JP2012521849A - 制御された生体分解性を有する管腔内デバイス - Google Patents
制御された生体分解性を有する管腔内デバイス Download PDFInfo
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- JP2012521849A JP2012521849A JP2012503508A JP2012503508A JP2012521849A JP 2012521849 A JP2012521849 A JP 2012521849A JP 2012503508 A JP2012503508 A JP 2012503508A JP 2012503508 A JP2012503508 A JP 2012503508A JP 2012521849 A JP2012521849 A JP 2012521849A
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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Abstract
Description
管腔内ステントなどの生体分解性デバイスは、現在、冠状動脈、気管路、及び消化管を含む患者の様々な体腔に移植されている。特定の状況では、ステントが治療部位での有用性がなくなるか、又は少なくとも大幅に減少すると、ステントの継続的な存在に伴う不都合なリスクを低減するために、生体分解性又は生体吸収性であることが望ましい。そのために、いくつかのステントは、これまで生体分解性又は生体吸収性である材料で全体が構成されていた。生体分解性でありながら生体適合性であり、またステントが移植された時に曝される荷重を支えるのに十分な強度を有する材料を選択することが望ましい。
101 生体分解性ステント
102 光分解性の外層
103 光分解性の内層
110 内面
111 外面
201 近位領域
202 遠位領域
203、230、303 光ファイバ
225、226 UV光、UV光波
250 体腔
270 光照射システム
271 UV光源
272 波長調整又は選択制御部
273 強度制御部
400 レンズ
425 UV波
Claims (17)
- 内径と外径を備えている概ね管状の本体であって、前記管状本体は生体分解性材料で形成されている管状本体と、
前記生体分解性管状本体の前記内径と前記外径の一方の少なくとも一部分に配置される光分解性の層であって、前記光分解性の層は、患者体内の移植部位に含まれる体液に対して化学的に不活性である光分解性材料から形成され、化学的に不活性な状態から光分解性の状態に選択的に活性化されるようになっており、前記光分解性の状態は、前記生体分解性材料の生体分解を開始するために、前記光分解性の層が配置されている前記生体分解性材料の前記部分を露出するように、光分解性の層の分解を開始する、光分解性の層と
を備える、ハイブリッド分解性ステント。 - 前記光分解性の層は、紫外線(UV)光照射システムにより、前記化学的に不活性な状態から前記光分解性の状態に選択的に活性化されるようになっている、請求項1に記載のハイブリッド分解性ステント。
- 前記UV光照射システムは紫外線(UV)光源と光ファイバ部分を備え、前記光ファイバ部分は、前記UV光源と連通する近位部分と、前記管状本体の前記内径と前記外径の少なくとも一方と連通する遠位部分を備えており、前記光ファイバ部分は、前記近位部分から前記遠位部分にUV光を伝播して、前記遠位部分から前記管状本体に光を照射する、請求項2に記載のハイブリッド分解性ステント。
- 前記光ファイバが前記UV光の向きを変えるためのレンズ面を備える、請求項3に記載のハイブリッド分解性ステント。
- 前記光分解性の材料はポリマーを含有するUV光分解性のケトカルボニルより成る、請求項1乃至4の何れかに記載のハイブリッド分解性ステント。
- 前記光分解性の材料は、さらにビニリデンモノマーから形成された合成ポリマーから成る、請求項5に記載のハイブリッド分解性ステント。
- 前記光分解性ケトカルボニルは合成ポリマーの総重量に基づいて、約0.01重量%から約5重量%の範囲の化学組成から成る、請求項6に記載のハイブリッド分解性ステント。
- 前記生体分解性管状本体は、その中に装填された生物活性物質より成る、請求項1乃至7の何れかに記載のハイブリッド分解性ステント。
- 前記光分解性の層は通気性がなく、且つ前記生体分解性管状本体の前記内径と前記外径の全長に沿って延在している、請求項1乃至8の何れかに記載のハイブリッド分解性ステント。
- 近位端と遠位端、並びに前記近位端から前記遠位端に延在するルーメンを有する、生体分解性の概ね管状の本体であって、前記管状本体は生体分解性管状本体の少なくとも一部分に配置された光分解性の材料を備えており、前記光分解性の材料が患者の体腔に最初に配備されるとき、化学的に不活性である管状本体と、
