JP2012519653A5 - - Google Patents
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- Publication number
- JP2012519653A5 JP2012519653A5 JP2011537754A JP2011537754A JP2012519653A5 JP 2012519653 A5 JP2012519653 A5 JP 2012519653A5 JP 2011537754 A JP2011537754 A JP 2011537754A JP 2011537754 A JP2011537754 A JP 2011537754A JP 2012519653 A5 JP2012519653 A5 JP 2012519653A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- optionally substituted
- substituent
- substituted
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000001424 substituent group Chemical group 0.000 claims 24
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 15
- 150000001875 compounds Chemical class 0.000 claims 12
- 125000005843 halogen group Chemical group 0.000 claims 12
- 125000005915 C6-C14 aryl group Chemical group 0.000 claims 11
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 11
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 9
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 9
- 125000003277 amino group Chemical group 0.000 claims 5
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 125000004432 carbon atoms Chemical group C* 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 4
- 239000000651 prodrug Substances 0.000 claims 4
- 229940002612 prodrugs Drugs 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000011780 sodium chloride Substances 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 125000004434 sulfur atoms Chemical group 0.000 claims 4
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 2
- 102100013072 CDC7 Human genes 0.000 claims 2
- 108060006674 CDC7 Proteins 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 150000001924 cycloalkanes Chemical class 0.000 claims 2
- 125000006254 cycloalkyl carbonyl group Chemical group 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 1
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 1
- LAEWHBYAMHWQBY-UHFFFAOYSA-N 1,2-dimethyl-6-(5-methyl-1H-pyrazol-4-yl)-2-(2,2,2-trifluoroethyl)-3H-thieno[3,2-d]pyrimidin-4-one Chemical compound S1C=2C(=O)NC(CC(F)(F)F)(C)N(C)C=2C=C1C=1C=NNC=1C LAEWHBYAMHWQBY-UHFFFAOYSA-N 0.000 claims 1
- KEGLXGGLMDEALO-UHFFFAOYSA-N 2'-fluoro-6-(5-methyl-1H-pyrazol-4-yl)spiro[1,3-dihydrothieno[3,2-d]pyrimidine-2,1'-cyclohexane]-4-one Chemical compound N1N=CC(C=2SC=3C(=O)NC4(C(CCCC4)F)NC=3C=2)=C1C KEGLXGGLMDEALO-UHFFFAOYSA-N 0.000 claims 1
- 125000005974 C6-C14 arylcarbonyl group Chemical group 0.000 claims 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 230000003449 preventive Effects 0.000 claims 1
- 0 **CCCI(*)*C([C@](*)[C@@]1O[C@@]1N)NC(*)* Chemical compound **CCCI(*)*C([C@](*)[C@@]1O[C@@]1N)NC(*)* 0.000 description 1
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15776009P | 2009-03-05 | 2009-03-05 | |
US61/157,760 | 2009-03-05 | ||
US29499110P | 2010-01-14 | 2010-01-14 | |
US61/294,991 | 2010-01-14 | ||
US29833810P | 2010-01-26 | 2010-01-26 | |
US61/298,338 | 2010-01-26 | ||
PCT/JP2010/054073 WO2010101302A1 (en) | 2009-03-05 | 2010-03-04 | Thienopyrimidine as cdc7 kinase inhibitors |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2012519653A JP2012519653A (ja) | 2012-08-30 |
JP2012519653A5 true JP2012519653A5 (US07846941-20101207-C00217.png) | 2013-03-07 |
JP5645839B2 JP5645839B2 (ja) | 2014-12-24 |
Family
ID=42112336
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011537754A Active JP5645839B2 (ja) | 2009-03-05 | 2010-03-04 | Cdc7キナーゼ阻害剤としてのチエノピリミジン |
Country Status (4)
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2011216404B2 (en) | 2010-02-17 | 2016-04-07 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
PE20141404A1 (es) * | 2011-12-30 | 2014-10-28 | Hanmi Pharm Ind Co Ltd | Derivados de tieno[3,2-d]pirimidina que tienen actividad inhibidora por las quinasas de las proteinas |
WO2015115355A1 (ja) | 2014-01-31 | 2015-08-06 | カルナバイオサイエンス株式会社 | 抗がん剤組成物 |
CN112409373A (zh) * | 2017-05-21 | 2021-02-26 | 南京正济医药研究有限公司 | 作为抗癌剂的取代的[5,6]环-4(3h)-嘧啶酮 |
GB201807147D0 (en) | 2018-05-01 | 2018-06-13 | Oncologica Uk Ltd | Therapeutic combination |
NL2021185B1 (en) | 2018-06-26 | 2020-01-06 | Stichting Het Nederlands Kanker Inst Antoni Van Leeuwenhoek Ziekenhuis | Combination Therapy and Use Thereof for Treating Cancer |
WO2021113492A1 (en) * | 2019-12-06 | 2021-06-10 | Schrödinger, Inc. | Cyclic compounds and methods of using same |
TW202300150A (zh) * | 2021-03-18 | 2023-01-01 | 美商薛定諤公司 | 環狀化合物及其使用方法 |
CN115260211B (zh) * | 2021-04-29 | 2024-02-06 | 长春金赛药业有限责任公司 | 含噻吩稠环类衍生物、药物组合物及其制备方法和应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1396488A1 (en) * | 2001-05-23 | 2004-03-10 | Mitsubishi Pharma Corporation | Fused heterocyclic compound and medicinal use thereof |
DE602004025803D1 (de) * | 2003-06-06 | 2010-04-15 | Arexis Ab | Verwendung von kondensierten heterozyklischen verbindungen als scce-hemmern zur behandlung von hautzuständen |
US7279575B2 (en) | 2003-08-08 | 2007-10-09 | Pfizer Italia S.R.L. | Pyrimidylpyrrole derivatives active as kinase inhibitors |
WO2005014572A1 (en) | 2003-08-08 | 2005-02-17 | Pharmacia Italia S.P.A. | Pyrimidylpyrrole derivatives active as kinase inhibitors |
JP2007531757A (ja) | 2004-03-30 | 2007-11-08 | カイロン コーポレイション | 抗癌剤としての置換チオフェン誘導体 |
WO2007011284A1 (en) * | 2005-07-15 | 2007-01-25 | Astrazeneca Ab | Therapeutic agents |
US20070142414A1 (en) * | 2005-12-16 | 2007-06-21 | Pharmacia Italia S.P.A. | N-substituted pyrrolopyridinones active as kinase inhibitors |
US20100113484A1 (en) * | 2006-12-13 | 2010-05-06 | Aska Pharmaceutical Co., Ltd. | Treating agent of uropathy |
EP2103613B1 (en) * | 2006-12-13 | 2016-02-17 | ASKA Pharmaceutical Co., Ltd. | Quinoxaline derivative |
-
2010
- 2010-03-04 EP EP10710108.1A patent/EP2403857B1/en active Active
- 2010-03-04 US US13/254,551 patent/US8691828B2/en active Active
- 2010-03-04 WO PCT/JP2010/054073 patent/WO2010101302A1/en active Application Filing
- 2010-03-04 JP JP2011537754A patent/JP5645839B2/ja active Active
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