JP2012509889A5 - - Google Patents
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- Publication number
- JP2012509889A5 JP2012509889A5 JP2011537663A JP2011537663A JP2012509889A5 JP 2012509889 A5 JP2012509889 A5 JP 2012509889A5 JP 2011537663 A JP2011537663 A JP 2011537663A JP 2011537663 A JP2011537663 A JP 2011537663A JP 2012509889 A5 JP2012509889 A5 JP 2012509889A5
- Authority
- JP
- Japan
- Prior art keywords
- administered
- vegf antibody
- cyclophosphamide
- subject
- m2iv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11710208P | 2008-11-22 | 2008-11-22 | |
| US61/117,102 | 2008-11-22 | ||
| US17800909P | 2009-05-13 | 2009-05-13 | |
| US61/178,009 | 2009-05-13 | ||
| US17930709P | 2009-05-18 | 2009-05-18 | |
| US61/179,307 | 2009-05-18 | ||
| PCT/US2009/065381 WO2010059969A2 (en) | 2008-11-22 | 2009-11-20 | Anti-angiogenesis therapy for the treatment of breast cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016163087A Division JP6850562B2 (ja) | 2008-11-22 | 2016-08-23 | 乳癌の治療のための化学療法と併用した抗ｖｅｇｆ抗体の使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012509889A JP2012509889A (ja) | 2012-04-26 |
| JP2012509889A5 true JP2012509889A5 (enExample) | 2013-01-24 |
| JP6041489B2 JP6041489B2 (ja) | 2016-12-07 |
Family
ID=42154236
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011537663A Active JP6041489B2 (ja) | 2008-11-22 | 2009-11-20 | 乳癌の治療のための化学療法と併用した抗ｖｅｇｆ抗体の使用 |
| JP2016163087A Active JP6850562B2 (ja) | 2008-11-22 | 2016-08-23 | 乳癌の治療のための化学療法と併用した抗ｖｅｇｆ抗体の使用 |
| JP2018080848A Withdrawn JP2018138583A (ja) | 2008-11-22 | 2018-04-19 | 乳癌の治療のための化学療法と併用した抗ｖｅｇｆ抗体の使用 |
| JP2020076277A Pending JP2020128389A (ja) | 2008-11-22 | 2020-04-22 | 乳癌の治療のための化学療法と併用した抗ｖｅｇｆ抗体の使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016163087A Active JP6850562B2 (ja) | 2008-11-22 | 2016-08-23 | 乳癌の治療のための化学療法と併用した抗ｖｅｇｆ抗体の使用 |
| JP2018080848A Withdrawn JP2018138583A (ja) | 2008-11-22 | 2018-04-19 | 乳癌の治療のための化学療法と併用した抗ｖｅｇｆ抗体の使用 |
| JP2020076277A Pending JP2020128389A (ja) | 2008-11-22 | 2020-04-22 | 乳癌の治療のための化学療法と併用した抗ｖｅｇｆ抗体の使用 |
Country Status (28)
| Country | Link |
|---|---|
| US (5) | US20100143351A1 (enExample) |
| EP (3) | EP3178478A1 (enExample) |
| JP (4) | JP6041489B2 (enExample) |
| KR (3) | KR20170015525A (enExample) |
| CN (2) | CN102223897B (enExample) |
| AR (1) | AR074203A1 (enExample) |
| AU (1) | AU2009316409A1 (enExample) |
| BR (1) | BRPI0916138A2 (enExample) |
| CA (1) | CA2744158A1 (enExample) |
| CL (1) | CL2011001186A1 (enExample) |
| CY (1) | CY1118549T1 (enExample) |
| DK (2) | DK2752189T3 (enExample) |
| ES (2) | ES2535404T5 (enExample) |
| HR (1) | HRP20170059T1 (enExample) |
| HU (2) | HUE024872T2 (enExample) |
| IL (2) | IL212998A (enExample) |
| LT (1) | LT2752189T (enExample) |
| MX (2) | MX340724B (enExample) |
| PH (1) | PH12014502507A1 (enExample) |
| PL (2) | PL2361085T5 (enExample) |
| PT (1) | PT2752189T (enExample) |
| RU (1) | RU2531948C2 (enExample) |
| SG (1) | SG171780A1 (enExample) |
| SI (2) | SI2361085T2 (enExample) |
| SM (1) | SMT201700173T1 (enExample) |
| TW (2) | TWI612971B (enExample) |
| WO (1) | WO2010059969A2 (enExample) |
| ZA (1) | ZA201103321B (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2774226T3 (es) | 2008-05-15 | 2020-07-17 | Celgene Corp | Formulaciones orales de análogos de citidina y métodos de uso de los mismos |
