JP2012516686A5 - - Google Patents
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- Publication number
- JP2012516686A5 JP2012516686A5 JP2011548377A JP2011548377A JP2012516686A5 JP 2012516686 A5 JP2012516686 A5 JP 2012516686A5 JP 2011548377 A JP2011548377 A JP 2011548377A JP 2011548377 A JP2011548377 A JP 2011548377A JP 2012516686 A5 JP2012516686 A5 JP 2012516686A5
- Authority
- JP
- Japan
- Prior art keywords
- cftr
- cell
- seq
- nucleic acid
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004027 cell Anatomy 0.000 claims 47
- 150000007523 nucleic acids Chemical class 0.000 claims 15
- 108020004707 nucleic acids Proteins 0.000 claims 14
- 102000039446 nucleic acids Human genes 0.000 claims 14
- 229920001184 polypeptide Polymers 0.000 claims 11
- 102000004196 processed proteins & peptides Human genes 0.000 claims 11
- 108090000765 processed proteins & peptides Proteins 0.000 claims 11
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 238000004113 cell culture Methods 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 210000000170 cell membrane Anatomy 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- SRZQYTPACFNBMN-UHFFFAOYSA-N n-[5-[2-(2-methoxyanilino)-1,3-thiazol-4-yl]-4-methyl-1,3-thiazol-2-yl]benzamide;hydrobromide Chemical compound Br.COC1=CC=CC=C1NC1=NC(C2=C(N=C(NC(=O)C=3C=CC=CC=3)S2)C)=CS1 SRZQYTPACFNBMN-UHFFFAOYSA-N 0.000 claims 1
- 230000001766 physiological effect Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14931209P | 2009-02-02 | 2009-02-02 | |
| US61/149,312 | 2009-02-02 | ||
| PCT/US2010/022778 WO2010088630A2 (en) | 2009-02-02 | 2010-02-01 | Cell lines expressing cftr and methods of using them |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012516686A JP2012516686A (ja) | 2012-07-26 |
| JP2012516686A5 true JP2012516686A5 (cg-RX-API-DMAC7.html) | 2013-03-21 |
Family
ID=42396394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011548377A Pending JP2012516686A (ja) | 2009-02-02 | 2010-02-01 | Ｃｆｔｒを発現する細胞株およびそれらを使用する方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20120058918A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2393930A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2012516686A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2751215A1 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2011008131A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2010088630A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2245046B1 (en) * | 2008-01-22 | 2019-09-04 | Chromocell Corporation | Novel cell lines expressing nav and methods using them |
| KR20100122491A (ko) * | 2008-02-01 | 2010-11-22 | 크로모셀 코포레이션 | 세포주 및 이의 제조 및 사용 방법 |
| JP6083559B2 (ja) | 2009-07-31 | 2017-02-22 | クロモセル コーポレーション | 細胞運命の修飾因子を同定および検証するための方法および組成物 |
| US20120302573A1 (en) * | 2011-05-25 | 2012-11-29 | Paul Francis Jackson | Methods of inhibiting pro matrix metalloproteinase activation |
| US20130014288A1 (en) * | 2011-06-06 | 2013-01-10 | Carnegie Mellon University | Novel reporter-tagged recombinant membrane proteins with transmembrane linkers |
| FR2999191B1 (fr) * | 2012-12-12 | 2016-02-05 | Lesaffre & Cie | Souches probiotiques pour le traitement et/ou la prevention de la diarrhee |
| WO2017196843A1 (en) * | 2016-05-09 | 2017-11-16 | Proteostasis Therapeutics, Inc. | Methods of identifying cftr modulators |
| EP3684463B1 (en) | 2017-09-19 | 2025-05-14 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement |
| US11717686B2 (en) | 2017-12-04 | 2023-08-08 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement to facilitate learning and performance |
| US12280219B2 (en) | 2017-12-31 | 2025-04-22 | NeuroLight, Inc. | Method and apparatus for neuroenhancement to enhance emotional response |
| WO2019133997A1 (en) | 2017-12-31 | 2019-07-04 | Neuroenhancement Lab, LLC | System and method for neuroenhancement to enhance emotional response |
| US11364361B2 (en) | 2018-04-20 | 2022-06-21 | Neuroenhancement Lab, LLC | System and method for inducing sleep by transplanting mental states |
| CN113382683A (zh) | 2018-09-14 | 2021-09-10 | 纽罗因恒思蒙特实验有限责任公司 | 改善睡眠的系统和方法 |
| US11786694B2 (en) | 2019-05-24 | 2023-10-17 | NeuroLight, Inc. | Device, method, and app for facilitating sleep |
| CN111910008B (zh) * | 2020-08-21 | 2022-05-31 | 云南农业大学 | 一种鸡生长发育相关的分子标记及其应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020164782A1 (en) * | 1999-02-10 | 2002-11-07 | Gregory Richard J. | Adenovirus vectors for gene therapy |
| AU6953100A (en) * | 1999-07-09 | 2001-01-30 | Mayo Foundation For Medical Education And Research | Cftr polypeptides, fragments thereof and methods of use to overcome biosyntheticmisprocessing |
| US7264948B2 (en) * | 2002-08-30 | 2007-09-04 | University Of Pittsburgh | Polypeptides for increasing mutant CFTR channel activity |
| US7939558B2 (en) * | 2004-06-04 | 2011-05-10 | The Regents Of The University Of California | Compounds having activity in increasing ion transport by mutant-CFTR and uses thereof |
| CA2600869A1 (en) * | 2005-03-18 | 2006-09-28 | The Regents Of The University Of California | Compounds having activity in correcting mutant-cftr processing and uses thereof |
| KR20130140221A (ko) * | 2005-04-13 | 2013-12-23 | 아스트라제네카 아베 | 감마 카르복실화를 필요로 하는 단백질 생산용 벡터를 포함하는 숙주 세포 |
| WO2007137239A2 (en) * | 2006-05-19 | 2007-11-29 | The Scripps Research Institute | Treatment of protein misfolding |
| CA2682100C (en) * | 2007-03-28 | 2017-11-21 | University Of Iowa Research Foundation | Transgenic animal models of disease |
-
2010
- 2010-02-01 US US13/147,327 patent/US20120058918A1/en not_active Abandoned
- 2010-02-01 WO PCT/US2010/022778 patent/WO2010088630A2/en not_active Ceased
- 2010-02-01 JP JP2011548377A patent/JP2012516686A/ja active Pending
- 2010-02-01 MX MX2011008131A patent/MX2011008131A/es not_active Application Discontinuation
- 2010-02-01 EP EP10736545A patent/EP2393930A4/en not_active Withdrawn
- 2010-02-01 CA CA2751215A patent/CA2751215A1/en not_active Abandoned
-
2014
- 2014-11-24 US US14/552,192 patent/US20150315554A1/en not_active Abandoned
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