JP2012518034A5 - - Google Patents
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- Publication number
- JP2012518034A5 JP2012518034A5 JP2011551028A JP2011551028A JP2012518034A5 JP 2012518034 A5 JP2012518034 A5 JP 2012518034A5 JP 2011551028 A JP2011551028 A JP 2011551028A JP 2011551028 A JP2011551028 A JP 2011551028A JP 2012518034 A5 JP2012518034 A5 JP 2012518034A5
- Authority
- JP
- Japan
- Prior art keywords
- solution
- injecting
- chromatography column
- daptomycin
- subjecting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- DOAKLVKFURWEDJ-QCMAZARJSA-N DAPTOMYCIN Chemical compound C([C@H]1C(=O)O[C@H](C)[C@@H](C(NCC(=O)N[C@@H](CCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@H](CO)C(=O)N[C@H](C(=O)N1)[C@H](C)CC(O)=O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)CCCCCCCCC)C(=O)C1=CC=CC=C1N DOAKLVKFURWEDJ-QCMAZARJSA-N 0.000 claims 3
- 229960005484 Daptomycin Drugs 0.000 claims 3
- 108010013198 Daptomycin Proteins 0.000 claims 3
- 238000004366 reverse phase liquid chromatography Methods 0.000 claims 2
- 238000005571 anion exchange chromatography Methods 0.000 claims 1
- 239000012149 elution buffer Substances 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 238000000855 fermentation Methods 0.000 claims 1
- 230000004151 fermentation Effects 0.000 claims 1
- 239000000706 filtrate Substances 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
Claims (1)
- ダプトマイシンを精製する方法であって、
ａ）ダプトマイシンを含む発酵ブロスを１つまたは複数の浄化工程に供する工程、
ｂ）工程ａ）の溶液を陰イオン交換クロマトグラフィーカラムに注入する工程、
ｃ）工程ｂ）の溶液を逆相クロマトグラフィーカラムに注入する工程、
ｄ）任意選択で工程ｃ）の溶液をさらに逆相クロマトグラフィーカラムに少なくとも１回注入する工程、
ｄ）工程ｄ）で得られた溶液を１つまたは複数のろ過工程に供する工程、および
ｅ）ｄ）のろ液を凍結乾燥させ、精製されたダプトマイシンの粉末を得る工程を含み、
工程ｃ）及び任意選択で工程ｄ）における溶出バッファーは水溶性アルコールである方法。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15366009P | 2009-02-19 | 2009-02-19 | |
| US61/153,660 | 2009-02-19 | ||
| PCT/NO2010/000066 WO2010095953A1 (en) | 2009-02-19 | 2010-02-19 | Process for purifying lipopeptides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012518034A JP2012518034A (ja) | 2012-08-09 |
| JP2012518034A5 true JP2012518034A5 (ja) | 2013-04-11 |
| JP5752609B2 JP5752609B2 (ja) | 2015-07-22 |
Family
ID=42116034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011551028A Active JP5752609B2 (ja) | 2009-02-19 | 2010-02-19 | リポペプチドを精製する方法 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US9150894B2 (ja) |
| EP (1) | EP2398817B2 (ja) |
| JP (1) | JP5752609B2 (ja) |
| KR (1) | KR101666144B1 (ja) |
| CN (1) | CN102325785B (ja) |
| AU (1) | AU2010216475B2 (ja) |
| BR (1) | BRPI1008300B1 (ja) |
| CA (1) | CA2748932C (ja) |
| DK (1) | DK2398817T4 (ja) |
| ES (1) | ES2543457T5 (ja) |
| HR (1) | HRP20150761T4 (ja) |
| HU (1) | HUE026818T2 (ja) |
| IL (1) | IL214374A (ja) |
| MX (1) | MX2011008621A (ja) |
| PL (1) | PL2398817T5 (ja) |
| PT (1) | PT2398817E (ja) |
| RU (1) | RU2526391C2 (ja) |
| SI (1) | SI2398817T2 (ja) |
| UA (1) | UA105785C2 (ja) |
| WO (1) | WO2010095953A1 (ja) |
| ZA (1) | ZA201104848B (ja) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2543457T5 (es) | 2009-02-19 | 2021-12-22 | Xellia Pharmaceuticals Aps | Procedimiento para purificar lipopéptidos |
| CN102690329B (zh) * | 2011-03-25 | 2014-06-04 | 杭州九源基因工程有限公司 | 一种戈舍瑞林多肽的纯化生产方法 |
| CN102875652A (zh) * | 2011-07-13 | 2013-01-16 | 北大方正集团有限公司 | 一种分离纯化达托霉素的方法 |
| CN103159829B (zh) * | 2011-12-08 | 2014-11-05 | 北大方正集团有限公司 | 达托霉素的提取方法 |
| CN102675426B (zh) * | 2012-04-26 | 2013-12-11 | 杭州华东医药集团生物工程研究所有限公司 | 一种达托霉素的提取纯化方法 |
| CN102924572B (zh) * | 2012-11-12 | 2014-12-03 | 华北制药集团新药研究开发有限责任公司 | 一种高纯度达托霉素的制备方法 |
| CN104387444B (zh) * | 2014-11-13 | 2017-12-08 | 北大医药重庆大新药业股份有限公司 | 一种达托霉素杂质rs‑2高纯度样品的制备方法 |
| SG11201704822WA (en) * | 2014-12-15 | 2017-07-28 | Merck Patent Gmbh | Target molecule capture from crude solutions |
| CN105001305A (zh) * | 2015-04-29 | 2015-10-28 | 利穗科技(苏州)有限公司 | 利用层析技术提取高纯度达托霉素的方法 |
