JP2012520899A - アルツハイマー病の処置のためのチオフェニルスルホンアミド - Google Patents

アルツハイマー病の処置のためのチオフェニルスルホンアミド Download PDF

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Publication number
JP2012520899A
JP2012520899A JP2012500962A JP2012500962A JP2012520899A JP 2012520899 A JP2012520899 A JP 2012520899A JP 2012500962 A JP2012500962 A JP 2012500962A JP 2012500962 A JP2012500962 A JP 2012500962A JP 2012520899 A JP2012520899 A JP 2012520899A
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JP
Japan
Prior art keywords
compound
sulfonamido
formula
chlorothiophene
halo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2012500962A
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English (en)
Japanese (ja)
Other versions
JP2012520899A5 (enExample
Inventor
ジョン・エドワード・スターレット・ジュニア
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of JP2012520899A publication Critical patent/JP2012520899A/ja
Publication of JP2012520899A5 publication Critical patent/JP2012520899A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2012500962A 2009-03-20 2010-03-18 アルツハイマー病の処置のためのチオフェニルスルホンアミド Pending JP2012520899A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16180109P 2009-03-20 2009-03-20
US61/161,801 2009-03-20
PCT/US2010/027805 WO2010107997A1 (en) 2009-03-20 2010-03-18 Thiophenyl sulfonamides for the treatment of alzheimer's disease

Publications (2)

Publication Number Publication Date
JP2012520899A true JP2012520899A (ja) 2012-09-10
JP2012520899A5 JP2012520899A5 (enExample) 2013-05-02

Family

ID=42262106

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012500962A Pending JP2012520899A (ja) 2009-03-20 2010-03-18 アルツハイマー病の処置のためのチオフェニルスルホンアミド

Country Status (5)

Country Link
US (1) US20110071199A1 (enExample)
EP (1) EP2408760A1 (enExample)
JP (1) JP2012520899A (enExample)
CN (1) CN102361862A (enExample)
WO (1) WO2010107997A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1465861B1 (en) 2001-12-20 2009-05-06 Bristol-Myers Squibb Company Alpha-(n-sulphonamido)acetamide derivatives as beta-amyloid inhibitors
US8044077B2 (en) 2009-03-19 2011-10-25 Bristol-Myers Squibb Company Alpha-(N-sulfonamido)acetamide compounds incorporating deuterium as inhibitors of beta amyloid peptide production
US7977362B2 (en) 2009-03-20 2011-07-12 Bristol-Myers Squibb Company Alpha-(N-benzenesulfonamido)cycloalkyl derivatives
US8252821B2 (en) 2009-04-14 2012-08-28 Bristol-Myers Squibb Company Bioavailable capsule compositions of amorphous alpha-(N-sulfonamido)acetamide compound
CN108840814B (zh) * 2018-07-24 2021-09-24 南京药石科技股份有限公司 一种8-氧代-2,6,9-三氮杂螺[4.5]癸烷-2-羧酸叔丁酯制备方法
EP4299062A1 (en) 2022-06-30 2024-01-03 Vilnius University Inhibition of protein amyloid aggregation using fluorinated benzenesulfonamides

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005513123A (ja) * 2001-12-20 2005-05-12 ブリストル−マイヤーズ　スクイブ　カンパニー β−アミロイドインヒビターとしてのα−（Ｎ−スルホンアミド）アセトアミド誘導体
US20060063799A1 (en) * 2004-09-23 2006-03-23 Gilligan Paul J Sulfonamide bicyclic compounds
WO2007098030A1 (en) * 2006-02-17 2007-08-30 Wyeth Selective n-sulfonylation of 2-amino trifluoroalkyl substituted alcohols

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5274094A (en) * 1990-08-15 1993-12-28 British Bio-Technology Limited Production of heterobicyclic containing benzene sulfonamides
GB9202791D0 (en) * 1992-02-11 1992-03-25 British Bio Technology Compounds
CZ291659B6 (cs) * 1995-11-17 2003-04-16 Warner-Lambert Company Sulfonamidové inhibitory matricových metaloproteináz
US6313123B1 (en) * 1999-01-27 2001-11-06 American Cyanamid Company Acetylenic sulfonamide thiol tace inhibitors
TWI336698B (en) * 2003-03-31 2011-02-01 Wyeth Corp Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof
RU2008129797A (ru) * 2006-02-17 2010-03-27 Вайет (Us) Способы получения сульфонамид-замещенных спиртов и их промежуточных соединений
EP2278878A4 (en) * 2008-05-08 2014-08-27 Bristol Myers Squibb Co 2-ARYL-GYCINAMID DERIVATIVES

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005513123A (ja) * 2001-12-20 2005-05-12 ブリストル−マイヤーズ　スクイブ　カンパニー β−アミロイドインヒビターとしてのα−（Ｎ−スルホンアミド）アセトアミド誘導体
US20060063799A1 (en) * 2004-09-23 2006-03-23 Gilligan Paul J Sulfonamide bicyclic compounds
WO2007098030A1 (en) * 2006-02-17 2007-08-30 Wyeth Selective n-sulfonylation of 2-amino trifluoroalkyl substituted alcohols

Also Published As

Publication number Publication date
US20110071199A1 (en) 2011-03-24
EP2408760A1 (en) 2012-01-25
CN102361862A (zh) 2012-02-22
WO2010107997A1 (en) 2010-09-23

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