| AR074203A1 (es) * | 2008-11-22 | 2010-12-29 | Genentech Inc | Terapia anti-angiogenesis para el tratamiento del cancer de mama. kit. uso. |
| CN110227154A (zh) | 2010-02-23 | 2019-09-13 | 霍夫曼-拉罗奇有限公司 | 用于治疗卵巢癌的抗血管发生疗法 |
| MY194408A (en) * | 2011-10-14 | 2022-11-30 | Genentech Inc | Uses for and Article of Manufacture Including Her2 Dimerization Inhibitor Pertuzumab |
| BR112014010417A2 (pt) | 2011-11-01 | 2014-11-18 | Celgene Corp | Métodos para o tratamento de cânceres com o uso de formulações orais de análogos de citidina |
| BR112014018964A2 (pt) | 2012-03-13 | 2020-05-12 | F. Hoffmann-La Roche Ag | Anticorpo anti-vegf e uso de um anticorpo anti-vegf |
| HRP20200060T1 (hr) | 2013-08-26 | 2020-04-03 | Novartis Ag | Nova uporaba |
| MX389256B (es) | 2013-10-04 | 2025-03-20 | Infinity Pharmaceuticals Inc | Compuestos heterociclicos y usos de los mismos. |
| EP4066834A1 (en) | 2014-03-19 | 2022-10-05 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| MX2016017396A (es) * | 2014-07-03 | 2017-05-01 | Imclone Llc | Terapia de combinacion. |
| EP3169374B1 (en) | 2014-07-14 | 2022-01-05 | University of Utah Research Foundation | In situ solidifying complex coacervates and methods of making and using thereof |
| CN104991065B (zh) * | 2015-07-07 | 2017-01-11 | 复旦大学附属金山医院 | 一种用于诊断乳腺癌的三联标志物及其应用 |
| CN108349985A (zh) | 2015-09-14 | 2018-07-31 | 无限药品股份有限公司 | 异喹啉酮的固体形式、其制备方法、包含其的组合物及其使用方法 |
| BR112018013407A2 (en) | 2015-12-30 | 2018-12-18 | Kodiak Sciences Inc. | antibodies and conjugates thereof |
| CN116531511A (zh) | 2017-03-02 | 2023-08-04 | 豪夫迈·罗氏有限公司 | Her2阳性乳腺癌的辅助治疗 |
| WO2019084548A1 (en) * | 2017-10-27 | 2019-05-02 | University Of Utah Research Foundation | COMPLEX LIQUID IN SITU SOLIDIFICATION COASTALITIES FOR LOCAL ADMINISTRATION OF ANTI-ANGIOGENIC AGENTS OR CHEMOTHERAPEUTIC AGENTS |
| JP7410876B2 (ja) | 2018-01-26 | 2024-01-10 | フルイデックス メディカル テクノロジー，リミティッド ライアビリティ カンパニー | 血管閉塞のためにその場凝固複合コアセルベートを使用する装置及び方法 |
| SG11202008242XA (en) | 2018-03-02 | 2020-09-29 | Kodiak Sciences Inc | Il-6 antibodies and fusion constructs and conjugates thereof |
| CN112262157A (zh) * | 2018-03-09 | 2021-01-22 | 加利福尼亚大学董事会 | 化药抗性癌症的组合治疗 |
| US11912784B2 (en) | 2019-10-10 | 2024-02-27 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| CN111710425A (zh) * | 2020-06-19 | 2020-09-25 | 复旦大学附属中山医院 | 一种免疫检查点抑制剂心脏毒性评估方法，系统及装置 |
| AU2024210067A1 (en) * | 2023-01-19 | 2025-08-07 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Anti-her2 antibody-drug conjugate for treating breast cancer |
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| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| WO1989006692A1 (en) | 1988-01-12 | 1989-07-27 | Genentech, Inc. | Method of treating tumor cells by inhibiting growth factor receptor function |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| ES2108048T3 (es) | 1990-08-29 | 1997-12-16 | Genpharm Int | Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos. |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
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| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| DE69129154T2 (de) | 1990-12-03 | 1998-08-20 | Genentech, Inc., South San Francisco, Calif. | Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften |
