JP2012510499A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012510499A5 JP2012510499A5 JP2011538991A JP2011538991A JP2012510499A5 JP 2012510499 A5 JP2012510499 A5 JP 2012510499A5 JP 2011538991 A JP2011538991 A JP 2011538991A JP 2011538991 A JP2011538991 A JP 2011538991A JP 2012510499 A5 JP2012510499 A5 JP 2012510499A5
- Authority
- JP
- Japan
- Prior art keywords
- vivo
- contrast agent
- synuclein
- imaging moiety
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000001727 in vivo Methods 0.000 claims 17
- 239000002872 contrast media Substances 0.000 claims 16
- 238000011503 in vivo imaging Methods 0.000 claims 12
- 102000003802 alpha-Synuclein Human genes 0.000 claims 8
- 108090000185 alpha-Synuclein Proteins 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 238000000034 method Methods 0.000 claims 8
- 239000001257 hydrogen Substances 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 4
- 239000012453 solvate Substances 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 208000018737 Parkinson disease Diseases 0.000 claims 3
- 239000011230 binding agent Substances 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 230000002285 radioactive effect Effects 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 125000004103 aminoalkyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 210000003403 autonomic nervous system Anatomy 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 210000004558 lewy body Anatomy 0.000 claims 2
- 229910021645 metal ion Inorganic materials 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000004001 thioalkyl group Chemical group 0.000 claims 2
- 150000003573 thiols Chemical class 0.000 claims 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 125000005021 aminoalkenyl group Chemical group 0.000 claims 1
- 125000002431 aminoalkoxy group Chemical group 0.000 claims 1
- 125000005014 aminoalkynyl group Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 1
- 150000001768 cations Chemical group 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000005159 cyanoalkoxy group Chemical group 0.000 claims 1
- 125000004966 cyanoalkyl group Chemical group 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 238000013399 early diagnosis Methods 0.000 claims 1
- 210000000105 enteric nervous system Anatomy 0.000 claims 1
- 125000000262 haloalkenyl group Chemical group 0.000 claims 1
- 125000004438 haloalkoxy group Chemical group 0.000 claims 1
- 125000000232 haloalkynyl group Chemical group 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000005020 hydroxyalkenyl group Chemical group 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 125000005016 hydroxyalkynyl group Chemical group 0.000 claims 1
- 239000012216 imaging agent Substances 0.000 claims 1
- 210000002241 neurite Anatomy 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 125000004971 nitroalkyl group Chemical group 0.000 claims 1
- 229910052755 nonmetal Inorganic materials 0.000 claims 1
- 238000012634 optical imaging Methods 0.000 claims 1
- 230000005298 paramagnetic effect Effects 0.000 claims 1
- 229910052700 potassium Inorganic materials 0.000 claims 1
- 239000011591 potassium Substances 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- 125000005309 thioalkoxy group Chemical group 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11906008P | 2008-12-02 | 2008-12-02 | |
| GB0821994.1 | 2008-12-02 | ||
| US61/119,060 | 2008-12-02 | ||
| GBGB0821994.1A GB0821994D0 (en) | 2008-12-02 | 2008-12-02 | In viva imaging method |
| PCT/EP2009/066120 WO2010063701A2 (en) | 2008-12-02 | 2009-12-01 | In vivo imaging method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012510499A JP2012510499A (ja) | 2012-05-10 |
| JP2012510499A5 true JP2012510499A5 (cg-RX-API-DMAC7.html) | 2012-12-27 |
Family
ID=40262535