| CN105481950B (zh) * | 2016-01-28 | 2019-01-04 | 丽珠集团福州福兴医药有限公司 | 一种达托霉素提取方法 |
| IT201600127655A1 (it) | 2016-12-16 | 2018-06-16 | Gnosis Spa | Processo per la purificazione di antibiotici lipopolipeptidici |
| CN108250270A (zh) * | 2016-12-29 | 2018-07-06 | 天津领世生物科技开发有限公司 | 一种从发酵液中富集提取达托霉素的方法 |
| CN112979756B (zh) * | 2019-12-13 | 2023-01-03 | 浙江昌海制药有限公司 | 达托霉素的提纯方法 |
| CN113004373A (zh) * | 2019-12-19 | 2021-06-22 | 鲁南制药集团股份有限公司 | 一种达托霉素的纯化方法 |
| RU2762182C1 (ru) * | 2020-12-08 | 2021-12-16 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт по изысканию новых антибиотиков имени Г.Ф. Гаузе" | Гауземицины А и В - гликолипопептидные антибактериальные антибиотики и способ их получения |
| CN113340691B (zh) * | 2021-06-05 | 2023-12-12 | 清华大学 | 一种提取海洋沉积物中不同赋存形态磷的方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4537717A (en) | 1982-05-21 | 1985-08-27 | Eli Lilly And Company | Derivatives of A-21978C cyclic peptides |
| US4885243A (en) | 1984-10-09 | 1989-12-05 | Eli Lilly And Company | Process for producing A-21978C derivatives |
| US4667016A (en) | 1985-06-20 | 1987-05-19 | Kirin-Amgen, Inc. | Erythropoietin purification |
| ZA883887B (en) | 1987-06-10 | 1990-02-28 | Lilly Co Eli | Chromatographic purification process |
| US4874843A (en) | 1987-12-03 | 1989-10-17 | Eli Lilly And Company | Chromatographic purification process |
| JP2661790B2 (ja) * | 1990-11-27 | 1997-10-08 | 電気化学工業株式会社 | 入尿トリプシンインヒビターの精製方法 |
| IL110669A (en) * | 1993-08-17 | 2008-11-26 | Kirin Amgen Inc | Erythropoietin analogs |
| US5650496A (en) | 1995-04-14 | 1997-07-22 | Cephalon, Inc. | IGF-I purification process |
| US6696412B1 (en) * | 2000-01-20 | 2004-02-24 | Cubist Pharmaceuticals, Inc. | High purity lipopeptides, Lipopeptide micelles and processes for preparing same |
| US20030045678A1 (en) * | 2000-12-18 | 2003-03-06 | Dennis Keith | Methods for preparing purified lipopeptides |
| US20060014674A1 (en) | 2000-12-18 | 2006-01-19 | Dennis Keith | Methods for preparing purified lipopeptides |
| EP2054521A4 (en) * | 2006-10-03 | 2012-12-19 | Novo Nordisk As | METHODS OF PURIFYING CONJUGATES OF POLYPEPTIDES |
| WO2009144739A1 (en) * | 2008-05-26 | 2009-12-03 | Biocon Limited | Amorphous daptomycin and a method of purification thereof |
| ES2543457T5 (es) | 2009-02-19 | 2021-12-22 | Xellia Pharmaceuticals Aps | Procedimiento para purificar lipopéptidos |
| CN101899094B (zh) * | 2009-06-01 | 2012-11-21 | 安徽丰原发酵技术工程研究有限公司 | 一种高纯达托霉素的制备方法 |
-
2010
- 2010-02-19 ES ES10707694T patent/ES2543457T5/es active Active
- 2010-02-19 BR BRPI1008300-6A patent/BRPI1008300B1/pt active IP Right Grant
- 2010-02-19 SI SI201030966T patent/SI2398817T2/sl unknown
- 2010-02-19 US US12/708,539 patent/US9150894B2/en active Active
- 2010-02-19 AU AU2010216475A patent/AU2010216475B2/en active Active
- 2010-02-19 CN CN201080008292.3A patent/CN102325785B/zh active Active
- 2010-02-19 MX MX2011008621A patent/MX2011008621A/es active IP Right Grant
- 2010-02-19 EP EP10707694.5A patent/EP2398817B2/en active Active
- 2010-02-19 RU RU2011137010/04A patent/RU2526391C2/ru active
- 2010-02-19 DK DK10707694.5T patent/DK2398817T4/da active
- 2010-02-19 JP JP2011551028A patent/JP5752609B2/ja active Active
- 2010-02-19 PL PL10707694T patent/PL2398817T5/pl unknown
- 2010-02-19 CA CA2748932A patent/CA2748932C/en active Active
- 2010-02-19 HU HUE10707694A patent/HUE026818T2/en unknown
- 2010-02-19 KR KR1020117021714A patent/KR101666144B1/ko active IP Right Grant
- 2010-02-19 PT PT107076945T patent/PT2398817E/pt unknown
- 2010-02-19 WO PCT/NO2010/000066 patent/WO2010095953A1/en active Application Filing
- 2010-02-19 UA UAA201111075A patent/UA105785C2/uk unknown
-
2011
- 2011-06-30 ZA ZA2011/04848A patent/ZA201104848B/en unknown
- 2011-08-01 IL IL214374A patent/IL214374A/en active IP Right Grant
-
2015
- 2015-07-10 HR HRP20150761TT patent/HRP20150761T4/hr unknown
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