JP2012509062A5 - - Google Patents

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Publication number
JP2012509062A5
JP2012509062A5 JP2011536388A JP2011536388A JP2012509062A5 JP 2012509062 A5 JP2012509062 A5 JP 2012509062A5 JP 2011536388 A JP2011536388 A JP 2011536388A JP 2011536388 A JP2011536388 A JP 2011536388A JP 2012509062 A5 JP2012509062 A5 JP 2012509062A5
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JP
Japan
Prior art keywords
specific binding
molecule
nucleic acid
target
linking
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Granted
Application number
JP2011536388A
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English (en)
Japanese (ja)
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JP5850746B2 (ja
JP2012509062A (ja
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Priority claimed from PCT/US2009/063210 external-priority patent/WO2010056577A1/en
Publication of JP2012509062A publication Critical patent/JP2012509062A/ja
Publication of JP2012509062A5 publication Critical patent/JP2012509062A5/ja
Application granted granted Critical
Publication of JP5850746B2 publication Critical patent/JP5850746B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2011536388A 2008-11-17 2009-11-04 連結分子を用いた標的分子の粒子ベースの検出における方法および組成物 Expired - Fee Related JP5850746B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11539908P 2008-11-17 2008-11-17
US61/115,399 2008-11-17
PCT/US2009/063210 WO2010056577A1 (en) 2008-11-17 2009-11-04 Methods and compositions in particle-based detection of target molecules using linking molecules

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015153520A Division JP2016005472A (ja) 2008-11-17 2015-08-03 連結分子を用いた標的分子の粒子ベースの検出における方法および組成物

Publications (3)

Publication Number Publication Date
JP2012509062A JP2012509062A (ja) 2012-04-19
JP2012509062A5 true JP2012509062A5 (OSRAM) 2012-12-20
JP5850746B2 JP5850746B2 (ja) 2016-02-03

Family

ID=41510638

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2011536388A Expired - Fee Related JP5850746B2 (ja) 2008-11-17 2009-11-04 連結分子を用いた標的分子の粒子ベースの検出における方法および組成物
JP2015153520A Pending JP2016005472A (ja) 2008-11-17 2015-08-03 連結分子を用いた標的分子の粒子ベースの検出における方法および組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2015153520A Pending JP2016005472A (ja) 2008-11-17 2015-08-03 連結分子を用いた標的分子の粒子ベースの検出における方法および組成物

Country Status (4)

Country Link
US (1) US9150910B2 (OSRAM)
EP (1) EP2358897B1 (OSRAM)
JP (2) JP5850746B2 (OSRAM)
WO (1) WO2010056577A1 (OSRAM)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9469868B2 (en) 2008-11-17 2016-10-18 Headway Technologies, Inc. Methods and compositions in particle-based detection of target molecules using covalent bond forming reactive pairs
CN103476951B (zh) 2011-02-16 2017-07-28 海德威技术公司 用于可检测的标记的靶标定位锚定的方法和组合物
US10114015B2 (en) 2013-03-13 2018-10-30 Meso Scale Technologies, Llc. Assay methods
JP6408552B2 (ja) 2013-03-13 2018-10-17 メソ スケール テクノロジーズ エルエルシー 改善されたアッセイ方法
CN112239774B (zh) 2014-05-15 2024-12-03 中尺度技术有限责任公司 改进的测定方法
US10415080B2 (en) 2016-11-21 2019-09-17 Nanostring Technologies, Inc. Chemical compositions and methods of using same
KR20250171474A (ko) 2018-05-14 2025-12-08 브루커 스페이셜 바이올로지, 인크. 화학 조성물 및 이의 사용 방법
IT201800005685A1 (it) * 2018-05-24 2019-11-24 Kit e procedimento per la rivelazione colorimetrica di un acido nucleico bersaglio in un campione.
WO2020223368A1 (en) * 2019-04-29 2020-11-05 Nautilus Biotechnology, Inc. Methods and systems for integrated on-chip single-molecule detection
KR20220084272A (ko) * 2019-07-26 2022-06-21 익사카 프랑스 세포 표적화 및 라벨링에 사용하기 위한 항-cd3 압타머
CN114574484A (zh) * 2022-03-17 2022-06-03 中国科学院北京基因组研究所(国家生物信息中心) 核酸检测试剂及其应用