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011538991A Withdrawn JP2012510499A (ja) | 2008-12-02 | 2009-12-01 | 生体内イメージング法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20110236307A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2389200A2 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2012510499A (cg-RX-API-DMAC7.html) |
| CN (1) | CN102300589A (cg-RX-API-DMAC7.html) |
| GB (1) | GB0821994D0 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2010063701A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101297815B1 (ko) * | 2010-11-18 | 2013-09-03 | 충남대학교산학협력단 | 폴리감마글루탐산과 광학영상다이의 복합체를 함유하는 센티넬 림프노드 감지용 광학영상 프로브 |
| CA2945938C (en) | 2014-06-25 | 2023-04-18 | Nucana Biomed Limited | Gemcitabine prodrugs |
| AU2017231781C1 (en) | 2016-03-11 | 2021-12-16 | Ac Immune Sa | Bicyclic compounds for diagnosis and therapy |
| CN120987917A (zh) | 2016-12-29 | 2025-11-21 | 箕星药业香港有限公司 | 金属酶抑制剂化合物 |
| EP3562306B1 (en) | 2016-12-29 | 2025-02-26 | Ji Xing Pharmaceuticals Hong Kong Limited | Metalloenzyme inhibitor compounds |
| KR20240038149A (ko) | 2017-04-26 | 2024-03-22 | 바실리어 파마슈티카 인터내셔널 리미티드 | 푸라자노벤즈이미다졸 및 이의 결정 형태의 제조 공정 |
| US11844846B2 (en) | 2018-05-16 | 2023-12-19 | Emory University | Styrylbenzothiazole derivatives and uses in imaging methods |
| CA3102038A1 (en) | 2018-06-08 | 2019-12-12 | Ac Immune Sa | Novel compounds for diagnosis |
| US20200085979A1 (en) | 2018-09-11 | 2020-03-19 | Stanley Satz | Precision medicine theranostics and diagnostics a combination thereof |
| CA3126224A1 (en) | 2019-01-08 | 2020-07-16 | Phasebio Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| KR20230008183A (ko) | 2020-05-07 | 2023-01-13 | 에이씨 이뮨 에스에이 | 진단을 위한 신규한 화합물 |
| AU2022385416A1 (en) | 2021-11-10 | 2024-05-02 | Ac Immune Sa | 4h-imidazo[1,5-b]pyrazole derivatives for diagnosis |
| CN118510781A (zh) | 2021-11-10 | 2024-08-16 | Ac免疫有限公司 | 二氢吡咯并[3,4c]-吡唑衍生物及其在诊断中的用途 |
| EP4430044A1 (en) | 2021-11-10 | 2024-09-18 | AC Immune SA | Dihydropyrrolo[3,4-c]pyrazole derivatives and their use in diagnosis |
| WO2024126840A1 (en) | 2022-12-16 | 2024-06-20 | Ac Immune Sa | Novel compounds for diagnosis |
| CN120344535A (zh) | 2022-12-16 | 2025-07-18 | Ac免疫有限公司 | 用于诊断的新化合物 |
| WO2025037013A1 (en) | 2023-08-16 | 2025-02-20 | Ac Immune Sa | Diagnostic compounds that bind to alpha-synuclein |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010047032A1 (en) * | 1999-12-30 | 2001-11-29 | Castillo Gerardo M. | Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases |
| US6379650B1 (en) * | 2001-03-19 | 2002-04-30 | Wesley Scott Ashton | Technetium 99m-N2S2-congo red complexes utilizing diamide dithiolate ligand systems for radioimaging |
| US7521481B2 (en) * | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
| US8329142B2 (en) * | 2003-05-29 | 2012-12-11 | Pettegrew Jay W | Compounds, compositions and methods for medical imaging of Parkinson's disease |
| WO2007011834A2 (en) * | 2005-07-15 | 2007-01-25 | The Regents Of The University Of California | Compounds and method for the diagnosis and treatment of amyloid associated diseases |
| JP2009519239A (ja) * | 2005-12-01 | 2009-05-14 | ユニバーシティ オブ ピッツバーグ オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション | アミロイド生成性タンパク質の造影剤としての同位体標識ベンゾチアゾール化合物 |
| US20080118938A1 (en) * | 2006-09-06 | 2008-05-22 | Lisbell Estrada | Methods and Compositions for the Detection of Protein Folding Disorders |
| BRPI0719763A2 (pt) * | 2006-10-02 | 2014-01-28 | Ac Immune Sa | Anticorpo, molécula de ácido nucleico, vetor de expressão, célula, composição, mistura, uso de um anticorpo quimérico ou um fragmento do mesmo ou um anticorpo humanizado ou um fragmento do mesmo e/ou uma parte funcional e/ou uma composição farmacêutica ou uma mistura, métodos para a preparação de uma composição farmacêutica ou de uma mistura, para prevenir, tratar ou aliviar os efeitos de uma doença, de diagnóstico de uma doença ou condição associada com amilóide em um paciente e de determinação do grau da carga de placa amiloidogênica em um tecido e/ou fluidos corporais, kits de teste para a detecção e