JP2012514006A - 3.1.0二環式GlyT1阻害剤ならびにその作製および使用の方法 - Google Patents

3.1.0二環式GlyT1阻害剤ならびにその作製および使用の方法 Download PDF

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JP2012514006A
JP2012514006A JP2011543717A JP2011543717A JP2012514006A JP 2012514006 A JP2012514006 A JP 2012514006A JP 2011543717 A JP2011543717 A JP 2011543717A JP 2011543717 A JP2011543717 A JP 2011543717A JP 2012514006 A JP2012514006 A JP 2012514006A
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optionally substituted
hydrogen
compound
disorder
carbons
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JP2012514006A5 (OSRAM
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クレイグ ダブリュー. リンズレイ,
ピー. ジェフリー コン,
チャールズ デイビッド ウェーバー,
コリーン エム. ニスウェンダー,
リチャード ウィリアムズ,
キャリー ケイ. ジョーンズ,
ダグラス ジェイ. シェフラー,
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バンダービルト ユニバーシティ
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    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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  • Diabetes (AREA)
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  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2011543717A 2008-12-29 2009-12-29 3.1.0二環式GlyT1阻害剤ならびにその作製および使用の方法 Pending JP2012514006A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14103008P 2008-12-29 2008-12-29
US61/141,030 2008-12-29
PCT/US2009/069716 WO2010078348A1 (en) 2008-12-29 2009-12-29 3.1.0 bicyclic glyt1 inhibitors and methods of making and using same

Publications (2)

Publication Number Publication Date
JP2012514006A true JP2012514006A (ja) 2012-06-21
JP2012514006A5 JP2012514006A5 (OSRAM) 2013-01-31

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JP2011543717A Pending JP2012514006A (ja) 2008-12-29 2009-12-29 3.1.0二環式GlyT1阻害剤ならびにその作製および使用の方法

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US (1) US8497289B2 (OSRAM)
EP (1) EP2381941A4 (OSRAM)
JP (1) JP2012514006A (OSRAM)
KR (1) KR20110117087A (OSRAM)
CN (1) CN102271677A (OSRAM)
AU (1) AU2009335120A1 (OSRAM)
BR (1) BRPI0923878A2 (OSRAM)
CA (1) CA2747602A1 (OSRAM)
IL (1) IL213541A0 (OSRAM)
MX (1) MX2011006845A (OSRAM)
RU (1) RU2011124709A (OSRAM)
WO (1) WO2010078348A1 (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017514871A (ja) * 2014-05-06 2017-06-08 ノースウェスタン ユニバーシティ Nmdar調節化合物の組合せ

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9012489B2 (en) * 2011-08-03 2015-04-21 Boehringer Ingelheim International Gmbh Phenyl-3-aza-bicyclo[3.1.0]hex-3-yl-methanones and the use thereof as medicament
US9987242B2 (en) 2015-05-05 2018-06-05 Northwestern University Treatment of Levodopa-induced Dyskinesias
AU2020266566B2 (en) * 2019-05-01 2025-11-06 Boehringer Ingelheim International Gmbh Solid forms of a GlyT1 inhibitor
AU2021324376A1 (en) 2020-08-13 2023-02-02 Boehringer Ingelheim International Gmbh Treatment of cognitive impairement associated with schizophrenia
MX2023004293A (es) 2020-10-13 2023-05-03 Boehringer Ingelheim Int Proceso de reelaboracion.
IL318673A (en) 2022-08-09 2025-03-01 Xizang Haisco Pharmaceutical Co Ltd PDE4B inhibitor and its use

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005037216A2 (en) * 2003-10-14 2005-04-28 Pfizer Products Inc. Bicyclic [3.1.0] derivatives as glycine transporter inhibitors
WO2006067529A1 (en) * 2004-12-21 2006-06-29 Merck Sharp & Dohme Limited Piperidine and azetidine derivatives as glyt1 inhibitors
WO2007060484A1 (en) * 2005-11-25 2007-05-31 Merck Sharp & Dohme Limited Azetidine derivatives as glyt1 inhibitors
WO2008038251A2 (en) * 2006-09-29 2008-04-03 Actelion Pharmaceuticals Ltd 3-aza-bicyclo[3.1.0]hexane derivatives
US20080319043A1 (en) * 2005-05-03 2008-12-25 Mohammad Salman 3,6-Disubstituted Azabicyclo (3.1.0) Hexane Derivatives as Muscarinic Receptor Antagonists

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5981168A (en) * 1998-05-15 1999-11-09 The University Of British Columbia Method and composition for modulating amyloidosis

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005037216A2 (en) * 2003-10-14 2005-04-28 Pfizer Products Inc. Bicyclic [3.1.0] derivatives as glycine transporter inhibitors
WO2006067529A1 (en) * 2004-12-21 2006-06-29 Merck Sharp & Dohme Limited Piperidine and azetidine derivatives as glyt1 inhibitors
US20080319043A1 (en) * 2005-05-03 2008-12-25 Mohammad Salman 3,6-Disubstituted Azabicyclo (3.1.0) Hexane Derivatives as Muscarinic Receptor Antagonists
WO2007060484A1 (en) * 2005-11-25 2007-05-31 Merck Sharp & Dohme Limited Azetidine derivatives as glyt1 inhibitors
WO2008038251A2 (en) * 2006-09-29 2008-04-03 Actelion Pharmaceuticals Ltd 3-aza-bicyclo[3.1.0]hexane derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017514871A (ja) * 2014-05-06 2017-06-08 ノースウェスタン ユニバーシティ Nmdar調節化合物の組合せ
JP2020138973A (ja) * 2014-05-06 2020-09-03 ノースウェスタン ユニバーシティ Nmdar調節化合物の組合せ

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Publication number Publication date
BRPI0923878A2 (pt) 2015-07-28
KR20110117087A (ko) 2011-10-26
WO2010078348A1 (en) 2010-07-08
IL213541A0 (en) 2011-07-31
US8497289B2 (en) 2013-07-30
CA2747602A1 (en) 2010-07-08
EP2381941A1 (en) 2011-11-02
US20100256192A1 (en) 2010-10-07
MX2011006845A (es) 2011-08-04
EP2381941A4 (en) 2012-08-01
AU2009335120A1 (en) 2011-07-07
RU2011124709A (ru) 2013-02-10
CN102271677A (zh) 2011-12-07

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