JP2012516897A - シュードモナス・エルギノーサ（ＰｓｅｕｄｏｍｏｎａｓＡｅｒｕｇｉｎｏｓａ）感染の治療のための抗生物質と抗体療法との組み合わせ - Google Patents

シュードモナス・エルギノーサ（ＰｓｅｕｄｏｍｏｎａｓＡｅｒｕｇｉｎｏｓａ）感染の治療のための抗生物質と抗体療法との組み合わせ Download PDF

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JP2012516897A
JP2012516897A JP2011549261A JP2011549261A JP2012516897A JP 2012516897 A JP2012516897 A JP 2012516897A JP 2011549261 A JP2011549261 A JP 2011549261A JP 2011549261 A JP2011549261 A JP 2011549261A JP 2012516897 A JP2012516897 A JP 2012516897A
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sequence
antibody
pharmaceutical composition
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マーク ベア
クリストファー アール． ベビントン
ジェフリー ティー． ヤラントン
スーザン リンチ
ユアンリン ソン
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University of California
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Gram-negative bacteria
    • C07K16/1214—Pseudomonadaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
    • A—HUMAN NECESSITIES
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
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  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2011549261A 2009-02-04 2010-02-04 シュードモナス・エルギノーサ（ＰｓｅｕｄｏｍｏｎａｓＡｅｒｕｇｉｎｏｓａ）感染の治療のための抗生物質と抗体療法との組み合わせ Pending JP2012516897A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14995709P 2009-02-04 2009-02-04
US61/149,957 2009-02-04
PCT/US2010/023214 WO2010091189A1 (en) 2009-02-04 2010-02-04 Combination antibiotic and antibody therapy for the treatment of pseudomonas aeruginosa infection

Publications (2)

Publication Number Publication Date
JP2012516897A true JP2012516897A (ja) 2012-07-26
JP2012516897A5 JP2012516897A5 (https=) 2013-03-21

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JP2011549261A Pending JP2012516897A (ja) 2009-02-04 2010-02-04 シュードモナス・エルギノーサ（ＰｓｅｕｄｏｍｏｎａｓＡｅｒｕｇｉｎｏｓａ）感染の治療のための抗生物質と抗体療法との組み合わせ

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Country Link
US (1) US20100272736A1 (https=)
EP (1) EP2393515A1 (https=)
JP (1) JP2012516897A (https=)
CA (1) CA2751433A1 (https=)
WO (1) WO2010091189A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2784033A1 (en) 2009-12-22 2011-07-21 Kalobios Pharmaceuticals, Inc. A method of treating a staphylococcus infection in a patient having a low-level pathogenic pseudomonas aeruginosa infection
BR112013031485B1 (pt) 2011-06-10 2022-06-14 Medimmune, Llc Anticorpo monoclonal isolado ou fragmento de ligação a antígeno do mesmo, composição farmacêutica, usos e método in vitro para bloqueio ou prevenção da ligação de p. aeruginosa a células epiteliais
BR112014011028B1 (pt) * 2011-11-07 2021-03-02 Medimmune, Llc anticorpo biespecífico, composição, e, uso da composição
CN118620074A (zh) * 2020-06-01 2024-09-10 北京三诺佳邑生物技术有限责任公司 特异性识别假单胞菌pcrv的抗体及其用途
FR3114970B1 (fr) * 2020-10-08 2023-06-30 Univ Tours Combinaison d’anticorps inhalés avec des agents immunomodulateurs pour le traitement ou la prévention d’inféctions respiratoires
WO2024261584A1 (en) * 2023-06-17 2024-12-26 Abgenics Lifesciences Private Limited A composition effective against beta-lactam antibiotic-resistant pseudomonas aeruginosa