光分解性の材料を化学的に不活性の状態から光分解性の状態に活性化するようになされ、光源とファイバ部分を備える光照射システムであって、前記ファイバ部分が前記光源と連通する近位部分と前記管状本体と連通する遠位部分を備えており、前記ファイバ部分は、紫外線(UV)光を前記近位部から前記遠位部に伝播して、前記遠位部から前記光分解性材料に照射するように構成されている光照射システムと
を備える分解性ステントキット。 - 前記ファイバ部分は光ファイバである、請求項10に記載のキット。
- 前記光照射システムは、前記光ファイバに配信されるようにUV光の量を調節する強度制御をさらに備えている、請求項10又は11に記載のキット。
- 前記管状本体は全て前記光分解性材料から形成されている、請求項10から12のいずれかに記載のキット。
- 前記光照射システムが光分解性の材料と相互作用する適切な波長のUV光を選択するための波長調整制御をさらに備えている、請求項10から13のいずれかに記載のキット。
- 前記光ファイバが前記UV光波を前記光分解性材料に選択的に導くための手段を有する、請求項10から14のいずれかに記載のキット。
- 前記光分解性の層が管状本体全体に配置されている、請求項10から15のいずれかに記載のキット。
- (a)生体分解性材料から形成され、内径と外径を備える概ね管状の本体であって、前記本体は前記生体分解性管状本体の前記内径と前記外径の一方の少なくとも一部分に配置される光分解性の層をさらに備えている管状の本体を提供するステップと、
(b)前記体内の内腔に前記管状本体を配備するステップと、
(c)細長い光照射導体を前記配備された管状本体に向かって前進するステップと、
(d)前記導体を通して前記ステントの前記光分解性の層に向かって、事前に選択された光の波長を照射するステップと、
(e)前記光分解性の層を化学的に不活性の状態から光分解性の状態に活性化するステップと、
(f)前記光分解性の層の少なくとも一部分を光分解するステップと
を含む患者の体腔内でステントを制御可能に分解するための方法。
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US12/414,144 | 2009-03-30 | ||
US12/414,144 US20100249912A1 (en) | 2009-03-30 | 2009-03-30 | Intraluminal device with controlled biodegradation |
PCT/US2010/028438 WO2010117629A2 (en) | 2009-03-30 | 2010-03-24 | Intraluminal device with controlled biodegradation |
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- 2010-03-24 WO PCT/US2010/028438 patent/WO2010117629A2/en active Application Filing
- 2010-03-24 JP JP2012503508A patent/JP5544008B2/ja active Active
- 2010-03-24 AU AU2010234964A patent/AU2010234964B2/en active Active
- 2010-03-24 EP EP10722452.9A patent/EP2413988B1/en active Active
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Cited By (2)
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JP2017113556A (ja) * | 2015-12-22 | 2017-06-29 | デピュイ・シンセス・プロダクツ・インコーポレイテッド | 光ファイバーを使用した光線療法の効率的送達法 |
JP7019288B2 (ja) | 2015-12-22 | 2022-02-15 | デピュイ・シンセス・プロダクツ・インコーポレイテッド | 光ファイバーを使用した光線療法の効率的送達法 |
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EP2413988A2 (en) | 2012-02-08 |
WO2010117629A2 (en) | 2010-10-14 |
AU2010234964B2 (en) | 2013-04-04 |
WO2010117629A3 (en) | 2011-01-20 |
EP2413988B1 (en) | 2015-03-04 |
CA2757268A1 (en) | 2010-10-14 |
JP5544008B2 (ja) | 2014-07-09 |
CA2757268C (en) | 2013-11-26 |
AU2010234964A1 (en) | 2011-10-27 |
US20100249912A1 (en) | 2010-09-30 |
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