diagnóstico de doenças e condições associadas com amilóide, região variável de cadeia leve, região variável de cadeia pesada, linhagem de célula, gene de anticorpo, e, métodos para desagregar fibras de beta-amilóide pré formadas, para prevenir a degradação de neurônio induzida por abeta, para diagnosticar uma predisposição a uma doença ou condição associada com amilóide em um paciente, para monitorar doença residual mínima em um paciente, para prognosticar a responsividade de um paciente que é tratado com um anticorpo ou uma composição de vacina, para reduzir a carga de placa no cérebro de um animal, para reduzir a quantidade de placas no cérebro de um animal, para diminuir a quantidade total de abeta solúvel no cérebro de um animal e para reter ou aumentar a capacidade de memória cognitiva em um mamífero. |
| EP2171478A4 (en) * | 2007-03-30 | 2013-01-30 | Univ California | IN VIVO IMAGING METHOD FOR SULPHOTRANSFERASES |
-
2008
- 2008-12-02 GB GBGB0821994.1A patent/GB0821994D0/en not_active Ceased
-
2009
- 2009-12-01 US US13/132,109 patent/US20110236307A1/en not_active Abandoned
- 2009-12-01 CN CN2009801562662A patent/CN102300589A/zh active Pending
- 2009-12-01 WO PCT/EP2009/066120 patent/WO2010063701A2/en not_active Ceased
- 2009-12-01 JP JP2011538991A patent/JP2012510499A/ja not_active Withdrawn
- 2009-12-01 EP EP09768015A patent/EP2389200A2/en not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012510499A5 (cg-RX-API-DMAC7.html) | ||
| JP6722663B2 (ja) | マクロファージおよび他のマンノース結合ｃ型レクチン受容体高発現細胞を標的化するための化合物および組成物、ならびにそれらを使用して治療するおよび診断する方法 | |
| US20250228985A1 (en) | Compounds and compositions for targeting macrophages and other mannose-binding c-type lectin receptor high expressing cells and methods of treating and diagnosis using same | |
| ES2914593T3 (es) | Agentes de unión a PSMA y usos de los mismos | |
| JP6607854B2 (ja) | Ｃｄ２０６発現細胞関連障害を診断および処置するための組成物、方法およびキット | |
| ES2554772T3 (es) | Azabenzoxazoles sustituidos novedosos | |
| JP5595903B2 (ja) | １８ｆ標識葉酸 | |
| EP3169336A1 (en) | Compositions for targeting macrophages and other cd206 high expressing cells and methods of treating and diagnosis | |
| US20250339405A1 (en) | a-SYNUCLEIN AGGREGATE BINDING AGENT AND IMAGING METHOD | |
| CN111447955A (zh) | 99mTc-替马诺塞和相关的分子构建体用于鉴定和诊断恶性肿瘤和用于监测治疗性抗肿瘤干预的用途 | |
| EP2291075A4 (en) | PEPTIDE COMPOUNDS RELEASING GASTRIN | |
| Hernandez Vargas et al. | High-contrast detection of somatostatin receptor subtype-2 for fluorescence-guided surgery | |
| US10806803B2 (en) | Compositions for targeting macrophages and other CD206 high expressing cells and methods of treating and diagnosis | |
| DK2776382T3 (en) | 18F saccharide-folates | |
| JPWO2010101298A1 (ja) | 蛍光ｍｒｉプローブ | |
| Bhojani et al. | Synthesis and investigation of a radioiodinated F3 peptide analog as a SPECT tumor imaging radioligand | |
| US20170202969A1 (en) | Compounds and compositions for targeting macrophages and other mannose-binding c-type lectin receptor high expressing cells and methods of treating and diagnosis using same | |
| Mushtaq et al. | Efficient and Site-Specific 125I-Radioiodination of Bioactive Molecules Using Oxidative Condensation Reaction | |
| WO2013138612A1 (en) | Synthesis and application of novel imaging agents conjugated to dpa 713 analogs for imaging inflammation | |
| Wan et al. | Polyamidoamine (PAMAM) dendrimer conjugate specifically activates the A3 adenosine receptor to improve post-ischemic/reperfusion function in isolated mouse hearts | |
| Kong et al. | Multifunctional Probe Based on “Chemical Antibody–Aptamer” for Noninvasive Detection of PD-L1 Expression in Cancer | |
| JP2023134629A (ja) | 高いｉｎ ｖｉｖｏ ＮＭＤ特異性を有するベンザゼピン－１，７－ジオールから誘導される放射性標識リガンド | |
| Ferro-Flores et al. | Synthesis and Evaluation of [18F] AlF-NOTA-iPD-L1 as a Potential Theranostic Pair for [177Lu] Lu-DOTA-iPD-L1 | |
| Bian et al. | Uridine-Based PET/NIRF Dual-Modality imaging for precision tumor diagnosis and surgery |