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| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| EP0666868B2 (en) | 1992-10-28 | 2006-06-14 | Genentech, Inc. | Use of anti-VEGF antibodies for the treatment of cancer |
| EP1005870B1 (en) | 1992-11-13 | 2009-01-21 | Biogen Idec Inc. | Therapeutic application of chimeric antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
| US5635388A (en) | 1994-04-04 | 1997-06-03 | Genentech, Inc. | Agonist antibodies against the flk2/flt3 receptor and uses thereof |
| IL117645A (en) | 1995-03-30 | 2005-08-31 | Genentech Inc | Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| US5739277A (en) | 1995-04-14 | 1998-04-14 | Genentech Inc. | Altered polypeptides with increased half-life |
| PT1516628E (pt) | 1995-07-27 | 2013-09-24 | Genentech Inc | Formulação de proteína liofilizada isotónica estável |
| US5730977A (en) | 1995-08-21 | 1998-03-24 | Mitsui Toatsu Chemicals, Inc. | Anti-VEGF human monoclonal antibody |
| GB9603256D0 (en) | 1996-02-16 | 1996-04-17 | Wellcome Found | Antibodies |
| US6100071A (en) | 1996-05-07 | 2000-08-08 | Genentech, Inc. | Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production |
| US20020032315A1 (en) | 1997-08-06 | 2002-03-14 | Manuel Baca | Anti-vegf antibodies |
| CN101665536B (zh) | 1997-04-07 | 2013-07-03 | 基因技术股份有限公司 | 抗-血管内皮生长因子的抗体 |
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| KR100870353B1 (ko) | 1997-04-07 | 2008-11-25 | 제넨테크, 인크. | 항-ｖｅｇｆ 항체 |
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| ES2434961T5 (es) | 1998-04-20 | 2018-01-18 | Roche Glycart Ag | Ingeniería de glicosilación de anticuerpos para mejorar la citotoxicidad celular dependiente del anticuerpo |
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| PT1355919E (pt) | 2000-12-12 | 2011-03-02 | Medimmune Llc | Moléculas com semivida longa, composições que as contêm e suas utilizações |
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| KR20160014775A (ko) * | 2003-05-30 | 2016-02-11 | 제넨테크, 인크. | 항-ｖｅｇｆ 항체를 사용한 치료 |
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| US20060009360A1 (en) | 2004-06-25 | 2006-01-12 | Robert Pifer | New adjuvant composition |
| WO2006008639A1 (en) | 2004-07-16 | 2006-01-26 | Pfizer Products Inc. | Combination treatment for non-hematologic malignancies using an anti-igf-1r antibody |
| PT1771474E (pt) | 2004-07-20 | 2010-05-03 | Genentech Inc | Inibidores de proteína 4 do tipo angiopoietina, combinações e sua utilização |
| US8367805B2 (en) * | 2004-11-12 | 2013-02-05 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| HUE029445T2 (en) * | 2006-12-19 | 2017-02-28 | Genentech Inc | VEGF-specific antagonists for adjuvant and neoadjuvant therapy and treatment of early-stage tumors |
| JP2010518013A (ja) * | 2007-02-01 | 2010-05-27 | ジェネンテック， インコーポレイテッド | 血管形成阻害剤を含む組み合わせ治療の方法 |
| AR074203A1 (es) * | 2008-11-22 | 2010-12-29 | Genentech Inc | Terapia anti-angiogenesis para el tratamiento del cancer de mama. kit. uso. |
| WO2020176087A1 (en) | 2019-02-27 | 2020-09-03 | Google Llc | Grayscale histogram generation |
-
2009
- 2009-11-20 AR ARP090104477A patent/AR074203A1/es unknown
- 2009-11-20 CA CA2744158A patent/CA2744158A1/en not_active Abandoned