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JPS62187417A (ja) * 1985-12-10 1987-08-15 ジエネテイツク　システムズ　コ−ポレ−シヨン 緑膿菌血清型に対する交さ反応性かつ交さ防御性単クロ−ン性抗体
JPS63500035A (ja) * 1985-06-06 1988-01-07 ジエネテイツク　システムズ　コ−ポレイシヨン プソイドモナス　アエルギノサ　外毒素ａに対する保護用ヒトモノクロ−ナル抗体
JPS63102697A (ja) * 1986-07-03 1988-05-07 ジエネテイツク　システムズ　コ−ポレ−シヨン シュ−ドモナスアエルギノ−ザ鞭毛に対するモノクロ−ナル抗体
JP2005500250A (ja) * 2001-01-26 2005-01-06 エムシーダブリユー リサーチ フオンデーシヨン インコーポレーテツド シュードモナスｖ抗原を用いる免疫化のための方法および組成物
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US5132405A (en) 1987-05-21 1992-07-21 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
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DE69930166T2 (de) 1998-11-25 2006-12-14 MCW Research Foundation, Inc., Milwaukee Verfahren und zusammensetzungen für impfung mit dem pseudomonas aeruginosa v-antigen
JP4782700B2 (ja) 2004-01-20 2011-09-28 カロバイオス ファーマシューティカルズ インコーポレイティッド 最低限必須な結合決定基を用いた抗体特異性の移入
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JPS62187417A (ja) * 1985-12-10 1987-08-15 ジエネテイツク　システムズ　コ−ポレ−シヨン 緑膿菌血清型に対する交さ反応性かつ交さ防御性単クロ−ン性抗体
JPS63102697A (ja) * 1986-07-03 1988-05-07 ジエネテイツク　システムズ　コ−ポレ−シヨン シュ−ドモナスアエルギノ−ザ鞭毛に対するモノクロ−ナル抗体
JP2005500250A (ja) * 2001-01-26 2005-01-06 エムシーダブリユー リサーチ フオンデーシヨン インコーポレーテツド シュードモナスｖ抗原を用いる免疫化のための方法および組成物
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JPN5012007144; ＦＡＵＲＥ　ＫＡＲＩＮＥ: 'ＥＦＦＥＣＴＳ　ＯＦ　ＭＯＮＯＣＬＯＮＡＬ　ＡＮＴＩ-ＰＣＲＶ　ＡＮＴＩＢＯＤＹ　ＯＮ　ＰＳＥＵＤＯＭＯＮＡＳ　ＡＥＲＵＧＩＮＯＳＡ-ＩＮＤＵＣＥＤ　以下備考' ＪＯＵＲＮＡＬ　ＯＦ　ＩＭＭＵＮＥ　ＢＡＳＥＤ　ＴＨＥＲＡＰＩＥＳ　ＡＮＤ　ＶＡＣＣＩＮＥＳ Ｖ１　Ｎ１, 20030813, Ｐ２, ＢＩＯＭＥＤ　ＣＥＮＴＲＡＬ　ＬＴＤ． *
JPN5012007145; ＮＥＥＬＹ　Ａ　Ｎ: 'ＰＡＳＳＩＶＥ　ＡＮＴＩ-ＰＣＲＶ　ＴＲＥＡＴＭＥＮＴ　ＰＲＯＴＥＣＴＳ　ＢＵＲＮＥＤ　ＭＩＣＥ　ＡＧＡＩＮＳＴ　ＰＳＥＵＤＯＭＯＮＡＳ　ＡＥＲＵＧＩＮＯＳＡ　ＣＨＡＬＬＥＮＧＥ' ＢＵＲＮＳ Ｖ３１　Ｎ２, 20050301, Ｐ１５３-１５８, ＢＵＴＴＥＲＷＯＲＴＨ　ＨＥＩＮＥＭＡＮＮ *
JPN5012007146; ＦＲＡＮＫ　Ｄ　Ｗ: 'ＧＥＮＥＲＡＴＩＯＮ　ＡＮＤ　ＣＨＡＲＡＣＴＥＲＩＺＡＴＩＯＮ　ＯＦ　Ａ　ＰＲＯＴＥＣＴＩＶＥ　ＭＯＮＯＣＬＯＮＡＬ　ＡＮＴＩＢＯＤＹ　ＴＯ　ＰＳＥＵＤＯＭＯＮＡＳ　ＡＥＲＵＧＩＮＯＳＡ　ＰＣＲＶ' ＪＯＵＲＮＡＬ　ＯＦ　ＩＮＦＥＣＴＩＯＵＳ　ＤＩＳＥＡＳＥＳ Ｖ１８６　Ｎ１, 20020701, Ｐ６４-７３, ＵＮＩＶＥＲＳＩＴＹ　ＯＦ　ＣＨＩＣＡＧＯ　ＰＲＥＳＳ *
JPN5012007147; ＢＡＥＲ　ＭＡＲＫ: 'ＡＮ　ＥＮＧＩＮＥＥＲＥＤ　ＨＵＭＡＮ　ＡＮＴＩＢＯＤＹ　ＦＡＢ　ＦＲＡＧＭＥＮＴ　ＳＰＥＣＩＦＩＣ　ＦＯＲ　ＰＳＥＵＤＯＭＯＮＡＳ　ＡＥＲＵＧＩＮＯＳＡ　ＰＣＲＶ　以下備考' ＩＮＦＥＣＴＩＯＮ　ＡＮＤ　ＩＭＭＵＮＩＴＹ Ｖ７７　Ｎ３, 20081222, Ｐ１０８３-１０９０ *
JPN5012007148; ＬＹＮＣＨ　Ｓ　Ｖ: 'ＮＯＶＥＬ　ＳＴＲＡＴＥＧＩＥＳ　ＴＯ　ＣＯＭＢＡＴ　ＢＡＣＴＥＲＩＡＬ　ＶＩＲＵＬＥＮＣＥ' ＣＵＲＲＥＮＴ　ＯＰＩＮＩＯＮ　ＩＮ　ＣＲＩＴＩＣＡＬ　ＣＡＲＥ Ｖ１４　Ｎ５, 200810, Ｐ５９３-５９９ *
JPN6015008426; 日本化学療法学会雑誌 Ｖｏｌ．　５３，Ｎｏ．　８, 2005, ｐ．　４７６-４８２ *
JPN6015008429; Ｔｈｅ　Ｊａｐａｎｅｓｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ａｎｔｉｂｉｏｔｉｃｓ Ｖｏｌ．　５９，Ｎｏ．　１, 2006, ｐ．　１１-２０ *
JPN6015008431; 感染症学雑誌 Ｖｏｌ．　８２，Ｎｏ．　５, 2008, ｐ．　４６６-４７０ *

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US20100272736A1 (en) 2010-10-28
WO2010091189A1 (en) 2010-08-12
EP2393515A1 (en) 2011-12-14
CA2751433A1 (en) 2010-08-12

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