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599303A (en) * 1983-12-12 1986-07-08 Hri Associates, Inc. Nucleic acid hybridization assay employing probes crosslinkable to target sequences
US4826967A (en) 1987-06-16 1989-05-02 Naxcor Psoralen-nucleoside adducts and method for their preparation
US5124246A (en) 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
US5512439A (en) 1988-11-21 1996-04-30 Dynal As Oligonucleotide-linked magnetic particles and uses thereof
US5028594A (en) 1988-12-27 1991-07-02 Naxcor Use of photodynamic compositions for cytotoxic effects
US5196306A (en) 1989-03-29 1993-03-23 E. I. Du Pont De Nemours And Company Method for the detection or quantitation of an analyte using an analyte dependent enzyme activation system
ES2063347T3 (es) 1989-03-29 1995-01-01 Du Pont Deposicion catalizada de indicador.
US5082934A (en) 1989-04-05 1992-01-21 Naxcor Coumarin derivatives for use as nucleotide crosslinking reagents
US7223833B1 (en) 1991-05-24 2007-05-29 Isis Pharmaceuticals, Inc. Peptide nucleic acid conjugates
GB9301122D0 (en) * 1993-01-21 1993-03-10 Scient Generics Ltd Method of analysis/separation
US5616464A (en) 1994-12-27 1997-04-01 Naxcor Nucleic acid sequence detection employing amplification probes
US6277570B1 (en) 1993-04-13 2001-08-21 Naxcor Nucleic acid sequence detection employing probes comprising non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
US6495676B1 (en) 1993-04-13 2002-12-17 Naxcor Nucleic acid sequence detection employing probes comprising non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
US5767259A (en) 1994-12-27 1998-06-16 Naxcor Oligonucleotides containing base-free linking groups with photoactivatable side chains
ATE210128T1 (de) 1993-04-13 2001-12-15 Naxcor Nicht-nucleosidische cumarin-derivate als reagenzien zum crosslinking von polynucleotiden
US5681697A (en) 1993-12-08 1997-10-28 Chiron Corporation Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor
US5580731A (en) 1994-08-25 1996-12-03 Chiron Corporation N-4 modified pyrimidine deoxynucleotides and oligonucleotide probes synthesized therewith
WO1997016567A1 (en) * 1995-11-03 1997-05-09 Naxcor Double-stranded conformational polymorphism analysis
AU2253397A (en) * 1996-01-23 1997-08-20 Affymetrix, Inc. Nucleic acid analysis techniques
US6582921B2 (en) 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
US6506564B1 (en) * 1996-07-29 2003-01-14 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US5981297A (en) 1997-02-05 1999-11-09 The United States Of America As Represented By The Secretary Of The Navy Biosensor using magnetically-detected label
MXPA01001894A (es) 1998-08-21 2002-04-24 Naxcor Ensayos utilizando acidos nucleicos inmovilizados reticulables.
US6303799B1 (en) 1998-11-10 2001-10-16 Naxcor Polynucleotide crosslinking agents
US20020051971A1 (en) 1999-05-21 2002-05-02 John R. Stuelpnagel Use of microfluidic systems in the detection of target analytes using microsphere arrays
US6743639B1 (en) 1999-10-13 2004-06-01 Nve Corporation Magnetizable bead detector
US6875621B2 (en) 1999-10-13 2005-04-05 Nve Corporation Magnetizable bead detector
US6770441B2 (en) 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
US6573048B1 (en) 2000-04-18 2003-06-03 Naxcor Degradable nucleic acid probes and nucleic acid detection methods
JP2003535600A (ja) * 2000-06-02 2003-12-02 バイエル コーポレイション インサイチュ分枝ｄｎａハイブリダイゼーションを用いた高感度遺伝子検出および位置決定