- 2009-11-20 SM SM20170173T patent/SMT201700173T1/it unknown
- 2009-11-20 TW TW104125142A patent/TWI612971B/zh not_active IP Right Cessation
- 2009-11-20 US US12/623,297 patent/US20100143351A1/en not_active Abandoned
- 2009-11-20 JP JP2011537663A patent/JP6041489B2/ja active Active
- 2009-11-20 WO PCT/US2009/065381 patent/WO2010059969A2/en not_active Ceased
- 2009-11-20 PL PL09764134T patent/PL2361085T5/pl unknown
- 2009-11-20 MX MX2014002003A patent/MX340724B/es unknown
- 2009-11-20 KR KR1020177002172A patent/KR20170015525A/ko not_active Ceased
- 2009-11-20 BR BRPI0916138A patent/BRPI0916138A2/pt not_active Application Discontinuation
- 2009-11-20 CN CN200980146589.3A patent/CN102223897B/zh not_active Expired - Fee Related
- 2009-11-20 AU AU2009316409A patent/AU2009316409A1/en not_active Abandoned
- 2009-11-20 CN CN201510520134.0A patent/CN105214086B/zh not_active Expired - Fee Related
- 2009-11-20 HU HUE09764134A patent/HUE024872T2/en unknown
- 2009-11-20 HU HUE13189711A patent/HUE032693T2/en unknown
- 2009-11-20 KR KR1020187030405A patent/KR20180117734A/ko not_active Ceased
- 2009-11-20 EP EP16188246.9A patent/EP3178478A1/en not_active Withdrawn
- 2009-11-20 ES ES09764134.4T patent/ES2535404T5/es active Active
- 2009-11-20 KR KR1020117014272A patent/KR101807319B1/ko not_active Expired - Fee Related
- 2009-11-20 SI SI200931187T patent/SI2361085T2/sl unknown
- 2009-11-20 DK DK13189711.8T patent/DK2752189T3/en active
- 2009-11-20 TW TW098139537A patent/TWI542359B/zh not_active IP Right Cessation
- 2009-11-20 DK DK09764134.4T patent/DK2361085T4/en active
- 2009-11-20 LT LTEP13189711.8T patent/LT2752189T/lt unknown
- 2009-11-20 MX MX2011005383A patent/MX2011005383A/es active IP Right Grant
- 2009-11-20 EP EP13189711.8A patent/EP2752189B1/en not_active Revoked
- 2009-11-20 SG SG2011036696A patent/SG171780A1/en unknown
- 2009-11-20 PL PL13189711T patent/PL2752189T3/pl unknown
- 2009-11-20 SI SI200931591T patent/SI2752189T1/sl unknown
- 2009-11-20 ES ES13189711.8T patent/ES2611337T3/es active Active
- 2009-11-20 PT PT131897118T patent/PT2752189T/pt unknown
- 2009-11-20 RU RU2011125518/15A patent/RU2531948C2/ru active
- 2009-11-20 EP EP09764134.4A patent/EP2361085B9/en not_active Not-in-force
-
2011
- 2011-05-06 ZA ZA2011/03321A patent/ZA201103321B/en unknown
- 2011-05-19 IL IL212998A patent/IL212998A/en active IP Right Grant
- 2011-05-20 CL CL2011001186A patent/CL2011001186A1/es unknown
-
2014
- 2014-11-10 PH PH12014502507A patent/PH12014502507A1/en unknown
-
2015
- 2015-05-15 US US14/714,177 patent/US20150246124A1/en not_active Abandoned
-
2016
- 2016-01-21 IL IL243741A patent/IL243741A0/en unknown
- 2016-05-13 US US15/154,797 patent/US20160243227A1/en not_active Abandoned
- 2016-08-23 JP JP2016163087A patent/JP6850562B2/ja active Active
- 2016-12-20 US US15/385,602 patent/US20170100478A1/en not_active Abandoned
-
2017
- 2017-01-16 HR HRP20170059TT patent/HRP20170059T1/hr unknown
- 2017-01-25 CY CY20171100116T patent/CY1118549T1/el unknown
-
2018
- 2018-04-19 JP JP2018080848A patent/JP2018138583A/ja not_active Withdrawn
-
2020
- 2020-04-22 JP JP2020076277A patent/JP2020128389A/ja active Pending
- 2020-05-15 US US16/874,936 patent/US20210093715A1/en not_active Abandoned
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