Bates Harry L | Decongestant preparation |
US5077104A (en) * | 1989-12-21 | 1991-12-31 | Alza Corporation | Nicotine packaging materials |
US5591768A (en) * | 1990-12-04 | 1997-01-07 | State Of Oregan, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University | Methods for treating circadian rhythm phase disturbances |
CA2116036A1 (en) * | 1991-10-18 | 1993-04-29 | F. Eugene Yates | Device for the transdermal administration of melatonin |
US5449683A (en) * | 1992-10-01 | 1995-09-12 | Massachussetts Institute Of Technology | Methods of inducing sleep using melatonin |
US5688520A (en) * | 1995-03-29 | 1997-11-18 | Minnesota Mining And Manufacturing Company | Transmucosal delivery of melatonin for prevention of migraine |
FR2751539B1 (fr) * | 1996-07-25 | 1998-12-04 | Oreal | Nouvelles compositions topiques comprenant de tres faibles doses de melatonine ou ses derives et leur utilisation en cosmetique |
AU750361B2 (en) * | 1997-03-26 | 2002-07-18 | Franciscus W.H.M. Merkus | Nasal melatonin composition |
US6268386B1 (en) * | 1998-06-25 | 2001-07-31 | Marshall Anlauf Thompson | Nicotine beverage |
US6358060B2 (en) * | 1998-09-03 | 2002-03-19 | Jsr Llc | Two-stage transmucosal medicine delivery system for symptom relief |
US6344222B1 (en) * | 1998-09-03 | 2002-02-05 | Jsr Llc | Medicated chewing gum delivery system for nicotine |
US20030211136A1 (en) * | 1998-09-25 | 2003-11-13 | Neema Kulkarni | Fast dissolving orally consumable films containing a sweetener |
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IL130171A (en) * | 1999-05-27 | 2004-06-01 | Neurim Pharma 1991 | Melatonin for use in preventing and treating tardive dyskinesia, pharmaceutical preparations containing it and its use in the manufacture of medicines |
SE523042C2 (sv) * | 2000-11-15 | 2004-03-23 | Bjoern Wennerholm | Användning av komposition omfattande melatonin (5-metoxi-N- acetyltryptamin) för framställning av ett läkemedel för behandling av obstruktiv sömnapne´ (OSA) |
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-
2009
- 2009-04-02 US US12/417,540 patent/US20100256197A1/en not_active Abandoned
-
2010
- 2010-03-30 EP EP20100759278 patent/EP2413919A4/en not_active Withdrawn
- 2010-03-30 WO PCT/US2010/029152 patent/WO2010114816A1/en active Application Filing
- 2010-03-30 CN CN2010800153558A patent/CN102625698A/zh active Pending
- 2010-03-30 JP JP2012503593A patent/JP2012522785A/ja active Pending
- 2010-03-30 CA CA2757446A patent/CA2757446A1/en not_active Abandoned
- 2010-03-30 SG SG2011071453A patent/SG174619A1/en unknown
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7029A (en) * | 1850-01-15 | Winnowing-machike | ||
JP2005247876A (ja) * | 1996-11-11 | 2005-09-15 | Lts Lohmann Therapie-Systeme Ag | 口部に適用される組成物及びその製造方法 |
WO2004054551A1 (de) * | 2002-12-05 | 2004-07-01 | Lts Lohmann Therapie-Systeme Ag | Filmförmige zubereitungen zur transmucosalen verabreichung von nicotin, sowie verfahren zu deren herstellung |
JP2006528636A (ja) * | 2003-07-24 | 2006-12-21 | スミスクライン・ビーチャム・コーポレイション | 経口溶解性フィルム |
JP2008538782A (ja) * | 2005-04-25 | 2008-11-06 | バイオプログレス・テクノロジー・リミテッド | ニコチンを含む水溶性フィルム |
WO2007095600A2 (en) * | 2006-02-17 | 2007-08-23 | Novartis Ag | Disintegrable oral films |
WO2007131615A1 (de) * | 2006-05-12 | 2007-11-22 | Lts Lohmann Therapie-Systeme Ag | Beutel-sammelpackung |
WO2008028560A1 (de) * | 2006-09-07 | 2008-03-13 | Lts Lohmann Therapie-Systeme Ag | Verpackung für wirkstoffhaltige filme und verfahren für deren herstellung |
Also Published As
Publication number | Publication date |
---|---|
US20100256197A1 (en) | 2010-10-07 |
CA2757446A1 (en) | 2010-10-07 |
EP2413919A4 (en) | 2013-01-02 |
EP2413919A1 (en) | 2012-02-08 |
CN102625698A (zh) | 2012-08-01 |
SG174619A1 (en) | 2011-10-28 |
WO2010114816A1 (en) | 2010-10-07 |
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