AU2002339853A1 (en) 2001-05-24 2002-12-03 Genospectra, Inc. Pairs of nucleic acid probes with interactive signaling moieties and nucleic acid probes with enhanced hybridization efficiency and specificity
US20070184436A1 (en) 2001-06-07 2007-08-09 Joel Myerson Generic capture probe arrays
WO2003037829A2 (en) 2001-11-01 2003-05-08 Rensselaer Polytechnic Institute Solid-phase array-based biocatalytic transformations
US8043868B2 (en) 2001-12-21 2011-10-25 Imec Method and apparatus for detecting an analyte
EP1495139A4 (en) * 2002-03-29 2006-06-28 Genentech Inc METHODS AND COMPOSITIONS FOR DETECTING AND QUANTIFYING NUCLEIC ACID ANALYTES
AUPS159702A0 (en) 2002-04-09 2002-05-16 Tong, Sun Wing Molecular detection and assay by magneto-thermal biochip micro-assay
US6800768B1 (en) 2002-09-06 2004-10-05 Naxcor, Inc. Non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
JP4898119B2 (ja) 2002-11-22 2012-03-14 エフ．ホフマン−ラ ロシュ アーゲー 検出できるラベルされたヌクレオシド類似体及びその使用方法
CN1580283A (zh) * 2003-08-13 2005-02-16 清华大学 一种检测核酸分子的方法
US20070282015A1 (en) 2003-09-30 2007-12-06 Chiron Corporation Novel Splice Variants of Human Dkkl1
US7906345B2 (en) 2003-11-12 2011-03-15 The Board Of Trustees Of The Leland Stanford Junior University Magnetic nanoparticles, magnetic detector arrays, and methods for their use in detecting biological molecules
US7332355B2 (en) 2003-11-18 2008-02-19 California Institute Of Technology Method and compositions for the detection of protein glycosylation
WO2006096185A2 (en) 2004-03-25 2006-09-14 The Government Of The United States Of American, As Represented By The Secretary Of The Navy Reagentless and reusable biosensors with tunable differential binding affinites and methods of making
EP1834181A2 (en) 2004-12-30 2007-09-19 Perkinelmer Las, Inc. Particle-based multiplex assay system with three or more assay reporters
ES2381279T3 (es) * 2005-05-06 2012-05-24 Gen-Probe Incorporated Métodos y productos para la captura de ácido nucleico diana
DE602006020715D1 (de) * 2005-05-12 2011-04-28 Affymetrix Inc Multiplex-assays für verzweigtkettige dna
WO2006124711A1 (en) 2005-05-16 2006-11-23 The Board Of Trustees Of The University Of Illinois Composition and method for providing localized delivery of a therapeutic agent
EP2711434B1 (en) * 2005-06-20 2016-09-14 Advanced Cell Diagnostics, Inc. Multiplex detection of nucleic acids
JP2009500020A (ja) 2005-07-01 2009-01-08 バイオヴェリス コーポレイション 核酸を検出、増幅および／また単離するための組成物および方法
WO2007056250A2 (en) 2005-11-04 2007-05-18 U.S. Genomics, Inc. Heterogeneous assay of analytes in solution using polymers
JP2007189991A (ja) * 2006-01-20 2007-08-02 Nippon Meat Packers Inc 遺伝子の検出方法
US8114636B2 (en) 2006-02-10 2012-02-14 Life Technologies Corporation Labeling and detection of nucleic acids
HRP20110554T1 (hr) 2006-10-31 2011-09-30 Baseclick Gmbh "klik" kemija za proizvodnju reporter molekula
US8709727B2 (en) * 2007-09-17 2014-04-29 Mattias Strömberg Magnetic detection of small entities
US20090111709A1 (en) 2007-09-18 2009-04-30 Burke Thomas J Affinity Measurements Using Frameless Multiplexed Microarrays
US9863939B2 (en) 2007-09-20 2018-01-09 Magarray, Inc. Analyte detection with magnetic sensors
GB0804495D0 (en) 2008-03-11 2008-04-16 Iti Scotland Ltd Surface attachment
US9469868B2 (en) 2008-11-17 2016-10-18 Headway Technologies, Inc. Methods and compositions in particle-based detection of target molecules using covalent bond forming reactive pairs
CN103476951B (zh) 2011-02-16 2017-07-28 海德威技术公司 用于可检测的标记的靶标定位锚定的方法和组合物

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